{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:29:21Z","timestamp":1788348561561,"version":"build-2803163510"},"reference-count":112,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Narodowe Centrum Nauki (Poland)","award":["2020\/39\/D\/NZ4\/01250"],"award-info":[{"award-number":["2020\/39\/D\/NZ4\/01250"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Retinoblastoma, a pediatric ocular malignancy, presents significant challenges in comprehending its molecular underpinnings and targeted therapeutic approaches. The dysregulated activity of histone deacetylases (HDACs) has been associated with retinoblastoma pathogenesis, influencing critical cellular processes like cell cycle regulation or retinal ganglion cell apoptosis. Through their deacetylase activity, HDACs exert control over key tumor suppressors and oncogenes, influencing the delicate equilibrium between proliferation and cell death. Furthermore, the interplay between HDACs and the retinoblastoma protein pathway, a pivotal aspect of retinoblastoma etiology, reveals a complex network of interactions influencing the tumor microenvironment. The examination of HDAC inhibitors, encompassing both established and novel compounds, offers insights into potential approaches to restore acetylation balance and impede retinoblastoma progression. Moreover, the identification of specific HDAC isoforms exhibiting varying expression in retinoblastoma provides avenues for personalized therapeutic strategies, allowing for interventions tailored to individual patient profiles. This review focuses on the intricate interrelationship between HDACs and retinoblastoma, shedding light on epigenetic mechanisms that control tumor development and progression. The exploration of HDAC-targeted therapies underscores the potential for innovative treatment modalities in the pursuit of more efficacious and personalized management strategies for this disease.<\/jats:p>","DOI":"10.3390\/ijms25136910","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:06:40Z","timestamp":1719234400000},"page":"6910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histone Deacetylases in Retinoblastoma"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-2396","authenticated-orcid":false,"given":"Malwina","family":"Lisek","sequence":"first","affiliation":[{"name":"Department of Molecular Neurochemistry, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3075-8675","authenticated-orcid":false,"given":"Julia","family":"Tomczak","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurochemistry, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Swiatek","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurochemistry, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kaluza","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurochemistry, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-9011","authenticated-orcid":false,"given":"Tomasz","family":"Boczek","sequence":"additional","affiliation":[{"name":"Department of Molecular Neurochemistry, Medical University of Lodz, 90-419 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bjophthalmol-2011-300739","article-title":"The incidence and distribution of retinoblastoma in Kenya","volume":"96","author":"Nyamori","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/bjo.2008.139618","article-title":"Retinoblastoma in Great Britain 1963\u20132002","volume":"93","author":"MacCarthy","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"ref_3","first-page":"S1","article-title":"National Retinoblastoma Strategy Canadian Guidelines for Care: Strat\u00e9gie th\u00e9rapeutique du r\u00e9tinoblastome guide clinique canadien","volume":"44","author":"Society","year":"2009","journal-title":"Can. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15021","DOI":"10.1038\/nrdp.2015.21","article-title":"Retinoblastoma","volume":"1","author":"Dimaras","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e35068","DOI":"10.1097\/MD.0000000000035068","article-title":"RB1 gene mutations and genetic spectrum in retinoblastoma cases","volume":"102","author":"Kebudi","year":"2023","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"104674","DOI":"10.1016\/j.ejmg.2022.104674","article-title":"Retinoblastoma: From genes to patient care","volume":"66","author":"Bouchoucha","year":"2023","journal-title":"Eur. J. Med. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3567","article-title":"Molecular mechanisms underlying RB protein function","volume":"14","author":"Dick","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_9","first-page":"31","article-title":"Regulatory interactions among E2Fs and cell cycle control proteins","volume":"208","author":"Cobrinik","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.1167\/iovs.06-0063","article-title":"Cell cycle-specific and cell type-specific expression of Rb in the developing human retina","volume":"47","author":"Lee","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nature08544","article-title":"Division and apoptosis of E2f-deficient retinal progenitors","volume":"462","author":"Chen","year":"2009","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.4161\/cc.21263","article-title":"Regulation of transcription and chromatin structure by pRB: Here, there and everywhere","volume":"11","author":"Talluri","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12964-023-01223-z","article-title":"Retinoblastoma: Present scenario and future