{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:44:39Z","timestamp":1790729079664,"version":"4.1.0"},"reference-count":123,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Innovation with FEDER funds","award":["PID2020-113430RB-I00"],"award-info":[{"award-number":["PID2020-113430RB-I00"]}]},{"name":"Spanish Ministry of Economy and Innovation with FEDER funds","award":["2021 SGR 554 00304"],"award-info":[{"award-number":["2021 SGR 554 00304"]}]},{"name":"Regional Catalonian Government","award":["PID2020-113430RB-I00"],"award-info":[{"award-number":["PID2020-113430RB-I00"]}]},{"name":"Regional Catalonian Government","award":["2021 SGR 554 00304"],"award-info":[{"award-number":["2021 SGR 554 00304"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Stroke is one of the leading causes of death. It not only affects adult people but also many children. It is estimated that, every year, 15 million people suffer a stroke worldwide. Among them, 5 million people die, while 5 million people are left permanently disabled. In this sense, the research to find new treatments should be accompanied with new therapies to combat neuronal death and to avoid developing cognitive impairment and dementia. Phytocannabinoids are among the compounds that have been used by mankind for the longest period of history. Their beneficial effects such as pain regulation or neuroprotection are widely known and make them possible therapeutic agents with high potential. These compounds bind cannabinoid receptors CB1 and CB2. Unfortunately, the psychoactive side effect has displaced them in the vast majority of areas. Thus, progress in the research and development of new compounds that show efficiency as neuroprotectors without this psychoactive effect is essential. On the one hand, these compounds could selectively bind the CB2 receptor that does not show psychoactive effects and, in glia, has opened new avenues in this field of research, shedding new light on the use of cannabinoid receptors as therapeutic targets to combat neurodegenerative diseases such as Alzheimer\u2019s, Parkinson\u2019s disease, or stroke. On the other hand, a new possibility lies in the formation of heteromers containing cannabinoid receptors. Heteromers are new functional units that show new properties compared to the individual protomers. Thus, they represent a new possibility that may offer the beneficial effects of cannabinoids devoid of the unwanted psychoactive effect. Nowadays, the approval of a mixture of CBD (cannabidiol) and \u03949-THC (tetrahydrocannabinol) to treat the neuropathic pain and spasticity in multiple sclerosis or purified cannabidiol to combat pediatric epilepsy have opened new therapeutic possibilities in the field of cannabinoids and returned these compounds to the front line of research to treat pathologies as relevant as stroke.<\/jats:p>","DOI":"10.3390\/ijms25126708","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T03:46:29Z","timestamp":1718855189000},"page":"6708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Potential of CBD Acting on Cannabinoid Receptors CB1 and CB2 in Ischemic Stroke"],"prefix":"10.3390","volume":"25","author":[{"given":"Iu","family":"Ra\u00efch","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Rivas-Santisteban","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron 171, 08035 Barcelona, Spain"},{"name":"Department of Biochemistry and Molecular Biomedicine, School of Biology, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-1550","authenticated-orcid":false,"given":"Joan Biel","family":"Rebassa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron 171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Cap\u00f3","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron 171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Santandreu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-0873","authenticated-orcid":false,"given":"Gemma","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain"},{"name":"Institute of Neuroscience, University of Barcelona (NeuroUB), Campus Mundet, Passeig de la Vall d\u2019Hebron 171, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0140-6736(98)90086-1","article-title":"Epidemiology of Stroke","volume":"352","author":"Warlow","year":"1998","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.neuropharm.2008.01.005","article-title":"Mechanisms of Ischemic Brain Damage","volume":"55","author":"Doyle","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12975-023-01126-8","article-title":"Collateral Flow: Prolonging the Ischemic Penumbra","volume":"14","author":"Dhar","year":"2023","journal-title":"Transl. Stroke Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100029","DOI":"10.1016\/j.dscb.2021.100029","article-title":"Brain