{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:38:18Z","timestamp":1783057098478,"version":"3.54.6"},"reference-count":211,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>While conventional medicine has advanced in recent years, there are still concerns about its potential adverse reactions. The ethnopharmacological knowledge established over many centuries and the existence of a variety of metabolites have made medicinal plants, such as the stinging nettle plant, an invaluable resource for treating a wide range of health conditions, considering its minimal adverse effects on human health. The aim of this review is to highlight the therapeutic benefits and biological activities of the edible Urtica dioica (UD) plant with an emphasis on its selective chemo-preventive properties against various types of cancer, whereby we decipher the mechanism of action of UD on various cancers including prostate, breast, leukemia, and colon in addition to evaluating its antidiabetic, microbial, and inflammatory properties. We further highlight the systemic protective effects of UD on the liver, reproductive, excretory, cardiovascular, nervous, and digestive systems. We present a critical assessment of the results obtained from in vitro and in vivo studies as well as clinical trials to highlight the gaps that require further exploration for future prospective studies.<\/jats:p>","DOI":"10.3390\/ijms25137501","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:38:04Z","timestamp":1720514284000},"page":"7501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Urtica dioica: Anticancer Properties and Other Systemic Health Benefits from In Vitro to Clinical Trials"],"prefix":"10.3390","volume":"25","author":[{"given":"Marc","family":"Abi Sleiman","sequence":"first","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-2819","authenticated-orcid":false,"given":"Maria","family":"Younes","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Hajj","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy","family":"Salameh","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Abi Rached","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimane","family":"Abi Younes","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0580-8247","authenticated-orcid":false,"given":"Lynn","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"Doumiati","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Frem","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramza","family":"Ishak","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Medawar","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-8425","authenticated-orcid":false,"given":"Hassan Y.","family":"Naim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-5703","authenticated-orcid":false,"given":"Sandra","family":"Rizk","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12967-016-0838-4","article-title":"Changing R&D Models in Research-Based Pharmaceutical Companies","volume":"14","author":"Schuhmacher","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and Resupply of Pharmacologically Active Plant-Derived Natural Products: A Review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pbiomolbio.2019.05.008","article-title":"Screening of Pharmacological Uses of Urtica dioica and Others Benefits","volume":"150","author":"Dhouibi","year":"2020","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hermed.2017.07.003","article-title":"Nutritional and Medicinal Applications of Moringa oleifera Lam.\u2014Review of Current Status and Future Possibilities","volume":"11","author":"Gupta","year":"2018","journal-title":"J. Herb. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kregiel, D., Pawlikowska, E., and Antolak, H. (2018). Urtica spp.: Ordinary Plants with Extraordinary Properties. Molecules, 23.","DOI":"10.3390\/molecules23071664"},{"key":"ref_6","first-page":"8","article-title":"Highlights on Nutritional and Therapeutic Value of Stinging Nettle (Urtica dioica)","volume":"7","author":"Otmani","year":"2015","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"118180","DOI":"10.1016\/j.indcrop.2024.118180","article-title":"Nettle (Urtica spp.) Phytotomy and Applications: Crop Variety Selection and Advanced Product Development for the Manufacturing of Natural Fiber Composites","volume":"210","author":"Bhardwaj","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Paulauskien\u0117, A., Tarasevi\u010dien\u0117, \u017d., and Laukagalis, V. (2021). Influence of Harvesting Time on the Chemical Composition of Wild Stinging Nettle (Urtica dioica L.). Plants, 10.","DOI":"10.3390\/plants10040686"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4274\/tjps.galenos.2021.12574","article-title":"Ethnopharmacobotanical Findings of Medicinal Plants in the K\u0131z\u0131lcahamam District of Ankara, Turkey","volume":"18","author":"Akaydin","year":"2021","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11694-016-9410-4","article-title":"Stinging Nettle (Urtica dioica L.): A Reservoir of Nutrition and Bioactive Components with Great Functional Potential","volume":"11","author":"Jan","year":"2017","journal-title":"Food Meas."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Baumli, J., Antal, N., Casoni, D., and Cimpoiu, C. (2023). Use of Secondary Metabolites Profiling and Antioxidant Activity to Unravel the Differences between Two Species of Nettle. Plants, 12.","DOI":"10.3390\/plants12183233"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mas\u0142owski, M., Aleksieiev, A., Miedzianowska, J., Efenberger-Szmechtyk, M., and Strzelec, K. (2022). Antioxidant and Anti\u2013Aging Activity of Freeze\u2013Dried Alcohol\u2013Water Extracts from Common Nettle (Urtica dioica L.) and Peppermint (Mentha piperita L.) in Elastomer Vulcanizates. Polymers, 14.","DOI":"10.3390\/polym14071460"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1039\/C9FO02442E","article-title":"Effect of High Hydrostatic Pressure Extraction on Biological Activities of Stinging Nettle Extracts","volume":"11","author":"Moreira","year":"2020","journal-title":"Food Funct."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.33380\/2305-2066-2020-9-3-59-66","article-title":"Determination of Nettle Leaves Extracts Antioxidant Activity by Various Methods","volume":"9","author":"Trineeva","year":"2020","journal-title":"Drug Dev. Regist."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ligor, M., Kie\u0142basa, A., Ratiu, I.-A., and Buszewski, B. (2021). Separation and Quantification of Selected Sapogenins Extracted from Nettle, White Dead-Nettle, Common Soapwort and Washnut. Molecules, 26.","DOI":"10.3390\/molecules26247705"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tarasevi\u010dien\u0117, \u017d., Vitkauskait\u0117, M., Paulauskien\u0117, A., and \u010cerniauskien\u0117, J. (2023). Wild Stinging Nettle (Urtica dioica L.) Leaves and Roots Chemical Composition and Phenols Extraction. Plants, 12.","DOI":"10.3390\/plants12020309"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An Overview","volume":"5","author":"Panche","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kasouni, A.I., Chatzimitakos, T.G., Stalikas, C.D., Trangas, T., Papoudou-Bai, A., and Troganis, A.N. (2021). The Unexplored Wound Healing Activity of Urtica dioica L. Extract: An In Vitro and In Vivo Study. Molecules, 26.","DOI":"10.3390\/molecules26206248"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"\u0110urovi\u0107, S., Koji\u0107, I., Radi\u0107, D., Smyatskaya, Y.A., Bazarnova, J.G., Filip, S., and Tosti, T. (2024). Chemical Constituents of Stinging Nettle (Urtica dioica L.): A Comprehensive Review on Phenolic and Polyphenolic Compounds and Their Bioactivity. