{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:43:59Z","timestamp":1793897039984,"version":"4.8.0"},"reference-count":234,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Project of Elite Varieties Breeding of Anhui Province","award":["2021YFD1200500"],"award-info":[{"award-number":["2021YFD1200500"]}]},{"name":"Joint Project of Elite Varieties Breeding of Anhui Province","award":["202204c06020018"],"award-info":[{"award-number":["202204c06020018"]}]},{"name":"Joint Project of Elite Varieties Breeding of Anhui Province","award":["SDKF-2023\u201304"],"award-info":[{"award-number":["SDKF-2023\u201304"]}]},{"name":"Joint Project of Elite Varieties Breeding of Anhui Province","award":["CARS-01-73"],"award-info":[{"award-number":["CARS-01-73"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFD1200500"],"award-info":[{"award-number":["2021YFD1200500"]}]},{"name":"National Key Research and Development Program of China","award":["202204c06020018"],"award-info":[{"award-number":["202204c06020018"]}]},{"name":"National Key Research and Development Program of China","award":["SDKF-2023\u201304"],"award-info":[{"award-number":["SDKF-2023\u201304"]}]},{"name":"National Key Research and Development Program of China","award":["CARS-01-73"],"award-info":[{"award-number":["CARS-01-73"]}]},{"name":"Anhui Provincial Key Research and Development Project","award":["2021YFD1200500"],"award-info":[{"award-number":["2021YFD1200500"]}]},{"name":"Anhui Provincial Key Research and Development Project","award":["202204c06020018"],"award-info":[{"award-number":["202204c06020018"]}]},{"name":"Anhui Provincial Key Research and Development Project","award":["SDKF-2023\u201304"],"award-info":[{"award-number":["SDKF-2023\u201304"]}]},{"name":"Anhui Provincial Key Research and Development Project","award":["CARS-01-73"],"award-info":[{"award-number":["CARS-01-73"]}]},{"name":"Open Research Fund Program of the Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement","award":["2021YFD1200500"],"award-info":[{"award-number":["2021YFD1200500"]}]},{"name":"Open Research Fund Program of the Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement","award":["202204c06020018"],"award-info":[{"award-number":["202204c06020018"]}]},{"name":"Open Research Fund Program of the Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement","award":["SDKF-2023\u201304"],"award-info":[{"award-number":["SDKF-2023\u201304"]}]},{"name":"Open Research Fund Program of the Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement","award":["CARS-01-73"],"award-info":[{"award-number":["CARS-01-73"]}]},{"name":"National Rice Industry Technology System","award":["2021YFD1200500"],"award-info":[{"award-number":["2021YFD1200500"]}]},{"name":"National Rice Industry Technology System","award":["202204c06020018"],"award-info":[{"award-number":["202204c06020018"]}]},{"name":"National Rice Industry Technology System","award":["SDKF-2023\u201304"],"award-info":[{"award-number":["SDKF-2023\u201304"]}]},{"name":"National Rice Industry Technology System","award":["CARS-01-73"],"award-info":[{"award-number":["CARS-01-73"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Copper (Cu) is an essential nutrient for plant growth and development. This metal serves as a constituent element or enzyme cofactor that participates in many biochemical pathways and plays a key role in photosynthesis, respiration, ethylene sensing, and antioxidant systems. The physiological significance of Cu uptake and compartmentalization in plants has been underestimated, despite the importance of Cu in cellular metabolic processes. As a micronutrient, Cu has low cellular requirements in plants. However, its bioavailability may be significantly reduced in alkaline or organic matter-rich soils. Cu deficiency is a severe and widespread nutritional disorder that affects plants. In contrast, excessive levels of available Cu in soil can inhibit plant photosynthesis and induce cellular oxidative stress. This can affect plant productivity and potentially pose serious health risks to humans via bioaccumulation in the food chain. Plants have evolved mechanisms to strictly regulate Cu uptake, transport, and cellular homeostasis during long-term environmental adaptation. This review provides a comprehensive overview of the diverse functions of Cu chelators, chaperones, and transporters involved in Cu homeostasis and their regulatory mechanisms in plant responses to varying Cu availability conditions. Finally, we identified that future research needs to enhance our understanding of the mechanisms regulating Cu deficiency or stress in plants. This will pave the way for improving the Cu utilization efficiency and\/or Cu tolerance of crops grown in alkaline or Cu-contaminated soils.<\/jats:p>","DOI":"10.3390\/ijms25136993","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T05:11:39Z","timestamp":1719465099000},"page":"6993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess"],"prefix":"10.3390","volume":"25","author":[{"given":"Ending","family":"Xu","sequence":"first","affiliation":[{"name":"Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Biology, College of Life Science, Nanjing Agriculture University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Gu","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Horticultural Research, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunneng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4109-6702","authenticated-orcid":false,"given":"Yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Rice Germplasm Innovation and Molecular Improvement, Rice Research Institute, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ncp.10328","article-title":"Copper deficiency: Causes, manifestations, and treatment","volume":"34","author":"Altarelli","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00204-014-1355-y","article-title":"Copper: Toxicological relevance and mechanisms","volume":"88","author":"Gaetke","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_3","first-page":"111","article-title":"Interactions between copper homeostasis and metabolism in plants","volume":"79","author":"Schulten","year":"2018","journal-title":"Prog. Bot."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-8137.2008.02738.x","article-title":"Biofortification of crops with seven mineral elements often lacking in human diets\u2013iron, zinc, copper, calcium, magnesium, selenium and iodine","volume":"182","author":"White","year":"2009","journal-title":"New Phytol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1139\/cjss-2019-0161","article-title":"Natural and anthropogenic sources of copper to organic soils: A global, geochemical perspective","volume":"100","author":"Shotyk","year":"2020","journal-title":"Can. J. Soil Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.geoderma.2006.11.012","article-title":"Copper fertilizer effects on copper distribution and vertical transport in soils","volume":"138","author":"Wei","year":"2007","journal-title":"Geoderma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"139434","DOI":"10.1016\/j.scitotenv.2020.139434","article-title":"Copper accumulation in agricultural soils: Risks for the food chain and soil microbial populations","volume":"734","author":"Fagnano","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10534-021-00306-z","article-title":"Copper: Uptake, toxicity and tolerance in plants and management of Cu-contaminated soil","volume":"34","author":"Mir","year":"2021","journal-title":"Biometals"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"124549","DOI":"10.1016\/j.chemosphere.2019.124549","article-title":"The role of organic amendment in soils affected by residual pollution of potentially harmful elements","volume":"237","author":"Nakamaru","year":"2019","journal-title":"Chemosphere"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S1806-66902012000100001","article-title":"Heavy metals adsorption after surface lime in a Rhodic Hapludox under no-tillage system","volume":"43","author":"Joris","year":"2012","journal-title":"Rev. Ci\u00eanc. Agr\u00f4n."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.envint.2019.04.032","article-title":"Fly ash and zeolite decrease metal uptake but do not improve rice growth in paddy soils contaminated with Cu and Zn","volume":"129","author":"Lee","year":"2019","journal-title":"Environ. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1469-8137.2009.02846.x","article-title":"Copper homeostasis","volume":"182","author":"Burkhead","year":"2009","journal-title":"New Phytol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00709-018-1286-1","article-title":"Copper uptake mechanism of Arabidopsis thaliana high-affinity COPT transporters","volume":"256","author":"Sanz","year":"2019","journal-title":"Protoplasma"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1365-313X.2010.04472.x","article-title":"The intracellular Arabidopsis COPT5 transport protein is required for photosynthetic electron transport under severe copper deficiency","volume":"65","author":"Puig","year":"2011","journal-title":"Plant J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1469-8137.2011.03798.x","article-title":"The tonoplast copper transporter COPT5 acts as an exporter and is required for interorgan allocation of copper in Arabidopsis thaliana","volume":"192","author":"Klaumann","year":"2011","journal-title":"New Phytol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33252","DOI":"10.1074\/jbc.M112.397810","article-title":"COPT6 is a plasma membrane transporter that functions in copper homeostasis in Arabidopsis and is a novel target of SQUAMOSA promoter-binding protein-like 7","volume":"287","author":"Jung","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/jxb\/eru020","article-title":"HMA1 and PAA1, two chloroplast-envelope PIB-ATPases, play distinct roles in chloroplast copper homeostasis","volume":"65","author":"Boutigny","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-313X.2005.02601.x","article-title":"The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots","volume":"45","author":"Mayo","year":"2006","journal-title":"Plant J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"36188","DOI":"10.1074\/jbc.M111.241034","article-title":"Biochemical characterization of AtHMA6\/PAA1, a chloroplast envelope Cu (I)-ATPase","volume":"286","author":"Catty","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.jplph.2014.04.014","article-title":"Characterization of the HMA7 gene and transcriptomic analysis of candidate genes for copper tolerance in two Silene vulgaris ecotypes","volume":"171","author":"Baloun","year":"2014","journal-title":"J. Plant Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/nph.13093","article-title":"The Clp protease system is required for copper ion-dependent turnover of the PAA2\/HMA8 copper transporter in chloroplasts","volume":"205","author":"Tapken","year":"2015","journal-title":"New Phytol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1104\/pp.106.082586","article-title":"Mutations in Arabidopsis yellow stripe-like1 and yellow stripe-like3 reveal their roles in metal ion homeostasis and loading of metal ions in seeds","volume":"141","author":"Waters","year":"2006","journal-title":"Plant Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-313X.2004.02128.x","article-title":"Arabidopsis\u00a0Yellow Stripe-Like2 (YSL2): A metal-regulated gene encoding a plasma membrane transporter of nicotianamine\u2013metal complexes","volume":"39","author":"DiDonato","year":"2004","journal-title":"Plant J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"47644","DOI":"10.1074\/jbc.M309338200","article-title":"Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis","volume":"278","author":"Wintz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/jxb\/ers315","article-title":"Transport properties of members of the ZIP family in plants and their role in Zn and Mn homeostasis","volume":"64","author":"Milner","year":"2013","journal-title":"J. Exp. Bot."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/tpj.15506","article-title":"Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana","volume":"108","author":"Lee","year":"2021","journal-title":"Plant J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1365-313x.2001.00985.x","article-title":"Evidence for the plant-specific intercellular transport of the Arabidopsis copper chaperone CCH","volume":"25","author":"Mira","year":"2001","journal-title":"Plant J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.4161\/psb.21147","article-title":"Overexpression of Arabidopsis ATX1 retards plant growth under severe copper deficiency","volume":"7","author":"Shin","year":"2012","journal-title":"Plant Signal Behav."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pe\u00f1arrubia, L., Romero, P., Carri\u00f3-Segu\u00ed, A., Andr\u00e9s-Border\u00eda, A., Moreno, J., and Sanz, A. (2015). Temporal aspects of copper homeostasis and its crosstalk with hormones. Front. Plant Sci., 6.","DOI":"10.3389\/fpls.2015.00255"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1104\/pp.010963","article-title":"AtCOX17, an Arabidopsis homolog of the yeast copper chaperone COX17","volume":"129","author":"Balandin","year":"2002","journal-title":"Plant Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.plaphy.2020.11.051","article-title":"The copper economy response is partially conserved in rice (Oryza sativa L.)","volume":"158","author":"Navarro","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1104\/pp.112.212407","article-title":"Arabidopsis copper transport protein COPT2 participates in the cross talk between iron deficiency responses and low-phosphate signaling","volume":"162","author":"Puig","year":"2013","journal-title":"Plant Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1111\/pce.14867","article-title":"OsCOPT7 is a copper exporter at the tonoplast and endoplasmic reticulum and controls Cu translocation to the shoots and grain of rice","volume":"47","author":"Tang","year":"2024","journal-title":"Plant Cell Environ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1104\/pp.113.226225","article-title":"A member of the heavy metal P-type ATPase OsHMA5 is involved in xylem loading of copper in rice","volume":"163","author":"Deng","year":"2013","journal-title":"Plant Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1104\/pp.107.102236","article-title":"Rice P1B-type heavy-metal ATPase, OsHMA9, is a metal efflux protein","volume":"145","author":"Lee","year":"2007","journal-title":"Plant Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/pcp\/pcy124","article-title":"OsYSL16 is required for preferential Cu distribution to floral organs in rice","volume":"59","author":"Zhang","year":"2018","journal-title":"Plant Cell Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1023\/B:PLAN.0000038271.96019.aa","article-title":"Identification and characterization of several new members of the ZIP family of metal ion in Medicago truncatula","volume":"54","author":"AF","year":"2004","journal-title":"Plant Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/nph.14992","article-title":"Medicago truncatula copper transporter 1 (MtCOPT1) delivers copper for symbiotic nitrogen fixation","volume":"218","author":"Senovilla","year":"2018","journal-title":"New Phytol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00425-014-2067-5","article-title":"Copper homeostasis in grapevine: Functional characterization of the Vitis vinifera copper transporter 1","volume":"240","author":"Martins","year":"2014","journal-title":"Planta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1093\/pcp\/pcs125","article-title":"Copper transport and compartmentation in grape cells","volume":"53","author":"Martins","year":"2012","journal-title":"Plant Cell Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jsb.2006.10.016","article-title":"Identification and subcellular localization of the soybean copper P1B-ATPase GmHMA8 transporter","volume":"158","author":"Bernal","year":"2007","journal-title":"J. Struct. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/pce.12263","article-title":"Identification and characterization of a novel copper transporter gene family TaCT1 in common wheat","volume":"37","author":"Li","year":"2014","journal-title":"Plant Cell Environ."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Billard, V., Ourry, A., Maillard, A., Garnica, M., Coquet, L., Jouenne, T., Cruz, F., Garcia-Mina, J.-M., Yvin, J.-C., and Etienne, P. (2014). Copper-deficiency in Brassica napus induces copper remobilization, molybdenum accumulation and modification of the expression of chloroplastic proteins. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109889"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liu, Y., Kong, L., Gong, C., Yang, G., Xu, E., Chen, W., Zhang, W., and Chen, X. (2023). Identification of plant cadmium resistance gene family in Brassica napus and functional analysis of BnPCR10. 1 involved in cadmium and copper tolerance. Plant Physiol. Biochem., 202.","DOI":"10.1016\/j.plaphy.2023.107989"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mikkelsen, M.D., Pedas, P., Schiller, M., Vincze, E., Mills, R.F., Borg, S., M\u00f8ller, A., Schjoerring, J.K., Williams, L.E., and Baekgaard, L. (2012). Barley HvHMA1 is a heavy metal pump involved in mobilizing organellar Zn and Cu and plays a role in metal loading into grains. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049027"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/pcp\/pcr126","article-title":"A novel barley yellow stripe 1-like transporter (HvYSL2) localized to the root endodermis transports metal-phytosiderophore complexes","volume":"52","author":"Araki","year":"2011","journal-title":"Plant Cell Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Dai, J., Wang, N., Xiong, H., Qiu, W., Nakanishi, H., Kobayashi, T., Nishizawa, N.K., and Zuo, Y. (2018). The yellow stripe-like (YSL) gene functions in internal copper transport in peanut. Genes, 9.","DOI":"10.3390\/genes9120635"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Migocka, M., and Malas, K. (2018). Plant responses to copper: Molecular and regulatory mechanisms of copper uptake, distribution and accumulation in plants. Plant Micronutrient Use Efficiency, Academic Press.","DOI":"10.1016\/B978-0-12-812104-7.00005-8"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"127436","DOI":"10.1016\/j.chemosphere.2020.127436","article-title":"Copper uptake, essentiality, toxicity, detoxification and risk assessment in soil-plant environment","volume":"259","author":"Shabbir","year":"2020","journal-title":"Chemosphere"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cohu, C.M., and Pilon, M. (2010). Cell biology of copper. Cell Biology of Metals Nutrients, Springer.","DOI":"10.1007\/978-3-642-10613-2_3"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"213253","DOI":"10.1016\/j.ccr.2020.213253","article-title":"Stability constants of bio-relevant, redox-active metals with amino acids: The challenges of weakly binding ligands","volume":"412","author":"Murphy","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nature08300","article-title":"Metalloproteins and metal sensing","volume":"460","author":"Waldron","year":"2009","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1105\/tpc.011817","article-title":"PAA1, a P-type ATPase of Arabidopsis, functions in copper transport in chloroplasts","volume":"15","author":"Shikanai","year":"2003","journal-title":"Plant Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.tplants.2020.03.003","article-title":"Chloroplast transition metal regulation for efficient photosynthesis","volume":"25","author":"Schmidt","year":"2020","journal-title":"Trends Plant Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/ppl.12940","article-title":"Comparative analysis of plastocyanin\u2013cytochrome f complex formation in higher plants, green algae and cyanobacteria","volume":"166","author":"Fedorov","year":"2019","journal-title":"Physiol. Plant"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/plphys\/kiad268","article-title":"Cyclophilin 37 maintains electron transport via the cytochrome b6\/f complex under high light in Arabidopsis","volume":"192","author":"Yang","year":"2023","journal-title":"Plant Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15354","DOI":"10.1073\/pnas.2005832117","article-title":"Plastocyanin is the long-range electron carrier between photosystem II and photosystem I in plants","volume":"117","author":"Pribil","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1073\/pnas.1422492112","article-title":"Copper economy in Chlamydomonas: Prioritized allocation and reallocation of copper to respiration vs. photosynthesis","volume":"112","author":"Kropat","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Howe, C.J., Nimmo, R.H., Barbrook, A.C., and Bendall, D.S. (2016). Cytochrome c6A of chloroplasts. Cytochrome Complexes: Evolution, Structures, Energy Transduction, Signaling, Springer.","DOI":"10.1007\/978-94-017-7481-9_33"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1016\/j.febslet.2006.05.067","article-title":"Crystal structure of oxidized cytochrome c6A from Arabidopsis thaliana","volume":"580","author":"Chida","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"31286","DOI":"10.1074\/jbc.M302876200","article-title":"Plastocyanin is indispensable for photosynthetic electron flow in Arabidopsis thaliana","volume":"278","author":"Weigel","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbapap.2004.12.012","article-title":"Comparative study of the stability of poplar plastocyanin isoforms","volume":"1748","author":"Shosheva","year":"2005","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0167-4838(93)90081-2","article-title":"Twin plastocyanin dimorphism in tobacco","volume":"1203","author":"Dimitrov","year":"1993","journal-title":"Biochim. Biophys. Acta Protein Struct. Mol. Enzymol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Yu, J., Wang, J., Lin, W., Li, S., Li, H., Zhou, J., Ni, P., Dong, W., Hu, S., and Zeng, C. (2005). The genomes of Oryza sativa: A history of duplications. PLoS Biol., 3.","DOI":"10.1371\/journal.pbio.0030038"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Rensing, S.A., Ick, J., Fawcett, J.A., Lang, D., Zimmer, A., Van de Peer, Y., and Reski, R. (2007). An ancient genome duplication contributed to the abundance of metabolic genes in the moss Physcomitrella patens. BMC Evol. Biol., 7.","DOI":"10.1186\/1471-2148-7-130"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00425-008-0869-z","article-title":"Contribution of plastocyanin isoforms to photosynthesis and copper homeostasis in Arabidopsis thaliana grown at different copper regimes","volume":"229","year":"2009","journal-title":"Planta"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/mp\/ssn041","article-title":"Mutants, overexpressors, and interactors of Arabidopsis plastocyanin isoforms: Revised roles of plastocyanin in photosynthetic electron flow and thylakoid redox state","volume":"2","author":"Pesaresi","year":"2009","journal-title":"Mol. Plant"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1021\/acs.jafc.2c07741","article-title":"Root hair development and adaptation to abiotic stress","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"112588","DOI":"10.1016\/j.phytochem.2020.112588","article-title":"Recent advances in polyphenol oxidase-mediated plant stress responses","volume":"181","author":"Zhang","year":"2021","journal-title":"Phytochemistry"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1093\/jxb\/erv141","article-title":"Polyphenol oxidase in leaves: Is there any significance to the chloroplastic localization?","volume":"66","author":"Boeckx","year":"2015","journal-title":"J. Exp. Bot."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mito.2014.02.011","article-title":"Mitochondria and copper homeostasis in plants","volume":"19","author":"Garcia","year":"2014","journal-title":"Mitochondrion"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/febs.15016","article-title":"Arabidopsis thaliana HCC1 is a Sco-like metallochaperone for CuA assembly in Cytochrome c Oxidase","volume":"287","author":"Llases","year":"2020","journal-title":"FEBS J."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Wikstr\u00f6m, M., Gennis, R.B., and Rich, P.R. (2023). Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase. Biochim. Biophys. Acta Bioenerg., 1864.","DOI":"10.1016\/j.bbabio.2022.148933"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.gene.2006.07.003","article-title":"Alveolate and chlorophycean mitochondrial cox2 genes split twice independently","volume":"383","author":"Waller","year":"2006","journal-title":"Gene"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-313X.2002.01263.x","article-title":"Gene transfer from mitochondrion to nucleus: Novel mechanisms for gene activation from Cox2","volume":"30","author":"Daley","year":"2002","journal-title":"Plant J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.bbabio.2011.09.005","article-title":"Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core","volume":"1817","author":"Soto","year":"2012","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"100919","DOI":"10.1016\/j.coelec.2021.100919","article-title":"Electrochemistry of copper efflux oxidase-like multicopper oxidases involved in copper homeostasis","volume":"32","author":"Mazurenko","year":"2022","journal-title":"Curr. Opin. Electrochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00425-004-1472-6","article-title":"Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana","volume":"221","author":"McCaig","year":"2005","journal-title":"Planta"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Stevens, R., Truffault, V., Baldet, P., and Gautier, H. (2017). Ascorbate oxidase in plant growth, development, and stress tolerance. Ascorbic Acid in Plant Growth, Development Stress Tolerance, Springer.","DOI":"10.1007\/978-3-319-74057-7_11"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1093\/jxb\/eri167","article-title":"Suppressed expression of the apoplastic ascorbate oxidase gene increases salt tolerance in tobacco and Arabidopsis plants","volume":"56","author":"Yamamoto","year":"2005","journal-title":"J. Exp. Bot."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1111\/j.1742-4658.2006.05247.x","article-title":"Phylogenetic comparison and classification of laccase and related multicopper oxidase protein sequences","volume":"273","author":"Hoegger","year":"2006","journal-title":"FEBS J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1105\/tpc.110.082792","article-title":"Disruption of LACCASE4 and 17 results in tissue-specific alterations to lignification of Arabidopsis thaliana stems","volume":"23","author":"Berthet","year":"2011","journal-title":"Plant Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.cj.2019.11.006","article-title":"The laccase gene GhLac1 modulates fiber initiation and elongation by coordinating jasmonic acid and flavonoid metabolism","volume":"8","author":"Hu","year":"2020","journal-title":"Crop J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1093\/jxb\/erl022","article-title":"Mutant identification and characterization of the laccase gene family in Arabidopsis","volume":"57","author":"Cai","year":"2006","journal-title":"J. Exp. Bot."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-3040.2005.01435.x","article-title":"Expression of a putative laccase gene, ZmLAC1, in maize primary roots under stress","volume":"29","author":"Liang","year":"2006","journal-title":"Plant Cell Environ."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1104\/pp.105.063388","article-title":"Plantacyanin plays a role in reproduction in Arabidopsis","volume":"138","author":"Dong","year":"2005","journal-title":"Plant Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Tyagi, S., Singh, S.P., and Upadhyay, S.K. (2019). Role of superoxide dismutases (SODs) in stress tolerance in plants. Molecular Approaches in Plant Biology Environmental Challenges, Springer.","DOI":"10.1007\/978-981-15-0690-1_3"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Liu, C., Wang, Y., Wang, Y., Du, Y., Song, C., Song, P., Yang, Q., He, F., Bai, X., and Huang, L. (2022). Glycine-serine-rich effector PstGSRE4 in Puccinia striiformis f. sp. tritici inhibits the activity of copper zinc superoxide dismutase to modulate immunity in wheat. PLoS Pathog., 18.","DOI":"10.1371\/journal.ppat.1010702"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1104\/pp.111.190223","article-title":"Copper chaperone-dependent and-independent activation of three copper-zinc superoxide dismutase homologs localized in different cellular compartments in Arabidopsis","volume":"158","author":"Huang","year":"2012","journal-title":"Plant Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1104\/pp.105.065284","article-title":"A copper chaperone for superoxide dismutase that confers three types of copper\/zinc superoxide dismutase activity in Arabidopsis","volume":"139","author":"Chu","year":"2005","journal-title":"Plant Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1126\/science.278.5339.817","article-title":"Delivering copper inside yeast and human cells","volume":"278","author":"Valentine","year":"1997","journal-title":"Science"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1074\/jbc.REV120.010854","article-title":"Ethylene signaling in plants","volume":"295","author":"Binder","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.tplants.2023.03.001","article-title":"The role of ethylene in plant temperature stress response","volume":"28","author":"Huang","year":"2023","journal-title":"Trends Plant Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1782051","DOI":"10.1080\/15592324.2020.1782051","article-title":"A brief appraisal of ethylene signaling under abiotic stress in plants","volume":"15","author":"Husain","year":"2020","journal-title":"Plant Signal. Behav."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e2215195120","DOI":"10.1073\/pnas.2215195120","article-title":"Basis for high-affinity ethylene binding by the ethylene receptor ETR1 of Arabidopsis","volume":"120","author":"Azhar","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature02681","article-title":"Structure of the molybdopterin-bound Cnx1G domain links molybdenum and copper metabolism","volume":"430","author":"Kuper","year":"2004","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hajiboland, R. (2012). Effect of micronutrient deficiencies on plants stress responses. Abiotic Stress Responses in Plants: Metabolism, Productivity Sustainability, Springer.","DOI":"10.1007\/978-1-4614-0634-1_16"},{"key":"ref_98","unstructured":"Marschner, H. (2011). Chapter 7\u2014Function of nutrients: Micronutrients A2\u2014Marschner, Petra. Marschner\u2019s Mineral Nutrition of Higher Plants, Academic Press."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1105\/tpc.17.00363","article-title":"Arabidopsis pollen fertility requires the transcription factors CITF1 and SPL7 that regulate copper delivery to anthers and jasmonic acid synthesis","volume":"29","author":"Yan","year":"2017","journal-title":"Plant Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"31","DOI":"10.56557\/pcbmb\/2022\/v23i11-127518","article-title":"Qualitative and quantitative traits of sweet pepper as influenced by copper nanoparticles","volume":"23","author":"Batool","year":"2022","journal-title":"Plant Cell Biotechnol. Mol. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s11947-014-1281-2","article-title":"Effect of nanochitosan-based coating with and without copper loaded on physicochemical and bioactive components of fresh strawberry fruit (Fragaria x ananassa Duchesne) during storage","volume":"7","author":"Eshghi","year":"2014","journal-title":"Food Bioprocess Technol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10924-023-02972-1","article-title":"A Biogenic Approach to Develop Guava Derived Edible Copper and Zinc Oxide Nanocoating to Extend Shelf Life and Efficiency for Food Preservation","volume":"32","author":"Sharma","year":"2024","journal-title":"J. Polym. Environ."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"13477","DOI":"10.1021\/acs.est.1c00839","article-title":"Unraveling metabolic and proteomic features in soybean plants in response to copper hydroxide nanowires compared to a commercial fertilizer","volume":"55","author":"Majumdar","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Yu, Y., Liu, H., Xia, H., and Chu, Z. (2023). Double-or Triple-Tiered Protection: Prospects for the Sustainable Application of Copper-Based Antimicrobial Compounds for Another Fourteen Decades. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310893"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Printz, B., Lutts, S., Hausman, J.-F., and Sergeant, K. (2016). Copper trafficking in plants and its implication on cell wall dynamics. Front. Plant Sci., 7.","DOI":"10.3389\/fpls.2016.00601"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"18003","DOI":"10.1007\/s11356-019-05073-6","article-title":"Copper environmental toxicology, recent advances, and future outlook: A review","volume":"26","author":"Rehman","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.geoderma.2008.02.011","article-title":"Copper content of soils and river sediments in a winegrowing area, and its distribution among soil or sediment components","volume":"145","year":"2008","journal-title":"Geoderma"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.chemosphere.2016.07.104","article-title":"Copper accumulation in vineyard soils: Rhizosphere processes and agronomic practices to limit its toxicity","volume":"162","author":"Brunetto","year":"2016","journal-title":"Chemosphere"},{"key":"ref_109","first-page":"62","article-title":"Distribution characteristics of effective medium and micronutrient element contents in paddy soils of China","volume":"36","author":"Lu","year":"2020","journal-title":"Trans. Chin. Soc. Agric. Eng."