Disorders Molecular Mechanisms of Oxidative Stress in Stroke and Cancer","volume":"5","author":"Chavda","year":"2022","journal-title":"Brain Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/STROKEAHA.121.036948","article-title":"Stroke Neuroinflammation, Stem Cells, and Stroke","volume":"53","author":"Anthony","year":"2022","journal-title":"Stroke"},{"key":"ref_6","first-page":"1","article-title":"Signaling Pathways Involved in Ischemic Stroke: Molecular Mechanisms and Therapeutic Interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000525220","article-title":"Forty Years of Descriptive Epidemiology of Stroke","volume":"56","year":"2022","journal-title":"Neuroepidemiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-Stroke Cognitive Impairment and Dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-510X(99)00299-3","article-title":"Heparin and Oral Anticoagulants in the Treatment of Brain Ischemia","volume":"173","author":"Chaves","year":"2000","journal-title":"J. Neurol. Sci."},{"key":"ref_10","first-page":"553","article-title":"Cannabinoids and the Cannabinoid Receptors: An Overview","volume":"58","author":"Lu","year":"2017","journal-title":"Handb. Cannabis Relat. Pathol. Biol. Pharmacol. Diagn. Treat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.03.006","article-title":"Expression of the Endocannabinoid Receptor 1 in Human Stroke: An Autoptic Study","volume":"25","author":"Caruso","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_12","first-page":"2631","article-title":"Neuroprotective Effect of Endogenous Cannabinoids on Ischemic Brain Injury Induced by the Excess Microglia-Mediated Inflammation","volume":"8","author":"Guo","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.18869\/nirp.bcn.8.2.139","article-title":"Correlation Between Cannabidiol-Induced Reduction of Infarct Volume and Inflammatory Factors Expression in Ischemic Stroke Model","volume":"8","author":"Khaksar","year":"2017","journal-title":"Basic Clin. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s13311-015-0381-7","article-title":"Cannabinoids in Neurodegenerative Disorders and Stroke\/Brain Trauma: From Preclinical Models to Clinical Applications","volume":"12","author":"Moro","year":"2015","journal-title":"Neurotherapeutics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1139\/Y05-143","article-title":"Microglia in Cerebral Ischemia: Molecular Actions and InteractionsThis Paper Is One of a Selection of Papers Published in This Special Issue, Entitled Young Investigator\u2019s Forum","volume":"84","author":"Lai","year":"2006","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"806417","DOI":"10.3389\/fphar.2021.806417","article-title":"The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation","volume":"12","author":"Young","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/glia.24172","article-title":"Endocannabinoid Signaling in Brain Diseases: Emerging Relevance of Glial Cells","volume":"71","author":"Tepavcevic","year":"2023","journal-title":"Glia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/jnnp.2004.042382","article-title":"Recurrent Stroke Associated with Cannabis Use","volume":"76","author":"Mateo","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Tsatsakis, A., Docea, A.O., Calina, D., Tsarouhas, K., Zamfira, L.M., Mitrut, R., Sharifi-Rad, J., Kovatsi, L., Siokas, V., and Dardiotis, E. (2019). A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091295"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/biof.1294","article-title":"Differential Effects of Endogenous, Phyto and Synthetic Cannabinoids on Thrombogenesis and Platelet Activity","volume":"42","author":"Grambow","year":"2016","journal-title":"BioFactors"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1161\/STROKEAHA.118.023587","article-title":"Cannabis and Cannabinoid Biology in Stroke","volume":"50","author":"Choi","year":"2019","journal-title":"Stroke"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.yebeh.2017.01.031","article-title":"Strokes Are Possible Complications of Cannabinoids Use","volume":"70","author":"Wolff","year":"2017","journal-title":"Epilepsy Behav."