{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:29:17Z","timestamp":1791772157051,"version":"4.3.4"},"reference-count":120,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues\/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases. In this narrative review, we delve into the current literature on EDC toxicity effects on the liver and pancreatic tissues in terms of impaired mitochondrial function and redox homeostasis.<\/jats:p>","DOI":"10.3390\/ijms25137420","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T12:21:03Z","timestamp":1720441263000},"page":"7420","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress"],"prefix":"10.3390","volume":"25","author":[{"given":"Adina V.","family":"Lin\u021ba","sequence":"first","affiliation":[{"name":"Department of Functional Sciences\u2014Chair of Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq., No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan M.","family":"Lolescu","sequence":"additional","affiliation":[{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. 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Murgu Sq., No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-7733","authenticated-orcid":false,"given":"Alexandru","family":"Blidi\u0219el","sequence":"additional","affiliation":[{"name":"Department of Surgery I\u2014Chair of Surgical Semiotics & Thoracic Surgery, \u201cVictor Babes\u0326\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timis\u0327oara, Romania"},{"name":"Centre for Hepato-Biliary and Pancreatic Surgery, \u201cVictor Babes\u0326\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timis\u0327oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Sturza","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences\u2014Chair of Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Borza","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences\u2014Chair of Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara, E. Murgu Sq. 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