{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:02:59Z","timestamp":1792875779923,"version":"4.5.0"},"reference-count":132,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID\u2014FONDECYT\u2014Chile","award":["11240905"],"award-info":[{"award-number":["11240905"]}]},{"name":"ANID\u2014FONDECYT\u2014Chile","award":["21230900"],"award-info":[{"award-number":["21230900"]}]},{"name":"National Research and Development Agency (ANID)\/Human Capital Sub-directorate\/National Doctorate Scholarships 2023","award":["11240905"],"award-info":[{"award-number":["11240905"]}]},{"name":"National Research and Development Agency (ANID)\/Human Capital Sub-directorate\/National Doctorate Scholarships 2023","award":["21230900"],"award-info":[{"award-number":["21230900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease is a pathology characterized by the progressive loss of neuronal connections, which leads to gray matter atrophy in the brain. Alzheimer\u2019s disease is the most prevalent type of dementia and has been classified into two types, early onset, which has been associated with genetic factors, and late onset, which has been associated with environmental factors. One of the greatest challenges regarding Alzheimer\u2019s disease is the high economic cost involved, which is why the number of studies aimed at prevention and treatment have increased. One possible approach is the use of resistance exercise training, given that it has been shown to have neuroprotective effects associated with Alzheimer\u2019s disease, such as increasing cortical and hippocampal volume, improving neuroplasticity, and promoting cognitive function throughout the life cycle. However, how resistance exercise training specifically prevents or ameliorates Alzheimer\u2019s disease has not been fully characterized. Therefore, the aim of this review was to identify the molecular basis by which resistance exercise training could prevent or treat Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/ijms25137084","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T13:26:43Z","timestamp":1719494803000},"page":"7084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Resistance Exercise Training as a New Trend in Alzheimer\u2019s Disease Research: From Molecular Mechanisms to Prevention"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0320-9710","authenticated-orcid":false,"given":"Alexis","family":"Sep\u00falveda-Lara","sequence":"first","affiliation":[{"name":"Doctorado en Ciencias menci\u00f3n Biolog\u00eda Celular y Molecular Aplicada, Facultad de Ciencias Agropecuarias, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Precl\u00ednicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4835-7821","authenticated-orcid":false,"given":"Gabriel Nasri","family":"Marzuca-Nassr","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Rehabilitaci\u00f3n, Facultad de Medicina, Universidad de la Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F., and Arab-Tehrany, E. (2022). Alzheimer\u2019s Disease: Treatment Strategies and Their Limitations. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213954"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13024-021-00467-y","article-title":"The informed road map to prevention of Alzheimer Disease: A call to arms","volume":"16","author":"McDade","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3233\/JAD-191300","article-title":"Health Outcome Prioritization in Alzheimer\u2019s Disease: Understanding the Ethical Landscape","volume":"77","author":"McKeown","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2147\/ciia.2006.1.2.143","article-title":"Economic considerations in the management of Alzheimer\u2019s disease","volume":"1","author":"Zhu","year":"2006","journal-title":"Clin. Interv. Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11062-019-09823-7","article-title":"Altered Neurochemistry in Alzheimer\u2019s Disease: Targeting Neurotransmitter Receptor Mechanisms and Therapeutic Strategy","volume":"51","author":"Kaur","year":"2019","journal-title":"Neurophysiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8383","DOI":"10.1038\/s41598-023-35082-y","article-title":"Multi-level meta-analysis of whether fostering creativity during physical activity interventions increases their impact on cognitive and academic outcomes during childhood","volume":"13","author":"Vasilopoulos","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/1874609816666230214100557","article-title":"Role of Education and Physical Activity in Executive Function Performance of Adult Population","volume":"16","author":"Sharma","year":"2023","journal-title":"Curr. Aging Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"afad061","DOI":"10.1093\/ageing\/afad061","article-title":"The impact of cognitive function on physical activity, physical function and quality of life in older adults following a hip fracture","volume":"52","author":"Runde","year":"2023","journal-title":"Age Ageing"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e15108","DOI":"10.7717\/peerj.15108","article-title":"Does the combination of exercise and cognitive training improve working memory in older adults? A