{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:30:40Z","timestamp":1790659840841,"version":"4.1.0"},"reference-count":114,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["Unit"],"award-info":[{"award-number":["Unit"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Breast cancer (BC) stands out as the most commonly type of cancer diagnosed in women worldwide, and chemotherapy, a key component of treatment, exacerbates cancer-induced skeletal muscle wasting, contributing to adverse health outcomes. Notably, the impact of chemotherapy on skeletal muscle seems to surpass that of the cancer itself, with inflammation identified as a common trigger for muscle wasting in both contexts. In skeletal muscle, pro-inflammatory cytokines modulate pathways crucial for the delicate balance between protein synthesis and breakdown, as well as satellite cell activation and myonuclear accretion. Physical exercise consistently emerges as a crucial therapeutic strategy to counteract cancer and chemotherapy-induced muscle wasting, ultimately enhancing patients\u2019 quality of life. However, a \u201cone size fits all\u201d approach does not apply to the prescription of exercise for BC patients, with factors such as age, menopause and comorbidities influencing the response to exercise. Hence, tailored exercise regimens, considering factors such as duration, frequency, intensity, and type, are essential to maximize efficacy in mitigating muscle wasting and improving disease outcomes. Despite the well-established anti-inflammatory role of aerobic exercise, resistance exercise proves equally or more beneficial in terms of mass and strength gain, as well as enhancing quality of life. This review comprehensively explores the molecular pathways affected by distinct exercise regimens in the skeletal muscle of cancer patients during chemotherapy, providing critical insights for precise exercise implementation to prevent skeletal muscle wasting.<\/jats:p>","DOI":"10.3390\/ijms25147533","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T13:22:36Z","timestamp":1720531356000},"page":"7533","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Restoring Skeletal Muscle Health through Exercise in Breast Cancer Patients and after Receiving Chemotherapy"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1411-9146","authenticated-orcid":false,"given":"In\u00eas","family":"Aires","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"CITAB, Inov4Agro, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-5917","authenticated-orcid":false,"given":"Jos\u00e9 Alberto","family":"Duarte","sequence":"additional","affiliation":[{"name":"CIAFEL, and Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sports, University of Porto (FADEUP), 4200-450 Porto, Portugal"},{"name":"UCIBIO-Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-5805","authenticated-orcid":false,"given":"Rui","family":"Vitorino","sequence":"additional","affiliation":[{"name":"iBiMED, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-7405","authenticated-orcid":false,"given":"Daniel","family":"Moreira-Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CIAFEL, and Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sports, University of Porto (FADEUP), 4200-450 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-4044","authenticated-orcid":false,"given":"Paula","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CITAB, Inov4Agro, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6872-4051","authenticated-orcid":false,"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1470-2045(00)00254-0","article-title":"Epidemiology of Breast Cancer","volume":"2","author":"Key","year":"2001","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1758835919833519","DOI":"10.1177\/1758835919833519","article-title":"HER2-Positive Breast Cancer: New Therapeutic Frontiers and Overcoming Resistance","volume":"11","author":"Pernas","year":"2019","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41416-020-01175-y","article-title":"Treatment Strategies for Breast Cancer Brain Metastases","volume":"124","author":"Bailleux","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Anampa, J., Makower, D., and Sparano, J.A. (2015). Progress in Adjuvant Chemotherapy for Breast Cancer: An Overview. BMC Med., 13.","DOI":"10.1186\/s12916-015-0439-8"},{"key":"ref_5","first-page":"3722","article-title":"Cardiotoxicity of Epirubicin and Doxorubicin: Assessment by Endomyocardial Biopsy","volume":"46","author":"Torti","year":"1986","journal-title":"Cancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"C577","DOI":"10.1152\/ajpcell.00264.2020","article-title":"Breast