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25063430"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Skalska-Kami\u0144ska, A., W\u00f3jciak, W., \u017buk, M., Paduch, R., and W\u00f3jciak, M. (2023). Protective Effect of Urtica dioica Extract against Oxidative Stress in Human Skin Fibroblasts. Life, 13.","DOI":"10.3390\/life13112182"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Repaji\u0107, M., Cegledi, E., Zori\u0107, Z., Pedisi\u0107, S., Elez Garofuli\u0107, I., Radman, S., Pal\u010di\u0107, I., and Dragovi\u0107-Uzelac, V. (2021). Bioactive Compounds in Wild Nettle (Urtica dioica L.) Leaves and Stalks: Polyphenols and Pigments upon Seasonal and Habitat Variations. Foods, 10.","DOI":"10.3390\/foods10010190"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jeszka-Skowron, M., Zgo\u0142a-Grze\u015bkowiak, A., Frankowski, R., Grze\u015bkowiak, T., and Jeszka, A.M. (2022). Variation in the Content of Bioactive Compounds in Infusions Prepared from Different Parts of Wild Polish Stinging Nettle (Urtica dioica L.). Molecules, 27.","DOI":"10.3390\/molecules27134242"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Devkota, H.P., Paudel, K.R., Khanal, S., Baral, A., Panth, N., Adhikari-Devkota, A., Jha, N.K., Das, N., Singh, S.K., and Chellappan, D.K. (2022). Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties. Molecules, 27.","DOI":"10.3390\/molecules27165219"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1007\/s11033-023-08355-y","article-title":"Inhibitory Potency of the Nettle Lectin on Neovascularization: A Biomolecule for Carbohydrate-Mediated Targeting of Angiogenesis","volume":"50","author":"Samadian","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s42452-020-2219-0","article-title":"Insights into the Bioactive Compounds and Physico-Chemical Characteristics of the Extracted Oils from Urtica dioica and Urtica Pilulifera","volume":"2","author":"Jafari","year":"2020","journal-title":"SN Appl. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mitrovi\u0107, J., Nikoli\u0107, N., Risti\u0107, I., Karabegovi\u0107, I., Savi\u0107, S., \u0160imurina, O., Cvetkovi\u0107, B., and Pe\u0161i\u0107, M. (2023). The Chemical Characterisation of Nettle (Urtica dioica L.) Seed Oil. Nat. Prod. Res., ahead of print.","DOI":"10.1080\/14786419.2023.2250525"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12934-023-02167-2","article-title":"Endophytic Bacteria Isolated from Urtica dioica L.\u2014Preliminary Screening for Enzyme and Polyphenols Production","volume":"22","author":"Chlebicz","year":"2023","journal-title":"Microb. Cell Factories"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"131724","DOI":"10.1016\/j.foodchem.2021.131724","article-title":"Recovery of Biologically Active Compounds from Stinging Nettle Leaves Part I: Supercritical Carbon Dioxide Extraction","volume":"373","author":"Popov","year":"2022","journal-title":"Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"129906","DOI":"10.1016\/j.foodchem.2021.129906","article-title":"A Yellow Chlorophyll Catabolite in Leaves of Urtica dioica L.: An Overlooked Phytochemical That Contributes to Health Benefits of Stinging Nettle","volume":"359","author":"Karg","year":"2021","journal-title":"Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/fsn3.259","article-title":"Comparison of Nutritional Properties of Stinging Nettle (Urtica dioica) Flour with Wheat and Barley Flours","volume":"4","author":"Adhikari","year":"2015","journal-title":"Food Sci. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e09717","DOI":"10.1016\/j.heliyon.2022.e09717","article-title":"Nutritional and Pharmacological Importance of Stinging Nettle (Urtica dioica L.): A Review","volume":"8","author":"Bhusal","year":"2022","journal-title":"Heliyon"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Koczkodaj, S., Przyby\u0142, J.L., Kosakowska, O., W\u0119glarz, Z., and B\u0105czek, K.B. (2023). Intraspecific Variability of Stinging Nettle (Urtica dioica L.). Molecules, 28.","DOI":"10.3390\/molecules28031505"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00580-021-03286-1","article-title":"Urtica dioica Extract\u2014Suitable Dietary Supplement Influencing the Growth Body Characteristics, Antioxidant Status, and Serum Biochemical Parameters of Broiler Chickens","volume":"30","author":"Behboodi","year":"2021","journal-title":"Comp. Clin. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/vms3.721","article-title":"Effects of Dietary Stinging Nettle (Urtica dioica) on Hormone Stress and Selected Serum Biochemical Parameters of Broilers Subjected to Chronic Heat Stress","volume":"8","author":"Hosseinian","year":"2022","journal-title":"Vet. Med. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nallan Chakravartula, S.S., Moscetti, R., Farinon, B., Vinciguerra, V., Merendino, N., Bedini, G., Neri, L., Pittia, P., and Massantini, R. (2021). Stinging Nettles as Potential Food Additive: Effect of Drying Processes on Quality Characteristics of Leaf Powders. Foods, 10.","DOI":"10.3390\/foods10061152"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhang, X., Zafar, M.H., Zhang, J., Wang, J., Yu, X., Liu, W., and Wang, M. (2023). Research Progress in Physiological Effects of Resistant Substances of Urtica dioica L. on Animal Performance and Feed Conversion. Front. Plant Sci., 14.","DOI":"10.3389\/fpls.2023.1164363"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.biosystemseng.2006.12.011","article-title":"Energy Consumption and Colour Characteristics of Nettle Leaves during Microwave, Vacuum and Convective Drying","volume":"96","author":"Alibas","year":"2007","journal-title":"Biosyst. Eng."},{"key":"ref_38","first-page":"649","article-title":"Convective and Microwave Drying Characteristics, Energy Requirementand Color Retention of Dehydrated Nettle Leaves (Urtica diocia L.)","volume":"40","author":"Lule","year":"2017","journal-title":"Legume Res."},{"key":"ref_39","first-page":"5714","article-title":"Phytochemistry and Pharmacologic Properties of Urtica dioica L.","volume":"6","author":"Asgarpanah","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.61186\/cmja.13.4.44","article-title":"The Effect of Interval Training and Urtica dioica Hydroalcoholic Extract on Some Growth and Immune Factors in C57 Rats with Melanoma Cancer","volume":"13","author":"Firoozi","year":"2024","journal-title":"Complement. Med. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e15904","DOI":"10.17795\/jjnpp-15904","article-title":"Introducing Urtica dioica, A Native Plant of Khuzestan, As an Antibacterial Medicinal Plant","volume":"9","author":"Motamedi","year":"2014","journal-title":"Jundishapur. J. Nat. Pharm. Prod."},{"key":"ref_42","first-page":"114903","article-title":"Health-Promoting Phytochemicals of Stinging Nettle (Urtica dioica L)","volume":"182","author":"Marotti","year":"2022","journal-title":"Grown under Organic Farming in Italian Environments. Ind. Crops Prod."},{"key":"ref_43","first-page":"548","article-title":"Changes in Total Polyphenol Content and Antioxidant Capacity of Stinging Nettle (Urtica dioica L.) from Spring to Autumn","volume":"64","author":"Koczka","year":"2020","journal-title":"Period. Polytech. Chem. Eng."},{"key":"ref_44","first-page":"1793","article-title":"Determination of Phytochemical Content by LC-MS\/MS, Investigation of Antioxidant Capacity, and Enzyme Inhibition Effects of Nettle (Urtica dioica)","volume":"27","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s40200-021-00942-9","article-title":"Anti-Diabetic Potential of Urtica dioica: Current Knowledge and Future Direction","volume":"21","author":"Chehri","year":"2022","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Jaiswal, V., and Lee, H.-J. (2022). Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities. Antioxidants, 11.","DOI":"10.3390\/antiox11122494"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Semwal, P., Rauf, A., Olatunde, A., Singh, P., Zaky, M.Y., Islam, M.M., Khalil, A.A., Aljohani, A.S.M., Al Abdulmonem, W., and Ribaudo, G. (2023). The Medicinal Chemistry of Urtica dioica L.: From Preliminary Evidence to Clinical Studies Supporting Its Neuroprotective Activity. Nat. Prod. Bioprospect., 13.","DOI":"10.1007\/s13659-023-00380-5"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Esposito, S., Bianco, A., Russo, R., Di Maro, A., Isernia, C., and Pedone, P.V. (2019). Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment. Molecules, 24.","DOI":"10.3390\/molecules24152753"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s44197-023-00103-6","article-title":"Global Burden of Prostate Cancer and Association with Socioeconomic Status, 1990\u20132019: A Systematic Analysis from the Global Burden of Disease Study","volume":"13","author":"Zhang","year":"2023","journal-title":"J. Epidemiol. Glob. Health"},{"key":"ref_50","first-page":"78","article-title":"Urtica dioica Dichloromethane Extract Induce Apoptosis from Intrinsic Pathway on Human Prostate Cancer Cells (PC3)","volume":"62","author":"Mohammadi","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"711","DOI":"10.4314\/tjpr.v13i5.9","article-title":"Urtica dioica Induces Cytotoxicity in Human Prostate Carcinoma LNCaP Cells: Involvement of Oxidative Stress, Mitochondrial Depolarization and Apoptosis","volume":"13","author":"Levy","year":"2014","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1055\/s-2000-11117","article-title":"Antiproliferative Effect on Human Prostate Cancer Cells by a Stinging Nettle Root (Urtica dioica) Extract","volume":"66","author":"Konrad","year":"2000","journal-title":"Planta Med."},{"key":"ref_53","first-page":"326","article-title":"Examination of the Association Between 3,4-Divanillyltetrahydrofuran Lignan (Urtica dioica Origin) and Prostate Cancer Cells by 131I Radiolabeling","volume":"36","author":"Tekin","year":"2021","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1074\/jbc.M408177200","article-title":"Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity *","volume":"280","author":"Brusselmans","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.15171\/apb.2019.024","article-title":"Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics","volume":"9","author":"Jan","year":"2019","journal-title":"Adv. Pharm. Bull."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/cbic.200300614","article-title":"Worms, Life, and Death (Nobel Lecture)","volume":"4","author":"Horvitz","year":"2003","journal-title":"ChemBioChem"},{"key":"ref_57","unstructured":"G\u00fcler, E. (2011). Investigaton of Chemopreventive Properties of Urtica dioica L., in MCF-7 and MDA231 Breast Cancer Cell Lines. [Ph.D.\u2014Doctoral Program, Middle East Technical University]."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of Reactive Oxygen Species (ROS) in Apoptosis Induction","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4161\/cbt.3.9.1038","article-title":"Aqueous Extract of Urtica dioica Makes Significant Inhibition on Adenosine Deaminase Activity in Prostate Tissue from Patients with Prostate Cancer","volume":"3","author":"Durak","year":"2004","journal-title":"Cancer Biol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.7314\/APJCP.2013.14.9.5317","article-title":"Antioxidant and Apoptotic Effects of an Aqueous Extract of Urtica dioica on the MCF-7 Human Breast Cancer Cell Line","volume":"14","author":"Fattahi","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3390\/12071496","article-title":"Comparative Evaluation of Various Total Antioxidant Capacity Assays Applied to Phenolic Compounds with the CUPRAC Assay","volume":"12","author":"Apak","year":"2007","journal-title":"Molecules"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14715\/cmb\/2018.64.3.16","article-title":"Urtica dioica Inhibits Cell Growth and Induces Apoptosis by Targeting Ornithine Decarboxylase and Adenosine Deaminase as Key Regulatory Enzymes in Adenosine and Polyamines Homeostasis in Human Breast Cancer Cell Lines","volume":"64","author":"Fattahi","year":"2018","journal-title":"Cell. Mol. Biol."},{"key":"ref_63","first-page":"803","article-title":"Effects of Urtica dioica extract on malignant biological behaviors of breast cancer cells and its possible mechanism","volume":"28","author":"Wenyuan","year":"2021","journal-title":"Chin. J. Cancer Biother."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"673","DOI":"10.31557\/APJCP.2022.23.2.673","article-title":"Anticancer Effects of Urtica dioica in Breast Cancer","volume":"23","author":"Karakol","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s12032-023-02193-5","article-title":"Identification of Novel Inhibitors from Urtica Spp against TNBC Targeting JAK2 Receptor for Breast Cancer Therapy","volume":"40","author":"Upreti","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopha.2017.06.021","article-title":"Urtica dioica Extract Suppresses miR-21 and Metastasis-Related Genes in Breast Cancer","volume":"93","author":"Mansoori","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.biopha.2016.07.056","article-title":"The Urtica dioica Extract Enhances Sensitivity of Paclitaxel Drug to MDA-MB-468 Breast Cancer Cells","volume":"83","author":"Mohammadi","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Nafeh, G., Abi Akl, M., Samarani, J., Bahous, R., Al Kari, G., Younes, M., Sarkis, R., and Rizk, S. (2023). Urtica dioica Leaf Infusion Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Cisplatin Treatment. Pharmaceuticals, 16.","DOI":"10.3390\/ph16060780"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hashem, A.H., and Salem, S.S. (2021). Green and Ecofriendly Biosynthesis of Selenium Nanoparticles Using Urtica dioica (Stinging Nettle) Leaf Extract: Antimicrobial and Anticancer Activity. Biotechnol. J., 17.","DOI":"10.1002\/biot.202100432"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/jemt.24306","article-title":"Apoptotic, Cytotoxic, Antioxidant, and Antibacterial Activities of Biosynthesized Silver Nanoparticles from Nettle Leaf","volume":"86","author":"Khatami","year":"2023","journal-title":"Microsc. Res. Tech."},{"key":"ref_71","first-page":"164","article-title":"Effects of Stinging Nettle (Urtica dioica L.) on Antioxidant Enzyme Activities in Rat Model of Mammary Gland Cancer","volume":"16","author":"Telo","year":"2017","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.clbc.2017.04.008","article-title":"Urtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo","volume":"17","author":"Mohammadi","year":"2017","journal-title":"Clin. Breast Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40164-020-00170-6","article-title":"Leukemia Incidence Trends at the Global, Regional, and National Level between 1990 and 2017","volume":"9","author":"Dong","year":"2020","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"468","DOI":"10.35440\/hutfd.1012538","article-title":"Exploring the Antiproliferative Mechanisms of Urtica dioica L. Extract in Human Promyelocytic Leukemia Cell Line: \u0130nsan Promiyelositik L\u00f6semi H\u00fccre Hatt\u0131nda Is\u0131rgan Ekstrakt\u0131n\u0131n Antiproliferatif Mekanizmalar\u0131n\u0131n Ara\u015ft\u0131r\u0131lmas\u0131","volume":"18","author":"Koyuncu","year":"2021","journal-title":"J. Harran Univ. Med. Fac.\/Harran \u00dcniversitesi T\u0131p Fak\u00fcltesi Derg."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Hodroj, M.H., Al Bast, N.a.H., Taleb, R.I., Borjac, J., and Rizk, S. (2020). Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis. Nutrients, 12.","DOI":"10.3390\/nu12092629"},{"key":"ref_76","first-page":"12","article-title":"In Vitro Cytotoxic Effect of Urtica dioica Extracts on Acute Myelogenous Leukemia Cell Line (Kg-1)","volume":"2","author":"Keshavarz","year":"2016","journal-title":"Arch. Med. Lab. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"121","DOI":"10.14715\/cmb\/2020.66.6.22","article-title":"Urtica dioica Agglutinin (a Plant Lectin) Has a Caspase-Dependent Apoptosis Induction Effect on the Acute Lymphoblastic Leukemia Cell Line","volume":"66","author":"Rashidbaghan","year":"2020","journal-title":"Cell. Mol. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s10528-020-10024-9","article-title":"The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid Leukemia Cell Line","volume":"59","author":"Rashidbaghan","year":"2021","journal-title":"Biochem. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1182\/blood.V94.10.3523.422k07_3523_3530","article-title":"Defective Apoptotic Signal Transduction Pathway Downstream of Caspase-3 in Human B-Lymphoma Cells: A Novel Mechanism of Nuclear Apoptosis Resistance","volume":"94","author":"Kawabata","year":"1999","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/sj.leu.2402401","article-title":"T and B Leukemic Cell Lines Exhibit Different Requirements for Cell Death: Correlation between Caspase Activation, DFF40\/DFF45 Expression, DNA Fragmentation and Apoptosis in T Cell Lines but Not in Burkitt\u2019s Lymphoma","volume":"16","author":"Luciano","year":"2002","journal-title":"Leukemia"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12029-016-9819-3","article-title":"The Herbal Medicine Utrica Dioica Inhibits Proliferation of Colorectal Cancer Cell Line by Inducing Apoptosis and Arrest at the G2\/M Phase","volume":"47","author":"Mohammadi","year":"2016","journal-title":"J. Gastrointest. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11101-020-09660-1","article-title":"Medicinal Plants: Active Compounds, Properties and Antiproliferative Effects in Colorectal Cancer","volume":"19","author":"Nieves","year":"2020","journal-title":"Phytochem. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/1871520620666200311095836","article-title":"Urtica dioica Extract Inhibits Cell Proliferation and Induces Apoptosis in HepG2 and HTC116 as Gastrointestinal Cancer Cell Lines","volume":"20","author":"Kardan","year":"2020","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/jps.20874","article-title":"Oxidative Stress and Apoptosis: Impact on Cancer Therapy","volume":"96","author":"Ozben","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00204-012-0906-3","article-title":"Oxidative Stress in Apoptosis and Cancer: An Update","volume":"86","author":"Segura","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_86","first-page":"90","article-title":"Cytotoxic Effects of Urtica dioica Radix on Human Colon (HT29) and Gastric (MKN45) Cancer Cells Mediated through Oxidative and Apoptotic Mechanisms","volume":"62","author":"Ghasemi","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/01635581.2021.1881568","article-title":"The Protective Role of Urtica dioica Seed Extract Against Azoxymethane-Induced Colon Carcinogenesis in Rats","volume":"74","author":"Uyar","year":"2022","journal-title":"Nutr. Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Rahmani, Z., Karimi, M., Saffari, I., Mirzaei, H., Nejati, M., and Sharafati Chaleshtori, R. (2024). Nanoemulsion and Nanoencapsulation of a Hydroethanolic Extract of Nettle (Urtica dioica) and Wormwood (Artemisia absinthium): Comparison of Antibacterial and Anticancer Activity. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1266573"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.phymed.2007.03.014","article-title":"A Comprehensive Review on the Stinging Nettle Effect and Efficacy Profiles. Part II: Urticae Radix","volume":"14","author":"Chrubasik","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_91","first-page":"1005","article-title":"Study the Apoptotic Effect of N_butanol Extract of Urtica dioica on T24 Bladder Cancer Cell Line","volume":"11","author":"Ahmed","year":"2020","journal-title":"Syst. Rev. Pharm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1038\/s41598-019-41372-1","article-title":"Urtica dioica L. Inhibits Proliferation and Enhances Cisplatin Cytotoxicity in NSCLC Cells via Endoplasmic Reticulum-Stress Mediated Apoptosis","volume":"9","author":"Ciaramella","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_93","first-page":"579","article-title":"Know the Signs and Symptoms of Diabetes","volume":"140","author":"Ramachandran","year":"2014","journal-title":"Indian J. Med. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"792","DOI":"10.5897\/AJPP11.246","article-title":"Effect of Urtica dioica Leaf Extract on Activities of Nucleoside Diphosphate Kinase and Acetyl Coenzyme, a Carboxylase, in Normal and Hyperglycemic Rats","volume":"5","author":"Qujeq","year":"2011","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_95","first-page":"1","article-title":"Antihyperglycemic and Antihyperlipidemic Activity of Urtica dioica on Type 2 Diabetic Model Rats","volume":"2","author":"Rokeya","year":"2011","journal-title":"Diabetology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S2221-1691(12)60032-X","article-title":"An Overview on Antidiabetic Medicinal Plants Having Insulin Mimetic Property","volume":"2","author":"Patel","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11011-014-9480-0","article-title":"Urtica dioica Extract Attenuates Depressive like Behavior and Associative Memory Dysfunction in Dexamethasone Induced Diabetic Mice","volume":"29","author":"Patel","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-8741(03)00220-4","article-title":"Induction of Insulin Secretion by a Component of Urtica dioica Leave Extract in Perifused Islets of Langerhans and Its in vivo Effects in Normal and Streptozotocin Diabetic Rats","volume":"89","author":"Farzami","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Rahmati, M., Keshvari, M., Mirnasouri, R., and Chehelcheraghi, F. (2021). Exercise and Urtica dioica Extract Ameliorate Hippocampal Insulin Signaling, Oxidative Stress, Neuroinflammation, and Cognitive Function in STZ-Induced Diabetic Rats. Biomed. Pharmacother., 139.","DOI":"10.1016\/j.biopha.2021.111577"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/ijpvm.ijpvm_293_21","article-title":"Urtica dioica (Gazaneh) Distillate Restores Glucose Metabolism in Diabetic Rats","volume":"14","author":"Akmali","year":"2023","journal-title":"Int. J. Prev. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4067\/S0717-95022010000200011","article-title":"Proliferation of the b-Cells of Pancreas in Diabetic Rats Treated with Urtica dioica","volume":"28","author":"Golalipour","year":"2010","journal-title":"Int. J. Morphol."},{"key":"ref_102","first-page":"21","article-title":"Effect of Urtica dioica Leaf Alcoholic and Aqueous Extracts on the Number and the Diameter of the Islets in Diabetic Rats","volume":"2","author":"Qujeq","year":"2013","journal-title":"Int. J. Mol. Cell Med."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"P\u00e9rez Guti\u00e9rrez, R.M., Mu\u00f1iz-Ramirez, A., Garcia-Campoy, A.H., and Mota Flores, J.M. (2021). Evaluation of the Antidiabetic Potential of Extracts of Urtica dioica, Apium Graveolens, and Zingiber Officinale in Mice, Zebrafish, and Pancreatic \u03b2-Cell. Plants, 10.","DOI":"10.3390\/plants10071438"},{"key":"ref_104","first-page":"315","article-title":"The Effect of Urtica dioica Extract on Blood Lipids Profile in Patients with Type 2 Diabetes: A Randomized Double-Blinded Clinical Trial","volume":"6","author":"Mehrizi","year":"2020","journal-title":"J. Nutr. Food Secur."