challenges","volume":"21","author":"Byroju","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ophtha.2013.11.021","article-title":"Diagnostic performance of magnetic resonance imaging and computed tomography for advanced retinoblastoma: A systematic review and meta-analysis","volume":"121","author":"Noij","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S1470-2045(14)70336-5","article-title":"Trilateral retinoblastoma: A systematic review and meta-analysis","volume":"15","author":"Kors","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.ajo.2015.09.009","article-title":"The Incidence of Trilateral Retinoblastoma: A Systematic Review and Meta-Analysis","volume":"160","author":"Kors","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/hmg\/ddn024","article-title":"Loss of RB1 induces non-proliferative retinoma: Increasing genomic instability correlates with progression to retinoblastoma","volume":"17","author":"Dimaras","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/ceo.12132","article-title":"The genomic landscape of retinoblastoma: A review","volume":"42","author":"Dimaras","year":"2014","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature10733","article-title":"A novel retinoblastoma therapy from genomic and epigenetic analyses","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/bjc.2013.283","article-title":"Gene expression profiling identifies different sub-types of retinoblastoma","volume":"109","author":"Kapatai","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1470-2045(13)70045-7","article-title":"Characterisation of retinoblastomas without RB1 mutations: Genomic, gene expression, and clinical studies","volume":"14","author":"Rushlow","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/1878-0261.13553","article-title":"Ceftriaxone exerts antitumor effects in MYCN-driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression","volume":"18","author":"Chittavanich","year":"2024","journal-title":"Mol. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100188","DOI":"10.1016\/j.xops.2022.100188","article-title":"High-Level","volume":"2","author":"Roohollahi","year":"2022","journal-title":"Ophthalmol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1172\/JCI57114","article-title":"Understanding pRb: Toward the necessary development of targeted treatments for retinoblastoma","volume":"122","author":"Sachdeva","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/jnci\/53.2.347","article-title":"Characteristics of an established cell line of retinoblastoma","volume":"53","author":"Reid","year":"1974","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_26","first-page":"1003","article-title":"Characterization of a new continuous cell line derived from a human retinoblastoma","volume":"37","author":"McFall","year":"1977","journal-title":"Cancer Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00418-014-1285-z","article-title":"Re-characterization of established human retinoblastoma cell lines","volume":"143","author":"Busch","year":"2015","journal-title":"Histochem. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)64653-6","article-title":"Metastatic and nonmetastatic models of retinoblastoma","volume":"157","author":"Hurwitz","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ijc.2910460123","article-title":"Newly established human retinoblastoma cell lines exhibit an \u201cimmortalized\u201d but not an invasive phenotype in vitro","volume":"46","author":"Griegel","year":"1990","journal-title":"Int. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109447","DOI":"10.1016\/j.exer.2023.109447","article-title":"The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma","volume":"230","author":"Sinenko","year":"2023","journal-title":"Exp. Eye Res."},{"key":"ref_31","first-page":"160","article-title":"Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines","volume":"39","author":"Busch","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jahagirdar, D., Jain, R., and Dandekar, P. (2023). In vitro triple culture model of retinoblastoma for pre-clinical investigations. Biotechnol. J., 18.","DOI":"10.1002\/biot.202200518"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ijc.2910520214","article-title":"Matrigel promotes retinoblastoma cell growth in vitro and in vivo","volume":"52","author":"Albini","year":"1992","journal-title":"Int. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Abuwatfa, W.H., Pitt, W.G., and Husseini, G.A. (2024). Scaffold-based 3D cell culture models in cancer research. J. Biomed. Sci., 31.","DOI":"10.1186\/s12929-024-00994-y"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Xiao, X., Zhou, X., Ming, H., Zhang, J., Huang, G., Zhang, Z., and Li, P. (2015). Chick Chorioallantoic Membrane Assay: A 3D Animal Model for Study of Human Nasopharyngeal Carcinoma. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130935"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112510","DOI":"10.1016\/j.yexcr.2021.112510","article-title":"The CAM assay in the study of the metastatic process","volume":"400","author":"Ribatti","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_37","first-page":"303","article-title":"The CAM Assay as an Alternative In Vivo Model for Drug Testing","volume":"265","author":"Ribatti","year":"2021","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jcp.26773","article-title":"The chick embryo chorioallantoic membrane as an in vivo experimental model to study human neuroblastoma","volume":"234","author":"Ribatti","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Doege, A., Steens, R., D\u00fcnker, N., and Busch, M.A. (2022). Retinoblastoma Cell Growth. Methods Protoc., 5.","DOI":"10.3390\/mps5020021"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/path.1706","article-title":"Molecular mechanisms of drug resistance","volume":"205","author":"Longley","year":"2005","journal-title":"J. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40942-020-00236-x","article-title":"Successful growth of fresh retinoblastoma cells in chorioallantoic membrane","volume":"6","author":"Fialho","year":"2020","journal-title":"Int. J. Retina Vitreous"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"782766","DOI":"10.3389\/fonc.2021.782766","article-title":"Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies","volume":"11","author":"Law","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_43","first-page":"256","article-title":"Heterotransplantation of retinoblastoma into the athymic \u201cnude\u201d mouse","volume":"16","author":"Gallie","year":"1977","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00685390","article-title":"A highly predictable animal model of retinoblastoma","volume":"57","author":"Kobayashi","year":"1982","journal-title":"Acta Neuropathol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kang, S.J., and Grossniklaus, H.E. (2011). Rabbit model of retinoblastoma. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/394730"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0006-8993(10)80005-8","article-title":"Intraretinal xenografts of differentiated human retinoblastoma cells integrate with the host retina","volume":"583","author":"Notter","year":"1992","journal-title":"Brain Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Okada, S., Vaeteewoottacharn, K., and Kariya, R. (2019). Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models. Cells, 8.","DOI":"10.20944\/preprints201906.0002.v1"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0953-4431(00)00041-2","article-title":"Ocular immune privilege: A review","volume":"12","author":"Koevary","year":"2000","journal-title":"Clin. Eye Vis. Care"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kaewkhaw, R., and Rojanaporn, D. (2020). Retinoblastoma: Etiology, Modeling, and Treatment. Cancers, 12.","DOI":"10.3390\/cancers12082304"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1167\/iovs.17-21760","article-title":"Looking for the Most Suitable Orthotopic Retinoblastoma Mouse Model in Order to Characterize the Tumoral Development","volume":"58","author":"Lemaitre","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/bjophthalmol-2020-318529","article-title":"Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: A preclinical and clinical study","volume":"106","author":"Bogan","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"101358","DOI":"10.1016\/j.mex.2021.101358","article-title":"Complete preclinical platform for intravitreal chemotherapy drug discovery for retinoblastoma: Assessment of pharmacokinetics, toxicity and efficacy using a rabbit model","volume":"8","author":"Daniels","year":"2021","journal-title":"MethodsX"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41416-019-0495-5","article-title":"The role of mouse tumour models in the discovery and development of anticancer drugs","volume":"121","author":"Ireson","year":"2019","journal-title":"Br. J. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1476-4598-12-71","article-title":"Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs","volume":"12","author":"Jo","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, X., Li, Y., Yao, T., and Jia, R. (2021). Benefits of Zebrafish Xenograft Models in Cancer Research. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.616551"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hason, M., and Bart\u016fn\u011bk, P. (2019). Zebrafish Models of Cancer-New Insights on Modeling Human Cancer in a Non-Mammalian Vertebrate. Genes, 10.","DOI":"10.3390\/genes10110935"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Maricic, N., Schwermer, M., Schramm, A., Morosan-Puopolo, G., Ketteler, P., and Brand-Saberi, B. (2022). Zebrafish as an Orthotopic Tumor Model for Retinoblastoma Mimicking Routes of Human Metastasis. Cancers, 14.","DOI":"10.3390\/cancers14235814"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Corson, T.W., Samuels, B.C., Wenzel, A.A., Geary, A.J., Riley, A.A., McCarthy, B.P., Hanenberg, H., Bailey, B.J., Rogers, P.I., and Pollok, K.E. (2014). Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099036"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10351","DOI":"10.1038\/srep10351","article-title":"Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/343665a0","article-title":"Retinoblastoma in transgenic mice","volume":"343","author":"Windle","year":"1990","journal-title":"Nature"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000370157","article-title":"Transgenic Models in Retinoblastoma Research","volume":"1","author":"Nair","year":"2015","journal-title":"Ocul. Oncol. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Donovan, S.L., Schweers, B., Martins, R., Johnson, D., and Dyer, M.A. (2006). Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol., 4.","DOI":"10.1186\/1741-7007-4-14"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1101\/gad.1203304","article-title":"Cell type-specific effects of Rb deletion in the murine retina","volume":"18","author":"MacPherson","year":"2004","journal-title":"Genes. Dev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1101\/gad.322004","article-title":"Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130","volume":"18","author":"Dannenberg","year":"2004","journal-title":"Genes. Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1172\/JCI88508","article-title":"A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence","volume":"127","author":"Wu","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"952","DOI":"10.4161\/cc.3.7.1002","article-title":"The first knockout mouse model of retinoblastoma","volume":"3","author":"Zhang","year":"2004","journal-title":"Cell Cycle"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ccr.2004.05.025","article-title":"Cell-specific effects of RB or RB\/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma","volume":"5","author":"Chen","year":"2004","journal-title":"Cancer Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ccr.2011.07.005","article-title":"Coexpression of normally incompatible developmental pathways in retinoblastoma genesis","volume":"20","author":"McEvoy","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cncr.25574","article-title":"Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma","volume":"117","author":"Nemeth","year":"2011","journal-title":"Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e1405","DOI":"10.1038\/cddis.2014.372","article-title":"The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA","volume":"5","author":"Clavier","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1101\/gad.10.10.1206","article-title":"RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila","volume":"10","author":"Du","year":"1996","journal-title":"Genes. Dev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000370155","article-title":"Drosophila as a Potential Model for Ocular Tumors","volume":"1","author":"Bennett","year":"2015","journal-title":"Ocul. Oncol. Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"949241","DOI":"10.3389\/fgene.2022.949241","article-title":"A platform for anticancer drug discovery and personalized therapies","volume":"13","author":"Munnik","year":"2022","journal-title":"Front. Genet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yexcr.2018.12.018","article-title":"Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines","volume":"375","author":"Schwermer","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.canlet.2016.06.012","article-title":"Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination","volume":"380","author":"Olaciregui","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1158\/0008-5472.CAN-07-0276","article-title":"Retinoblastoma: From the two-hit hypothesis to targeted chemotherapy","volume":"67","author":"MacPherson","year":"2007","journal-title":"Cancer Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12943-015-0360-y","article-title":"Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas","volume":"14","author":"Xie","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhao, Z., and Shilatifard, A. (2019). Epigenetic modifications of histones in cancer. Genome Biol., 20.","DOI":"10.1186\/s13059-019-1870-5"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/CS20120504","article-title":"Histone deacetylases as targets for treatment of multiple diseases","volume":"124","author":"Tang","year":"2013","journal-title":"Clin. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13148-016-0225-2","article-title":"Histone acetyltransferases: Challenges in targeting bi-substrate enzymes","volume":"8","author":"Wapenaar","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrd.2016.256","article-title":"Marked for death: Targeting epigenetic changes in cancer","volume":"16","author":"Pfister","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0077-2","article-title":"Targeting of epigenetic regulators in neuroblastoma","volume":"50","author":"Jubierre","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1172\/JCI69738","article-title":"New and emerging HDAC inhibitors for cancer treatment","volume":"124","author":"West","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12943-019-1127-7","article-title":"Role of HDACs in normal and malignant hematopoiesis","volume":"19","author":"Wang","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_85","first-page":"460","article-title":"Histone deacetylase inhibitors differentially regulate c-Myc expression in retinoblastoma cells","volume":"19","author":"Yu","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Guzman, F., Fazeli, Y., Khuu, M., Salcido, K., Singh, S., and Benavente, C.A. (2020). Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation. Cancers, 12.","DOI":"10.3390\/cancers12102807"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.21037\/tcr.2019.10.30","article-title":"HDAC6 inhibitor WT161 induces apoptosis in retinoblastoma cells and synergistically interacts with cisplatin","volume":"8","author":"Sun","year":"2019","journal-title":"Transl. Cancer Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Janostiak, R., Torres-Sanchez, A., Posas, F., and de Nadal, E. (2022). Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies. Cancers, 14.","DOI":"10.3390\/cancers14051265"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbrc.2016.03.129","article-title":"Downregulation of HDAC9 inhibits cell proliferation and tumor formation by inducing cell cycle arrest in retinoblastoma","volume":"473","author":"Zhang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000439594","article-title":"Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma","volume":"2","author":"Batra","year":"2015","journal-title":"Ocul. Oncol. Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/BJ20070151","article-title":"Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1","volume":"407","author":"Wong","year":"2007","journal-title":"Biochem. J."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Marshall, G.M., Liu, P.Y., Gherardi, S., Scarlett, C.J., Bedalov, A., Xu, N., Iraci, N., Valli, E., Ling, D., and Thomas, W. (2011). SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002135"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000368718","article-title":"Expression of SIRT2 and SIRT6 in retinoblastoma","volume":"53","author":"Orellana","year":"2015","journal-title":"Ophthalmic Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"a026831","DOI":"10.1101\/cshperspect.a026831","article-title":"HDACs and HDAC Inhibitors in Cancer Development and Therapy","volume":"6","author":"Li","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/cells4020135","article-title":"HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities","volume":"4","author":"Koeneke","year":"2015","journal-title":"Cells"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"E2592","DOI":"10.1073\/pnas.1300113110","article-title":"Histone deacetylase 10 promotes autophagy-mediated cell survival","volume":"110","author":"Oehme","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.molcel.2014.12.013","article-title":"Deacetylation of nuclear LC3 drives autophagy initiation under starvation","volume":"57","author":"Huang","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng1531","article-title":"Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer","volume":"37","author":"Fraga","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ruiz-P\u00e9rez, M.V., Henley, A.B., and Arsenian-Henriksson, M. (2017). The MYCN Protein in Health and Disease. Genes, 8.","DOI":"10.3390\/genes8040113"},{"key":"ref_100","first-page":"130","article-title":"Review: New horizons in retinoblastoma treatment: An updated review article","volume":"28","author":"Azimi","year":"2022","journal-title":"Mol. Vis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"822330","DOI":"10.3389\/fonc.2022.822330","article-title":"Treatment of Retinoblastoma: What Is the Latest and What Is the Future","volume":"12","author":"Schaiquevich","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0002-9440(10)65277-7","article-title":"p27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers","volume":"154","author":"Lloyd","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2481865","DOI":"10.1155\/2016\/2481865","article-title":"Histone Deacetylase Inhibitors Increase p27(Kip1) by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation","volume":"2016","author":"Borriello","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/nar\/gkn961","article-title":"UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells","volume":"37","author":"Kim","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1147939","article-title":"UHRF1 plays a role in maintaining DNA methylation in mammalian cells","volume":"317","author":"Bostick","year":"2007","journal-title":"Science"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Qi, X., Liu, Y., Peng, Y., Fu, Y., Yin, L., and Li, X. (2023). UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination. J. Cell Biol., 222.","DOI":"10.1083\/jcb.202210093"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/1878-0261.12607","article-title":"UHRF1 downmodulation enhances antitumor effects of histone deacetylase inhibitors in retinoblastoma by augmenting oxidative stress-mediated apoptosis","volume":"14","author":"Kim","year":"2020","journal-title":"Mol. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.apsb.2023.02.007","article-title":"Targeting histone deacetylases for cancer therapy: Trends and challenges","volume":"13","author":"Liang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"80109","DOI":"10.18632\/oncotarget.19019","article-title":"HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer","volume":"8","author":"Hideshima","year":"2017","journal-title":"Oncotarget"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.62.14.8","article-title":"Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model","volume":"62","author":"Kaczmarek","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Phimmachanh, M., Han, J.Z.R., O\u2019Donnell, Y.E.I., Latham, S.L., and Croucher, D.R. (2020). Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.578770"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"948217","DOI":"10.3389\/fchem.2022.948217","article-title":"Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer","volume":"10","author":"Pramanik","year":"2022","journal-title":"Front. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/6910\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:03:42Z","timestamp":1760108622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/6910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":112,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25136910"],"URL":"https:\/\/doi.org\/10.3390\/ijms25136910","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]}}}