Cancer-Associated Skeletal Muscle Mitochondrial Dysfunction and Lipid Accumulation Is Reversed by PPARG","volume":"320","author":"Wilson","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Roda, E., Luca, F.D., Locatelli, C.A., Ratto, D., Di Iorio, C., Savino, E., Bottone, M.G., and Rossi, P. (2020). From a Medicinal Mushroom Blend a Direct Anticancer Effect on Triple-Negative Breast Cancer: A Preclinical Study on Lung Metastases. Molecules, 25.","DOI":"10.3390\/molecules25225400"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Luca, F.D., Roda, E., Ratto, D., Desiderio, A., Venuti, M.T., Ramieri, M., Bottone, M.G., Savino, E., and Rossi, P. (2023). Fighting Secondary Triple-Negative Breast Cancer in Cerebellum: A Powerful Aid from a Medicinal Mushrooms Blend. Biomed. Pharmacother., 159.","DOI":"10.1016\/j.biopha.2023.114262"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/0971-5851.60050","article-title":"Exercise in Cancer","volume":"30","author":"Rajarajeswaran","year":"2009","journal-title":"Indian J. Med. Paediatr. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/bjc.1985.273","article-title":"Lower Prevalence of Breast Cancer and Cancers of the Reproductive System among Former College Athletes Compared to Non-Athletes","volume":"52","author":"Frisch","year":"1985","journal-title":"Br. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118790","DOI":"10.1016\/j.lfs.2020.118790","article-title":"Dissecting the Molecular Pathways Involved in the Effects of Physical Activity on Breast Cancers Cells: A Narrative Review","volume":"265","author":"Orlandella","year":"2021","journal-title":"Life Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1249\/MSS.0b013e3181e0c112","article-title":"American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors","volume":"42","author":"Schmitz","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s42978-020-00074-1","article-title":"Advanced Exercise Prescription for Cancer Patients and Its Application in Germany","volume":"2","author":"Schumann","year":"2020","journal-title":"J. Sci. Sport Exerc."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Thomas, G.A. (2022). Using a Network Physiology Approach to Prescribe Exercise for Exercise Oncology. Front. Netw. Physiol., 2.","DOI":"10.3389\/fnetp.2022.877676"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00520-016-3402-0","article-title":"Weight Loss versus Muscle Loss: Re-Evaluating Inclusion Criteria for Future Cancer Cachexia Interventional Trials","volume":"25","author":"Roeland","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"C24","DOI":"10.1152\/ajpcell.00333.2021","article-title":"Skeletal Muscle Wasting: The Estrogen Side of Sexual Dimorphism","volume":"322","author":"McMillin","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1113\/EP087007","article-title":"Sexual Dimorphism of Substrate Utilization: Differences in Skeletal Muscle Mitochondrial Volume Density and Function","volume":"103","author":"Montero","year":"2018","journal-title":"Exp. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/SPC.0000000000000011","article-title":"Impact of Sarcopenia on the Prognosis and Treatment Toxicities in Patients Diagnosed with Cancer","volume":"7","author":"Antoun","year":"2013","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1519\/JSC.0000000000003230","article-title":"Resistance Training for Older Adults: Position Statement from the National Strength and Conditioning Association","volume":"33","author":"Fragala","year":"2019","journal-title":"J. Strength. Cond. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10549-011-1444-z","article-title":"Strength Training Stops Bone Loss and Builds Muscle in Postmenopausal Breast Cancer Survivors: A Randomized, Controlled Trial","volume":"127","author":"Dobek","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3322\/caac.21639","article-title":"A Systematic Review of Rehabilitation and Exercise Recommendations in Oncology Guidelines","volume":"71","author":"Stout","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1249\/MSS.0000000000001446","article-title":"Exercise Prescription and Adherence for Breast Cancer: One Size Does Not FITT All","volume":"50","author":"Kirkham","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Mallard, J., Hucteau, E., Hureau, T.J., and Pagano, A.F. (2021). Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights from Other Cancers. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.719643"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-Associated Cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"C744","DOI":"10.1152\/ajpcell.00002.2018","article-title":"Skeletal Muscle Atrophy and Dysfunction in Breast Cancer Patients: Role for Chemotherapy-Derived Oxidant Stress","volume":"315","author":"Guigni","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1200\/JCO.2006.08.2024","article-title":"Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicenter Randomized Controlled Trial","volume":"25","author":"Courneya","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_28","first-page":"5623","article-title":"Comparing Endurance and Resistance Training with Standard Care during Chemotherapy for Patients with Primary Breast Cancer","volume":"35","author":"Schmidt","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00432-019-02911-5","article-title":"Molecular and Cellular Adaptations to Exercise Training in Skeletal Muscle from Cancer Patients Treated with Chemotherapy","volume":"145","author":"Farup","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wengstr\u00f6m, Y., Bolam, K.A., Mijwel, S., Sundberg, C.J., Backman, M., Browall, M., Norrbom, J., and Rundqvist, H. (2017). Optitrain: A Randomised Controlled Exercise Trial for Women with Breast Cancer Undergoing Chemotherapy. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3079-x"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/apha.12721","article-title":"Long-Term Exercise Training Prevents Mammary Tumorigenesis-Induced Muscle Wasting in Rats through the Regulation of TWEAK Signalling","volume":"219","author":"Figueira","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Alves de Lima, E., de Teixeira, A.A.S., Biondo, L.A., Diniz, T.A., Silveira, L.S., Coletti, D., Busquets Rius, S., and Rosa Neto, J.C. (2020). Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy. Cancers, 12.","DOI":"10.3390\/cancers12113466"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1096\/fj.201801862R","article-title":"Moderate Exercise in Mice Improves Cancer Plus Chemotherapy-Induced Muscle Wasting and Mitochondrial Alterations","volume":"33","author":"Pin","year":"2019","journal-title":"FASEB J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1152\/japplphysiol.00429.2011","article-title":"Exercise Protects against Doxorubicin-Induced Markers of Autophagy Signaling in Skeletal Muscle","volume":"111","author":"Smuder","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1249\/MSS.0000000000000926","article-title":"Effects of Exercise on Doxorubicin-Induced Skeletal Muscle Dysfunction","volume":"48","author":"Bredahl","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"418","DOI":"10.32098\/mltj.03.2017.03","article-title":"Effects of Endurance Exercise and Doxorubicin on Skeletal Muscle Myogenic Regulatory Factor Expression","volume":"7","author":"Quinn","year":"2017","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcsm.12165","article-title":"Muscle Strength in Breast Cancer Patients Receiving Different Treatment Regimes: Muscle Strength in Breast Cancer Patients","volume":"8","author":"Klassen","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jgo.2021.08.003","article-title":"A Randomized-Controlled Trial Comparing Supervised Aerobic Training to Resistance Training Followed by Unsupervised Exercise on Physical Functioning in Older Breast Cancer Survivors","volume":"13","author":"Dieckmann","year":"2022","journal-title":"J. Geriatr. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"American College of Sports, Medicine American College of Sports, and Medicine Position Stand (2009). Progression Models in Resistance Training for Healthy Adults. Med. Sci. Sports Exerc., 41, 687\u2013708.","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1055\/s-2007-1021104","article-title":"Isokinetic Evaluation of Muscular Performance: Implications for Muscle Testing and Rehabilitation","volume":"15","author":"Kannus","year":"1994","journal-title":"Int. J. Sports Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1503\/cmaj.051073","article-title":"Effects of Exercise on Breast Cancer Patients and Survivors: A Systematic Review and Meta-Analysis","volume":"175","author":"McNeely","year":"2006","journal-title":"Can. Med. Assoc. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/17437190903384291","article-title":"Group versus Individual Exercise Interventions for Women with Breast Cancer: A Meta-Analysis","volume":"4","author":"Floyd","year":"2010","journal-title":"Health Psychol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11764-011-0210-x","article-title":"The Effect of Resistance Training on Muscle Strength and Physical Function in Older, Postmenopausal Breast Cancer Survivors: A Randomized Controlled Trial","volume":"6","author":"Dobek","year":"2012","journal-title":"J. Cancer Surviv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejon.2004.03.007","article-title":"A Pilot Study of a Supervised Group Exercise Programme as a Rehabilitation Treatment for Women with Breast Cancer Receiving Adjuvant Treatment","volume":"9","author":"Campbell","year":"2005","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/cncr.29863","article-title":"Patient-Reported Outcomes, Body Composition, and Nutrition Status in Patients with Head and Neck Cancer: Results from an Exploratory Randomized Controlled Exercise Trial","volume":"122","author":"Capozzi","year":"2016","journal-title":"Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0148607187011003219","article-title":"Body Cell Mass in Cancer-Bearing and Anorexic Patients","volume":"11","author":"Moley","year":"1987","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Friesen, D.E., Baracos, V.E., and Tuszynski, J.A. (2015). Modeling the Energetic Cost of Cancer as a Result of Altered Energy Metabolism: Implications for Cachexia. Theor. Biol. Med. Model., 12.","DOI":"10.1186\/s12976-015-0015-0"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cncr.34533","article-title":"Early Skeletal Muscle Deconditioning and Reduced Exercise Capacity during (Neo)Adjuvant Chemotherapy in Patients with Breast Cancer","volume":"129","author":"Mallard","year":"2023","journal-title":"Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clnu.2009.07.001","article-title":"Resting Energy Expenditure and Body Composition in Patients with Newly Detected Cancer","volume":"29","author":"Cao","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12905-024-02900-y","article-title":"Resting Energy Expenditure, Body Composition, and Metabolic Alterations in Breast Cancer Survivors vs. Healthy Controls: A Cross-Sectional Study","volume":"24","author":"Soom","year":"2024","journal-title":"BMC Women\u2019s Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ijo.2008.25","article-title":"Increased Visceral Fat and Decreased Energy Expenditure during the Menopausal Transition","volume":"32","author":"Lovejoy","year":"2008","journal-title":"Int. J. Obes."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1158\/1078-0432.CCR-06-3067","article-title":"Body Composition as an Independent Determinant of 5-Fluorouracil-Based Chemotherapy Toxicity","volume":"13","author":"Prado","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/01.NCC.0000265004.64440.5f","article-title":"Resting Energy Expenditure and Body Mass Changes in Women during Adjuvant Chemotherapy for Breast Cancer","volume":"30","author":"Campbell","year":"2007","journal-title":"Cancer Nurs."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e054412","DOI":"10.1136\/bmjopen-2021-054412","article-title":"Body Composition and Chemotherapy Toxicity in Women with Early Breast Cancer (CANDO-3): Protocol for an Observational Cohort Study","volume":"12","author":"Durkin","year":"2022","journal-title":"BMJ Open"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1113\/jphysiol.2008.153916","article-title":"Differential Effects of Resistance and Endurance Exercise in the Fed State on Signalling Molecule Phosphorylation and Protein Synthesis in Human Muscle","volume":"586","author":"Wilkinson","year":"2008","journal-title":"J. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jcsm.12678","article-title":"Phenotypic Features of Cancer Cachexia-related Loss of Skeletal Muscle Mass and Function: Lessons from Human and Animal Studies","volume":"12","author":"Martin","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e14608","DOI":"10.14814\/phy2.14608","article-title":"Comparative Plasma Proteomics in Muscle Atrophy during Cancer-Cachexia and Disuse: The Search for Atrokines","volume":"8","author":"Lim","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.2617-1619.2019.tb00011.x","article-title":"Chemotherapy-Induced Loss of Bone and Muscle Mass in a Mouse Model of Breast Cancer Bone Metastases and Cachexia","volume":"2","author":"Hain","year":"2019","journal-title":"JCSM Rapid Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1113\/jphysiol.2014.286518","article-title":"Increased Mitochondrial Emission of Reactive Oxygen Species and Calpain Activation Are Required for Doxorubicin-Induced Cardiac and Skeletal Muscle Myopathy","volume":"593","author":"Min","year":"2015","journal-title":"J. Physiol."},{"key":"ref_60","first-page":"e54893","article-title":"The Colon-26 Carcinoma Tumor-Bearing Mouse as a Model for the Study of Cancer Cachexia","volume":"117","author":"Bonetto","year":"2016","journal-title":"JoVE J. Vis. Exp."