},{"key":"ref_110","first-page":"161","article-title":"Research progress and development trends of cultivated land quality evaluation\u2014Taking Qingyuan City\u2019s cultivated land fertility as an example","volume":"23","author":"Liu","year":"2021","journal-title":"Shanxi Agric. Econ."},{"key":"ref_111","first-page":"183","article-title":"Evaluation on the soil quality and suitability of green food producing area in nehe city of heilongjiang province","volume":"31","author":"Zhang","year":"2022","journal-title":"Geol. Resour."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4141\/P04-089","article-title":"Relative effectiveness of various sources, methods, times and rates of copper fertilizers in improving grain yield of wheat on a Cu-deficient soil","volume":"85","author":"Malhi","year":"2005","journal-title":"Can. J. Plant Sci."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Sinclair, A.H., and Edwards, A.C. (2008). Micronutrient deficiency problems in agricultural crops in Europe. Micronutrient Deficiencies in Global Crop Production, Springer.","DOI":"10.1007\/978-1-4020-6860-7_9"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcis.2004.04.005","article-title":"Adsorption of heavy metal ions on soils and soils constituents","volume":"277","author":"Bradl","year":"2004","journal-title":"J. Colloid Interface Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1007\/s12665-015-4518-0","article-title":"Sorption of Zn (II) and Cu (II) by four Argentinean soils as affected by pH, oxides, organic matter and clay content","volume":"74","author":"Soulages","year":"2015","journal-title":"Environ. Earth Sci."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Ning, Y., Zhang, X., Li, B., Wang, Y., and Guo, J. (2019). Distribution of Cd and Cu fractions in Chinese soils and their relationships with soil pH: A meta-analysis. Sustainability, 11.","DOI":"10.3390\/su11020337"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00299-019-02447-5","article-title":"Root exudates: From plant to rhizosphere and beyond","volume":"39","year":"2020","journal-title":"Plant Cell Rep."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Ma, W., Tang, S., Dengzeng, Z., Zhang, D., Zhang, T., and Ma, X. (2022). Root exudates contribute to belowground ecosystem hotspots: A review. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.937940"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/nph.14175","article-title":"Copper and cobalt accumulation in plants: A critical assessment of the current state of knowledge","volume":"213","author":"Lange","year":"2017","journal-title":"New Phytol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.scitotenv.2018.12.243","article-title":"Biogeochemistry of soil organic matter in agroecosystems & environmental implications","volume":"658","author":"Ondrasek","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10653-021-01044-4","article-title":"Soil organic matter and biological activity under long-term contamination with copper","volume":"44","author":"Zamulina","year":"2022","journal-title":"Environ. Geochem. Health"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.envpol.2019.03.020","article-title":"Current state and dynamics of heavy metal soil pollution in Russian Federation\u2014A review","volume":"249","author":"Barsova","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.agron.2018.01.003","article-title":"Advances in molecular approaches for understanding soil organic matter composition, origin, and turnover: A historical overview","volume":"149","author":"Rumpel","year":"2018","journal-title":"Adv. Agron."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.envpol.2018.12.070","article-title":"Association between extracted copper and dissolved organic matter in dairy-manure amended soils","volume":"246","author":"Strawn","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.envpol.2010.02.003","article-title":"Effects of biochar and greenwaste compost amendments on mobility, bioavailability and toxicity of inorganic and organic contaminants in a multi-element polluted soil","volume":"158","author":"Beesley","year":"2010","journal-title":"Environ. Pollut."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"125516","DOI":"10.1016\/j.chemosphere.2019.125516","article-title":"Status of copper accumulation in agricultural soils across China (1985\u20132016)","volume":"244","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"111050","DOI":"10.1016\/j.envres.2021.111050","article-title":"Potential environmental pollution from copper metallurgy and methods of management","volume":"197","author":"Izydorczyk","year":"2021","journal-title":"Environ. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00253-003-1244-4","article-title":"Phytoremediation: An overview of metallic ion decontamination from soil","volume":"61","author":"Singh","year":"2003","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_129","first-page":"305","article-title":"An overview of current status of copper pollution in soil in China and remediation efforts research","volume":"25","author":"Wang","year":"2018","journal-title":"Erath Sci. Front."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"134975","DOI":"10.1016\/j.chemosphere.2022.134975","article-title":"Use of cover crops in vineyards to prevent groundwater pollution by copper and organic fungicides. Soil column studies","volume":"303","author":"Ortega","year":"2022","journal-title":"Chemosphere"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s13593-018-0503-9","article-title":"Thirteen decades of antimicrobial copper compounds applied in agriculture. A review","volume":"38","author":"Lamichhane","year":"2018","journal-title":"Agron. Sustain. Dev."},{"key":"ref_132","first-page":"1711","article-title":"Advances in Copper Resistant Mechanisms and Control Methods of Citrus Canker","volume":"43","author":"Yao","year":"2016","journal-title":"Acta Hortic. Sin."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11270-020-04577-z","article-title":"Environmental Implications from Long-term Citrus Cultivation and Wide Use of Cu Fungicides in Mediterranean Soils","volume":"231","author":"Triantafyllidis","year":"2020","journal-title":"Water Air Soil Pollut."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aquatox.2013.05.008","article-title":"Effects of nanomolar copper on water plants\u2014Comparison of biochemical and biophysical mechanisms of deficiency and sublethal toxicity under environmentally relevant conditions","volume":"140","author":"Thomas","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S1677-04202005000100012","article-title":"Copper in plants","volume":"17","author":"Yruela","year":"2005","journal-title":"Braz. J. Plant Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.aquatox.2016.05.016","article-title":"Deficiency and toxicity of nanomolar copper in low irradiance\u2014A physiological and metalloproteomic study in the aquatic plant Ceratophyllum demersum","volume":"177","author":"Thomas","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1399-3054.2007.00879.x","article-title":"Regulation of superoxide dismutase expression by copper availability","volume":"129","author":"Cohu","year":"2007","journal-title":"Physiol. Plant"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1071\/FP08288","article-title":"Copper in plants: Acquisition, transport and interactions","volume":"36","author":"Yruela","year":"2009","journal-title":"Funct. Plant Biol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Farid, M., Farooq, M.A., Fatima, A., Abubakar, M., Ali, S., Raza, N., Alhaithloul, H.A.S., and Soliman, M.H. (2021). Copper-induced responses in different plant species. Approaches to the Remediation of Inorganic Pollutants, Springer.","DOI":"10.1007\/978-981-15-6221-1_13"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3054.1992.tb08756.x","article-title":"Changes in carotenoids and fatty acids in photosystem II of Cudeficient pea plants","volume":"84","author":"Ayala","year":"1992","journal-title":"Physiol. Plant"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.plaphy.2019.12.006","article-title":"Specificity of Cd, Cu, and Fe effects on barley growth, metal contents in leaves and chloroplasts, and activities of photosystem I and photosystem II","volume":"147","author":"Lysenko","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1021\/es3050746","article-title":"Toxicity and deficiency of copper in Elsholtzia splendens affect photosynthesis biophysics, pigments and metal accumulation","volume":"47","author":"Peng","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_143","first-page":"97","article-title":"Heavy metal uptake by plants and cyanobacteria","volume":"44","author":"Kroneck","year":"2005","journal-title":"Met. Ions Biol. Syst."