systematic review and meta-analysis","volume":"11","author":"Wu","year":"2023","journal-title":"PeerJ"},{"key":"ref_10","first-page":"499","article-title":"Effects of a physical exercise or motor activity protocol on cognitive function, lipid profile, and BDNF levels in older adults with mild cognitive impairment","volume":"479","author":"Saretto","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jagp.2016.11.007","article-title":"Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults","volume":"25","author":"Rosano","year":"2017","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/j.1532-5415.2008.01994.x","article-title":"Exercise Training and Plasma C-Reactive Protein and Interleukin-6 in Elderly People","volume":"56","author":"Nicklas","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s11064-022-03713-x","article-title":"Modulation of Inflammatory Mediators and Microglial Activation Through Physical Exercise in Alzheimer\u2019s and Parkinson\u2019s Diseases","volume":"47","author":"Ibrahim","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12974-019-1653-7","article-title":"Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer\u2019s disease mice","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflam."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbr.2017.03.044","article-title":"Protective effects of different exercise modalities in an Alzheimer\u2019s disease-like model","volume":"328","author":"Karademir","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Azevedo, C.V., Hashiguchi, D., Campos, H.C., Figueiredo, E.V., Otaviano, S.F.S.D., Penitente, A.R., Arida, R.M., and Longo, B.M. (2023). The effects of resistance exercise on cognitive function, amyloidogenesis, and neuroinflammation in Alzheimer\u2019s disease. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1131214"},{"key":"ref_17","first-page":"5919501","article-title":"Hippocampal Growth Factor and Myokine Cathepsin B Expression following Aerobic and Resistance Training in 3xTg-AD Mice","volume":"2020","author":"Pena","year":"2020","journal-title":"Int. J. Chronic Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3233\/JAD-190729","article-title":"Resistance Exercise Decreases Amyloid Load and Modulates Inflammatory Responses in the APP\/PS1 Mouse Model for Alzheimer\u2019s Disease","volume":"73","author":"Hashiguchi","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.neubiorev.2017.06.012","article-title":"Physical exercise as an epigenetic modulator of brain plasticity and cognition","volume":"80","author":"Fernandes","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1093\/brain\/awad059","article-title":"Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated","volume":"146","author":"Robinson","year":"2023","journal-title":"Brain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/10738584211024531","article-title":"Alzheimer\u2019s Disease Genetics: A Dampened Microglial Response?","volume":"29","author":"Chatila","year":"2023","journal-title":"Neuroscientist"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Singh, N.A., and Sintini, I. (2024). Editorial: New insights into atypical Alzheimer\u2019s disease: From clinical phenotype to biomarkers. Front. Neurosci., 18.","DOI":"10.3389\/fnins.2024.1414443"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1007\/s00415-024-12297-1","article-title":"Atypical Alzheimer\u2019s disease: New insights into an overlapping spectrum between the language and visual variants","volume":"271","author":"Singh","year":"2024","journal-title":"J. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Onisiforou, A., Christodoulou, C.C., Zamba-Papanicolaou, E., Zanos, P., and Georgiou, P. (2024). Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer\u2019s disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1345498"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11910-024-01330-5","article-title":"Thaker, A.A. Lobar Microbleeds in the Posterior Cortical Atrophy Syndrome: A Comparison to Typical Alzheimer\u2019s Disease","volume":"24","author":"Pelak","year":"2024","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Sadeghi, M.A., Stevens, D., Kundu, S., Sanghera, R., Dagher, R., Yedavalli, V., Jones, C., Sair, H., and Luna, L.P. (2024). Detecting Alzheimer\u2019s Disease Stages and Frontotemporal Dementia in Time Courses of Resting-State fMRI Data Using a Machine Learning Approach. J. Imaging Inform. Med.","DOI":"10.1007\/s10278-024-01101-1"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Katsumi, Y., Howe, I.A., Eckbo, R., Wong, B., Quimby, M., Hochberg, D., McGinnis, S.M., Putcha, D., Wolk, D., and Touroutoglou, A. (2024). Default mode network tau predicts future clinical decline in atypical early Alzheimer\u2019s disease. medRxiv.","DOI":"10.1101\/2024.04.17.24305620"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kametani, F., and Hasegawa, M. (2018). Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer\u2019s Disease. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00025"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/jpet.102.041616","article-title":"The Cholinergic Hypothesis of Age and Alzheimer\u2019s Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development","volume":"306","author":"Terry","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/alz.12192","article-title":"Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer\u2019s disease","volume":"17","author":"Arnsten","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Arru\u00e9, L., Cigna-M\u00e9ndez, A., Barbosa, T., Borrego-Mu\u00f1oz, P., Struve-Villalobos, S., Oviedo, V., Mart\u00ednez-Garc\u00eda, C., Sep\u00falveda-Lara, A., Mill\u00e1n, N., and M\u00e1rquez Montesinos, J.C.E. (2022). New Drug Design Avenues Targeting Alzheimer\u2019s Disease by Pharmacoinformatics-Aided Tools. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14091914"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s11011-021-00760-1","article-title":"Association between thyroid function and Alzheimer\u2019s disease: A systematic review","volume":"36","author":"Figueroa","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.3390\/ijms13055751","article-title":"Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells","volume":"13","author":"Raza","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fortes, M.A.S., Scervino, M.V.M., Marzuca-Nassr, G.N., Vitzel, K.F., da Justa Pinheiro, C.H., and Curi, R. (2017). Hypertrophy Stimulation at the Onset of Type I Diabetes Maintains the Soleus but Not the EDL Muscle Mass in Wistar Rats. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00830"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2147\/CIA.S400527","article-title":"Pathophysiological Association of Alzheimer\u2019s Disease and Hypertension: A Clinical Concern for Elderly Population","volume":"18","author":"Yao","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1038\/s41598-022-26607-y","article-title":"Streptozotocin-induced Alzheimer\u2019s disease investigation by one-dimensional plasmonic grating chip","volume":"12","author":"Kadhim","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1463-1326.2012.01585.x","article-title":"Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes","volume":"14","author":"Hussey","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.118.032410","article-title":"Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults","volume":"138","author":"Jefferson","year":"2018","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/2012.jama.10503","article-title":"Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension","volume":"308","author":"Kaess","year":"2012","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1161\/ATVBAHA.117.310296","article-title":"Carotid Artery Remodeling Is Segment Specific","volume":"38","author":"Watase","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4103\/1673-5374.336869","article-title":"Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer\u2019s disease","volume":"17","author":"Bajwa","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","article-title":"A \u201cmitochondrial cascade hypothesis\u201d for sporadic Alzheimer\u2019s disease","volume":"63","author":"Swerdlow","year":"2004","journal-title":"Med. Hypotheses"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3233\/JAD-170585","article-title":"Mitochondria and Mitochondrial Cascades in Alzheimer\u2019s Disease","volume":"62","author":"Swerdlow","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Song, M., and Fan, X. (2023). Systemic Metabolism and Mitochondria in the Mechanism of Alzheimer\u2019s Disease: Finding Potential Therapeutic Targets. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098398"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JAD-221286","article-title":"The Alzheimer\u2019s Disease Mitochondrial Cascade Hypothesis: A Current Overview","volume":"92","author":"Swerdlow","year":"2023","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rose, J., Brian, C., Pappa, A., Panayiotidis, M.I., and Franco, R. (2020). Mitochondrial Metabolism in Astrocytes Regulates Brain Bioenergetics, Neurotransmission and Redox Balance. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.536682"},{"key":"ref_47","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"El-Osta, H., and Circu, M.L. (2016). Mitochondrial ROS and Apoptosis. Mitochondrial Mechanisms of Degeneration and Repair in Parkinson\u2019s Disease, Springer International Publishing.","DOI":"10.1007\/978-3-319-42139-1_1"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Han, Y., Liu, D., Cheng, Y., Ji, Q., Liu, M., Zhang, B., and Zhou, S. (2023). Maintenance of mitochondrial homeostasis for Alzheimer\u2019s disease: Strategies and challenges. Redox Biol., 63.","DOI":"10.1016\/j.redox.2023.102734"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"de Veij Mestdagh, C.F., Smit, A.B., Henning, R.H., and van Kesteren, R.E. (2023). Mitochondrial Targeting against Alzheimer\u2019s Disease: Lessons from Hibernation. Cells, 13.","DOI":"10.3390\/cells13010012"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrn.2018.19","article-title":"Lactate in the brain: From metabolic end-product to signalling molecule","volume":"19","author":"Magistretti","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/MCO.0000000000000069","article-title":"Role