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.20463\/pan.2020.0010","article-title":"Protective Effects of Endurance Exercise on Skeletal Muscle Remodeling against Doxorubicin-Induced Myotoxicity in Mice","volume":"24","author":"Kwon","year":"2020","journal-title":"Phys. Act. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"19709","DOI":"10.1074\/jbc.RA119.008426","article-title":"Doxorubicin Causes Lesions in the Electron Transport System of Skeletal Muscle Mitochondria That Are Associated with a Loss of Contractile Function","volume":"294","author":"Tarpey","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Christensen, J.F., Andersen, J.L., Adamsen, L., Lindegaard, B., Mackey, A.L., Nielsen, R.H., R\u00f8rth, M., and Daugaard, G. (2011). Progressive Resistance Training and Cancer Testis (PROTRACT)\u2014Efficacy of Resistance Training on Muscle Function, Morphology and Inflammatory Profile in Testicular Cancer Patients Undergoing Chemotherapy: Design of a Randomized Controlled Trial. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-326"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jcsm.13185","article-title":"Resistance and Endurance Exercise Training Improves Muscle Mass and the Inflammatory\/Fibrotic Transcriptome in a Rhabdomyosarcoma Model","volume":"14","author":"Collao","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2044-5040-2-14","article-title":"IL-6 Regulation on Skeletal Muscle Mitochondrial Remodeling during Cancer Cachexia in the ApcMin\/+ Mouse","volume":"2","author":"White","year":"2012","journal-title":"Skelet. Muscle"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"26991","DOI":"10.1038\/srep26991","article-title":"Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer","volume":"6","author":"Pigna","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"43202","DOI":"10.18632\/oncotarget.6439","article-title":"Combination of Exercise Training and Erythropoietin Prevents Cancer-Induced Muscle Alterations","volume":"6","author":"Pin","year":"2015","journal-title":"Oncotarget"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3892\/etm.2015.2693","article-title":"Upregulation of Peroxiredoxin III in Doxorubicin-Induced Cytotoxicity and the FoxO3a-Dependent Expression in H9c2 Cardiac Cells","volume":"10","author":"LIU","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_69","first-page":"15","article-title":"Nuclear Magnetic Resonance in Conjunction with Functional Genomics Suggests Mitochondrial Dysfunction in a Murine Model of Cancer Cachexia","volume":"27","author":"Constantinou","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"McLean, J.B., Moylan, J.S., and Andrade, F.H. (2014). Mitochondria Dysfunction in Lung Cancer-Induced Muscle Wasting in C2C12 Myotubes. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00503"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0006-291X(03)01483-9","article-title":"NAD+ Repletion Prevents PARP-1-Induced Glycolytic Blockade and Cell Death in Cultured Mouse Astrocytes","volume":"308","author":"Ying","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.00217.2011","article-title":"Doxorubicin Acts via Mitochondrial ROS to Stimulate Catabolism in C2C12 Myotubes","volume":"302","author":"Gilliam","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00280-016-3045-3","article-title":"Mitochondria: Inadvertent Targets in Chemotherapy-Induced Skeletal Muscle Toxicity and Wasting?","volume":"78","author":"Sorensen","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Doerr, V., Montalvo, R.N., Kwon, O.S., Talbert, E.E., Hain, B.A., Houston, F.E., and Smuder, A.J. (2020). Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction. Antioxidants, 9.","DOI":"10.3390\/antiox9030263"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e7582730","DOI":"10.1155\/2018\/7582730","article-title":"Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib","volume":"2018","author":"Gorini","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1152\/japplphysiol.00776.2009","article-title":"Doxorubicin Acts through Tumor Necrosis Factor Receptor Subtype 1 to Cause Dysfunction of Murine Skeletal Muscle","volume":"107","author":"Gilliam","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Rommel, C., Vanhaesebroeck, B., and Vogt, P.K. (2011). PI3 Kinase Regulation of Skeletal Muscle Hypertrophy and Atrophy. Phosphoinositide 3-kinase in Health and Disease: Volume 1, Springer. Current Topics in Microbiology and Immunology.","DOI":"10.1007\/978-3-642-14816-3"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e6043064","DOI":"10.1155\/2018\/6043064","article-title":"Secreted Frizzled-Related Protein-2 Inhibits Doxorubicin-Induced Apoptosis