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/mpp.13099","article-title":"Cu\/Zn superoxide dismutase (VdSOD1) mediates reactive oxygen species detoxification and modulates virulence in Verticillium dahliae","volume":"22","author":"Tian","year":"2021","journal-title":"Mol. Plant Pathol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e00288","DOI":"10.1002\/pld3.288","article-title":"Copper deficiency alters shoot architecture and reduces fertility of both gynoecium and androecium in Arabidopsis thaliana","volume":"4","author":"Vatamaniuk","year":"2020","journal-title":"Plant Direct"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"8148","DOI":"10.1007\/s11356-015-4496-5","article-title":"The effect of excess copper on growth and physiology of important food crops: A review","volume":"22","author":"Adrees","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/clen.201200262","article-title":"Identification of the phytoremediation potential of Indian mustard genotypes for copper, evaluated from a hydroponic experiment","volume":"41","author":"Ansari","year":"2013","journal-title":"CLEAN-Soil Air Water"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Wairich, A., De Conti, L., Lamb, T.I., Keil, R., Neves, L.O., Brunetto, G., Sperotto, R.A., and Ricachenevsky, F.K. (2022). Throwing copper around: How plants control uptake, distribution, and accumulation of copper. Agronomy, 12.","DOI":"10.3390\/agronomy12050994"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"11827","DOI":"10.1007\/s11356-019-04450-5","article-title":"Synergistic effects of chromium and copper on photosynthetic inhibition, subcellular distribution, and related gene expression in Brassica napus cultivars","volume":"26","author":"Li","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"30188","DOI":"10.1007\/s11356-019-06170-2","article-title":"Excess copper effects on growth, uptake of water and nutrients, carbohydrates, and PSII photochemistry revealed by OJIP transients in Citrus seedlings","volume":"26","author":"Li","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s11099-012-0045-3","article-title":"Monitoring moderate Cu and Cd toxicity by chlorophyll fluorescence and P 700 absorbance in pea leaves","volume":"50","author":"Wodala","year":"2012","journal-title":"Photosynthetica"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"15479","DOI":"10.1007\/s11356-015-4610-8","article-title":"Morphology, ultrastructure and mineral uptake is affected by copper toxicity in young plants of Inga subnuda subs","volume":"22","author":"Souza","year":"2015","journal-title":"luschnathiana (Benth.) TD Penn. Environ. Sci. Pollut. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1039\/C5MT00244C","article-title":"Mechanisms of metal toxicity in plants","volume":"8","author":"Andresen","year":"2016","journal-title":"Metallomics"},{"key":"ref_154","first-page":"39","article-title":"Copper and copper-containing pesticides: Metabolism, toxicity and oxidative stress","volume":"2","author":"Husak","year":"2015","journal-title":"J. Vasyl Stefanyk Precarpathian Natl. Univ."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1399-3054.2004.0286.x","article-title":"Copper effect on cytochrome b559 of photosystem II under photoinhibitory conditions","volume":"120","author":"Bernal","year":"2004","journal-title":"Physiol. Plant"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1104\/pp.90.1.175","article-title":"Copper toxicity affects photosystem II electron transport at the secondary quinone acceptor, QB","volume":"90","author":"Mohanty","year":"1989","journal-title":"Plant Physiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1104\/pp.004788","article-title":"Excess copper predisposes photosystem II to photoinhibition in vivo by outcompeting iron and causing decrease in leaf chlorophyll","volume":"129","author":"Kairavuo","year":"2002","journal-title":"Plant Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1399-3054.2000.1100419.x","article-title":"Copper effect on the protein composition of photosystem II","volume":"110","author":"Yruela","year":"2000","journal-title":"Physiol. Plant"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1007\/s11356-014-3917-1","article-title":"Lipids and proteins\u2014Major targets of oxidative modifications in abiotic stressed plants","volume":"22","author":"Anjum","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Gupta, S.K., Sharma, M., Deeba, F., and Pandey, V. (2017). Role of reactive oxygen species in photophosphorylation and damage to D1 protein: Past and present. Reactive Oxygen Species in Plants, Wiley Online Library.","DOI":"10.1002\/9781119324928.ch9"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"49029","DOI":"10.1007\/s11356-022-19380-y","article-title":"Ethylene-nitrogen synergism induces tolerance to copper stress by modulating antioxidant system and nitrogen metabolism and improves photosynthetic capacity in mustard","volume":"29","author":"Rather","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Al Mahmud, J., Bhuyan, M.B., Anee, T.I., Nahar, K., Fujita, M., and Hasanuzzaman, M. (2019). Reactive oxygen species metabolism and antioxidant defense in plants under metal\/metalloid stress. Plant Abiotic Stress Tolerance, Springer.","DOI":"10.1007\/978-3-030-06118-0_10"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"100182","DOI":"10.1016\/j.plgene.2019.100182","article-title":"Antioxidant enzymes regulation in plants in reference to reactive oxygen species (ROS) and reactive nitrogen species (RNS)","volume":"19","author":"Kapoor","year":"2019","journal-title":"Plant Gene"},{"key":"ref_164","first-page":"87","article-title":"Growth in excess copper induces changes in the lipid composition and fluidity of PSII-enriched membranes in wheat","volume":"108","author":"Quartacci","year":"2000","journal-title":"Physiol. Plant"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cotox.2018.10.003","article-title":"Lipid peroxidation derived reactive aldehydes in alcoholic liver disease","volume":"13","author":"Ali","year":"2019","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.envexpbot.2019.06.004","article-title":"Lipid peroxidation-derived reactive carbonyl species (RCS): Their interaction with ROS and cellular redox during environmental stresses","volume":"165","author":"Yalcinkaya","year":"2019","journal-title":"Environ. Exp. Bot."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jhazmat.2009.10.016","article-title":"Zinc reduces copper toxicity induced oxidative stress by promoting antioxidant defense in freshly grown aquatic duckweed Spirodela polyrhiza L.","volume":"175","author":"Upadhyay","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"103220","DOI":"10.1016\/j.etap.2019.103220","article-title":"The potential exposure and hazards of copper nanoparticles: A review","volume":"71","author":"Ameh","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.plaphy.2020.10.023","article-title":"Copper toxicity affects phosphorus uptake mechanisms at molecular and physiological levels in Cucumis sativus plants","volume":"157","author":"Feil","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10534-017-0045-7","article-title":"Proteome characterization of copper stress responses in the roots of sorghum","volume":"30","author":"Roy","year":"2017","journal-title":"Biometals"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"100008","DOI":"10.1016\/j.stress.2021.100008","article-title":"Iron homeostasis in plants and its crosstalk with copper, zinc, and manganese","volume":"1","author":"Rai","year":"2021","journal-title":"Plant Stress"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.envexpbot.2016.05.007","article-title":"Citrus rootstocks regulate the nutritional status and antioxidant system of trees under copper stress","volume":"130","author":"Hippler","year":"2016","journal-title":"Environ. Exp. Bot."