of cholesterol metabolism in the pathogenesis of Alzheimer\u2019s disease","volume":"17","author":"Allinquant","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"106611","DOI":"10.1016\/j.isci.2023.106611","article-title":"APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility","volume":"26","author":"Capitini","year":"2023","journal-title":"iScience"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.tcb.2023.09.004","article-title":"The cell biology of APOE in the brain","volume":"34","author":"Windham","year":"2024","journal-title":"Trends Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.tins.2022.01.002","article-title":"Brain cell type-specific cholesterol metabolism and implications for learning and memory","volume":"45","author":"Li","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110670","DOI":"10.1016\/j.brainresbull.2023.110670","article-title":"ApoE4-mediated blood-brain barrier damage in Alzheimer\u2019s disease: Progress and prospects","volume":"199","author":"Zhou","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Akyol, O., Akyol, S., Chou, M.C., Chen, S., Liu, C.K., Selek, S., Soares, J.C., and Chen, C.H. (2023). Lipids and lipoproteins may play a role in the neuropathology of Alzheimer\u2019s disease. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1275932"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0531-5565(99)00022-4","article-title":"The importance of inflammatory mechanisms for the development of Alzheimer\u2019s disease","volume":"34","author":"Eikelenboom","year":"1999","journal-title":"Exp. Gerontol."},{"key":"ref_59","first-page":"1","article-title":"Modelos animales no transg\u00e9nicos de demencia. consideraciones metodol\u00f3gicas y relevancia farmacol\u00f3gica","volume":"1","year":"2023","journal-title":"Rev. Cienc. Farm. Aliment."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Morales, I., Guzm\u00c3\u00a1n-Mart\u00c3nez, L., Cerda-Troncoso, C., Far\u00c3as, G.A., and Maccioni, R.B. (2014). Neuroinflammation in the pathogenesis of Alzheimer\u2019s disease. A rational framework for the search of novel therapeutic approaches. Front. Cell. Neurosci., 8.","DOI":"10.3389\/fncel.2014.00112"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Arias, C., Sep\u00falveda, P., Castillo, R.L., and Salazar, L.A. (2023). Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1\u03b1 and Th17 Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043073"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: The devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neubiorev.2017.01.044","article-title":"Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions","volume":"75","author":"Wenger","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1096\/fj.08-115055","article-title":"Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates","volume":"23","author":"Verhoef","year":"2009","journal-title":"FASEB J."},{"key":"ref_65","unstructured":"World Health Organization (2024, March 01). Global Action Plan on Physical Activity 2018\u20132030: More Active People for a Healthier World: At-A-Glance. 2018. Available online: https:\/\/iris.who.int\/handle\/10665\/272721."},{"key":"ref_66","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: Definitions and distinctions for health-related research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public Health Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1249\/JSR.0b013e3181e7da73","article-title":"Uncomplicated Resistance Training and Health-Related Outcomes","volume":"9","author":"Phillips","year":"2010","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo","volume":"3","author":"Bodine","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"C120","DOI":"10.1152\/ajpcell.1999.276.1.C120","article-title":"Phosphorylation of p70 S6k correlates with increased skeletal muscle mass following resistance exercise","volume":"276","author":"Baar","year":"1999","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bolster, D., Kubica, N., Crozier, S., Williamson, D., Farrell, P., Kimball, S., and Jefferson, L.S. (2004). Understanding skeletal muscle hypertrophy: Integration of cell signalling. Physiol. News Mag., 18\u201319.","DOI":"10.36866\/pn.55.18"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.biocel.2005.04.018","article-title":"Skeletal muscle hypertrophy and atrophy signaling pathways","volume":"37","author":"Glass","year":"2005","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Vainshtein, A., and Sandri, M. (2020). Signaling Pathways That Control Muscle Mass. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134759"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1007\/s00018-013-1330-4","article-title":"Skeletal muscle hypertrophy and regeneration: Interplay between the myogenic regulatory factors (MRFs) and insulin-like growth factors (IGFs) pathways","volume":"70","author":"Zanou","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Fernandes, T., Soci, \u00da.P., Melo, S.F., Alves, C.R., and Oliveira, E.M. (2012). Signaling Pathways that Mediate Skeletal Muscle Hypertrophy: Effects of Exercise Training. Skeletal Muscle\u2014From Myogenesis to Clinical Relations, InTech.","DOI":"10.5772\/51087"},{"key":"ref_75","first-page":"65","article-title":"Training Principles: Evaluation of Modes and Methods of Resistance Training","volume":"22","author":"Stone","year":"2000","journal-title":"Strength Cond. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1249\/JSR.0000000000000576","article-title":"Sports Training Principles","volume":"18","author":"Kasper","year":"2019","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease\u2014Insights from amyloid-\u03b2 metabolism beyond the brain","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/jcsm.12830","article-title":"Skeletal muscle atrophy-induced hemopexin accelerates onset of cognitive impairment in Alzheimer\u2019s disease","volume":"12","author":"Nagase","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/BF03401785","article-title":"Elevated A\u03b2 and Apolipoprotein E in A\u03b2PP Transgenic Mice and Its Relationship to Amyloid Accumulation in Alzheimer\u2019s Disease","volume":"6","author":"Kuo","year":"2000","journal-title":"Mol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"104268","DOI":"10.1016\/j.archger.2020.104268","article-title":"Sarcopenia and frailty in individuals with dementia: A systematic review","volume":"92","author":"Waite","year":"2021","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00401-008-0449-0","article-title":"Inclusion-body myositis: Muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer\u2019s and Parkinson\u2019s disease brains","volume":"116","author":"Askanas","year":"2008","journal-title":"Acta Neuropathol."},{"key":"ref_83","first-page":"1291","article-title":"Pathogenesis of inclusion body myositis: Autoimmune or degenerative disease?","volume":"65","author":"Uruha","year":"2013","journal-title":"Brain Nerve"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archneurol.2010.38","article-title":"Reduced Lean Mass in Early Alzheimer Disease and Its Association With Brain Atrophy","volume":"67","author":"Burns","year":"2010","journal-title":"Arch. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2174\/1567205012666150204124852","article-title":"Age-Dependent Biochemical Dysfunction in Skeletal Muscle of Triple- Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"12","author":"Castro","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e20230032","DOI":"10.1590\/1980-5764-dn-2023-0032","article-title":"Brain insulin resistance and Alzheimer\u2019s disease: A systematic review","volume":"18","author":"Andrade","year":"2024","journal-title":"Dement Neuropsychol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Shafi, O. (2016). Inverse relationship between Alzheimer\u2019s disease and cancer, and other factors contributing to Alzheimer\u2019s disease: A systematic review. BMC Neurol., 16.","DOI":"10.1186\/s12883-016-0765-2"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3233\/JAD-230600","article-title":"Impact of Suramin on Key Pathological Features of Sporadic Alzheimer\u2019s Disease-Derived Forebrain Neurons","volume":"98","author":"Culibrk","year":"2024","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Kommaddi, R.P., Gowaikar, R., PA, H., Diwakar, L., Singh, K., and Mondal, A. (2024). Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer\u2019s disease mouse model. J. Biol. Chem., 300.","DOI":"10.1016\/j.jbc.2023.105619"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2023.11.023","article-title":"ApoE Mimic Peptide COG1410 Reduces A\u03b2 Deposition and Improves Cognitive Function by Inducing the Transformation of A1\/A2 Reactive Astrocytes and Increasing the BDNF Concentration in Brain of APP\/PS1 Double Transgenic Mice","volume":"537","author":"Qiao","year":"2024","journal-title":"Neuroscience"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Numakawa, T., and Kajihara, R. (2024). An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031596"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/glia.24505","article-title":"Dynamics of myelin deficits in the 5xFAD mouse model for Alzheimer\u2019s disease and the protective role of BDNF","volume":"72","author":"Zota","year":"2024","journal-title":"Glia"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e209198","DOI":"10.1212\/WNL.0000000000209198","article-title":"Association of Neurotrophic Factors at Midlife With In Vivo Measures of \u03b2-Amyloid and Tau Burden 15 Years Later in Dementia-Free Adults","volume":"102","author":"Weinstein","year":"2024","journal-title":"Neurology"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Asadi, M.R., Gharesouran, J., Sabaie, H., Zaboli Mahdiabadi, M., Mazhari, S.A., Sharifi-Bonab, M., Shirvani-Farsani, Z., Taheri, M., Sayad, A., and Rezazadeh, M. (2024). Neurotrophin growth factors and their receptors as promising blood biomarkers for Alzheimer\u2019s Disease: A gene expression analysis study. Mol. Biol. Rep., 51.","DOI":"10.1007\/s11033-023-08959-4"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40035-022-00279-0","article-title":"Brain-derived neurotrophic factor in Alzheimer\u2019s disease and its pharmaceutical