{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:41:01Z","timestamp":1780544461185,"version":"3.54.1"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jeonnam Technopark","award":["J0122029-05"],"award-info":[{"award-number":["J0122029-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The decline in the function and mass of skeletal muscle during aging or other pathological conditions increases the incidence of aging-related secondary diseases, ultimately contributing to a decreased lifespan and quality of life. Much effort has been made to surmise the molecular mechanisms underlying muscle atrophy and develop tools for improving muscle function. Enhancing mitochondrial function is considered critical for increasing muscle function and health. This study is aimed at evaluating the effect of an aqueous extract of Gloiopeltis tenax (GTAE) on myogenesis and muscle atrophy caused by dexamethasone (DEX). The GTAE promoted myogenic differentiation, accompanied by an increase in peroxisome proliferator-activated receptor \u03b3 coactivator \u03b1 (PGC-1\u03b1) expression and mitochondrial content in myoblast cell culture. In addition, the GTAE alleviated the DEX-mediated myotube atrophy that is attributable to the Akt-mediated inhibition of the Atrogin\/MuRF1 pathway. Furthermore, an in vivo study using a DEX-induced muscle atrophy mouse model demonstrated the efficacy of GTAE in protecting muscles from atrophy and enhancing mitochondrial biogenesis and function, even under conditions of atrophy. Taken together, this study suggests that the GTAE shows propitious potential as a nutraceutical for enhancing muscle function and preventing muscle wasting.<\/jats:p>","DOI":"10.3390\/ijms25126806","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:44:49Z","timestamp":1718941489000},"page":"6806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Extract of Gloiopeltis tenax Enhances Myogenesis and Alleviates Dexamethasone-Induced Muscle Atrophy"],"prefix":"10.3390","volume":"25","author":[{"given":"Si-Hyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Eun","family":"Leem","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratories of Marine New Drugs, Redone Technologies Co., Ltd., Jangseong-gun 57247, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-In","family":"Jeong","sequence":"additional","affiliation":[{"name":"Laboratories of Marine New Drugs, Redone Technologies Co., Ltd., Jangseong-gun 57247, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8176-0658","authenticated-orcid":false,"given":"Jihye","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratories of Marine New Drugs, Redone Technologies Co., Ltd., Jangseong-gun 57247, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Sun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stellavato, A., Abate, L., Vassallo, V., Donniacuo, M., Rinaldi, B., and Schiraldi, C. (2020). An in vitro study to assess the effect of hyaluronan-based gels on muscle-derived cells: Highlighting a new perspective in regenerative medicine. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0236164"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105807","DOI":"10.1016\/j.phrs.2021.105807","article-title":"Skeletal muscle atrophy: From mechanisms to treatments","volume":"172","author":"Yin","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/BOR.0b013e328358d59b","article-title":"Sarcopenia in older adults","volume":"24","author":"Walston","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_4","first-page":"177","article-title":"Clinical definition of sarcopenia","volume":"11","author":"Santilli","year":"2014","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Meng, S.J., and Yu, L.J. (2010). Oxidative stress, molecular inflammation and sarcopenia. Int. J. Mol. Sci., 11.","DOI":"10.3390\/ijms11041509"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1249\/JES.0000000000000101","article-title":"Mitochondria initiate and regulate sarcopenia","volume":"45","author":"Alway","year":"2017","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1113\/JP278761","article-title":"Mimicking exercise: What matters most and where to next?","volume":"599","author":"Hawley","year":"2021","journal-title":"J. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cmet.2016.10.022","article-title":"Exercise Mimetics: Impact on health and performance","volume":"25","author":"Fan","year":"2017","journal-title":"Cell Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"194821","DOI":"10.1155\/2012\/194821","article-title":"Skeletal muscle mitochondria and aging: A review","volume":"2012","author":"Peterson","year":"2012","journal-title":"J. Aging Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1474-9726.2007.00347.x","article-title":"Mitochondrial function and apoptotic susceptibility in aging skeletal muscle","volume":"7","author":"Chabi","year":"2008","journal-title":"Aging Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/cvr\/cvn098","article-title":"Transcriptional control of mitochondrial biogenesis: The central role of PGC-1 alpha","volume":"79","author":"Garnier","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.3390\/md10122634","article-title":"Chemical composition and antioxidant\/antimicrobial activities in supercritical carbon dioxide fluid extract of Gloiopeltis tenax","volume":"10","author":"Zheng","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1089\/jmf.2007.0688","article-title":"Purification, structural characterization, and antioxidant activity of antioxidant substance from the red seaweed Gloiopeltis tenax","volume":"12","author":"Lim","year":"2009","journal-title":"J. Med. Food"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1055\/s-2006-958029","article-title":"The effects of an algal polysaccharide from Gloiopeltis tenax on transplantable tumors and immune activities in mice","volume":"61","author":"Ren","year":"1995","journal-title":"Planta Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1039\/c0cc01487g","article-title":"Efficient and chemoselective alkylation of amines\/amino acids using alcohols as alkylating reagents under mild