{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:53:10Z","timestamp":1789678390747,"version":"4.0.1"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of the Principality of Asturias","award":["(PA-21-PF-BP20-122)"],"award-info":[{"award-number":["(PA-21-PF-BP20-122)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Krause\u2019s corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part of the cationic ion channels required for mechanosensitivity in mammalian cells. They are involved in somatosensitivity, especially in the different qualities of touch, but also in pain and proprioception. In the present study, immunohistochemistry and immunofluorescence were used to analyze the occurrence and cellular location of PIEZO1 and PIEZO2 in human clitoral Krause\u2019s corpuscles. Both PIEZO1 and PIEZO2 were detected in Krause\u2019s corpuscles in both the axon and the terminal glial cells. The presence of PIEZOs in the terminal glial cells of Kraus\u2019s corpuscles is reported here for the first time. Based on the distribution of PIEZO1 and PIEZO2, it may be assumed they could be involved in mechanical stimuli, sexual behavior, and sexual pleasure.<\/jats:p>","DOI":"10.3390\/ijms25126722","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T03:46:29Z","timestamp":1718855189000},"page":"6722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause\u2019s Corpuscles"],"prefix":"10.3390","volume":"25","author":[{"given":"Patricia","family":"Cuendias","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia, Santiago de Chile 4810010, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-1632","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Suazo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia, Santiago de Chile 4810010, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Cobo","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda, Hospital Universitario \u201cMarqu\u00e9s de Valdecilla\u201d, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-6653","authenticated-orcid":false,"given":"Jorge","family":"Garc\u00eda-Piqueras","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"},{"name":"Departamento de Anatom\u00eda, Histolog\u00eda y Neurociencia, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-1095","authenticated-orcid":false,"given":"Yolanda","family":"Garc\u00eda-Mesa","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cobo, R., Garc\u00eda-Piqueras, J., Cobo, J., and Vega, J.A. 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