{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:49:26Z","timestamp":1792028966750,"version":"4.4.0"},"reference-count":51,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Institute of Clinical and Experimental Lymphology (Novosibirsk)","award":["122022800132\u20131"],"award-info":[{"award-number":["122022800132\u20131"]}]},{"name":"Research Institute of Clinical and Experimental Lymphology (Novosibirsk)","award":["124030400004\u20138"],"award-info":[{"award-number":["124030400004\u20138"]}]},{"name":"Novosibirsk Branch of S. Fedorov Eye Microsurgery Federal State Institution","award":["122022800132\u20131"],"award-info":[{"award-number":["122022800132\u20131"]}]},{"name":"Novosibirsk Branch of S. Fedorov Eye Microsurgery Federal State Institution","award":["124030400004\u20138"],"award-info":[{"award-number":["124030400004\u20138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cell-based therapies using corneal stromal stem cells (CSSC), corneal keratocytes, or a combination of both suppress corneal scarring. The number of quiescent keratocytes in the cornea is small; it is difficult to expand them in vitro in quantities suitable for transplantation. This study examined the therapeutic effect of corneal fibroblasts reversed into keratocytes (rCF) in a mouse model of mechanical corneal injury. The therapeutic effect of rCF was studied in vivo (slit lamp, optical coherence tomography) and ex vivo (transmission electron microscopy and immunofluorescence staining). Injection of rCF into the injured cornea was accompanied by recovery of corneal thickness, improvement of corneal transparency, reduction of type III collagen in the stroma, absence of myofibroblasts, and the improvement in the structural organization of collagen fibers. TEM results showed that 2 months after intrastromal injection of cells, there was a decrease in the fibril density and an increase in the fibril diameter and the average distance between collagen fibrils. The fibrils were well ordered and maintained the short-range order and the number of nearest-neighbor fibrils, although the averaged distance between them increased. Our results demonstrated that the cell therapy of rCF from ReLEx SMILe lenticules promotes the recovery of transparent corneal stroma after injury.<\/jats:p>","DOI":"10.3390\/ijms25137053","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:19:02Z","timestamp":1719487142000},"page":"7053","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reversed Corneal Fibroblasts Therapy Restores Transparency of Mouse Cornea after Injury"],"prefix":"10.3390","volume":"25","author":[{"given":"Maria A.","family":"Surovtseva","sequence":"first","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1921-8072","authenticated-orcid":false,"given":"Kristina Yu.","family":"Krasner","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"},{"name":"Novosibirsk Branch of S. Fedorov Eye Microsurgery Federal State Institution, 10 Kolkhidskaya Str., 630096 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-2763","authenticated-orcid":false,"given":"Irina I.","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-0508","authenticated-orcid":false,"given":"Nikolay V.","family":"Surovtsev","sequence":"additional","affiliation":[{"name":"Institute of Automation and Electrometry, Russian Academy of Sciences, 1 Academician Koptyug St., 630090 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-4451","authenticated-orcid":false,"given":"Elena V.","family":"Chepeleva","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-656X","authenticated-orcid":false,"given":"Natalia A.","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-8676","authenticated-orcid":false,"given":"Alexander P.","family":"Lykov","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-093X","authenticated-orcid":false,"given":"Nataliya P.","family":"Bgatova","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina A.","family":"Alshevskaya","sequence":"additional","affiliation":[{"name":"Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Russian Federation, 2, Building 4 Bolshaya Pirogovskaya St., 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-8984","authenticated-orcid":false,"given":"Alexander N.","family":"Trunov","sequence":"additional","affiliation":[{"name":"Novosibirsk Branch of S. Fedorov Eye Microsurgery Federal State Institution, 10 Kolkhidskaya Str., 630096 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery V.","family":"Chernykh","sequence":"additional","affiliation":[{"name":"Novosibirsk Branch of S. Fedorov Eye Microsurgery Federal State Institution, 10 Kolkhidskaya Str., 630096 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Poveshchenko","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2 Timakova Str., 630060 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","unstructured":"Willmann, D., Fu, L., and Melanson, S.W. (2024, June 17). Corneal Injury, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459283\/."},{"key":"ref_2","first-page":"214","article-title":"Corneal blindness: A global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull. 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