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Pre-pregnancy underweight is an early risk factor for impaired fetal growth. The aim of this study was to investigate whether a pre-pregnancy body mass index (ppBMI) of &lt;18.5 kg\/m2, as early as at the beginning of pregnancy, is associated with changes in the umbilical cord metabolome. In a sample of the Survey of Neonates in Pomerania (SNIP) birth cohort, the cord blood metabolome of n = 240 newborns of mothers with a ppBMI of &lt;18.5 kg\/m2 with n = 208 controls (ppBMI of 18.5\u201324.9 kg\/m2) was measured by NMR spectrometry. A maternal ppBMI of &lt;18.5 kg\/m2 was associated with increased concentrations of HDL4 cholesterol, HDL4 phospholipids, VLDL5 cholesterol, HDL 2, and HDL4 Apo-A1, as well as decreased VLDL triglycerides and HDL2 free cholesterol. A ppBMI of &lt;18.5 kg\/m2 combined with poor intrauterine growth (a gestational weight gain (GWG) &lt; 25th percentile) was associated with decreased concentrations of total cholesterol; cholesterol transporting lipoproteins (LDL4, LDL6, LDL free cholesterol, and HDL2 free cholesterol); LDL4 Apo-B; total Apo-A2; and HDL3 Apo-A2. In conclusion, maternal underweight at the beginning of pregnancy already results in metabolic changes in the lipid profile in the cord blood, but the pattern changes when poor GWG is followed by pre-pregnancy underweight.<\/jats:p>","DOI":"10.3390\/ijms25147552","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"7552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Maternal Pre-Pregnancy Underweight on Cord Blood Metabolome: An Analysis of the Population-Based Survey of Neonates in Pomerania (SNiP)"],"prefix":"10.3390","volume":"25","author":[{"given":"Alexander","family":"Lichtwald","sequence":"first","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine, Division SHIP\u2014Clinical Epidemiological Research, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja Erika","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Winter","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Kolbe","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Allenberg","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6678-7964","authenticated-orcid":false,"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-264X","authenticated-orcid":false,"given":"Matthias","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, University Medicine Greifswald, 17475 Greifswald, Germany"},{"name":"German Centre for Child and Adolescent Health (DZKL), Partner Site Greifswald\/Rostock, 17475 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/jech.46.1.8","article-title":"The maternal and fetal origins of cardiovascular disease","volume":"46","author":"Barker","year":"1992","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1001\/jama.2019.3820","article-title":"Association of Gestational Weight Gain with Adverse Maternal and Infant Outcomes","volume":"321","author":"Voerman","year":"2019","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Voerman, E., Santos, S., Patro Golab, B., Amiano, P., Ballester, F., Barros, H., Bergstr\u00f6m, A., Charles, M.-A., Chatzi, L., and Chevrier, C. (2019). Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002744"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00404-006-0219-y","article-title":"Effect of prepregnancy body mass index categories on obstetrical and neonatal outcomes","volume":"275","author":"Abenhaim","year":"2007","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bhattacharya, S., Campbell, D.M., Liston, W.A., and Bhattacharya, S. (2007). Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health, 7.","DOI":"10.1186\/1471-2458-7-168"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJM199801153380302","article-title":"Prepregnancy weight and the risk of adverse pregnancy outcomes","volume":"338","author":"Cnattingius","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijgo.2006.06.021","article-title":"Pre-pregnancy body mass index and pregnancy outcomes","volume":"95","author":"Doherty","year":"2006","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0140-6736(07)61690-0","article-title":"Maternal and child undernutrition: Global and regional exposures and health consequences","volume":"371","author":"Black","year":"2008","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Dzakpasu, S., Fahey, J., Kirby, R.S., Tough, S.C., Chalmers, B., Heaman, M.I., Bartholomew, S., Biringer, A., Darling, E.K., and Lee, L.S. (2015). Contribution of prepregnancy body mass index and gestational weight gain to adverse neonatal outcomes: Population attributable fractions for Canada. BMC Pregnancy Childbirth, 15.","DOI":"10.1186\/s12884-015-0452-0"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1001\/jama.2017.3635","article-title":"Association of Gestational Weight Gain with Maternal and Infant Outcomes: A Systematic Review and Meta-analysis","volume":"317","author":"Goldstein","year":"2017","journal-title":"JAMA"},{"key":"ref_11","unstructured":"IQTIG\u2014Institut f\u00fcr Qualit\u00e4tssicherung und Transparenz im Gesundheitswesen (2020). Bundesauswertung zum Erfassungsjahr 2019. Geburtshilfe: Qualit\u00e4tsindikatoren und Kennzahlen, IQTIG."