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Fan, S., Raychaudhuri, S., Kraus, O., Shahinozzaman, M., Lofti, L., and Obanda, D.N. (2020). Urtica dioica Whole Vegetable as a Functional Food Targeting Fat Accumulation and Insulin Resistance-a Preliminary Study in a Mouse Pre-Diabetic Model. Nutrients, 12.","DOI":"10.3390\/nu12041059"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"146351","DOI":"10.1016\/j.gene.2022.146351","article-title":"Exercise and Urtica dioica Extract Ameliorate Mitochondrial Function and the Expression of Cardiac Muscle Nuclear Respiratory Factor 2 and Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha in STZ-Induced Diabetic Rats","volume":"822","author":"Seyydi","year":"2022","journal-title":"Gene"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s13197-023-05789-x","article-title":"Phytoconstituents from Urtica dioica (Stinging Nettle) of Sikkim Himalaya and Their Molecular Docking Interactions Revealed Their Nutraceutical Potential as \u03b1-Amylase and \u03b1-Glucosidase Inhibitors","volume":"60","author":"Sharma","year":"2023","journal-title":"J. Food Sci. Technol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Altamimi, M.A., Abu-Reidah, I.M., Altamimi, A., and Jaradat, N. (2022). Hydroethanolic Extract of Urtica dioica L. (Stinging Nettle) Leaves as Disaccharidase Inhibitor and Glucose Transport in Caco-2 Hinderer. Molecules, 27.","DOI":"10.3390\/molecules27248872"},{"key":"ref_109","first-page":"465","article-title":"Evaluation of Alpha- Amylase Inhibition by Urtica dioica and Juglans Regia Extracts","volume":"17","author":"Rahimzadeh","year":"2014","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1042\/BST20221066","article-title":"Insulin Signalling and GLUT4 Trafficking in Insulin Resistance","volume":"51","author":"Fazakerley","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2174\/1389557521666210929143112","article-title":"Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Clinical Trials","volume":"22","author":"Tabrizi","year":"2022","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.7754\/Clin.Lab.2012.121019","article-title":"Improved Glycemic Control in Patients with Advanced Type 2 Diabetes Mellitus Taking Urtica dioica Leaf Extract: A Randomized Double-Blind Placebo-Controlled Clinical Trial","volume":"59","author":"Kianbakht","year":"2013","journal-title":"Clin. Lab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e137563","DOI":"10.5812\/ijp-137563","article-title":"Urtica dioica (Nettle) in Type 1 Diabetes Mellitus: A Randomized Controlled Trial","volume":"33","author":"Shahrokhi","year":"2023","journal-title":"Iran. J. Pediatr."},{"key":"ref_114","first-page":"e93732","article-title":"Metabolic Effects of Glucose Lowering Substance of Urtica dioica on Normal and Diabetic Mice, and Patients with Type I Diabetes Mellitus","volume":"1","author":"Riazi","year":"2007","journal-title":"J. Compr. Ped."},{"key":"ref_115","first-page":"138","article-title":"Evaluation of the Inhibition Activity of Alcoholic Extracts of Urtica dioica, Sylibium marianum and Origanum vulgare Plants against Some Pathogenic Microorganisms Related with Food Diseases","volume":"26","author":"Ali","year":"2021","journal-title":"Ann. Agri Bio Res."},{"key":"ref_116","first-page":"e52083","article-title":"Investigation of the Antibacterial Properties and Mode of Action of Compounds from Urtica dioica L.","volume":"16","author":"Du","year":"2024","journal-title":"Cureus"},{"key":"ref_117","first-page":"198","article-title":"The Antifungal Effects of Hydroalcoholic Extracts of Nigella Sativa and Urtica dioica on Fungal Agents in Comparison with Amphotericin B","volume":"39","author":"Pournajafian","year":"2021","journal-title":"J. Isfahan Med. Sch."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"154648","DOI":"10.1016\/j.phymed.2023.154648","article-title":"Urtica dioica Agglutinin (UDA) as a Potential Candidate for Inhibition of SARS-CoV-2 Omicron Variants: In Silico Prediction and Experimental Validation","volume":"111","author":"Hosseini","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_119","first-page":"1567","article-title":"Screening antimicrobial activity of various extracts of Urtica dioica","volume":"60","author":"Ibrahim","year":"2012","journal-title":"Rev. Biol. Trop."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4314\/ajtcam.v11i5.6","article-title":"Antimicrobial Activity of Methanolic Extracts of Sambucus Ebulus and Urtica dioica Against Clinical Isolates of Methicillin Resistant Staphylococcus aureus","volume":"11","author":"Salehzadeh","year":"2014","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijbiomac.2021.04.150","article-title":"The Biological Synthesis of Gold\/Perlite Nanocomposite Using Urtica dioica Extract and Its Chitosan-Capped Derivative for Healing Wounds Infected with Methicillin-Resistant Staphylococcus aureus","volume":"183","author":"Farahpour","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"102163","DOI":"10.1016\/j.mtcomm.2021.102163","article-title":"Synergy Effect of Urtica dioica and ZnO NPs on Microstructure, Antibacterial Activity and Cytotoxicity of Electrospun PCL Scaffold for Wound Dressing Application","volume":"26","author":"Ghiyasi","year":"2021","journal-title":"Mater. Today Commun."},{"key":"ref_123","first-page":"35","article-title":"In Vitro Antimicrobial Activity of Iris Pseudacorus and Urtica dioica","volume":"16","author":"Ramtin","year":"2013","journal-title":"Zahedan J. Res. Med. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Elez Garofuli\u0107, I., Malin, V., Repaji\u0107, M., Zori\u0107, Z., Pedisi\u0107, S., Sterni\u0161a, M., Smole Mo\u017eina, S., and Dragovi\u0107-Uzelac, V. (2021). Phenolic Profile, Antioxidant Capacity and Antimicrobial Activity of Nettle Leaves Extracts Obtained by Advanced Extraction Techniques. Molecules, 26.","DOI":"10.3390\/molecules26206153"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"361","DOI":"10.30699\/ijmm.14.4.361","article-title":"Antimicrobial Activity of Aqueous and Alcoholic Extracts of Chamomile, Fleawort, Aquatic Pennyroyal and Nettle Plants on Klebsiella Pneumoniae and Comparing Their Effects with Common Antibiotics","volume":"14","author":"Anvari","year":"2020","journal-title":"Iran. J. Med. Microbiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"101050","DOI":"10.1016\/j.fochx.2023.101050","article-title":"Effect of Urtica dioica L. Essential Oil (Forms of Free and Nanoliposome) on Some Inoculated Pathogens (Escherichia coli and Listeria monocytogenes) in Minced Camel Meat","volume":"20","author":"Shabani","year":"2023","journal-title":"Food Chem. X"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Khan, M.Z., Azad, A.K., Jan, S., Safdar, M., Bibi, S., Majid, A.M.S.A., Albadrani, G.M., Nouh, N.A.T., Abdulhakim, J.A., and Abdel-Daim, M.M. (2023). An Experimental and Computational Analysis of Plant Compounds from Whole Urtica dioica L. Plant\u2019s Essential Oil for Antioxidant and Antibacterial Activities. Metabolites, 13.","DOI":"10.3390\/metabo13040502"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11130-022-01020-y","article-title":"In Vitro Bioactivities of Food Grade Extracts from Yarrow (Achillea millefolium L.) and Stinging Nettle (Urtica dioica L.) Leaves","volume":"78","author":"Mannila","year":"2023","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_129","first-page":"481","article-title":"Phytocompounds Of Three Medicinal Plants (Juniperus communis, Urtica dioica and Coleus forskohlii) of North West Himalayas Increases the Potency of Antibacterial and Antifungal Antibiotics","volume":"20","author":"Rolta","year":"2020","journal-title":"Plant Arch."