{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:46:25Z","timestamp":1792143985534,"version":"4.4.0"},"reference-count":60,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1781\/16"],"award-info":[{"award-number":["1781\/16"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["3-15689"],"award-info":[{"award-number":["3-15689"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Israel Ministry of Science","award":["1781\/16"],"award-info":[{"award-number":["1781\/16"]}]},{"name":"Israel Ministry of Science","award":["3-15689"],"award-info":[{"award-number":["3-15689"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesity is a major public health concern that is associated with negative health outcomes. Exercise and dietary restriction are commonly recommended to prevent or combat obesity. This study investigates how voluntary exercise mitigates abnormal gene expression in the hypothalamic arcuate nucleus (ARC) of diet-induced obese (DIO) rats. Using a transcriptomic approach, novel genes in the ARC affected by voluntary wheel running were assessed alongside physiology, pharmacology, and bioinformatics analysis to evaluate the role of miR-211 in reversing obesity. Exercise curbed weight gain and fat mass, and restored ARC gene expression. High-fat diet (HFD) consumption can dysregulate satiety\/hunger mechanisms in the ARC. Transcriptional clusters revealed that running altered gene expression patterns, including inflammation and cellular structure genes. To uncover regulatory mechanisms governing gene expression in DIO attenuation, we explored miR-211, which is implicated in systemic inflammation. Exercise ameliorated DIO overexpression of miR-211, demonstrating its pivotal role in regulating inflammation in the ARC. Further, in vivo central administration of miR-211-mimic affected the expression of immunity and cell cycle-related genes. By cross-referencing exercise-affected and miR-211-regulated genes, potential candidates for obesity reduction through exercise were identified. This research suggests that exercise may rescue obesity through gene expression changes mediated partially through miR-211.<\/jats:p>","DOI":"10.3390\/ijms25137188","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:58:42Z","timestamp":1719925122000},"page":"7188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exercise Rescues Obesogenic-Related Genes in the Female Hypothalamic Arcuate Nucleus: A Potential Role of miR-211 Modulation"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-1828","authenticated-orcid":false,"given":"Kayla","family":"Rapps","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel"},{"name":"Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7528809, Israel"},{"name":"Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1804-5787","authenticated-orcid":false,"given":"Asaf","family":"Marco","sequence":"additional","affiliation":[{"name":"Neuro-Epigenetics Laboratory, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6878-1902","authenticated-orcid":false,"given":"Hilla","family":"Pe\u2019er-Nissan","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel"},{"name":"Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-9551","authenticated-orcid":false,"given":"Tatiana","family":"Kisliouk","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7528809, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Stemp","sequence":"additional","affiliation":[{"name":"Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Yadid","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, Bar Ilan University, Ramat Gan 5290002, Israel"},{"name":"Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-4384","authenticated-orcid":false,"given":"Aron","family":"Weller","sequence":"additional","affiliation":[{"name":"Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel"},{"name":"Department of Psychology, Bar Ilan University, Ramat Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-5665","authenticated-orcid":false,"given":"Noam","family":"Meiri","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Agricultural Research Organization, The Volcani Center, Rishon LeZion 7528809, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s42255-019-0145-5","article-title":"Inter-organ cross-talk in metabolic syndrome","volume":"1","author":"Priest","year":"2019","journal-title":"Nat. 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