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/apa.15701","article-title":"Maternal pre-pregnancy underweight as a risk factor for the offspring: Survey of Neonates in Pomerania","volume":"110","author":"Domanski","year":"2021","journal-title":"Acta Paediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16153","DOI":"10.3390\/ijms150916153","article-title":"Maternal-fetal nutrient transport in pregnancy pathologies: The role of the placenta","volume":"15","author":"Brett","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Roland, M.C.P., Friis, C.M., Voldner, N., Godang, K., Bollerslev, J., Haugen, G., and Henriksen, T. (2012). Fetal growth versus birthweight: The role of placenta versus other determinants. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039324"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"T135","DOI":"10.1530\/JOE-18-0683","article-title":"Epidemiological evidence for the developmental origins of health and disease: Effects of prenatal undernutrition in humans","volume":"242","author":"Roseboom","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00404-012-2403-6","article-title":"Prepregnancy body mass index and gestational weight gain with the outcome of pregnancy: A 13-year study of 292,568 cases in China","volume":"286","author":"Liu","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Andersen, L.G., Angquist, L., Eriksson, J.G., Forsen, T., Gamborg, M., Osmond, C., Baker, J.L., and S\u00f8rensen, T.I.A. (2010). Birth weight, childhood body mass index and risk of coronary heart disease in adults: Combined historical cohort studies. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0014126"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJMoa044160","article-title":"Trajectories of growth among children who have coronary events as adults","volume":"353","author":"Barker","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3109\/14767058.2012.714639","article-title":"Physiopathology of intrauterine growth retardation: From classic data to metabolomics","volume":"25","author":"Ottonello","year":"2012","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/sj.ijo.0803515","article-title":"Early growth, and coronary heart disease and type 2 diabetes: Experiences from the Helsinki Birth Cohort Studies","volume":"30","author":"Eriksson","year":"2006","journal-title":"Int. J. Obes."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1799S","DOI":"10.3945\/ajcn.110.000638","article-title":"Early growth and coronary heart disease and type 2 diabetes: Findings from the Helsinki Birth Cohort Study (HBCS)","volume":"94","author":"Eriksson","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental Origins of Chronic Disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1038\/s41598-018-31832-5","article-title":"Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction","volume":"8","author":"Miranda","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/jc.2006-1281","article-title":"Glucose and lipid metabolism in small-for-gestational-age infants at 72 hours of age","volume":"92","author":"Wang","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1515\/jpm.2011.135","article-title":"Maternal and fetal cord blood lipids in intrauterine growth restriction","volume":"40","author":"Pecks","year":"2012","journal-title":"J. Perinat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/S0301-2115(03)00172-6","article-title":"Placental transport of amino acids in normal and growth-restricted pregnancies","volume":"110","author":"Cetin","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0002-9378(90)90860-A","article-title":"Umbilical amino acid concentrations in normal and growth-retarded fetuses sampled in utero by cordocentesis","volume":"162","author":"Cetin","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1161\/CIRCRESAHA.120.315898","article-title":"Metabolomics and Proteomics in Type 2 Diabetes","volume":"126","author":"Chen","year":"2020","journal-title":"Circ. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Priante, E., Verlato, G., Giordano, G., Stocchero, M., Visentin, S., Mardegan, V., and Baraldi, E. (2019). Intrauterine Growth Restriction: New Insight from the Metabolomic Approach. Metabolites, 9.","DOI":"10.3390\/metabo9110267"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yuan, X., Ma, Y., Wang, J., Zhao, Y., Zheng, W., Yang, R., Zhang, L., Yan, X., and Li, G. (2024). The influence of maternal prepregnancy weight and gestational weight gain on the umbilical cord blood metabolome: A case-control study. BMC Pregnancy Childbirth, 24.","DOI":"10.1186\/s12884-024-06507-x"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mir, S.A., Chen, L., Burugupalli, S., Burla, B., Ji, S., Smith, A.A.T., Narasimhan, K., Ramasamy, A., Tan, K.M.-L., and Huynh, K. (2022). Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: A mother-offspring cohort study. BMC Med., 20.","DOI":"10.1186\/s12916-022-02432-y"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1017\/S2040174416000362","article-title":"Lipids and leukocytes in newborn umbilical vein blood, birth weight and maternal body mass index","volume":"7","author":"Brittos","year":"2016","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000243407","article-title":"Lipids, lipoproteins and apolipoproteins AI, AII, B, CII, CIII and E in newborns","volume":"60","author":"Averna","year":"1991","journal-title":"Biol. Neonate"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0026-0495(83)90207-X","article-title":"Decline in the concentration of low-density lipoprotein-cholesterol in human fetal plasma near term","volume":"32","author":"Parker","year":"1983","journal-title":"Metabolism"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1152\/physiolgenomics.00109.2011","article-title":"Fetal HDL\/apoE: A novel regulator of gene expression in human placental endothelial cells","volume":"43","author":"Augsten","year":"2011","journal-title":"Physiol. Genom."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Stadler, J.T., Wadsack, C., and Marsche, G. (2021). Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease. Biomedicines, 9.","DOI":"10.3390\/biomedicines9040349"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ahj.2016.07.005","article-title":"Cholesterol efflux capacity: An introduction for clinicians","volume":"180","author":"Anastasius","year":"2016","journal-title":"Am. Heart J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1210\/jc.2015-3525","article-title":"Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults","volume":"101","author":"Rauschert","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Paavola, T., Bergmann, U., Kuusisto, S., Kakko, S., Savolainen, M.J., and Salonurmi, T. (2021). Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic of Metabolic Syndrome and Premature Coronary Heart Disease-Family Study. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094908"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1159\/000343204","article-title":"Childhood obesity is associated with changes in the serum metabolite profile","volume":"5","author":"Wahl","year":"2012","journal-title":"Obes. Facts"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1515\/jpem-2019-0552","article-title":"Definition and early diagnosis of metabolic syndrome in children","volume":"33","author":"Bussler","year":"2020","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/obr.12132","article-title":"Gestational weight gain in relation to offspring obesity over the life course: A systematic review and bias-adjusted meta-analysis","volume":"15","author":"Mamun","year":"2014","journal-title":"Obes. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"dvz004","DOI":"10.1093\/eep\/dvz004","article-title":"Pregnancy lipidomic profiles and DNA methylation in newborns from the CHAMACOS cohort","volume":"5","author":"Tindula","year":"2019","journal-title":"Environ. Epigenet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ajpa.22393","article-title":"The \u201cearly life\u201d origins of obesity-related health disorders: New discoveries regarding the intergenerational transmission of developmentally programmed traits in the global cardiometabolic health crisis","volume":"152","author":"Benyshek","year":"2013","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"34857","DOI":"10.1038\/srep34857","article-title":"Lipid metabolism is associated with developmental epigenetic programming","volume":"6","author":"Marchlewicz","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Drozdz, D., Alvarez-Pitti, J., W\u00f3jcik, M., Borghi, C., Gabbianelli, R., Mazur, A., Herceg-\u010cavrak, V., Lopez-Valcarcel, B.G., Brzezi\u0144ski, M., and Lurbe, E. (2021). Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood. Nutrients, 13.","DOI":"10.3390\/nu13114176"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-3016.2007.00870.x","article-title":"Cord blood lipid profile and associated factors: Baseline data of a birth cohort study","volume":"21","author":"Kelishadi","year":"2007","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1093\/eurheartj\/ehab551","article-title":"Triglyceride-rich lipoproteins and their remnants: Metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society","volume":"42","author":"Ginsberg","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s12291-012-0252-5","article-title":"Correlation of cord blood lipid heterogeneity in neonates with their anthropometry at birth","volume":"28","author":"Nayak","year":"2013","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0971-5916.195025","article-title":"Small-for-gestational-age versus appropriate-for-gestational-age: Comparison of cord blood lipid profile & insulin levels in term newborns (SAGA-ACT study)","volume":"144","author":"Lobo","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.12659\/MSM.890929","article-title":"Cord blood C-peptide, insulin, HbA1c, and lipids levels in small- and large-for-gestational-age newborns","volume":"20","author":"Hou","year":"2014","journal-title":"Med. Sci. Monit."