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"153930","DOI":"10.1016\/j.phymed.2022.153930","article-title":"Role of Medicinal Plants in Inhibiting SARS-CoV-2 and in the Management of Post-COVID-19 Complications","volume":"98","author":"Mukherjee","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Barre, A., Van Damme, E.J.M., Simplicien, M., Le Poder, S., Klonjkowski, B., Benoist, H., Peyrade, D., and Roug\u00e9, P. (2021). Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives. Cells, 10.","DOI":"10.3390\/cells10071619"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.antiviral.2011.02.003","article-title":"Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication in a Lethal SARS-CoV BALB\/c Mouse Model by Stinging Nettle Lectin, Urtica dioica Agglutinin","volume":"90","author":"Kumaki","year":"2011","journal-title":"Antivir. Res"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Wang, X., Terrie, L., Wu, G., Van Damme, E.J.M., Thorrez, L., Fooks, A.R., Banyard, A.C., Jochmans, D., and Neyts, J. (2023). Urtica dioica Agglutinin Prevents Rabies Virus Infection in a Muscle Explant Model. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051353"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Badirzadeh, A., Heidari-Kharaji, M., Fallah-Omrani, V., Dabiri, H., Araghi, A., and Chirani, A.S. (2020). Antileishmanial Activity of Urtica dioica Extract against Zoonotic Cutaneous Leishmaniasis. PLoS Neglected Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007843"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s11686-023-00727-5","article-title":"Urtica dioica Extract Leads to Cyst Reduction, Enhanced Cell-Mediated Immune Response, and Antioxidant Activity in Experimental Toxoplasmosis","volume":"68","author":"Peyvandi","year":"2023","journal-title":"Acta Parasit."},{"key":"ref_136","first-page":"193","article-title":"Antinociceptive and Anti-Inflammatory Effects of Urtica dioica Leaf Extract in Animal Models","volume":"3","author":"Hajhashemi","year":"2013","journal-title":"Avicenna J. Phytomed."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0014-5793(98)01622-6","article-title":"Plant Extracts from Stinging Nettle (Urtica dioica), an Antirheumatic Remedy, Inhibit the Proinflammatory Transcription Factor NF-\u03baB","volume":"442","author":"Riehemann","year":"1999","journal-title":"FEBS Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"509383","DOI":"10.1155\/2012\/509383","article-title":"Botanical Extracts from Rosehip (Rosa Canina), Willow Bark (Salix Alba), and Nettle Leaf (Urtica dioica) Suppress IL-1 \u03b2-Induced NF-\u03baB Activation in Canine Articular Chondrocytes","volume":"2012","author":"Shakibaei","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.phymed.2012.09.016","article-title":"Lipophilic Stinging Nettle Extracts Possess Potent Anti-Inflammatory Activity, Are Not Cytotoxic and May Be Superior to Traditional Tinctures for Treating Inflammatory Disorders","volume":"20","author":"Johnson","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_140","first-page":"52","article-title":"Original title: Antiphlogistische Effekte von Extractum Urticae dioicae foliorum im Vergleich zu Kaffeoyl\u00e4pfels\u00e4ure [Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid]","volume":"46","author":"Obertreis","year":"1996","journal-title":"Arzneimittelforschung"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/MNM-190367","article-title":"The Effect of Urtica dioica Leaf Extract Intake on Serum TNF-\u03b1, Stool Calprotectin and Erythrocyte Sedimentation Rate in Patients with Inflammatory Bowel Disease: A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial","volume":"13","author":"Nematgorgani","year":"2020","journal-title":"Mediterr. J. Nutr. Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"100556","DOI":"10.1016\/j.hermed.2022.100556","article-title":"Therapeutic Efficacy of Urtica dioica and Evening Primrose in Patients with Rheumatoid Arthritis: A Randomized Double-Blind, Placebo-Controlled Clinical Trial","volume":"32","author":"Abbasi","year":"2022","journal-title":"J. Herb. Med."},{"key":"ref_143","first-page":"112","article-title":"Efficacy of Supportive Therapy of Allergic Rhinitis by Stinging Nettle (Urtica dioica) Root Extract: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial","volume":"16","author":"Bakhshaee","year":"2017","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Vogel, H.G., and Vogel, W.H. (1997). Drug Discovery and Evaluation: Pharmacological Assays, Springer.","DOI":"10.1007\/978-3-662-03333-3"},{"key":"ref_145","unstructured":"ESCOP (2010). 2nd Edition of the ESCOP Monographs: Two Volume, ESCOP."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0965-2299(99)80119-8","article-title":"Nettle Sting of Urtica dioica for Joint Pain\u2014An Exploratory Study of This Complementary Therapy","volume":"7","author":"Randall","year":"1999","journal-title":"Complement. Ther. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: An Organ with Predominant Innate Immunity","volume":"47","author":"Gao","year":"2008","journal-title":"Hepatology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/01480545.2011.598531","article-title":"Ameliorative Influence of Urtica dioica L against Cisplatin-Induced Toxicity in Mice Bearing Ehrlich Ascites Carcinoma","volume":"35","author":"Musa","year":"2012","journal-title":"Drug Chem. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"167","DOI":"10.33899\/ijvs.2021.129606.1666","article-title":"Protective Effect of Urtica dioica in Liver and Kidney Damages Induce by Ethylene Glycol in Rabbits: A Histopathological Study","volume":"36","author":"Rajab","year":"2021","journal-title":"Iraqi J. Vet. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/10590500902885684","article-title":"8-Hydroxy-2\u2032-Deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis","volume":"27","author":"Valavanidis","year":"2009","journal-title":"J. Environ. Sci. Health Part C"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4103\/jomfp.JOMFP_140_17","article-title":"Evaluation of Glutathione Peroxidase in the Blood and Tumor Tissue of Oral Squamous Cell Carcinoma Patients","volume":"22","author":"Deshpande","year":"2018","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"e18382","DOI":"10.1590\/s2175-97902019000318382","article-title":"Radioprotective Profile of Urtica dioica L. Seed Extract on Oxidative DNA-Damage in Liver Tissue and Whole Blood of Radiation-Administered Rats","volume":"56","author":"Huyut","year":"2020","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e18354","DOI":"10.1590\/s2175-97902019000318354","article-title":"Protective Effects of Urtica dioica L. Seed Extract on Liver Tissue Injury and Antioxidant Capacity in Irradiated Rats","volume":"56","author":"Uyar","year":"2020","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5530\/pj.2020.12.25","article-title":"Correction of Toxic Liver Damage with a Multicomponent Herbal Extract in an Animal Experiment","volume":"12","author":"Ferubko","year":"2020","journal-title":"Pharmacogn. J."},{"key":"ref_155","first-page":"711","article-title":"Potential Health Risk Assessment Associated with Heavy Metal Accumulation in Native Urtica dioica","volume":"72","author":"Barboiu","year":"2020","journal-title":"Rom. Rep. Phys."},{"key":"ref_156","first-page":"2562","article-title":"Occurrence and Toxicities of Heavy Metals: Amelioration by Asparagus racemosus & Urtica diocia","volume":"20","author":"Singh","year":"2020","journal-title":"Plant Arch."