{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:31:07Z","timestamp":1789471867156,"version":"build-2803163510"},"reference-count":113,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research, Development, and Innovation Office [Hungary]","award":["OTKA 145898"],"award-info":[{"award-number":["OTKA 145898"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurodegenerative diseases affect an increasing part of the population of modern societies, burdening healthcare systems and causing immense suffering at the personal level. The pathogenesis of several of these disorders involves dysregulation of gene expression, which depends on several molecular processes ranging from transcription to protein stability. microRNAs (miRNAs) are short non-coding RNA molecules that modulate gene expression by suppressing the translation of partially complementary mRNAs. miR-137 is a conserved, neuronally enriched miRNA that is implicated in neurodegeneration. Here, we review the current body of knowledge about the role that miR-137 plays in five prominent neurodegenerative disorders, including Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, and multiple sclerosis. The presented data indicate that, rather than having a general neuroprotective role, miR-137 modulates the pathology of distinct disorders differently.<\/jats:p>","DOI":"10.3390\/ijms25137229","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:58:42Z","timestamp":1719925122000},"page":"7229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of miR-137 in Neurodegenerative Disorders"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-626X","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Bodai","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Borosta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Ferencz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e9desz","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"},{"name":"Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6189-3100","authenticated-orcid":false,"given":"N\u00f3ra","family":"Zsindely","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"},{"name":"Department of Genetics, Faculty of Science and Informatics, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00441-012-1438-0","article-title":"Micro-RNAs (miRNAs): Genomic Organisation, Biogenesis and Mode of Action","volume":"349","author":"Hussain","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41576-023-00611-y","article-title":"microRNAs in Action: Biogenesis, Function and Regulation","volume":"24","author":"Shang","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Stavast, C.J., and Erkeland, S.J. (2019). The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation. Cells, 8.","DOI":"10.3390\/cells8111465"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Brennecke, J., Stark, A., Russell, R.B., and Cohen, S.M. (2005). Principles of MicroRNA\u2013Target Recognition. PLoS Biol., 3.","DOI":"10.1371\/journal.pbio.0030085"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gu, S., Jin, L., Zhang, F., Sarnow, P., and Kay, M.A. (2009). The Biological Basis for microRNA Target Restriction to the 3\u2019 Untranslated Region in Mammalian mRNAs. Nat. Struct. Mol. Biol., 16.","DOI":"10.1038\/nsmb.1552"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA Sequences to Function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most Mammalian mRNAs Are Conserved Targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a Risk Factor for Neurodegenerative Disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_9","unstructured":"(2024, May 24). GHE: Life Expectancy and Healthy Life Expectancy. Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\/ghe-life-expectancy-and-healthy-life-expectancy."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ding, C., Wu, Y., Chen, X., Chen, Y., Wu, Z., Lin, Z., Kang, D., Fang, W., and Chen, F. (2022). Global, Regional, and National Burden and Attributable Risk Factors of Neurological Disorders: The Global Burden of Disease Study 1990\u20132019. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.952161"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102017","DOI":"10.1016\/j.arr.2023.102017","article-title":"A Comprehensive Review of Protein Misfolding Disorders, Underlying Mechanism, Clinical Diagnosis, and Therapeutic Strategies","volume":"90","author":"Basha","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-Cell Transcriptomic Analysis of Alzheimer\u2019s Disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00401-023-02597-7","article-title":"Transcriptomic Profiling of Parkinson\u2019s Disease Brains Reveals Disease Stage Specific Gene Expression Changes","volume":"146","author":"Cappelletti","year":"2023","journal-title":"Acta Neuropathol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Malla, B., Guo, X., Senger, G., Chasapopoulou, Z., and Yildirim, F. (2021). A Systematic Review of Transcriptional Dysregulation in Huntington\u2019s Disease Studied by RNA Sequencing. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.751033"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ju\u017awik, C.A., S Drake, S., Zhang, Y., Paradis-Isler, N., Sylvester, A., Amar-Zifkin, A., Douglas, C., Morquette, B., Moore, C.S., and Fournier, A.E. (2019). microRNA Dysregulation in Neurodegenerative Diseases: A Systematic Review. Prog. Neurobiol., 182.","DOI":"10.1016\/j.pneurobio.2019.101664"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ib\u00e1\u00f1ez-Ventoso, C., Vora, M., and Driscoll, M. (2008). Sequence Relationships among C. Elegans, D. Melanogaster and Human microRNAs Highlight the Extensive Conservation of microRNAs in Biology. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002818"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1101\/gad.1884710","article-title":"Mammalian microRNAs: Experimental Evaluation of Novel and Previously Annotated Genes","volume":"24","author":"Chiang","year":"2010","journal-title":"Genes Dev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"D36","DOI":"10.1093\/nar\/gku1055","article-title":"Gene: A Gene-Centered Information Resource at NCBI","volume":"43","author":"Brown","year":"2015","journal-title":"Nucleic. Acids Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"miRDB: An Online Database for Prediction of Functional microRNA Targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: Annotating High Confidence microRNAs Using Deep Sequencing Data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1136\/jmedgenet-2011-100294","article-title":"Chromosome 1p21.3 Microdeletions Comprising DPYD and MIR137 Are Associated with Intellectual Disability","volume":"48","author":"Willemsen","year":"2011","journal-title":"J. Med. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41596-019-0128-8","article-title":"Protocol Update for Large-Scale Genome and Gene Function Analysis with the PANTHER Classification System (v.14.0)","volume":"14","author":"Mi","year":"2019","journal-title":"Nat. Protoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.200908151","article-title":"Cross Talk between microRNA and Epigenetic Regulation in Adult Neurogenesis","volume":"189","author":"Szulwach","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41467-019-08390-z","article-title":"The Functional Synergism of microRNA Clustering Provides Therapeutically Relevant Epigenetic Interference in Glioblastoma","volume":"10","author":"Bhaskaran","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/mp.2014.53","article-title":"MIR137 Variants Identified in Psychiatric Patients Affect Synaptogenesis and Neuronal Transmission Gene Sets","volume":"20","author":"Strazisar","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.exphem.2006.12.002","article-title":"MicroRNA Expression Profiling during Human Cord Blood-Derived CD34 Cell Erythropoiesis","volume":"35","author":"Choong","year":"2007","journal-title":"Exp. Hematol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1073\/pnas.1018493108","article-title":"A Program of microRNAs Controls Osteogenic Lineage Progression by Targeting Transcription Factor Runx2","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12015-014-9582-4","article-title":"Gene and MicroRNA Profiling of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells","volume":"11","author":"Wang","year":"2015","journal-title":"Stem. Cell Rev. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Necela, B.M., Carr, J.M., Asmann, Y.W., and Thompson, E.A. (2011). Differential Expression of microRNAs in Tumors from Chronically Inflamed or Genetic (APC(Min\/+)) Models of Colon Cancer. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018501"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000430349","article-title":"A MicroRNA Signature in Gestational Diabetes Mellitus Associated with Risk of Macrosomia","volume":"37","author":"Li","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/ijc.28091","article-title":"MiR-137 Functions as a Tumor Suppressor in Neuroblastoma by Downregulating KDM1A","volume":"133","author":"Althoff","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.leukres.2017.01.028","article-title":"miR-137 Downregulates c-Kit Expression in Acute Myeloid Leukemia","volume":"57","author":"Hu","year":"2017","journal-title":"Leuk. Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) (2011). Consortium Genome-Wide Association Study Identifies Five New Schizophrenia Loci. Nat. Genet., 43, 969\u2013976.","DOI":"10.1038\/ng.940"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bcp.2017.07.008","article-title":"MicroRNA: Basic Concepts and Implications for Regeneration and Repair of Neurodegenerative Diseases","volume":"141","author":"Saraiva","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer Disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14820","DOI":"10.1523\/JNEUROSCI.3883-11.2011","article-title":"MicroRNA-137\/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid \u03b2, Novel Targets in Sporadic Alzheimer\u2019s Disease","volume":"31","author":"Geekiyanage","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13024-017-0191-y","article-title":"Dissecting the Role of Non-Coding RNAs in the Accumulation of Amyloid and Tau Neuropathologies in Alzheimer\u2019s Disease","volume":"12","author":"Patrick","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Nunez-Iglesias, J., Liu, C.