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1111\/j.1742-4658.2007.05975.x","article-title":"Modulation of the Endocannabinoid System by Focal Brain Ischemia in the Rat Is Involved in Neuroprotection Afforded by 17\u03b2-Estradiol","volume":"274","author":"Amantea","year":"2007","journal-title":"FEBS J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neuroscience.2004.08.044","article-title":"Anandamide Content Is Increased and CB1 Cannabinoid Receptor Blockade Is Protective during Transient, Focal Cerebral Ischemia","volume":"129","author":"Muthian","year":"2004","journal-title":"Neuroscience"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-psych-113011-143739","article-title":"The Endocannabinoid System and the Brain","volume":"64","author":"Mechoulam","year":"2013","journal-title":"Annu. Rev. Psychol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1089\/can.2015.0005","article-title":"Allosteric Modulators of the CB 1 Cannabinoid Receptor: A Structural Update Review","volume":"1","author":"Morales","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41589-022-01038-y","article-title":"Molecular Mechanism of Allosteric Modulation for the Cannabinoid Receptor CB1","volume":"18","author":"Yang","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00019.2008","article-title":"Endocannabinoid-Mediated Control of Synaptic Transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev-neuro-062111-150420","article-title":"Multiple Functions of Endocannabinoid Signaling in the Brain","volume":"35","author":"Katona","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The Molecular Logic of Endocannabinoid Signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/jnc.13288","article-title":"Cannabinoid Receptor Type 1 Agonist ACEA Improves Motor Recovery and Protects Neurons in Ischemic Stroke in Mice","volume":"135","author":"Caltana","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroscience.2012.09.080","article-title":"Cannabinoid Receptor Subtypes 1 and 2 Mediate Long-Lasting Neuroprotection and Improve Motor Behavior Deficits after Transient Focal Cerebral Ischemia","volume":"227","author":"Schmidt","year":"2012","journal-title":"Neuroscience"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/jcbfm.2010.134","article-title":"Ascl1 Lineage Cells Contribute to Ischemia-Induced Neurogenesis and Oligodendrogenesis","volume":"31","author":"Zhang","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2006.12.022","article-title":"High-Cholesterol Feeding Aggravates Cerebral Infarction via Decreasing the CB1 Receptor","volume":"414","author":"Hayakawa","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00401-006-0110-8","article-title":"Neuroprotective Cannabinoid Receptor Antagonist SR141716A Prevents Downregulation of Excitotoxic NMDA Receptors in the Ischemic Penumbra","volume":"112","author":"Sommer","year":"2006","journal-title":"Acta Neuropathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neulet.2016.07.041","article-title":"The CB1 Antagonist, SR141716A, Is Protective in Permanent Photothrombotic Cerebral Ischemia","volume":"630","author":"Reichenbach","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pnpbp.2015.10.010","article-title":"Endocannabinoid CB1 Receptor Activation upon Global Ischemia Adversely Impact Recovery of Reward and Stress Signaling Molecules, Neuronal Survival and Behavioral Impulsivity","volume":"66","author":"Knowles","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1523\/JNEUROSCI.22-22-09771.2002","article-title":"Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-out Mice","volume":"22","author":"Jin","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.neuropharm.2006.12.003","article-title":"Cannabinoid Modulation of Neuronal Function after Oxygen\/Glucose Deprivation in Area CA1 of the Rat Hippocampus","volume":"52","author":"Youssef","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1523\/JNEUROSCI.21-17-06475.2001","article-title":"Neuroprotection by Delta9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced in Vivo Excitotoxicity","volume":"21","author":"Veldhuis","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s12017-014-8314-x","article-title":"Functions of the CB1 and CB2 Receptors in Neuroprotection at the Level of the Blood\u2013Brain Barrier","volume":"16","author":"Vendel","year":"2014","journal-title":"NeuroMolecular Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Eskla, K.L., Vellama, H., Tarve, L., Eichelmann, H., Jagom\u00e4e, T., Porosk, R., Oja, V., R\u00e4mma, H., Peet, N., and Laisk, A. (2022). Hypothermia Alleviates Reductive Stress, a Root Cause of Ischemia Reperfusion Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231710108"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.2174\/138161208785740054","article-title":"Role of Cannabinoids and Endocannabinoids in Cerebral Ischemia","volume":"14","author":"Hillard","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.bjp.0707261","article-title":"Cannabinoids as Therapeutic Agents in Cardiovascular Disease: A Tale of Passions and Illusions","volume":"151","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1210\/en.2004-0638","article-title":"Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis","volume":"145","author":"Patel","year":"2004","journal-title":"Endocrinology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4155\/ppa-2021-0002","article-title":"Cannabinoid Receptor Type 2 Ligands: An Analysis of Granted Patents since 2010","volume":"10","author":"Brennecke","year":"2021","journal-title":"Pharm. Pat. Anal."