{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T23:02:28Z","timestamp":1783897348139,"version":"3.55.0"},"reference-count":72,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAPES (Coordination for the Improvement of Higher Education Personnel)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"FAPERJ (Rio de Janeiro State Research Foundation)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"CNPq (The National Council for Scientific and Technological Development)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"IOC (Oswaldo Cruz Institute)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Salivary glands\u2019 neoplasms are hard to diagnose and present a complex etiology. However, several viruses have been detected in these neoplasms, such as HCMV, which can play a role in certain cancers through oncomodulation. The co-infections between HCMV with betaherpesviruses (HHV-6 and HHV-7) and polyomaviruses (JCV and BKV) has been investigated. The aim of the current study is to describe the frequency of HCMV and co-infections in patients presenting neoplastic and non-neoplastic lesions, including in the salivary gland. Multiplex quantitative polymerase chain reaction was used for betaherpesvirus and polyomavirus quantification purposes after DNA extraction. In total, 50.7% of the 67 analyzed samples were mucocele, 40.3% were adenoma pleomorphic, and 8.9% were mucoepidermoid carcinoma. Overall, 20.9% of samples presented triple-infections with HCMV\/HHV-6\/HHV-7, whereas 9.0% were co-infections with HCMV\/HHV-6 and HCMV\/HHV-7. The largest number of co-infections was detected in pleomorphic adenoma cases. All samples tested negative for polyomaviruses, such as BKV and JCV. It was possible to conclude that HCMV can be abundant in salivary gland lesions. A high viral load can be useful to help better understand the etiological role played by viruses in these lesions. A lack of JCV and BKV in the samples analyzed herein does not rule out the involvement of these viruses in one or more salivary gland lesion subtypes.<\/jats:p>","DOI":"10.3390\/ijms25147502","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:38:04Z","timestamp":1720514284000},"page":"7502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cytomegalovirus in Adenoma and Carcinoma Lesions: Detecting Mono-Infection and Co-Infection in Salivary Glands"],"prefix":"10.3390","volume":"25","author":[{"given":"Ana Carolina Silva","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Vasques","family":"Raposo Vedovi","sequence":"additional","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Rodrigues","family":"de Almeida Ribeiro","sequence":"additional","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-3241","authenticated-orcid":false,"given":"Katrini Guidolini","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Social Medicine Department, Federal University of Esp\u00edrito Santo, Espirito Santo CEP 2975-910, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Pelajo Machado","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Paulo","family":"de Abreu Manso","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Cristina","family":"Euzebio Pereira Dias de Oliveira","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Lobo","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Stomatology Department, Dentistry School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina Simioni","family":"de Rosa","sequence":"additional","affiliation":[{"name":"Stomatology Department, Dentistry School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Regina","family":"Tozetto-Mendoza","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Tropical Medicine Institute of S\u00e3o Paulo, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Mamana","family":"Fernandes de Souza","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Tropical Medicine Institute of S\u00e3o Paulo, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Trierveiler","family":"Martins","sequence":"additional","affiliation":[{"name":"Stomatology Department, Dentistry School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9521","authenticated-orcid":false,"given":"Paulo Henrique","family":"Braz-Silva","sequence":"additional","affiliation":[{"name":"Stomatology Department, Dentistry School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"},{"name":"Virology Laboratory, Tropical Medicine Institute of S\u00e3o Paulo, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo CEP 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Salete","family":"de Paula","sequence":"additional","affiliation":[{"name":"Molecular Virology and Parasitology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 4365 Brasil Ave., Manguinhos, Rio de Janeiro CEP 21040-360, 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