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"119561","DOI":"10.1016\/j.envpol.2022.119561","article-title":"Copper stress in grapevine: Consequences, responses, and a novel mitigation strategy using 5-aminolevulinic acid","volume":"307","author":"Yang","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"110105","DOI":"10.1016\/j.ecoenv.2019.110105","article-title":"Excess copper inhibits the growth of rice seedlings by decreasing uptake of nitrate","volume":"190","author":"Huo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"141055","DOI":"10.1016\/j.scitotenv.2020.141055","article-title":"Use of polymeric nanoparticles to improve seed germination and plant growth under copper stress","volume":"745","author":"Xin","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.chemosphere.2006.10.075","article-title":"Excess copper induced physiological and proteomic changes in germinating rice seeds","volume":"67","author":"Ahsan","year":"2007","journal-title":"Chemosphere"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Kul, R., Ekinci, M., Turan, M., Ors, S., and Yildirim, E. (2021). How abiotic stress conditions affects plant roots. Plant Roots, IntechOpen.","DOI":"10.5772\/intechopen.95286"},{"key":"ref_178","first-page":"365","article-title":"Copper effects on photosynthetic activity and membrane leakage of Azolla filiculoides and A. caroliniana","volume":"12","author":"Alarcon","year":"2010","journal-title":"Int. J. Agric. Biol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.sajb.2018.11.007","article-title":"Root morphology and leaf gas exchange in Peltophorum dubium (Spreng.) Taub.(Caesalpinioideae) exposed to copper-induced toxicity","volume":"121","author":"Marques","year":"2019","journal-title":"S. Afr. J. Bot."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.plaphy.2010.05.005","article-title":"Response to copper excess in Arabidopsis thaliana: Impact on the root system architecture, hormone distribution, lignin accumulation and mineral profile","volume":"48","author":"Lequeux","year":"2010","journal-title":"Plant Physiol. Biochem."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Lu, F., Hu, P., Lin, M., Ye, X., Chen, L., and Huang, Z. (2022). Photosynthetic characteristics and chloroplast ultrastructure responses of citrus leaves to copper toxicity induced by Bordeaux mixture in greenhouse. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179835"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/plb.13222","article-title":"Comparative effects of ascobin and glutathione on copper homeostasis and oxidative stress metabolism in mitigation of copper toxicity in rice","volume":"23","author":"Sohag","year":"2021","journal-title":"Plant Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.ecoenv.2010.05.014","article-title":"Copper toxicity in expanding leaves of Phaseolus vulgaris L.: Antioxidant enzyme response and nutrient element uptake","volume":"73","author":"Bouazizi","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Saleem, M.H., Ali, S., Irshad, S., Hussaan, M., Rizwan, M., Rana, M.S., Hashem, A., Abd_Allah, E.F., and Ahmad, P. (2020). Copper uptake and accumulation, ultra-structural alteration, and bast fibre yield and quality of fibrous jute (Corchorus capsularis L.) plants grown under two different soils of China. Plants, 9.","DOI":"10.3390\/plants9030404"},{"key":"ref_185","unstructured":"Upadhyay, S.K. (2022). Chapter 12\u2014Advances in understanding of copper function and transport in plants. Cation Transporters in Plants, Academic Press."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.plaphy.2021.05.048","article-title":"The significance of ion-exchange properties of plant root cell walls for nutrient and water uptake by plants","volume":"166","author":"Meychik","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/jipb.13055","article-title":"The plant cell wall: Biosynthesis, construction, and functions","volume":"63","author":"Zhang","year":"2021","journal-title":"J. Integr. Plant Biol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1093\/jxb\/erw060","article-title":"Transporters involved in mineral nutrient uptake in rice","volume":"67","author":"Sasaki","year":"2016","journal-title":"J. Exp. Bot."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.tplants.2014.05.007","article-title":"The node, a hub for mineral nutrient distribution in graminaceous plants","volume":"19","author":"Yamaji","year":"2014","journal-title":"Trends Plant Sci."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Chen, G., Li, J., Han, H., Du, R., and Wang, X. (2022). Physiological and Molecular Mechanisms of Plant Responses to Copper Stress. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112950"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pbi.2009.04.011","article-title":"Essential transition metal homeostasis in plants","volume":"12","author":"Pilon","year":"2009","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"127810","DOI":"10.1016\/j.chemosphere.2020.127810","article-title":"Copper bioavailability, uptake, toxicity and tolerance in plants: A comprehensive review","volume":"262","author":"Kumar","year":"2021","journal-title":"Chemosphere"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1073\/pnas.0810286106","article-title":"Three-dimensional structure of the human copper transporter hCTR1","volume":"106","author":"Aller","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1023\/A:1022345507112","article-title":"Identification of a copper transporter family in Arabidopsis thaliana","volume":"51","author":"Puig","year":"2003","journal-title":"Plant Mol. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.tplants.2005.08.008","article-title":"P1B-ATPases--an ancient family of transition metal pumps with diverse functions in plants","volume":"10","author":"Williams","year":"2005","journal-title":"Trends Plant Sci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0005-2736(00)00138-3","article-title":"The ZIP family of metal transporters","volume":"1465","author":"Guerinot","year":"2000","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/B978-0-12-394390-3.00011-2","article-title":"Genetic and biochemical approaches for studying the yellow stripe-like transporter family in plants","volume":"69","author":"Conte","year":"2012","journal-title":"Curr. Top. Membr."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"25057","DOI":"10.1074\/jbc.R000006200","article-title":"Metallochaperones, an intracellular shuttle service for metal ions","volume":"275","author":"Culotta","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1104\/pp.18.00425","article-title":"OsATX1 interacts with heavy metal P1B-type ATPases and affects copper transport and distribution","volume":"178","author":"Zhang","year":"2018","journal-title":"Plant Physiol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"15603","DOI":"10.1038\/ncomms15603","article-title":"Natural allelic variation of FRO2 modulates Arabidopsis root growth under iron deficiency","volume":"8","author":"Satbhai","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/nph.18661","article-title":"Ferrous iron uptake via IRT1\/ZIP evolved at least twice in green plants","volume":"237","author":"Rodrigues","year":"2023","journal-title":"New Phytol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1105\/tpc.111.090431","article-title":"Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4\/FRO5 and the copper dependence of iron homeostasis in Arabidopsis","volume":"24","author":"Bernal","year":"2012","journal-title":"Plant Cell"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"15348","DOI":"10.1074\/jbc.M313321200","article-title":"The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development","volume":"279","author":"Puig","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1104\/pp.110.153676","article-title":"Deregulated