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Research Center of Germplasm Resources Conservation and Utilization","award":["No. NJYT22104"],"award-info":[{"award-number":["No. NJYT22104"]}]},{"name":"Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization","award":["No. 2021BS03003"],"award-info":[{"award-number":["No. 2021BS03003"]}]},{"name":"Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization","award":["No. 21400-23269204"],"award-info":[{"award-number":["No. 21400-23269204"]}]},{"name":"Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization","award":["No. 2022LJRC0009"],"award-info":[{"award-number":["No. 2022LJRC0009"]}]},{"name":"Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and Utilization","award":["No. 21400-222526"],"award-info":[{"award-number":["No. 21400-222526"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Absent in melanoma 2 (AIM2), a key component of the IFI20X\/IFI16 (PYHIN) protein family, is characterized as a DNA sensor to detect cytosolic bacteria and DNA viruses. However, little is known about its immunological role during pathogenic Clostridium perfringens (C. perfringens) infection, an extracellular bacterial pathogen. In a pathogenic C. perfringens gas gangrene model, Aim2\u2212\/\u2212 mice are more susceptible to pathogenic C. perfringens soft tissue infection, revealing the importance of AIM2 in host protection. Notably, Aim2 deficiency leads to a defect in bacterial killing and clearance. Our in vivo and in vitro findings further establish that inflammasome signaling is impaired in the absence of Aim2 in response to pathogenic C. perfringens. Mechanistically, inflammasome signaling downstream of active AIM2 promotes pathogen control. Importantly, pathogenic C. perfringens-derived genomic DNA triggers inflammasome signaling activation in an AIM2-dependent manner. Thus, these observations uncover a central role for AIM2 in host defense and triggering innate immunity to combat pathogenic C. perfringens infections.<\/jats:p>","DOI":"10.3390\/ijms25126571","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:52:10Z","timestamp":1718355130000},"page":"6571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection"],"prefix":"10.3390","volume":"25","author":[{"given":"Zhaoguo","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Lou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aobo","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1134-1715","authenticated-orcid":false,"given":"Shuixing","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4103\/0255-0857.55443","article-title":"Genetic diversity among toxigenic clostridia isolated from soil, water, meat and associated polluted sites in South India","volume":"27","author":"Sathish","year":"2009","journal-title":"Indian J. 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