-C., Morgan, T.E., Finch, C.E., and Zhou, X.J. (2010). Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer\u2019s Disease Cortex Reveals Altered miRNA Regulation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008898"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"111352","DOI":"10.1016\/j.mad.2020.111352","article-title":"Genome-Wide Profiling and Predicted Significance of Post-Mortem Brain microRNA in Alzheimer\u2019s Disease","volume":"191","author":"Henriques","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Li, Q.S., and Cai, D. (2021). Integrated miRNA-Seq and mRNA-Seq Study to Identify miRNAs Associated With Alzheimer\u2019s Disease Using Post-Mortem Brain Tissue Samples. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.620899"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1073\/pnas.0710263105","article-title":"Loss of microRNA Cluster miR-29a\/b-1 in Sporadic Alzheimer\u2019s Disease Correlates with Increased BACE1\/Beta-Secretase Expression","volume":"105","author":"Papadopoulou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.expneurol.2011.11.026","article-title":"Blood Serum miRNA: Non-Invasive Biomarkers for Alzheimer\u2019s Disease","volume":"235","author":"Geekiyanage","year":"2012","journal-title":"Exp. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/ame2.12368","article-title":"miRNA-137-5p Improves Spatial Memory and Cognition in Alzheimer\u2019s Mice by Targeting Ubiquitin-Specific Peptidase 30","volume":"6","author":"Jiang","year":"2023","journal-title":"Anim. Models Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroscience.2018.03.016","article-title":"Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia","volume":"379","author":"Wei","year":"2018","journal-title":"Neuroscience"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Kumar, P., Dezso, Z., MacKenzie, C., Oestreicher, J., Agoulnik, S., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., and Oda, Y. (2013). Circulating miRNA Biomarkers for Alzheimer\u2019s Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069807"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13195-020-00627-0","article-title":"Differential Blood miRNA Expression in Brain Amyloid Imaging-Defined Alzheimer\u2019s Disease and Controls","volume":"12","author":"Wu","year":"2020","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.bbrc.2019.08.033","article-title":"Knockdown of lncRNA SNHG1 Attenuated A\u03b225-35-Inudced Neuronal Injury via Regulating KREMEN1 by Acting as a ceRNA of miR-137 in Neuronal Cells","volume":"518","author":"Wang","year":"2019","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"114560","DOI":"10.1016\/j.expneurol.2023.114560","article-title":"Memory Impairment Was Ameliorated by Corticolimbic Microinjections of Arachidonylcyclopropylamide (ACPA) and miRNA-Regulated Lentiviral Particles in a Streptozotocin-Induced Alzheimer\u2019s Rat Model","volume":"370","author":"Hosseininia","year":"2023","journal-title":"Exp. Neurol."},{"key":"ref_50","first-page":"7490","article-title":"Up-Regulation of miR-137 Can Inhibit PTN in Target Manner to Regulate PTN\/PTPRZ Pathway to Prevent Cognitive Dysfunction Caused by Propofol","volume":"12","author":"Yang","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.12659\/MSM.908765","article-title":"Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer\u2019s Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells","volume":"24","author":"Jiang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/kjm2.12485","article-title":"Long Non-Coding RNA Opa Interacting Protein 5-Antisense RNA 1 Promotes Mitochondrial Autophagy and Protects SH-SY5Y Cells from 1-Methyl-4-Phenylpyridine-Induced Damage by Binding to microRNA-137 and Upregulating NIX","volume":"38","author":"Zhao","year":"2022","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"146331","DOI":"10.1016\/j.brainres.2019.146331","article-title":"Serum Secreted miR-137-Containing Exosomes Affects Oxidative Stress of Neurons by Regulating OXR1 in Parkinson\u2019s Disease","volume":"1722","author":"Jiang","year":"2019","journal-title":"Brain Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"16999","DOI":"10.3390\/ijms140816999","article-title":"Regulation of Huntingtin Gene Expression by miRNA-137,-214,-148a, and Their Respective isomiRs","volume":"14","author":"Kozlowska","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2217\/epi-2021-0288","article-title":"Epigenetic Axis of SNHG19\/miR-137\/TNFAIP1 Modulates Amyloid Beta Peptide 25-35-Induced SH-SY5Y Cytotoxicity","volume":"14","author":"Li","year":"2022","journal-title":"Epigenomics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbrc.2018.01.022","article-title":"LncRNA GAS5 Regulates Ischemic Stroke as a Competing Endogenous RNA for miR-137 to Regulate the Notch1 Signaling Pathway","volume":"496","author":"Chen","year":"2018","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ross, S.P., Baker, K.E., Fisher, A., Hoff, L., Pak, E.S., and Murashov, A.K. (2018). miRNA-431 Prevents Amyloid-\u03b2-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer\u2019s Disease by Silencing Kremen1. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00087"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.neurobiolaging.2008.08.022","article-title":"High-Fat Diet Aggravates Amyloid-Beta and Tau Pathologies in the 3xTg-AD Mouse Model","volume":"31","author":"Julien","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.plipres.2009.10.004","article-title":"Dietary Fats, Cerebrovasculature Integrity and Alzheimer\u2019s Disease Risk","volume":"49","author":"Takechi","year":"2010","journal-title":"Prog. Lipid Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.neurobiolaging.2013.02.001","article-title":"Inhibition of Serine Palmitoyltransferase Reduces A\u03b2 and Tau Hyperphosphorylation in a Murine Model: A Safe Therapeutic Strategy for Alzheimer\u2019s Disease","volume":"34","author":"Geekiyanage","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Herradon, G., Ramos-Alvarez, M.P., and Gramage, E. (2019). Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP\u03b2\/\u03b6 Axis: Relevance in Therapeutic Development. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00377"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00001756-199601310-00068","article-title":"HB-GAM Is a Cytokine Present in Alzheimer\u2019s and Down\u2019s Syndrome Lesions","volume":"7","author":"Wisniewski","year":"1996","journal-title":"Neuroreport"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Xiong, Y., and Lim, C.-S. (2021). Understanding the Modulatory Effects of Cannabidiol on Alzheimer\u2019s Disease. Brain Sci., 11.","DOI":"10.3390\/brainsci11091211"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/brain\/awr046","article-title":"Molecular Reorganization of Endocannabinoid Signalling in Alzheimer\u2019s Disease","volume":"134","author":"Mulder","year":"2011","journal-title":"Brain"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","article-title":"Genetics and Pathogenesis of Parkinson\u2019s Syndrome","volume":"18","author":"Ye","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Hoss, A.G., Labadorf, A., Beach, T.G., Latourelle, J.C., and Myers, R.H. (2016). microRNA Profiles in Parkinson\u2019s Disease Prefrontal Cortex. Front. Aging Neurosci., 8.","DOI":"10.3389\/fnagi.2016.00036"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s12031-014-0428-y","article-title":"MiRNA Profile in the Substantia Nigra of Parkinson\u2019s Disease and Healthy Subjects","volume":"54","author":"Cardo","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/hmg\/ddr210","article-title":"MicroRNA Profiling of Parkinson\u2019s Disease Brains Identifies Early Downregulation of miR-34b\/c Which Modulate Mitochondrial Function","volume":"20","author":"Porta","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1007\/s00415-013-6900-8","article-title":"Profile of microRNAs in the Plasma of Parkinson\u2019s Disease Patients and Healthy Controls","volume":"260","author":"Cardo","year":"2013","journal-title":"J. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s10072-017-2841-9","article-title":"Plasma Levels of miR-137 and miR-124 Are Associated with Parkinson\u2019s Disease but Not with Parkinson\u2019s Disease with Depression","volume":"38","author":"Li","year":"2017","journal-title":"Neurol. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e706","DOI":"10.1002\/ctm2.706","article-title":"Long Non-coding RNA OIP5-AS1 (Cyrano): A Context-specific Regulator of Normal and Disease Processes","volume":"12","author":"Wooten","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"10691","DOI":"10.1074\/jbc.M113.537050","article-title":"MicroRNA-137 Is a Novel Hypoxia-Responsive microRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX","volume":"289","author":"Li","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Oliver, P.L., Finelli, M.J., Edwards, B., Bitoun, E., Butts, D.L., Becker, E.B.E., Cheeseman, M.T., Davies, B., and Davies, K.E. (2011). Oxr1 Is Essential for Protection against Oxidative Stress-Induced Neurodegeneration. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002338"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"20417314211004816","DOI":"10.1177\/20417314211004816","article-title":"Priming Mesenchymal Stem Cells with Uric Acid Enhances Neuroprotective Properties in Parkinsonian Models","volume":"12","author":"Kim","year":"2021","journal-title":"J. Tissue Eng."