Mediated through the Akt-mTOR Pathway in Soleus Muscle","volume":"2018","author":"Merino","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1123\/ijsnem.2018-0339","article-title":"Resistance Training, Antioxidant Status, and Antioxidant Supplementation","volume":"29","author":"Ismaeel","year":"2019","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1196\/annals.1354.061","article-title":"Exercise and Hormesis: Activation of Cellular Antioxidant Signaling Pathway","volume":"1067","author":"Ji","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bbamcr.2006.06.010","article-title":"The Contraction Induced Increase in Gene Expression of Peroxisome Proliferator-Activated Receptor (PPAR)-Gamma Coactivator 1alpha (PGC-1alpha), Mitochondrial Uncoupling Protein 3 (UCP3) and Hexokinase II (HKII) in Primary Rat Skeletal Muscle Cells Is Dependent on Reactive Oxygen Species","volume":"1763","author":"Silveira","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/s41598-017-02088-2","article-title":"Cancer Cachexia Associates with a Systemic Autophagy-Inducing Activity Mimicked by Cancer Cell-Derived IL-6 Trans-Signaling","volume":"7","author":"Pettersen","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2007.11.004","article-title":"FoxO3 Coordinately Activates Protein Degradation by the Autophagic\/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells","volume":"6","author":"Zhao","year":"2007","journal-title":"Cell Metab."},{"key":"ref_84","first-page":"251","article-title":"Autophagy in Breast Cancer and Its Implications for Therapy","volume":"3","author":"Jain","year":"2013","journal-title":"Am. J. Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2013.12.014","article-title":"Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy","volume":"53","author":"Rogov","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"C1291","DOI":"10.1152\/ajpcell.00531.2009","article-title":"Autophagy in Health and Disease. 3. Involvement of Autophagy in Muscle Atrophy","volume":"298","author":"Sandri","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1101\/gad.1318305","article-title":"Runx1 Prevents Wasting, Myofibrillar Disorganization, and Autophagy of Skeletal Muscle","volume":"19","author":"Wang","year":"2005","journal-title":"Genes Dev."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"de Testa, M.T.J., Cella, P.S., Marinello, P.C., Frajacomo, F.T.T., de S. Padilha, C., Perandini, P.C., Moura, F.A., Duarte, J.A., Cecchini, R., and Guarnier, F.A. (2022). Resistance Training Attenuates Activation of STAT3 and Muscle Atrophy in Tumor-Bearing Mice. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.880787"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1007\/s00520-019-04772-7","article-title":"Effects of Exercise on Inflammation in Patients Receiving Chemotherapy: A Nationwide NCORP Randomized Clinical Trial","volume":"27","author":"Kleckner","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1165\/ajrcmb.26.5.4598","article-title":"Production of Interleukin-6 by Skeletal Myotubes","volume":"26","author":"Kosmidou","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/ERC-20-0507","article-title":"Exercise Intensity and Markers of Inflammation during and after (Neo-) Adjuvant Cancer Treatment","volume":"28","author":"Schauer","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/GME.0000000000000969","article-title":"Resistance Training Reduces Inflammation and Fatigue and Improves Physical Function in Older Breast Cancer Survivors","volume":"25","author":"Serra","year":"2018","journal-title":"Menopause"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1249\/MSS.0b013e3182644984","article-title":"Resistance Training Reduces Subclinical Inflammation in Obese, Postmenopausal Women","volume":"44","author":"Phillips","year":"2012","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"18024","DOI":"10.1038\/s41598-018-36626-3","article-title":"Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome","volume":"8","author":"Henriques","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_95","first-page":"62","article-title":"Effects of Tumor Removal and Body Weight Loss on Insulin Resistance in Patients with Cancer","volume":"116","author":"Yoshikawa","year":"1994","journal-title":"Surgery"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/bbrc.1998.9794","article-title":"Insulin Resistance in Cancer Patients Is Associated with Enhanced Tumor Necrosis Factor-\u03b1 Expression in Skeletal Muscle","volume":"253","author":"Noguchi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hojman, P., Fjelbye, J., Zerahn, B., Christensen, J.F., Dethlefsen, C., Lonkvist, C.K., Brandt, C., Gissel, H., Pedersen, B.K., and