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Unraveling the intricate pathomolecular mechanisms underlying the syndrome is vital to address these needs. High-throughput platforms are particularly well-suited for this purpose, as they enable the integration of different datasets, such as transcriptomic and epigenetic profiles. In this narrative review, we summarize relevant studies investigating changes in both the coding and non-coding transcriptome and epigenome in MFS-induced TAA. The collective findings highlight the implicated pathways, such as TGF-\u03b2 signaling, extracellular matrix structure, inflammation, and mitochondrial dysfunction. Potential candidates as biomarkers, such as miR-200c, as well as therapeutic targets emerged, like Tfam, associated with mitochondrial respiration, or miR-632, stimulating endothelial-to-mesenchymal transition. While these discoveries are promising, rigorous and extensive validation in large patient cohorts is indispensable to confirm their clinical relevance and therapeutic potential.<\/jats:p>","DOI":"10.3390\/ijms25137367","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T12:21:03Z","timestamp":1720441263000},"page":"7367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Coding and Non-Coding Transcriptomic Landscape of Aortic Complications in Marfan Syndrome"],"prefix":"10.3390","volume":"25","author":[{"given":"Nathasha Samali","family":"Udugampolage","sequence":"first","affiliation":[{"name":"Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Frolova","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, 20097 Milan, Italy"},{"name":"Department of Biosciences, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Taurino","sequence":"additional","affiliation":[{"name":"Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-6057","authenticated-orcid":false,"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[{"name":"Cardiovascular-Genetic Center, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-7738","authenticated-orcid":false,"given":"Fabio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-060X","authenticated-orcid":false,"given":"Christine","family":"Voellenkle","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ccl.2021.06.003","article-title":"Thoracic Aortic Aneurysm: A Clinical Review","volume":"39","author":"Senser","year":"2021","journal-title":"Cardiol. 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