{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:46:50Z","timestamp":1790117210643,"version":"4.0.1"},"reference-count":53,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Dental and Craniofacial Research of the National Institutes of Health","award":["R01DE025476"],"award-info":[{"award-number":["R01DE025476"]}]},{"name":"National Institute of Dental and Craniofacial Research of the National Institutes of Health","award":["R56DE032903"],"award-info":[{"award-number":["R56DE032903"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The leading cause of composite restoration failure is secondary caries, and although caries is a multifactorial problem, weak, damage-prone adhesives play a pivotal role in the high susceptibility of composite restorations to secondary caries. Our group has developed synthetic resins that capitalize on free-radical polymerization and sol-gel reactions to provide dental adhesives with enhanced properties. The resins contain \u03b3-methacryloxypropyltrimethoxysilane (MPS) as the Si-based compound. This study investigated the properties of methacrylate-based resins containing methacryloxymethyltrimethoxysilane (MMeS) as a short-chain alternative. The degree of conversion (DC), polymerization kinetics, water sorption, mechanical properties, and leachates of MMeS- and MPS-resins with 55 and 30 wt% BisGMA-crosslinker were determined. The formulations were used as model adhesives, and the adhesive\/dentin (a\/d) interfaces were analyzed using chemometrics-assisted micro-Raman spectroscopy. The properties of the 55 wt% formulations were comparable. In the 30 wt% BisGMA formulations, the MMeS-resin exhibited faster polymerization, lower DC, reduced leachates, and increased storage and loss moduli, glass transition (Tg), crosslink density, and heterogeneity. The spectroscopic results indicated a comparable spatial distribution of resin, mineralized, and demineralized dentin across the a\/d interfaces. The hydrolytically stable experimental short-chain-silane-monomer dental adhesive provides enhanced mechanical properties through autonomous strengthening and offers a promising strategy for the development of restorative dental materials with extended service life.<\/jats:p>","DOI":"10.3390\/ijms25137061","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:19:02Z","timestamp":1719487142000},"page":"7061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Engineering Interfacial Integrity with Hydrolytic-Resistant, Self-Reinforcing Dentin Adhesive"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-3864","authenticated-orcid":false,"given":"Erhan","family":"Demirel","sequence":"first","affiliation":[{"name":"Institute for Bioengineering Research, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering Research, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"},{"name":"Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Maslak, Istanbul 34469, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngwoo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Petroleum Engineering, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Florida International University, Miami, FL 33174-1630, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-2218","authenticated-orcid":false,"given":"Candan","family":"Tamerler","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering Research, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"},{"name":"Department of Mechanical Engineering, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"},{"name":"Bioengineering Program, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-826X","authenticated-orcid":false,"given":"Paulette","family":"Spencer","sequence":"additional","affiliation":[{"name":"Institute for Bioengineering Research, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"},{"name":"Department of Mechanical Engineering, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"},{"name":"Bioengineering Program, University of Kansas, 1530 W. 15th Street, Lawrence, KS 66045-7608, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.2341\/15-126-LIT","article-title":"From \u2018Direct Versus Indirect\u2019 Toward an Integrated Restorative Concept in the Posterior Dentition","volume":"41","author":"Opdam","year":"2016","journal-title":"Oper. 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