Gehl, J. (2014). Voluntary Exercise Prevents Cisplatin-Induced Muscle Wasting during Chemotherapy in Mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109030"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1249\/MSS.0000000000000242","article-title":"Aerobic and Strength Training in Concomitant Metabolic Syndrome and Type 2 Diabetes","volume":"46","author":"Earnest","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.2337\/diacare.26.11.2977","article-title":"Effective Exercise Modality to Reduce Insulin Resistance in Women with Type 2 Diabetes","volume":"26","author":"Cuff","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1073\/pnas.0607795103","article-title":"PGC-1\u03b1 Protects Skeletal Muscle from Atrophy by Suppressing FoxO3 Action and Atrophy-Specific Gene Transcription","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2006.12.003","article-title":"The Transcriptional Coactivator PGC-1\u03b2 Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle","volume":"5","author":"Arany","year":"2007","journal-title":"Cell Metab."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","article-title":"The IGF-1\/PI3K\/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors","volume":"14","author":"Stitt","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1139\/apnm-2016-0436","article-title":"Resistance Exercise Attenuates Skeletal Muscle Oxidative Stress, Systemic Pro-Inflammatory State, and Cachexia in Walker-256 Tumor-Bearing Rats","volume":"42","author":"Padilha","year":"2017","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jcp.20757","article-title":"Myostatin Induces Cachexia by Activating the Ubiquitin Proteolytic System through an NF-\u03baB-Independent, FoxO1-Dependent Mechanism","volume":"209","author":"McFarlane","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"E99","DOI":"10.1152\/ajpendo.1997.273.1.E99","article-title":"Mixed Muscle Protein Synthesis and Breakdown after Resistance Exercise in Humans","volume":"273","author":"Phillips","year":"1997","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1249\/00003677-199800260-00004","article-title":"Role of Insulin-like Growth Factor-I in the Regulation of Skeletal Muscle Adaptation to Increased Loading","volume":"26","author":"Adams","year":"1998","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1249\/MSS.0b013e31828cf5f3","article-title":"Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy","volume":"45","author":"Jorquera","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10226","DOI":"10.1038\/s41598-021-89232-1","article-title":"Total Testosterone Is Not Associated with Lean Mass or Handgrip Strength in Pre-Menopausal Females","volume":"11","author":"Alexander","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/cs0840095","article-title":"Muscle Weakness in Women Occurs at an Earlier Age than in Men, but Strength Is Preserved by Hormone Replacement Therapy","volume":"84","author":"Phillips","year":"1993","journal-title":"Clin. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1210\/jc.2013-2835","article-title":"Testosterone and Progesterone, but Not Estradiol, Stimulate Muscle Protein Synthesis in Postmenopausal Women","volume":"99","author":"Smith","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.celrep.2019.06.025","article-title":"Estrogen Regulates the Satellite Cell Compartment in Females","volume":"28","author":"Collins","year":"2019","journal-title":"Cell Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1469-7793.2001.0161m.x","article-title":"The Influence of Menstrual Cycle Phase on Skeletal Muscle Contractile Characteristics in Humans","volume":"530","author":"Boot","year":"2001","journal-title":"J. Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/2193-1801-3-668","article-title":"Effects of Follicular versus Luteal Phase-Based Strength Training in Young Women","volume":"3","author":"Sung","year":"2014","journal-title":"Springerplus"},{"key":"ref_114","first-page":"65","article-title":"Antiandrogens in Hormonal Contraception Limit Muscle Strength Gain in Strength Training: Comparison Study","volume":"44","author":"Leko","year":"2003","journal-title":"Croat. Med. J."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/14\/7533\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:12:15Z","timestamp":1760109135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/14\/7533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":114,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25147533"],"URL":"https:\/\/doi.org\/10.3390\/ijms25147533","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]}}}