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1053\/plac.2002.0773","article-title":"The role of the placenta in fetal programming-a review","volume":"23","author":"Godfrey","year":"2002","journal-title":"Placenta"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/bmj.301.6746.259","article-title":"Fetal and placental size and risk of hypertension in adult life","volume":"301","author":"Barker","year":"1990","journal-title":"BMJ"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/bmj.315.7112.837","article-title":"Mother\u2019s weight in pregnancy and coronary heart disease in a cohort of Finnish men: Follow up study","volume":"315","author":"Eriksson","year":"1997","journal-title":"BMJ"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(96)04257-2","article-title":"Mothers\u2019 pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK","volume":"348","author":"Martyn","year":"1996","journal-title":"Lancet"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1093\/eurheartj\/ehad547","article-title":"Significance of lipids, lipoproteins, and apolipoproteins during the first 14\u201316 months of life","volume":"44","author":"Sillesen","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhang, Y., Ma, Z., Zhu, Y., and Chen, Z. (2021). Altered amino acid metabolism between coronary heart disease patients with and without type 2 diabetes by quantitative 1H NMR based metabolomics. J. Pharm. Biomed. Anal., 206.","DOI":"10.1016\/j.jpba.2021.114381"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.17219\/acem\/104542","article-title":"Branched chain amino acids: Passive biomarkers or the key to the pathogenesis of cardiometabolic diseases?","volume":"28","author":"Daroszewski","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111762","DOI":"10.1016\/j.nut.2022.111762","article-title":"Potential roles of branched-chain amino acids in neurodegeneration","volume":"103\u2013104","author":"Yoo","year":"2022","journal-title":"Nutrition"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11892-018-1048-7","article-title":"Branched Chain Amino Acids in Metabolic Disease","volume":"18","author":"Arany","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Yao, M., Yang, Z., Rong, X., Hu, X., Yao, N., Zhu, M., Wang, X., Zhu, X., and Yin, J. (2022). The Exploration of Fetal Growth Restriction Based on Metabolomics: A Systematic Review. Metabolites, 12.","DOI":"10.3390\/metabo12090860"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00726-022-03157-1","article-title":"Effects of maternal branched-chain amino acid and alanine supplementation on growth and biomarkers of protein metabolism in dams fed a low-protein diet and their offspring","volume":"54","author":"Choi","year":"2022","journal-title":"Amino Acids"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ije\/dyy291","article-title":"Prospective associations of maternal choline status with offspring body composition in the first 5 years of life in two large mother-offspring cohorts: The Southampton Women\u2019s Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort","volume":"48","author":"Crozier","year":"2019","journal-title":"Int. J. Epidemiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"902","DOI":"10.2337\/dc16-2452","article-title":"Maternal BMI and Glycemia Impact the Fetal Metabolome","volume":"40","author":"Lowe","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1198\/000313001300339897","article-title":"The Abuse of Power","volume":"55","author":"Hoenig","year":"2001","journal-title":"Am. Stat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1365-3016.2009.01078.x","article-title":"Survey of Neonates in Pomerania (SNiP): A population-based birth study\u2014Objectives, design and population coverage","volume":"24","author":"Ebner","year":"2010","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/ppe.12645","article-title":"Survey of Neonates in Pomerania (SNiP): Study design and cohort update","volume":"34","author":"Kantorczyk","year":"2020","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1055\/s-0034-1385857","article-title":"Neue Perzentilwerte f\u00fcr die K\u00f6rperma\u00dfe neugeborener Einlinge: Ergebnisse der deutschen Perinatalerhebung der Jahre 2007\u20132011 unter Beteiligung aller 16 Bundesl\u00e4nder","volume":"218","author":"Voigt","year":"2014","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00003081-200606000-00007","article-title":"Placenta and fetal growth restriction","volume":"49","author":"Salafia","year":"2006","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/aje\/kwp182","article-title":"Placental weight relative to birth weight and long-term cardiovascular mortality: Findings from a cohort of 31,307 men and women","volume":"170","author":"Risnes","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1039\/C3AN02188B","article-title":"Human plasma stability during handling and storage: Impact on NMR metabolomics","volume":"139","author":"Pinto","year":"2014","journal-title":"Analyst"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/14\/7552\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:12:32Z","timestamp":1760109152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/14\/7552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":71,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25147552"],"URL":"https:\/\/doi.org\/10.3390\/ijms25147552","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]}}}