conditions","volume":"46","author":"Xu","year":"2010","journal-title":"Chem. Commun"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13568-016-0244-6","article-title":"Floridoside production by the red microalga Galdieria sulphuraria under different conditions of growth and osmotic stress","volume":"6","year":"2016","journal-title":"AMB Express"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ngoennet, S., Nishikawa, Y., Hibino, T., Waditee-Sirisattha, R., and Kageyama, H. (2018). A method for the isolation and characterization of mycosporine-like amino acids from cyanobacteria. Methods Protoc., 1.","DOI":"10.3390\/mps1040046"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/nure.12091","article-title":"Seaweed and human health","volume":"72","author":"Brown","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Collins, K.G., Fitzgerald, G.F., Stanton, C., and Ross, R.P. (2016). Looking beyond the terrestrial: The potential of seaweed derived bioactives to treat non-communicable diseases. Mar. Drugs, 14.","DOI":"10.3390\/md14030060"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lomartire, S., and Goncalves, A.M.M. (2022). An overview of potential seaweed-derived bioactive compounds for pharmaceutical applications. Mar. Drugs, 20.","DOI":"10.3390\/md20020141"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/B978-0-12-387669-0.00024-7","article-title":"Seaweed proteins and amino acids as nutraceuticals","volume":"64","author":"Cerna","year":"2011","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/fsn3.3100","article-title":"The anti-obesity and anti-diabetic effects of the edible seaweed Gloiopeltis furcata (Postels et Ruprecht) J. Agardh in mice fed a high-fat diet","volume":"11","author":"Murakami","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"115482","DOI":"10.1016\/j.carbpol.2019.115482","article-title":"Anti-diabetic activities of agaropectin-derived oligosaccharides from Gloiopeltis furcata via regulation of mitochondrial function","volume":"229","author":"Wang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1039\/C5FO00668F","article-title":"Induction of the superoxide anion radical scavenging capacity of dried \u2018funori\u2019 Gloiopeltis furcata by Lactobacillus plantarum S-SU1 fermentation","volume":"6","author":"Kuda","year":"2015","journal-title":"Food Funct."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1248\/cpb.58.1236","article-title":"Anticholinesterase and antioxidant constituents from Gloiopeltis furcata","volume":"58","author":"Fang","year":"2010","journal-title":"Chem. Pharm. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ptr.2020","article-title":"Methanol extract of the seaweed Gloiopeltis furcata induces G2\/M arrest and inhibits cyclooxygenase-2 activity in human hepatocarcinoma HepG2 cells","volume":"21","author":"Bae","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sutikno, L.A., Lee, G.H., Harwanto, D., Choi, J.S., and Hong, Y.K. (2019). The ethanol extract from the rhodophyta Gloiopeltis furcata and its active ingredient docosahexaenoic acid improve exercise performance in mice. J. Food Biochem., 43.","DOI":"10.1111\/jfbc.12980"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/978-94-024-1079-2_88","article-title":"The taurine content of Japanese seaweed","volume":"975","author":"Kawasaki","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Merckx, C., and De Paepe, B. (2022). The role of taurine in skeletal muscle functioning and its potential as a supportive treatment for duchenne muscular dystrophy. Metabolites, 12.","DOI":"10.3390\/metabo12020193"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"dmm050540","DOI":"10.1242\/dmm.050540","article-title":"Taurine activates the AKT-mTOR axis to restore muscle mass and contractile strength in human 3D in vitro models of steroid myopathy","volume":"17","author":"Mughal","year":"2024","journal-title":"Dis. Model. Mech."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1139\/apnm-2020-0005","article-title":"PGC-1alpha-mediated regulation of mitochondrial function and physiological implications","volume":"45","author":"Halling","year":"2020","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coemr.2019.02.002","article-title":"Mitochondrial regulator PGC-1a-Modulating the modulator","volume":"5","author":"Miller","year":"2019","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Tadaishi, M., Miura, S., Kai, Y., Kano, Y., Oishi, Y., and Ezaki, O. (2011). Skeletal muscle-specific expression of PGC-1alpha-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028290"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s00125-015-3671-z","article-title":"The hitchhiker\u2019s guide to PGC-1alpha isoform structure and biological functions","volume":"58","author":"Pettersson","year":"2015","journal-title":"Diabetologia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","article-title":"Maintenance of skeletal muscle mitochondria in health, exercise, and aging","volume":"81","author":"Hood","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/s41422-018-0078-7","article-title":"Skeletal muscle mitochondrial remodeling in exercise and diseases","volume":"28","author":"Gan","year":"2018","journal-title":"Cell Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1073\/pnas.0607795103","article-title":"PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41419-020-2552-7","article-title":"ZNF746\/PARIS overexpression induces cellular senescence through FoxO1\/p21 axis activation in myoblasts","volume":"11","author":"Bae","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/jcsm.13308","article-title":"Cdon ablation in motor neurons causes age-related motor neuron degeneration and impaired sciatic nerve repair","volume":"14","author":"Kim","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6806\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:01:57Z","timestamp":1760108517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/12\/6806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ijms25126806"],"URL":"https:\/\/doi.org\/10.3390\/ijms25126806","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}