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This study presents a highly effective approach for synthesizing derivatives of 3,4-disubstituted maleimides through the direct isomerization of \u03b1-succinimide-substituted allenoates, followed by a cascade \u03b3\u2032-addition and aryl imines using PR3 as a catalyst. The resulting series of 3,4-disubstituted maleimides exhibited excellent stereoselectivities, achieving yields of up to 86%. To our knowledge, the phosphine-mediated \u03b3\u2032-addition reaction of allenoates is seldom reported.<\/jats:p>","DOI":"10.3390\/ijms25136916","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:06:40Z","timestamp":1719234400000},"page":"6916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of 3,4-Disubstituted Maleimide Derivatives via Phosphine-Catalyzed Isomerization of \u03b1-Succinimide-Substituted Allenoates Cascade \u03b3\u2032-Addition with Aryl Imines"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-092X","authenticated-orcid":false,"given":"Zhenzhen","family":"Gao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoshen","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanchong","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-0050","authenticated-orcid":false,"given":"Xuekun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-2278","authenticated-orcid":false,"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, Liaocheng University, Liaocheng 252059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10593-018-2240-z","article-title":"3,4-Disubstituted maleimides: Synthesis and biological activity","volume":"54","author":"Panov","year":"2018","journal-title":"Chem. 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