{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T03:44:28Z","timestamp":1772682268066,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) Peanut allergy is associated with high risk of anaphylaxis which could be prevented by oral immunotherapy. Patients eligible for immunotherapy are selected on the basis of a food challenge, although currently the assessment of antibodies against main peanut molecules (Ara h 1, 2, 3 and 6) is thought to be another option. (2) The current study assessed the relationship between the mentioned antibodies, challenge outcomes, skin tests and some other parameters in peanut-sensitized children. It involved 74 children, divided into two groups, based on their response to a food challenge. (3) Both groups differed in results of skin tests, levels of component-specific antibodies and peanut exposure history. The antibody levels were then used to calculate thresholds for prediction of challenge results or symptom severity. While the antibody-based challenge prediction revealed statistical significance, it failed in cases of severe symptoms. Furthermore, no significant correlation was observed between antibody levels, symptom-eliciting doses and the risk of severe anaphylaxis. Although in some patients it could result from interference with IgG4, the latter would not be a universal explanation of this phenomenon. (4) Despite some limitations, antibody-based screening may be an alternative to the food challenge, although its clinical relevance still requires further studies.<\/jats:p>","DOI":"10.3390\/ijms25137415","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T12:21:03Z","timestamp":1720441263000},"page":"7415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is Component-Specific Antibody Testing Sufficient to Replace the Oral Food Challenge in the Diagnostics of Peanut-Sensitized Children? A Proof-of-Concept Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2226-3509","authenticated-orcid":false,"given":"Klementyna","family":"\u0141y\u017cwa","sequence":"first","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Prasek","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Krupa-\u0141aska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Krejner-Bienias","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Chojnowska-W\u00f3jtowicz","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wioletta","family":"Zag\u00f3rska","sequence":"additional","affiliation":[{"name":"Startmed Medical Center, Partyzantow 23, 05-092 Lomianki, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Kulus","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Grzela","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, Banacha 2, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Grzela","sequence":"additional","affiliation":[{"name":"Biostructure Research Center, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-104X","authenticated-orcid":false,"given":"Katarzyna","family":"Grzela","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw, Zwirki i Wigury 63A, 05-092 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/all.12305","article-title":"The epidemiology of food allergy in Europe: A systematic review and meta-analysis","volume":"69","author":"Nwaru","year":"2014","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.jaci.2010.03.029","article-title":"US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up","volume":"125","author":"Sicherer","year":"2010","journal-title":"J. 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