copper transport affects Arabidopsis development especially in the absence of environmental cycles","volume":"153","author":"Puig","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Offermanns, S., and Rosenthal, W. (2020). Non-selective Cation Channels. Encyclopedia of Molecular Pharmacology, Springer International Publishing.","DOI":"10.1007\/978-3-030-21573-6"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1105\/tpc.108.060137","article-title":"SQUAMOSA Promoter Binding Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis","volume":"21","author":"Yamasaki","year":"2009","journal-title":"Plant Cell"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1105\/tpc.110.078022","article-title":"The bacterial pathogen Xanthomonas oryzae overcomes rice defenses by regulating host copper redistribution","volume":"22","author":"Yuan","year":"2010","journal-title":"Plant Cell"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Yuan, M., Li, X., Xiao, J., and Wang, S. (2011). Molecular and functional analyses of COPT\/Ctr-type copper transporter-like gene family in rice. BMC Plant Biol., 11.","DOI":"10.1186\/1471-2229-11-69"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1071\/FP12158","article-title":"Copper in xylem and phloem saps from rice (Oryza sativa): The effect of moderate copper concentrations in the growth medium on the accumulation of five essential metals and a speciation analysis of copper-containing compounds","volume":"40","author":"Ando","year":"2012","journal-title":"Funct. Plant Biol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1104\/pp.110.159103","article-title":"Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures","volume":"154","author":"Chu","year":"2010","journal-title":"Plant Physiol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1105\/tpc.112.103820","article-title":"YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice","volume":"24","author":"Zheng","year":"2012","journal-title":"Plant Cell"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"128063","DOI":"10.1016\/j.jhazmat.2021.128063","article-title":"Mapping and functional analysis of high-copper accumulation mutant oshc1 in rice","volume":"426","author":"Guan","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"12138","DOI":"10.1038\/ncomms12138","article-title":"A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain","volume":"7","author":"Huang","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"15717","DOI":"10.1074\/jbc.M114.618355","article-title":"Functional and Biochemical Characterization of Cucumber Genes Encoding Two Copper ATPases CsHMA5.1 and CsHMA5.2","volume":"290","author":"Migocka","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"100496","DOI":"10.1016\/j.xplc.2022.100496","article-title":"Co-regulation of mitochondrial and chloroplast function: Molecular components and mechanisms","volume":"4","author":"He","year":"2023","journal-title":"Plant Commun."},{"key":"ref_216","first-page":"E5480","article-title":"Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis","volume":"111","author":"Merchant","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"35334","DOI":"10.1074\/jbc.M404747200","article-title":"Specific copper transfer from the Cox17 metallochaperone to both Sco1 and Cox11 in the assembly of yeast cytochrome C oxidase","volume":"279","author":"Horng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/jxb\/erq269","article-title":"HCC1, the Arabidopsis homologue of the yeast mitochondrial copper chaperone SCO1, is essential for embryonic development","volume":"62","author":"Steinebrunner","year":"2011","journal-title":"J. Exp. Bot."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Steinebrunner, I., Gey, U., Andres, M., Garcia, L., and Gonzalez, D.H. (2014). Divergent functions of the Arabidopsis mitochondrial SCO proteins: HCC1 is essential for COX activity while HCC2 is involved in the UV-B stress response. Front. Plant Sci., 5.","DOI":"10.3389\/fpls.2014.00087"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Radin, I., Mansilla, N., R\u00f6del, G., and Steinebrunner, I. (2015). The Arabidopsis COX11 homolog is essential for cytochrome c oxidase activity. Front. Plant Sci., 6.","DOI":"10.3389\/fpls.2015.01091"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"37263","DOI":"10.1074\/jbc.M110.170027","article-title":"The copper transporter RAN1 is essential for biogenesis of ethylene receptors in Arabidopsis","volume":"285","author":"Binder","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.283.5404.996","article-title":"A copper cofactor for the ethylene receptor ETR1 from Arabidopsis","volume":"283","author":"Esch","year":"1999","journal-title":"Science"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1105\/tpc.12.3.443","article-title":"A strong loss-of-function mutation in RAN1 results in constitutive activation of the ethylene response pathway as well as a rosette-lethal phenotype","volume":"12","author":"Woeste","year":"2000","journal-title":"Plant Cell"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"114116","DOI":"10.1016\/j.ecoenv.2022.114116","article-title":"Plant cadmium resistance 6 from Salix linearistipularis (SlPCR6) affects cadmium and copper uptake in roots of transgenic Populus","volume":"245","author":"Hu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1093\/plcell\/koac215","article-title":"Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7","volume":"34","author":"Schulten","year":"2022","journal-title":"Plant Cell"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Garcia-Molina, A., Xing, S., and Huijser, P. (2014). Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response. BMC Plant Biol., 14.","DOI":"10.1186\/s12870-014-0231-5"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1104\/pp.113.228239","article-title":"A conserved KIN17 curved DNA-binding domain protein assembles with SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE7 to adapt Arabidopsis growth and development to limiting copper availability","volume":"164","author":"Xing","year":"2014","journal-title":"Plant Physiol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1105\/tpc.114.127340","article-title":"MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper","volume":"26","author":"Zhang","year":"2014","journal-title":"Plant Cell"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1074\/jbc.M801406200","article-title":"MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis","volume":"283","author":"Pilon","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jxb\/erv474","article-title":"Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana","volume":"67","author":"Sanz","year":"2016","journal-title":"J. Exp. Bot."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Andr\u00e9s-Col\u00e1s, N., Carri\u00f3-Segu\u00ed, A., Abdel-Ghany, S.E., Pilon, M., and Pe\u00f1arrubia, L. (2018). Expression of the Intracellular COPT3-Mediated Cu Transport Is Temporally Regulated by the TCP16 Transcription Factor. Front. Plant Sci., 9.","DOI":"10.3389\/fpls.2018.00910"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Ji, C., Li, H., Ding, J., Yu, L., Jiang, C., Wang, C., Wang, S., Ding, G., Shi, L., and Xu, F. (2024). Rice transcription factor OsWRKY37 positively regulates flowering time and grain fertility under copper deficiency. Plant Physiol.","DOI":"10.1093\/plphys\/kiae187"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/pce.14000","article-title":"FIT and bHLH Ib transcription factors modulate iron and copper crosstalk in Arabidopsis","volume":"44","author":"Cai","year":"2021","journal-title":"Plant Cell Environ."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"e2116623119","DOI":"10.1073\/pnas.2116623119","article-title":"The PCY-SAG14 phytocyanin module regulated by PIFs and miR408 promotes dark-induced leaf senescence in Arabidopsis","volume":"119","author":"Hao","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/6993\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:04:56Z","timestamp":1760108696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/6993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":234,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25136993"],"URL":"https:\/\/doi.org\/10.3390\/ijms25136993","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}