{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:04:23Z","timestamp":1761563063744,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]},{"name":"Consejer\u00eda de Salud y Familias (Junta de Andaluc\u00eda, Spain)","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]},{"name":"Consejer\u00eda de Universidad, Investigaci\u00f3n e Innovaci\u00f3n (Junta de Andaluc\u00eda, Spain)","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]},{"name":"European Regional Development Fund (FEDER)","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]},{"name":"Margarita Salas Fellowship (University of Seville, Spain)","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]},{"name":"Consejer\u00eda de Transformaci\u00f3n Econ\u00f3mica, Industria, Conocimiento y Universidades de la Junta de Andaluc\u00eda (Spain)","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]},{"name":"Nicolas Monardes program from the Consejer\u00eda de Salud de Andaluc\u00eda (Spain)","award":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"],"award-info":[{"award-number":["PI09\/01016","PE-0098-2019","PI-2013-575","P10-CTS6928","P11-CTS8161","P11-CTS8081","CTS-151","DOC_01610","RC-0005-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesity is frequently accompanied by non-alcoholic fatty liver disease (NAFLD). These two diseases are associated with altered lipid metabolism, in which reverse cholesterol transport (LXR\u03b1\/ABCA1\/ABCG1) and leptin response (leptin receptor (Ob-Rb)\/Sam68) are involved. The two pathways were evaluated in peripheral blood mononuclear cells (PBMCs) from 86 patients with morbid obesity (MO) before and six months after Roux-en-Y gastric bypass (RYGB) and 38 non-obese subjects. In the LXR\u03b1 pathway, LXR\u03b1, ABCA1, and ABCG1 mRNA expressions were decreased in MO compared to non-obese subjects (p &lt; 0.001, respectively). Ob-Rb was decreased (p &lt; 0.001), whereas Sam68 was increased (p &lt; 0.001) in MO. RYGB did not change mRNA gene expressions. In the MO group, the LXR\u03b1 pathway (LXR\u03b1\/ABCA1\/ABCG1) negatively correlated with obesity-related variables (weight, body mass index, and hip), inflammation (C-reactive protein), and liver function (alanine-aminotransferase, alkaline phosphatase, and fatty liver index), and positively with serum albumin. In the Ob-R pathway, Ob-Rb and Sam68 negatively correlated with alanine-aminotransferase and positively with albumin. The alteration of LXR\u03b1 and Ob-R pathways may play an important role in NAFLD development in MO. It is possible that MO patients may require more than 6 months following RYBGB to normalize gene expression related to reverse cholesterol transport or leptin responsiveness.<\/jats:p>","DOI":"10.3390\/ijms25147549","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"7549","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Expression of Genes Related to Reverse Cholesterol Transport and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells Are Decreased in Morbid Obesity and Related to Liver Function"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6956-7740","authenticated-orcid":false,"given":"Carlos","family":"Jim\u00e9nez-Cortegana","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville Medical School, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3727-1843","authenticated-orcid":false,"given":"Soledad","family":"L\u00f3pez-Enr\u00edquez","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville Medical School, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-2039","authenticated-orcid":false,"given":"Gonzalo","family":"Alba","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville Medical School, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-2792","authenticated-orcid":false,"given":"Consuelo","family":"Santa-Mar\u00eda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Seville Pharmacy School, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gracia M.","family":"Mart\u00edn-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Universitario Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Moreno-Ruiz","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Cirug\u00eda General, Digestiva y Trasplantes, Hospital Regional Universitario de M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-4331","authenticated-orcid":false,"given":"Sergio","family":"Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Garc\u00eda-Serrano","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rodr\u00edguez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailec","family":"Ho-Pl\u00e1garo","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-0127","authenticated-orcid":false,"given":"Mar\u00eda I.","family":"Fontalba-Romero","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Regional Universitario de M\u00e1laga, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3491-2724","authenticated-orcid":false,"given":"Eduardo","family":"Garc\u00eda-Fuentes","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"},{"name":"CIBER Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 29010 M\u00e1laga, Spain"},{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Garrido-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Endocrinolog\u00eda y Nutrici\u00f3n, Hospital Universitario Virgen de la Victoria, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, 29010 M\u00e1laga, Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-8680","authenticated-orcid":false,"given":"V\u00edctor","family":"S\u00e1nchez-Margalet","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Molecular Biology and Immunology, University of Seville Medical School, 41009 Seville, Spain"},{"name":"Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo\/Virgen Macarena, CSIC, Universidad de Sevilla, 41013 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11695-009-0021-6","article-title":"Changes in Oxidative Stress and Insulin Resistance in Morbidly Obese Patients After Bariatric Surgery","volume":"20","author":"Murri","year":"2010","journal-title":"Obes. 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