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/ACO.0000000000000616","article-title":"An Overview of the Cannabinoid Type 2 Receptor System and Its Therapeutic Potential","volume":"31","author":"Bie","year":"2018","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.tips.2022.06.010","article-title":"Developing the Cannabinoid Receptor 2 (CB2) Pharmacopoeia: Past, Present, and Future","volume":"43","author":"Whiting","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"852631","DOI":"10.3389\/fphar.2022.852631","article-title":"The Binding Mode to Orthosteric Sites and\/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors","volume":"13","author":"Franco","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.31887\/DCNS.2020.22.3\/blutz","article-title":"Neurobiology of Cannabinoid Receptor Signaling","volume":"22","author":"Lutz","year":"2020","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fneur.2020.00087","article-title":"Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology","volume":"11","author":"Tanaka","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zou, S., and Kumar, U. (2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030833"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"174398","DOI":"10.1016\/j.ejphar.2021.174398","article-title":"Pharmacological Potential of JWH133, a Cannabinoid Type 2 Receptor Agonist in Neurodegenerative, Neurodevelopmental and Neuropsychiatric Diseases","volume":"909","author":"Hashiesh","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/STROKEAHA.111.631044","article-title":"Cannabinoid Type 2 Receptor Activation Downregulates Stroke-Induced Classic and Alternative Brain Macrophage\/Microglial Activation Concomitant to Neuroprotection","volume":"43","author":"Zarruk","year":"2012","journal-title":"Stroke"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/STROKEAHA.116.014793","article-title":"Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome after Stroke","volume":"48","author":"Cuartero","year":"2017","journal-title":"Stroke"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Yu, S.-J., Reiner, D., Shen, H., Wu, K.-J., Liu, Q.-R., and Wang, Y. (2015). Time-Dependent Protection of CB2 Receptor Agonist in Stroke. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132487"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1479-5876-7-97","article-title":"Inflammatory Mechanisms in Ischemic Stroke: Therapeutic Approaches","volume":"7","author":"Lakhan","year":"2009","journal-title":"J. Transl. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/14728222.2021.1971196","article-title":"The CB2 Cannabinoid Receptor as a Therapeutic Target in the Central Nervous System","volume":"25","author":"Maldonado","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1007\/s00018-016-2300-4","article-title":"The CB2 Receptor and Its Role as a Regulator of Inflammation","volume":"73","author":"Turcotte","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbi.2017.10.021","article-title":"Selective Activation of Cannabinoid Receptor-2 Reduces Neuroinflammation after Traumatic Brain Injury via Alternative Macrophage Polarization","volume":"68","author":"Braun","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1096\/fj.09-141275","article-title":"Activation of Cannabinoid 2 Receptors Protects against Cerebral Ischemia by Inhibiting Neutrophil Recruitment","volume":"24","author":"Murikinati","year":"2010","journal-title":"FASEB J."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lillo, J., Ra\u00efch, I., Silva, L., Zafra, D.A., Lillo, A., Ferreiro-Vera, C., S\u00e1nchez de Medina, V., Mart\u00ednez-Orgado, J., Franco, R., and Navarro, G. (2022). Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen\/Glucose-Deprived Neurons. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179695"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuropharm.2019.02.004","article-title":"Increased Expression of Cannabinoid CB2 and Serotonin 5-HT1A Heteroreceptor Complexes in a Model of Newborn Hypoxic-Ischemic Brain Damage","volume":"152","author":"Franco","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e00682","DOI":"10.1002\/prp2.682","article-title":"Diversity of Molecular Targets and Signaling Pathways for CBD","volume":"8","author":"Devi","year":"2020","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3389\/fphar.2017.00744","article-title":"Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2receptors","volume":"8","author":"Varani","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bcp.2018.08.046","article-title":"Cannabidiol Skews Biased Agonism at Cannabinoid CB1 and CB2 Receptors with Smaller Effect in CB1-CB2 Heteroreceptor Complexes","volume":"157","author":"Navarro","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"611278","DOI":"10.3389\/fnbeh.2020.611278","article-title":"Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy","volume":"14","author":"Velasco","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/jcbfm.2014.218","article-title":"Cannabinoids in Experimental Stroke: A Systematic Review and Meta-Analysis","volume":"35","author":"England","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.STR.0000163083.59201.34","article-title":"Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine 1A Receptor\u2013Dependent Mechanism","volume":"36","author":"Mishima","year":"2005","journal-title":"Stroke"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11011-018-0366-4","article-title":"Serotonin 5-HT1A Receptors Modulate Depression-Related Symptoms Following Mild Traumatic Brain Injury in Male Adult Mice","volume":"34","author":"Shokouhi","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1203\/PDR.0b013e3182276b11","article-title":"Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs","volume":"70","author":"Lafuente","year":"2011","journal-title":"Pediatr. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuropharm.2013.03.027","article-title":"Mechanisms of Cannabidiol Neuroprotection in Hypoxic\u2013Ischemic Newborn Pigs: Role of 5HT1A and CB2 Receptors","volume":"71","author":"Pazos","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/glia.23694","article-title":"Potentiation of Cannabinoid Signaling in Microglia by Adenosine A2A Receptor Antagonists","volume":"67","author":"Franco","year":"2019","journal-title":"Glia"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2017.08.015","article-title":"Receptor-Heteromer Mediated Regulation of Endocannabinoid Signaling in Activated Microglia. Role of CB1 and CB2 Receptors and Relevance for Alzheimer\u2019s Disease and Levodopa-Induced Dyskinesia","volume":"67","author":"Navarro","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","article-title":"High-Level Neuronal Expression of Abeta 1-42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation","volume":"20","author":"Mucke","year":"2000","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.expneurol.2014.08.019","article-title":"Angiotensin Type 1 Receptor Blockage Reduces L-Dopa-Induced Dyskinesia in the 6-OHDA Model of Parkinson\u2019s Disease. Involvement of Vascular Endothelial Growth Factor and Interleukin-1\u03b2","volume":"261","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1750-3639.2003.tb00475.x","article-title":"A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation","volume":"13","author":"Angulo","year":"2003","journal-title":"Brain Pathol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.neurobiolaging.2012.06.005","article-title":"CB2 Receptor and Amyloid Pathology in Frontal Cortex of Alzheimer\u2019s Disease Patients","volume":"34","author":"Solas","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/WNF.0000000000000073","article-title":"Japanese Istradefylline Study Group A Long-Term Study of Istradefylline Safety and Efficacy in Patients with Parkinson Disease","volume":"38","author":"Kondo","year":"2015","journal-title":"Clin. Neuropharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/mds.25418","article-title":"Japanese Istradefylline Study Group Adenosine A2A Receptor Antagonist Istradefylline Reduces Daily OFF Time in Parkinson\u2019s Disease","volume":"28","author":"Mizuno","year":"2013","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-57369-0_1","article-title":"Constituents of Cannabis Sativa","volume":"1264","author":"Rock","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_82","unstructured":"Expert Committee on Drug Dependence, WHO (2018). CANNABIDIOL (CBD) Critical Review Report, WHO."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"104801","DOI":"10.1016\/j.phrs.2020.104801","article-title":"Pharmacological Potential of Varinic-, Minor-, and Acidic Phytocannabinoids","volume":"158","author":"Franco","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1111\/bph.13250","article-title":"Cannabidiol Is a Negative Allosteric Modulator of the Cannabinoid CB1 Receptor","volume":"172","author":"Laprairie","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.1476-5381.2010.01166.x","article-title":"Effects of Cannabinoids and Cannabinoid-Enriched Cannabis Extracts on TRP Channels and Endocannabinoid Metabolic Enzymes","volume":"163","author":"Ligresti","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.nbd.2009.10.023","article-title":"The Neuroprotective Effect of Cannabidiol in an in Vitro Model of Newborn Hypoxic-Ischemic Brain Damage in Mice Is Mediated by CB2 and Adenosine Receptors","volume":"37","author":"Castillo","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s11064-005-6978-1","article-title":"Agonistic Properties of Cannabidiol at 5-HT1a Receptors","volume":"30","author":"Russo","year":"2005","journal-title":"Neurochem. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjp.0704327","article-title":"Molecular Targets for Cannabidiol and Its Synthetic Analogues: Effect on Vanilloid VR1 Receptors and on the Cellular Uptake and Enzymatic Hydrolysis of Anandamide","volume":"134","author":"Bisogno","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2337\/dc16-0650","article-title":"Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study","volume":"39","author":"Jadoon","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e920","DOI":"10.1038\/tp.2016.195","article-title":"Cannabidiol Is a Partial Agonist at Dopamine D2High Receptors, Predicting Its Antipsychotic Clinical Dose","volume":"6","author":"Seeman","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.bbrc.2020.10.021","article-title":"Involvement of Dopamine Receptor in the Actions of Non-Psychoactive Phytocannabinoids","volume":"533","author":"Shrader","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tips.2008.12.004","article-title":"The Enigmatic Pharmacology of GPR55","volume":"30","author":"Ross","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00210-006-0033-x","article-title":"Cannabidiol Is an Allosteric Modulator at Mu- and Delta-Opioid Receptors","volume":"372","author":"Kathmann","year":"2006","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/adb.12495","article-title":"Cannabidiol Reduces Ethanol Consumption, Motivation and Relapse in Mice","volume":"23","author":"Navarrete","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.taap.2019.02.011","article-title":"DMH-CBD, a Cannabidiol Analog with Reduced Cytotoxicity, Inhibits TNF Production by Targeting NF-KB Activity Dependent on A2A Receptor","volume":"368","author":"Silva","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"147586","DOI":"10.1016\/j.brainres.2021.147586","article-title":"Effects of Cannabinoid (CBD) on Blood Brain Barrier Permeability after Brain Injury in Rats","volume":"1768","author":"Jiang","year":"2021","journal-title":"Brain Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Calapai, F., Cardia, L., Sorbara, E.E., Navarra, M., Gangemi, S., Calapai, G., and Mannucci, C. (2020). Cannabinoids, Blood\u2013Brain Barrier, and Brain Disposition. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12030265"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"11286","DOI":"10.1038\/s41598-022-15134-5","article-title":"Effects of Chronic Cannabidiol in a Mouse Model of Naturally Occurring Neuroinflammation, Neurodegeneration, and Spontaneous Seizures","volume":"12","author":"Dearborn","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2016.01.033","article-title":"Cannabidiol, Neuroprotection and Neuropsychiatric Disorders","volume":"112","author":"Campos","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1478-811X-8-12","article-title":"Cannabinoid Receptor CB1 Mediates Baseline and Activity-Induced Survival of New Neurons in Adult Hippocampal Neurogenesis","volume":"8","author":"Wolf","year":"2010","journal-title":"Cell Commun. Signal."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.npp.1300340","article-title":"Effects of Cannabidiol (CBD) on Regional Cerebral Blood Flow","volume":"29","author":"Crippa","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/epi.14629","article-title":"Cannabidiol Reduces Seizures and Associated Behavioral Comorbidities in a Range of Animal Seizure and Epilepsy Models","volume":"60","author":"Patra","year":"2019","journal-title":"Epilepsia"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Santiago-Casta\u00f1eda, C., Huerta de la Cruz, S., Mart\u00ednez-Aguirre, C., Orozco-Su\u00e1rez, S.A., and Rocha, L. (2022). Cannabidiol Reduces Short- and Long-Term High Glutamate Release after Severe Traumatic Brain Injury and Improves Functional Recovery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081609"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1007\/s12035-018-1143-4","article-title":"Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex","volume":"56","author":"Sales","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/can.2020.0109","article-title":"Cannabidiol-Driven Alterations to