{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:10:10Z","timestamp":1790485810355,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2019\/25295-0"],"award-info":[{"award-number":["2019\/25295-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["23038.003092\/2014-61"],"award-info":[{"award-number":["23038.003092\/2014-61"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["523\/2014"],"award-info":[{"award-number":["523\/2014"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["472613\/2013-8"],"award-info":[{"award-number":["472613\/2013-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAPES","award":["2019\/25295-0"],"award-info":[{"award-number":["2019\/25295-0"]}]},{"name":"CAPES","award":["23038.003092\/2014-61"],"award-info":[{"award-number":["23038.003092\/2014-61"]}]},{"name":"CAPES","award":["523\/2014"],"award-info":[{"award-number":["523\/2014"]}]},{"name":"CAPES","award":["472613\/2013-8"],"award-info":[{"award-number":["472613\/2013-8"]}]},{"name":"CAPES","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"CNPq","award":["2019\/25295-0"],"award-info":[{"award-number":["2019\/25295-0"]}]},{"name":"CNPq","award":["23038.003092\/2014-61"],"award-info":[{"award-number":["23038.003092\/2014-61"]}]},{"name":"CNPq","award":["523\/2014"],"award-info":[{"award-number":["523\/2014"]}]},{"name":"CNPq","award":["472613\/2013-8"],"award-info":[{"award-number":["472613\/2013-8"]}]},{"name":"CNPq","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2013Brasil","award":["2019\/25295-0"],"award-info":[{"award-number":["2019\/25295-0"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2013Brasil","award":["23038.003092\/2014-61"],"award-info":[{"award-number":["23038.003092\/2014-61"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2013Brasil","award":["523\/2014"],"award-info":[{"award-number":["523\/2014"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2013Brasil","award":["472613\/2013-8"],"award-info":[{"award-number":["472613\/2013-8"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2013Brasil","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Goldblatt model of hypertension (2K-1C) in rats is characterized by renal sympathetic nerve activity (rSNA). We investigated the effects of unilateral renal denervation of the clipped kidney (DNX) on sodium transporters of the unclipped kidneys and the cardiovascular, autonomic, and renal functions in 2K-1C and control (CTR) rats. The mean arterial pressure (MAP) and rSNA were evaluated in experimental groups. Kidney function and NHE3, NCC, ENaC\u03b2, and ENaC\u03b3 protein expressions were assessed. The glomerular filtration rate (GRF) and renal plasma flow were not changed by DNX, but the urinary (CTR: 0.0042 \u00b1 0.001; 2K-1C: 0.014 \u00b1 0.003; DNX: 0.005 \u00b1 0.0013 mL\/min\/g renal tissue) and filtration fractions (CTR: 0.29 \u00b1 0.02; 2K-1C: 0.51 \u00b1 0.06; DNX: 0.28 \u00b1 0.04 mL\/min\/g renal tissue) were normalized. The Na+\/H+ exchanger (NHE3) was reduced in 2K-1C, and DNX normalized NHE3 (CTR: 100 \u00b1 6; 2K-1C: 44 \u00b1 14, DNX: 84 \u00b1 13%). Conversely, the Na+\/Cl\u2212 cotransporter (NCC) was increased in 2K-1C and was reduced by DNX (CTR: 94 \u00b1 6; 2K-1C: 144 \u00b1 8; DNX: 60 \u00b1 15%). In conclusion, DNX in Goldblatt rats reduced blood pressure and proteinuria independently of GRF with a distinct regulation of NHE3 and NCC in unclipped kidneys.<\/jats:p>","DOI":"10.3390\/ijms25136962","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T05:11:39Z","timestamp":1719465099000},"page":"6962","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Total Denervation of the Ischemic Kidney Induces Differential Responses in Sodium Transporters\u2019 Expression in the Contralateral Kidney in Goldblatt Rats"],"prefix":"10.3390","volume":"25","author":[{"given":"Caroline G.","family":"Shimoura","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-3009","authenticated-orcid":false,"given":"Tales L.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Municipal University of S\u00e3o Caetano do Sul, Sao Paulo 01327-000, Brazil"},{"name":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele S.","family":"Lincevicius","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-8359","authenticated-orcid":false,"given":"Renato O.","family":"Crajoinas","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, Faculty of Medicine, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Oliveira-Sales","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Metropolitan University of Santos, Santos 11045-002, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-2325","authenticated-orcid":false,"given":"Vanessa A.","family":"Varela","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar N.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassia T.","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-0817","authenticated-orcid":false,"given":"Ruy R.","family":"Campos","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Physiology, School of Medicine, Federal University of Sao Paulo, Sao Paulo 04023-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/s41440-019-0233-7","article-title":"Mechanisms underlying the effects of renal denervation in renovascular hypertension","volume":"42","author":"Braga","year":"2019","journal-title":"Hypertens. 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