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"012008","DOI":"10.1088\/1755-1315\/735\/1\/012008","article-title":"The Effect of Aqueous Urtica dioica Extract in Male Rats Exposed to Copper Sulfate Poisoning","volume":"735","author":"Aldulaimi","year":"2021","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_158","first-page":"1313","article-title":"Effects of Urtica dioica Extract on Experimental Acute Pancreatitis Model in Rats","volume":"7","author":"Yilmaz","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.trechm.2019.04.009","article-title":"Challenges and Opportunities in Central Nervous System Drug Discovery","volume":"1","author":"Danon","year":"2019","journal-title":"Trends Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2310881","DOI":"10.1002\/adfm.202310881","article-title":"Multifunctional Nanotheranostics for Overcoming the Blood\u2013Brain Barrier","volume":"34","author":"Beygi","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ano, Y., Kita, M., Kitaoka, S., and Furuyashiki, T. (2019). Leucine\u2013Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress. Nutrients, 11.","DOI":"10.3390\/nu11092161"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"de Munter, J., Pavlov, D., Gorlova, A., Sicker, M., Proshin, A., Kalueff, A.V., Svistunov, A., Kiselev, D., Nedorubov, A., and Morozov, S. (2021). Increased Oxidative Stress in the Prefrontal Cortex as a Shared Feature of Depressive- and PTSD-Like Syndromes: Effects of a Standardized Herbal Antioxidant. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.661455"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2013.07.029","article-title":"Effect of Urtica dioica on Memory Dysfunction and Hypoalgesia in an Experimental Model of Diabetic Neuropathy","volume":"552","author":"Patel","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/01913123.2023.2287664","article-title":"Protective Effects of Urtica dioica on the Cerebral Cortex Damage Induced by Potassium Bromate in Adult Male Albino Rats","volume":"48","author":"Mahmoud","year":"2024","journal-title":"Ultrastruct. Pathol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"112801","DOI":"10.1016\/j.jep.2020.112801","article-title":"Effects of Endurance Exercise and Urtica dioica on the Functional, Histological and Molecular Aspects of the Hippocampus in STZ-Induced Diabetic Rats","volume":"256","author":"Keshvari","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"18134","DOI":"10.1007\/s11356-020-12025-y","article-title":"Urtica dioica Extracts Abolish Scopolamine-Induced Neuropathies in Rats","volume":"28","author":"Mosaad","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Rahmati, M., Keshvari, M., Xie, W., Yang, G., Jin, H., Li, H., Chehelcheraghi, F., and Li, Y. (2022). Resistance Training and Urtica dioica Increase Neurotrophin Levels and Improve Cognitive Function by Increasing Age in the Hippocampus of Rats. Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113306"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"102328","DOI":"10.1016\/j.tice.2024.102328","article-title":"The Role of Stinging Nettle (Urtica dioica L.) in the Management of Rotenone-Induced Parkinson\u2019s Disease in Rats","volume":"87","author":"Albadawi","year":"2024","journal-title":"Tissue Cell"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/dmrr.2239","article-title":"Advances in the Epidemiology, Pathogenesis and Management of Diabetic Peripheral Neuropathy","volume":"28","author":"Tesfaye","year":"2012","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"485","DOI":"10.33899\/ijvs.2021.130563.1848","article-title":"Efficacy of Urtiea Dicica Extract for Amelioration of Brain Lesions Induced by Ethylene Glycol in Male Rabbits","volume":"36","author":"Alsaidya","year":"2022","journal-title":"Iraqi J. Vet. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e06195","DOI":"10.1016\/j.heliyon.2021.e06195","article-title":"Antiepileptic Effects of Antioxidant Potent Extract from Urtica dioica Linn. Root on Pentylenetetrazole and Maximal Electroshock Induced Seizure Models","volume":"7","author":"Loshali","year":"2021","journal-title":"Heliyon"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1038\/s41467-023-38834-6","article-title":"Native American Ataxia Medicines Rescue Ataxia-Linked Mutant Potassium Channel Activity via Binding to the Voltage Sensing Domain","volume":"14","author":"Manville","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"172","DOI":"10.32598\/CJNS.7.26.6","article-title":"Comparative Protective Effects of Viola Spathulata, Urtica dioica, and Lamium Album on Endoplasmic Reticulum (ER) Stress in Rat Stroke Model","volume":"7","author":"Hedayati","year":"2021","journal-title":"Casp. J. Neurol. Sci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-8741(02)00055-7","article-title":"Cardiovascular Effects of Urtica dioica L. (Urticaceae) Roots Extracts: In Vitro and in Vivo Pharmacological Studies","volume":"81","author":"Testai","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ptr.1087","article-title":"Cardiovascular Effects of Urtica dioica L. in Isolated Rat Heart and Aorta","volume":"16","author":"Legssyer","year":"2002","journal-title":"Phytother. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tcm.2019.07.001","article-title":"Evaluating and Managing Bradycardia","volume":"30","author":"Sidhu","year":"2020","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/s41598-022-05766-y","article-title":"The Association between Elevated Lipid Profile and Liver Enzymes: A Study on Bangladeshi Adults","volume":"12","author":"Kathak","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_178","first-page":"102","article-title":"Decreased Cardiovascular Risk and Resistance to Hyperlipemia-Induced Hepatic Damage in Rats by Aqueous Extract of Urtica dioica","volume":"2","author":"Alisi","year":"2008","journal-title":"Afr. J. Biochem. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ptr.1906","article-title":"Inhibition of Rat Platelet Aggregation by Urtica dioica Leaves Extracts","volume":"20","author":"Bnouham","year":"2006","journal-title":"Phytother. Res."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Shamsi, M., Ganji, A., Mosayebi, G., Amirhoseiny, E.S., Shohani, S., and Ghazavi, A. (2023). Chamomile and Urtica dioica Extracts Improve Immunological and Histological Alterations Associated with Polycystic Ovarian Syndrome in DHEA -Induced Mice. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-03936-7"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Bandariyan, E., Mogheiseh, A., and Ahmadi, A. (2021). The Effect of Lutein and Urtica dioica Extract on in Vitro Production of Embryo and Oxidative Status in Polycystic Ovary Syndrome in a Model of Mice. BMC Complement. Med. Ther., 21.","DOI":"10.1186\/s12906-021-03229-x"},{"key":"ref_182","first-page":"1","article-title":"Investigating the Effects of Hydro-Alcoholic Urtica dioica Extract and Retinoic Acid on Follicular Development: An Animal Study","volume":"37","author":"Jasim","year":"2023","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"e17277","DOI":"10.1016\/j.heliyon.2023.e17277","article-title":"The Modulator Role of Urtica dioica on Deleterious Effects of Retinoic Acid High Doses on Histological Parameters and Fertilization of Rats","volume":"9","author":"Du","year":"2023","journal-title":"Heliyon"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"29","DOI":"10.9734\/ijbcrr\/2022\/v31i830344","article-title":"Ethanolic Root Extract of Urtica dioica Exhibits Pro-Fertility and Antioxidant Activities in Female Albino Rats","volume":"31","author":"Oladimeji","year":"2022","journal-title":"Int. J. Biochem. Res. Rev."