{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:36:43Z","timestamp":1791851803834,"version":"4.3.4"},"reference-count":66,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Ministry of Education and Research (BMBF)","award":["CRC 1436"],"award-info":[{"award-number":["CRC 1436"]}]},{"name":"Medical Faculty of the Otto von Guericke University Magdeburg","award":["CRC 1436"],"award-info":[{"award-number":["CRC 1436"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG)","award":["CRC 1436"],"award-info":[{"award-number":["CRC 1436"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neuronal plasticity. Here, we investigated the effects of controlled normobaric hypoxia (NH) combined with physical inactivity on BDNF blood levels and executive functions. A total of 25 healthy adults (25.8 \u00b1 3.3 years, 15 female) were analyzed in a randomized controlled cross-over study. Each intervention began with a 30 min resting phase under normoxia (NOR), followed by a 90 min continuation of NOR or NH (peripheral oxygen saturation [SpO2] 85\u201380%). Serum and plasma samples were collected every 15 min. Heart rate and SpO2 were continuously measured. Before and after each exposure, cognitive tests were performed and after 24 h another follow-up blood sample was taken. NH decreased SpO2 (p &lt; 0.001, \u03b7p2 = 0.747) and increased heart rate (p = 0.006, \u03b7p2 = 0.116) significantly. The 30-min resting phase under NOR led to a significant BDNF reduction in serum (p &lt; 0.001, \u03b7p2 = 0.581) and plasma (p &lt; 0.001, \u03b7p2 = 0.362). Continuation of NOR further significantly reduced BDNF after another 45 min (p = 0.018) in serum and after 30 min (p = 0.040) and 90 min (p = 0.005) in plasma. There was no significant BDNF decline under NH. A 24 h follow-up examination showed a significant decline in serum BDNF, both after NH and NOR. Our results show that NH has the potential to counteract physical inactivity-induced BDNF decline. Therefore, our study emphasizes the need for a physically active lifestyle and its positive effects on BDNF. This study also demonstrates the need for a standardized protocol for future studies to determine BDNF in serum and plasma.<\/jats:p>","DOI":"10.3390\/ijms25147536","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T15:27:20Z","timestamp":1720538840000},"page":"7536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-5943","authenticated-orcid":false,"given":"Yves","family":"Duderstadt","sequence":"first","affiliation":[{"name":"Division of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany"},{"name":"Department of Sports Science, Chair of Health and Physical Activity, Otto-von-Guericke University, 39104 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-4374","authenticated-orcid":false,"given":"Stefanie","family":"Schreiber","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany"},{"name":"Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), 39120 Magdeburg, Germany"},{"name":"Division of Neurology, University Hospital Magdeburg, 39120 Magdeburg, Germany"},{"name":"Center for Behavioral Brain Sciences (CBBS), 39120 Magdeburg, Germany"},{"name":"German Center for Mental Health (DZPG), 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-0151","authenticated-orcid":false,"given":"Johannes","family":"Burtscher","sequence":"additional","affiliation":[{"name":"Institute of Sports Science, University Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-0796","authenticated-orcid":false,"given":"Lutz","family":"Schega","sequence":"additional","affiliation":[{"name":"Department of Sports Science, Chair of Health and Physical Activity, Otto-von-Guericke University, 39104 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Notger G.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany"},{"name":"Faculty of Health Sciences Brandenburg, University of Potsdam, 14476 Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Brigadski","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Otto-von-Guericke University, 39120 Magdeburg, Germany"},{"name":"Department of Informatics and Microsystems Technology, University of Applied Sciences, 67659 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-6532","authenticated-orcid":false,"given":"R\u00fcdiger C.","family":"Braun-Dullaeus","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-323X","authenticated-orcid":false,"given":"Volkmar","family":"Le\u00dfmann","sequence":"additional","affiliation":[{"name":"Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), 39120 Magdeburg, Germany"},{"name":"Center for Behavioral Brain Sciences (CBBS), 39120 Magdeburg, Germany"},{"name":"German Center for Mental Health (DZPG), 39120 Magdeburg, Germany"},{"name":"Institute of Physiology, Otto-von-Guericke University, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Angiology, University Hospital Magdeburg, 39120 Magdeburg, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany"},{"name":"Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), 39120 Magdeburg, Germany"},{"name":"German Center for Mental Health (DZPG), 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuropharm.2013.05.043","article-title":"Pre- and postsynaptic twists in BDNF secretion and action in synaptic 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