potential","volume":"11","author":"Gao","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/jnr.22075","article-title":"Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies","volume":"87","author":"Leem","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","article-title":"Transport of brain-derived neurotrophic factor across the blood\u2013brain barrier","volume":"37","author":"Pan","year":"1998","journal-title":"Neuropharmacology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e13564","DOI":"10.1111\/obr.13564","article-title":"Long-term effects of different exercise training modes on cytokines and adipokines in individuals with overweight\/obesity and cardiometabolic diseases: A systematic review, meta-analysis, and meta-regression of randomized controlled trials","volume":"24","author":"Baraquet","year":"2023","journal-title":"Obes. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"368504241227088","DOI":"10.1177\/00368504241227088","article-title":"Resistance training and inter-interindividual response differences on cardiorespiratory fitness in older adults: An ancillary meta-analysis of randomized controlled trials","volume":"107","author":"Kelley","year":"2024","journal-title":"Sci. Prog."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"F\u00e9lix-Soriano, E., and Stanford, K.I. (2023). Exerkines and redox homeostasis. Redox Biol., 63.","DOI":"10.1016\/j.redox.2023.102748"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12944-020-1195-0","article-title":"Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate","volume":"19","author":"Teixeira","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"108554","DOI":"10.1016\/j.celrep.2020.108554","article-title":"Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans","volume":"33","author":"Morville","year":"2020","journal-title":"Cell. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"de Greg\u00f3rio, E., Mendes, G.C., Somensi, L.B., Freire, C.G., Lopes, L.F., Lima, K.R., Carrazoni, G.S., Neves, B.S., Picua, S.S., and da Silva, L.M. (2022). Neuroprotective effects of strength training in a neuroinflammatory animal model. BMC Neurosci., 23.","DOI":"10.1186\/s12868-022-00708-w"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-022-02483-1","article-title":"Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflam."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12035-022-03069-x","article-title":"Resistance Training Modulates Hippocampal Neuroinflammation and Protects Anxiety-Depression-like Dyad Induced by an Emotional Single Prolonged Stress Model","volume":"60","author":"Jung","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s11556-024-00344-9","article-title":"Resistance training\u2019s impact on blood biomarkers and cognitive function in older adults with low and high risk of mild cognitive impairment: A randomized controlled trial","volume":"21","author":"Vints","year":"2024","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1519\/JSC.0000000000004270","article-title":"Lower-Body Resistance Training Reduces Interleukin-1\u03b2 and Transforming Growth Factor-\u03b21 Levels and Fatigue and Increases Physical Performance in Breast Cancer Survivors","volume":"37","author":"Martins","year":"2023","journal-title":"J. Strength Cond. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1177\/1099800420958068","article-title":"Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis","volume":"23","author":"Niyazi","year":"2021","journal-title":"Biol. Res. Nurs."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Lopes, L.M.P., Oliveira ECd Becker, L.K., Costa, G.d.P., Pinto, K.M.d.C., Talvani, A., Carraro, J.C.C., and Coelho, D.B. (2020). Resistance Training Associated with Dietetic Advice Reduces Inflammatory Biomarkers in the Elderly. Biomed. Res. Int., 2020.","DOI":"10.1155\/2020\/7351716"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Schwappacher, R., Dieterich, W., Reljic, D., Pilarsky, C., Mukhopadhyay, D., Chang, D.K., Biankin, E.V., Siebler, J., Herrmann, H.J., and Neurath, M.F. (2021). Muscle-Derived Cytokines Reduce Growth, Viability and Migratory Activity of Pancreatic Cancer Cells. Cancers, 13.","DOI":"10.3390\/cancers13153820"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"330","DOI":"10.12965\/jer.2244388.194","article-title":"Does Gotu kola supplementation improve cognitive function, inflammation, and oxidative stress more than multicomponent exercise alone?\u2014A randomized controlled study","volume":"18","author":"Phoemsapthawee","year":"2022","journal-title":"J. Exerc. Rehabil."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e15922","DOI":"10.14814\/phy2.15922","article-title":"Resistance training does not increase myocellular garbage dumps: A pilot study on lipofuscin in skeletal muscle fibers of resistance trained young men","volume":"12","author":"Jacko","year":"2024","journal-title":"Physiol. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Key, M.N., and Szabo-Reed, A.N. (2023). Impact of Diet and Exercise Interventions on Cognition and Brain Health in Older Adults: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15112495"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"112141","DOI":"10.1016\/j.exger.2023.112141","article-title":"A systematic review of exercise modalities that reduce pro-inflammatory cytokines in humans and animals\u2019 models with mild cognitive impairment or dementia","volume":"175","author":"Ayari","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Alanazi, M.A. (2024). The Role of Physical Activity in Adjunctive Nursing Management of Neuro-Degenerative Diseases among Older Adults: A Systematic Review of Interventional Studies. Life, 14.","DOI":"10.3390\/life14050597"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/geronb\/gbz072","article-title":"A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults","volume":"76","author":"Zammit","year":"2021","journal-title":"J. Gerontol. Ser. B"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s40520-024-02700-2","article-title":"Multidomain interventions for sarcopenia and cognitive flexibility in older adults for promoting healthy aging: A systematic review and meta-analysis of randomized controlled trials","volume":"36","author":"Linhares","year":"2024","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.44.2.459","article-title":"Nature of Dividing Nuclei in Skeletal Muscle of Growing Rats","volume":"44","author":"Moss","year":"1970","journal-title":"J. Cell. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1038\/s41598-023-29406-1","article-title":"Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer\u2019s disease","volume":"13","author":"Rahmati","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jshs.2023.06.005","article-title":"The influence of resistance exercise training prescription variables on skeletal muscle mass, strength, and physical function in healthy adults: An umbrella review","volume":"13","author":"Mcleod","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1136\/bjsports-2023-106807","article-title":"Resistance training prescription for muscle strength and hypertrophy in healthy adults: A systematic review and Bayesian network meta-analysis","volume":"57","author":"Currier","year":"2023","journal-title":"Br. J. Sports Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/jnc.13658","article-title":"BDNF isoforms: A round trip ticket between neurogenesis and serotonin?","volume":"138","author":"Foltran","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"zqae005","DOI":"10.1093\/function\/zqae005","article-title":"Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity","volume":"5","author":"Edman","year":"2024","journal-title":"Function"},{"key":"ref_124","first-page":"562","article-title":"The importance of neuromuscular rate of force development for physical function in aging and common neurodegenerative disorders\u2014A systematic review","volume":"22","author":"Lomborg","year":"2022","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/09638288.2022.2037744","article-title":"Effectiveness of physical exercise at improving functional capacity in older adults living with Alzheimer\u2019s disease: A systematic review of randomized controlled trials","volume":"45","author":"Cezar","year":"2023","journal-title":"Disabil. Rehabil."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Rodrigues Junior, C.F., Murata, G.M., Gerlinger-Romero, F., Nachbar, R.T., Marzuca-Nassr, G.N., Gorj\u00e3o, R., Vitzel, K.F., Hirabara, S.M., Pithon-Curi, T.C., and Curi, R. (2023). Changes in Skeletal Muscle Protein Metabolism Signaling Induced by Glutamine Supplementation and Exercise. Nutrients, 15.","DOI":"10.3390\/nu15224711"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1152\/japplphysiol.00237.2022","article-title":"Exercise training modifies the whole blood DNA methylation profile in middle-aged and older women","volume":"134","author":"Noronha","year":"2023","journal-title":"J. Appl. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s12015-022-10361-9","article-title":"Physical Activity Modulates miRNAs Levels and Enhances MYOD Expression in Myoblasts","volume":"18","author":"Dorelli","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez, D., and Caballero, J. (2016). Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040525"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"111948","DOI":"10.1016\/j.exger.2022.111948","article-title":"Alzheimer\u2019s disease genes and proteins associated with resistance and aerobic training: An in silico analysis","volume":"168","author":"Coutinho","year":"2022","journal-title":"Exp. Gerontol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"102356","DOI":"10.1016\/j.arr.2024.102356","article-title":"Does resistance training in older adults lead to structural brain changes associated with a lower risk of Alzheimer\u2019s dementia? A narrative review","volume":"98","author":"Nicola","year":"2024","journal-title":"Ageing Res. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/7084\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:06:36Z","timestamp":1760108796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/7084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":132,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25137084"],"URL":"https:\/\/doi.org\/10.3390\/ijms25137084","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]}}}