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/1828051X.2021.2007801","article-title":"The Regulative Effect of Urtica dioica on Sex Hormones Imbalance: Elevated Follicle-Stimulating Hormone\/Luteinizing Hormone Ratio \u22654.5 Is Associated with Low Performance in Aged Breeder Quails","volume":"21","author":"Farzinpour","year":"2022","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ctim.2019.04.003","article-title":"Urtica dioica in Comparison with Placebo and Acupuncture: A New Possibility for Menopausal Hot Flashes: A Randomized Clinical Trial","volume":"44","author":"Kargozar","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_187","first-page":"135","article-title":"Use of Lipid-Lowering Medicinal Herbs during Pregnancy: A Systematic Review on Safety and Dosage","volume":"13","author":"Heidarian","year":"2017","journal-title":"ARYA Atheroscler."},{"key":"ref_188","unstructured":"(2024, July 02). Urticae Herba\u2014Herbal Medicinal Product|European Medicines Agency. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/herbal\/urticae-herba#documents."},{"key":"ref_189","unstructured":"Stinging Nettle (2006). Drugs and Lactation Database (LactMed\u00ae)."},{"key":"ref_190","first-page":"401","article-title":"Protective Effect of Urtica dioica L against Nicotine-Induced Damage on Sperm Parameters, Testosterone and Testis Tissue in Mice","volume":"12","author":"Jalili","year":"2014","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jep.2003.09.028","article-title":"Antioxidant, Antimicrobial, Antiulcer and Analgesic Activities of Nettle (Urtica dioica L.)","volume":"90","author":"Oktay","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00384-004-0619-z","article-title":"Ameliorative Effect of IDS 30, a Stinging Nettle Leaf Extract, on Chronic Colitis","volume":"20","author":"Konrad","year":"2005","journal-title":"Int. J. Colorectal. Dis."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Dakhli, N., Rtibi, K., Arrari, F., Ayari, A., and Sebai, H. (2023). Prophylactic Coloprotective Effect of Urtica dioica Leaves against Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis in Rats. Medicina, 59.","DOI":"10.20944\/preprints202310.1054.v1"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Fan, S., Raychaudhuri, S., Page, R., Shahinozzaman, M., and Obanda, D.N. (2021). Metagenomic Insights into the Effects of Urtica dioica Vegetable on the Gut Microbiota of C57BL\/6J Obese Mice, Particularly the Composition of Clostridia. J. Nutr. Biochem., 91.","DOI":"10.1016\/j.jnutbio.2021.108594"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1080\/14786419.2018.1539975","article-title":"Effect of a Mixture of Botanicals Extracts plus Mannitol on Hydration and Bloating Sensation. An Open Label Study in Women with High Extra Cellular Water","volume":"34","author":"Perna","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.hermed.2017.05.002","article-title":"Effects of Urtica dioica Leaf Extract on Inflammation, Oxidative Stress, ESR, Blood Cell Count and Quality of Life in Patients with Inflammatory Bowel Disease","volume":"9","author":"Nematgorgani","year":"2017","journal-title":"J. Herb. Med."},{"key":"ref_197","first-page":"205","article-title":"The Effects of Urtica dioica L. Ethanolic Extract against Urinary Calculi in Rats","volume":"24","author":"Sen","year":"2020","journal-title":"Marmara Pharm. J."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Maisto, M., Schiano, E., Luccheo, G., Luccheo, L., Alfieri, E., Piccolo, V., Iannuzzo, F., Di Lorenzo, R., and Tenore, G.C. (2023). Efficacy of a Multicomponent Nutraceutical Formulation for the Prevention and Treatment of Urinary Tract Stones. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098316"},{"key":"ref_199","first-page":"535","article-title":"Urtica dioica in the Management of Benign Prostate Hyperplasia (BPH)","volume":"10","author":"Mahboubi","year":"2020","journal-title":"Nat. Prod. J."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/J157v05n04_01","article-title":"Urtica dioica for Treatment of Benign Prostatic Hyperplasia: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Crossover Study","volume":"5","author":"Safarinejad","year":"2005","journal-title":"J. Herb. Pharmacother."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3923\/pjbs.2020.1338.1344","article-title":"Urtica dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial","volume":"23","author":"Sheikhsole","year":"2020","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_202","first-page":"23","article-title":"The Histological and Histometrical Effects of Urtica dioica Extract on Rat\u2019s Prostate Hyperplasia","volume":"6","author":"Moradi","year":"2015","journal-title":"Vet. Res. Forum"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5812\/ircmj.2386","article-title":"The Efficacy of Stinging Nettle (Urtica dioica) in Patients with Benign Prostatic Hyperplasia: A Randomized Double-Blind Study in 100 Patients","volume":"15","author":"Ghorbanibirgani","year":"2013","journal-title":"Iran. Red. Crescent. Med. J."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4314\/ajtcam.v13i2.17","article-title":"The Efficacy and Safety of Urtica dioica in Treating Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis","volume":"13","author":"Men","year":"2016","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1756287219879533","DOI":"10.1177\/1756287219879533","article-title":"WS PRO 160 I 120 Mg (a Combination of Sabal and Urtica Extract) in Patients with LUTS Related to BPH","volume":"11","author":"Funk","year":"2019","journal-title":"Ther. Adv. Urol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1464-410X.2000.00776.x","article-title":"Combined Sabal and Urtica Extract Compared with Finasteride in Men with Benign Prostatic Hyperplasia: Analysis of Prostate Volume and Therapeutic Outcome","volume":"86","year":"2000","journal-title":"BJU Int."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00345-014-1338-x","article-title":"Fixed-Dose Combination PRO 160\/120 of Sabal and Urtica Extracts Improves Nocturia in Men with LUTS Suggestive of BPH: Re-Evaluation of Four Controlled Clinical Studies","volume":"32","author":"Oelke","year":"2014","journal-title":"World J. Urol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1055\/s-2006-957756","article-title":"Lignans from the Roots of Urtica dioica and Their Metabolites Bind to Human Sex Hormone Binding Globulin (SHBG)","volume":"63","author":"Gansser","year":"1997","journal-title":"Planta Med."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2006-957993","article-title":"The Effect of Extracts of the Roots of the Stinging Nettle (Urtica dioica) on the Interaction of SHBG with Its Receptor on Human Prostatic Membranes","volume":"61","author":"Hryb","year":"1995","journal-title":"Planta Med."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Saponaro, M., Giacomini, I., Morandin, G., Cocetta, V., Ragazzi, E., Orso, G., Carnevali, I., Berretta, M., Mancini, M., and Pagano, F. (2020). Serenoa Repens and Urtica dioica Fixed Combination: In-Vitro Validation of a Therapy for Benign Prostatic Hyperplasia (BPH). Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239178"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/uro2010006","article-title":"Soybean Extracts (Glycine Max) with Curcuma, Boswellia, Pinus and Urtica Are Able to Improve Quality of Life in Patients Affected by CP\/CPPS: Is the Pro-Inflammatory Cytokine IL-8 Level Decreasing the Physiopathological Link?","volume":"2","author":"Cai","year":"2022","journal-title":"Uro"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/7501\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:11:55Z","timestamp":1760109115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/13\/7501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":211,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25137501"],"URL":"https:\/\/doi.org\/10.3390\/ijms25137501","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]}}}