{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:59:23Z","timestamp":1791053963937,"version":"4.1.0"},"reference-count":184,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PNRR: \u201cHealth Extended ALliance for Innovative Therapies, Advanced Lab-research, and Integrated Approaches of Precision\u201d","award":["E63C22002080006"],"award-info":[{"award-number":["E63C22002080006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sarcopenia refers to the progressive loss and atrophy of skeletal muscle function, often associated with aging or secondary to conditions involving systemic inflammation, oxidative stress, and mitochondrial dysfunction. Recent evidence indicates that skeletal muscle function is not only influenced by physical, environmental, and genetic factors but is also significantly impacted by nutritional deficiencies. Natural compounds with antioxidant properties, such as resveratrol and vitamin D, have shown promise in preventing mitochondrial dysfunction in skeletal muscle cells. These antioxidants can slow down muscle atrophy by regulating mitochondrial functions and neuromuscular junctions. This review provides an overview of the molecular mechanisms leading to skeletal muscle atrophy and summarizes recent advances in using resveratrol and vitamin D supplementation for its prevention and treatment. Understanding these molecular mechanisms and implementing combined interventions can optimize treatment outcomes, ensure muscle function recovery, and improve the quality of life for patients.<\/jats:p>","DOI":"10.3390\/ijms25147503","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T08:38:04Z","timestamp":1720514284000},"page":"7503","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia"],"prefix":"10.3390","volume":"25","author":[{"given":"Cristina","family":"Russo","sequence":"first","affiliation":[{"name":"Section of Pathology, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-3542","authenticated-orcid":false,"given":"Maria Stella","family":"Valle","sequence":"additional","affiliation":[{"name":"Section of Physiology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-0432","authenticated-orcid":false,"given":"Floriana","family":"D\u2019Angeli","sequence":"additional","affiliation":[{"name":"Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Surdo","sequence":"additional","affiliation":[{"name":"Italian Center for the Study of Osteopathy (CSDOI), 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-7963","authenticated-orcid":false,"given":"Lucia","family":"Malaguarnera","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/jcsm.13243","article-title":"Sarcopenia and health-related quality of life: A systematic review and meta-analysis","volume":"14","author":"Beaudart","year":"2023","journal-title":"J. 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