Inflammatory Protein Landscape of Lipopolysaccharide-Activated Macrophages In Vitro May Be Mediated by Autophagy and Oxidative Stress","volume":"6","author":"Yeisley","year":"2021","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Atalay, S., Jarocka-Karpowicz, I., and Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants, 9.","DOI":"10.3390\/antiox9010021"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphar.2019.00352","article-title":"Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain Injury","volume":"10","author":"Belardo","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(03)00569-X","article-title":"Post-Ischemic Treatment with Cannabidiol Prevents Electroencephalographic Flattening, Hyperlocomotion and Neuronal Injury in Gerbils","volume":"346","author":"Braida","year":"2003","journal-title":"Neurosci. Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuropharm.2016.12.017","article-title":"Cannabidiol Reduces Brain Damage and Improves Functional Recovery in a Neonatal Rat Model of Arterial Ischemic Stroke","volume":"116","author":"Vargas","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.brainresbull.2022.01.001","article-title":"Antioxidant and Anti-Apoptotic Effects of Cannabidiol in Model of Ischemic Stroke in Rats","volume":"180","author":"Khaksar","year":"2022","journal-title":"Brain Res. Bull."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13019-023-02476-y","article-title":"Research Progress in the Management of Vascular Disease with Cannabidiol: A Review","volume":"19","author":"Guo","year":"2024","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/can.2016.0034","article-title":"An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies","volume":"2","author":"Iffland","year":"2017","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/157488611798280924","article-title":"Safety and Side Effects of Cannabidiol, a Cannabis Sativa Constituent","volume":"6","author":"Alexandre","year":"2011","journal-title":"Curr. Drug Saf."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1474-4422(15)00379-8","article-title":"Cannabidiol in Patients with Treatment-Resistant Epilepsy: An Open-Label Interventional Trial","volume":"15","author":"Devinsky","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.yebeh.2016.11.012","article-title":"Cannabinoids in Treatment-Resistant Epilepsy: A Review","volume":"70","author":"Gloss","year":"2017","journal-title":"Epilepsy Behav."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.seizure.2016.01.004","article-title":"CBD-Enriched Medical Cannabis for Intractable Pediatric Epilepsy","volume":"35","author":"Tzadok","year":"2016","journal-title":"Seizure"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1172\/JCI89354","article-title":"Astrocytic Calcium Release Mediates Peri-Infarct Depolarizations in a Rodent Stroke Model","volume":"127","author":"Rakers","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Meyer, E., Rieder, P., Gobbo, D., Candido, G., Scheller, A., de Oliveira, R.M.W., and Kirchhoff, F. (2022). Cannabidiol Exerts a Neuroprotective and Glia-Balancing Effect in the Subacute Phase of Stroke. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112886"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lana, D., Landucci, E., Mazzantini, C., Magni, G., Pellegrini-Giampietro, D.E., and Giovannini, M.G. (2022). The Protective Effect of CBD in a Model of In Vitro Ischemia May Be Mediated by Agonism on TRPV2 Channel and Microglia Activation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012144"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"584533","DOI":"10.3389\/fphar.2020.584533","article-title":"Cannabidiol for the Treatment of Neonatal Hypoxic-Ischemic Brain Injury","volume":"11","author":"Villa","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2018.11.020","article-title":"Neuroprotection by Cannabidiol and Hypothermia in a Piglet Model of Newborn Hypoxic-Ischemic Brain Damage","volume":"146","author":"Barata","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bmc.2015.01.059","article-title":"Cannabidiol (CBD) and Its Analogs: A Review of Their Effects on Inflammation","volume":"23","author":"Burstein","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fnins.2016.00323","article-title":"Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia","volume":"10","author":"Lafuente","year":"2016","journal-title":"Front. Neurosci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:00:39Z","timestamp":1760108439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":123,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25126708"],"URL":"https:\/\/doi.org\/10.3390\/ijms25126708","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]}}}