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Kong, Y., Liang, X., Liu, L., Zhang, D., Wan, C., Gan, Z., and Yuan, L. (2015). High Throughput Sequencing Identifies MicroRNAs Mediating \u03b1-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson\u2019s Disease Model. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0137432"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s Disease: A Clinical Review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington Disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved Seed Pairing, Often Flanked by Adenosines, Indicates That Thousands of Human Genes Are MicroRNA Targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Hoss, A.G., Labadorf, A., Latourelle, J.C., Kartha, V.K., Hadzi, T.C., Gusella, J.F., MacDonald, M.E., Chen, J.-F., Akbarian, S., and Weng, Z. (2015). miR-10b-5p Expression in Huntington\u2019s Disease Brain Relates to Age of Onset and the Extent of Striatal Involvement. BMC Med. Genom., 8.","DOI":"10.1186\/s12920-015-0083-3"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1093\/nar\/gkq575","article-title":"A Myriad of miRNA Variants in Control and Huntington\u2019s Disease Brain Regions Detected by Massively Parallel Sequencing","volume":"38","author":"Pantano","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological Classification of Huntington\u2019s Disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1007\/s12035-023-03437-1","article-title":"Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies","volume":"60","author":"Nassar","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ng1219","article-title":"Huntingtin Interacts with REST\/NRSF to Modulate the Transcription of NRSE-Controlled Neuronal Genes","volume":"35","author":"Zuccato","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12017-009-8063-4","article-title":"Gene Dysregulation in Huntington\u2019s Disease: REST, MicroRNAs and Beyond","volume":"11","author":"Johnson","year":"2009","journal-title":"Neuromol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.12090","article-title":"Dysregulation of REST-Regulated Coding and Non-Coding RNAs in a Cellular Model of Huntington\u2019s Disease","volume":"124","author":"Soldati","year":"2013","journal-title":"J. Neurochem."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zsindely, N., Nagy, G., Si\u00e1gi, F., Farkas, A., and Bodai, L. (2023). Dysregulated miRNA and mRNA Expression Affect Overlapping Pathways in a Huntington\u2019s Disease Model. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241511942"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","article-title":"Altered microRNA Regulation in Huntington\u2019s Disease Models","volume":"227","author":"Lee","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_88","first-page":"e48691","article-title":"Advances in Understanding and Treating Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review","volume":"15","author":"Gupta","year":"2023","journal-title":"Cureus"},{"key":"ref_89","first-page":"1826","article-title":"miRNA-9 Expression Is Upregulated in the Spinal Cord of G93A-SOD1 Transgenic Mice","volume":"6","author":"Zhou","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mcn.2015.12.008","article-title":"Expression of MicroRNAs in Human Post-Mortem Amyotrophic Lateral Sclerosis Spinal Cords Provides Insight into Disease Mechanisms","volume":"71","author":"Hur","year":"2016","journal-title":"Mol. Cell Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s40478-014-0173-z","article-title":"Analysis of microRNA from Archived Formalin-Fixed Paraffin-Embedded Specimens of Amyotrophic Lateral Sclerosis","volume":"2","author":"Wakabayashi","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Chen, Y., Wei, Q., Chen, X., Li, C., Cao, B., Ou, R., Hadano, S., and Shang, H.-F. (2016). Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis. Front. Mol. Neurosci., 9.","DOI":"10.3389\/fnmol.2016.00069"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gene.2012.07.058","article-title":"A miRNA Signature in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis","volume":"508","author":"Guida","year":"2012","journal-title":"Gene"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Liguori, M., Nuzziello, N., Introna, A., Consiglio, A., Licciulli, F., D\u2019Errico, E., Scarafino, A., Distaso, E., and Simone, I.L. (2018). Dysregulation of MicroRNAs and Target Genes Networks in Peripheral Blood of Patients With Sporadic Amyotrophic Lateral Sclerosis. Front. Mol. Neurosci., 11.","DOI":"10.3389\/fnmol.2018.00288"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"De Felice, B., Manfellotto, F., Fiorentino, G., Annunziata, A., Biffali, E., Pannone, R., and Federico, A. (2018). Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing. Front. Genet., 9.","DOI":"10.3389\/fgene.2018.00310"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13041-015-0161-7","article-title":"Identification of Plasma microRNAs as a Biomarker of Sporadic Amyotrophic Lateral Sclerosis","volume":"8","author":"Takahashi","year":"2015","journal-title":"Mol. Brain"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neurobiolaging.2017.03.027","article-title":"Serum miRNAs miR-206, 143\u20133p and 374b-5p as Potential Biomarkers for Amyotrophic Lateral Sclerosis (ALS)","volume":"55","author":"Waller","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1007\/s12035-023-03520-7","article-title":"Differential Expression of miRNAs in Amyotrophic Lateral Sclerosis Patients","volume":"60","author":"Gomes","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/mus.26106","article-title":"Correlating Serum Micrornas and Clinical Parameters in Amyotrophic Lateral Sclerosis","volume":"58","author":"Raheja","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1038\/s41598-023-32717-y","article-title":"Small RNA Sequencing of Circulating Small Extracellular Vesicles microRNAs in Patients with Amyotrophic Lateral Sclerosis","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2018.12.016","article-title":"Identification of a Circulating miRNA Signature in Extracellular Vesicles Collected from Amyotrophic Lateral Sclerosis Patients","volume":"1708","author":"Saucier","year":"2019","journal-title":"Brain Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jns.2016.06.046","article-title":"MicroRNAs-424 and 206 Are Potential Prognostic Markers in Spinal Onset Amyotrophic Lateral Sclerosis","volume":"368","author":"Avansini","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/brain\/awu249","article-title":"Serum microRNAs in Patients with Genetic Amyotrophic Lateral Sclerosis and Pre-Manifest Mutation Carriers","volume":"137","author":"Freischmidt","year":"2014","journal-title":"Brain"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple Sclerosis\u2014A Review","volume":"26","author":"Dobson","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/brain\/awp300","article-title":"MicroRNA Profiling of Multiple Sclerosis Lesions Identifies Modulators of the Regulatory Protein CD47","volume":"132","author":"Junker","year":"2009","journal-title":"Brain"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/brain\/awr200","article-title":"Impaired Neurosteroid Synthesis in Multiple Sclerosis","volume":"134","author":"Noorbakhsh","year":"2011","journal-title":"Brain"},{"key":"ref_107","first-page":"127","article-title":"Identification of miR-24 and miR-137 as Novel Candidate Multiple Sclerosis miRNA Biomarkers Using Multi-Staged Data Analysis Protocol","volume":"6","author":"Ehya","year":"2017","journal-title":"Mol. Biol. Res. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/acschemneuro.0c00150","article-title":"LncRNA GAS5 and miR-137 Polymorphisms and Expression Are Associated with Multiple Sclerosis Risk: Mechanistic Insights and Potential Clinical Impact","volume":"11","author":"Senousy","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10895-016-1988-8","article-title":"Design and Fabrication a Gold Nanoparticle-DNA Based Nanobiosensor for Detection of microRNA Involved in Alzheimer\u2019s Disease","volume":"27","author":"Delkhahi","year":"2017","journal-title":"J. Fluoresc."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Rahaie, M., and Noroozi, S.K. (2019). A Nanobiosensor Based on Graphene Oxide and DNA Binding Dye for Multi-microRNAs Detection. Biosci. Rep., 39.","DOI":"10.1042\/BSR20181404"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"55709","DOI":"10.1039\/C7RA09767K","article-title":"Early Detection of Alzheimer\u2019s Disease Using a Biosensor Based on Electrochemically-Reduced Graphene Oxide and Gold Nanowires for the Quantification of Serum microRNA-137","volume":"7","author":"Azimzadeh","year":"2017","journal-title":"RSC Adv."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"6661799","DOI":"10.1155\/2021\/6661799","article-title":"Graphene Oxide-Gold Star Construct on Triangular Electrodes for Alzheimer\u2019s Disease Identification","volume":"2021","author":"Chang","year":"2021","journal-title":"J. Anal. Methods Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1002\/bab.2306","article-title":"Gold Nanourchin Enhances Detection of Alzheimer\u2019s Disease Biomarker \u201cmiRNA-137\u201d on Dual Electrode Sensing Surface","volume":"69","author":"Pan","year":"2022","journal-title":"Biotechnol. Appl. Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/7229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:08:06Z","timestamp":1760108886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/7229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":113,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25137229"],"URL":"https:\/\/doi.org\/10.3390\/ijms25137229","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,30]]}}}