{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:49:00Z","timestamp":1787028540823,"version":"build-2736575974"},"reference-count":148,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre (PL)","doi-asserted-by":"publisher","award":["2019\/35\/N\/NZ4\/03706"],"award-info":[{"award-number":["2019\/35\/N\/NZ4\/03706"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Peroxisome proliferator-activated receptors (PPARs) may play an important role in the pathomechanism\/pathogenesis of Alzheimer\u2019s disease (AD) and several other neurological\/neuropsychiatric disorders. AD leads to progressive alterations in the redox state, ion homeostasis, lipids, and protein metabolism. Significant alterations in molecular processes and the functioning of several signaling pathways result in the degeneration and death of synapses and neuronal cells, leading to the most severe dementia. Peroxisome proliferator-activated receptor alpha (PPAR-\u03b1) is among the processes affected by AD; it regulates the transcription of genes related to the metabolism of cholesterol, fatty acids, other lipids and neurotransmission, mitochondria biogenesis, and function. PPAR-\u03b1 is involved in the cholesterol transport to mitochondria, the substrate for neurosteroid biosynthesis. PPAR-\u03b1-coding enzymes, such as sulfotransferases, which are responsible for neurosteroid sulfation. The relation between PPAR-\u03b1 and cholesterol\/neurosteroids may have a significant impact on the course and progression of neurodegeneration\/neuroprotection processes. Unfortunately, despite many years of intensive studies, the pathogenesis of AD is unknown and therapy for AD and other neurodegenerative diseases is symptomatic, presenting a significant goal and challenge today. This review presents recent achievements in therapeutic approaches for AD, which are targeting PPAR-\u03b1 and its relation to cholesterol and neurosteroids in AD and neuropsychiatric disorders.<\/jats:p>","DOI":"10.3390\/ijms25137106","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T06:51:53Z","timestamp":1719557513000},"page":"7106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Current View on PPAR-\u03b1 and Its Relation to Neurosteroids in Alzheimer\u2019s Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy"],"prefix":"10.3390","volume":"25","author":[{"given":"Sylwia","family":"\u017buli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Cellular Signaling, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawi\u0144skiego St., 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9509-8751","authenticated-orcid":false,"given":"Anna K.","family":"Strosznajder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical University of Warsaw, Nowowiejska St. 27, 00-665 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6213-1212","authenticated-orcid":false,"given":"Joanna B.","family":"Strosznajder","sequence":"additional","affiliation":[{"name":"Department of Cellular Signaling, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawi\u0144skiego St., 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nrd3869","article-title":"Drug repositioning for Alzheimer\u2019s disease","volume":"11","author":"Corbett","year":"2012","journal-title":"Nat. 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