{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:30:36Z","timestamp":1790443836308,"version":"4.1.0"},"reference-count":118,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministery of Science, Technology and Innovation of Colombia (MINCIENCIAS)","award":["844\/2019"],"award-info":[{"award-number":["844\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is the most common form of dementia. Currently, there is no single test that can diagnose AD, especially in understudied populations and developing countries. Instead, diagnosis is based on a combination of medical history, physical examination, cognitive testing, and brain imaging. Exosomes are extracellular nanovesicles, primarily composed of RNA, that participate in physiological processes related to AD pathogenesis such as cell proliferation, immune response, and neuronal and cardiovascular function. However, the identification and understanding of the potential role of long non-coding RNAs (lncRNAs) in AD diagnosis remain largely unexplored. Here, we clinically, cognitively, and genetically characterized a sample of 15 individuals diagnosed with AD (cases) and 15 controls from Barranquilla, Colombia. Advanced bioinformatics, analytics and Machine Learning (ML) techniques were used to identify lncRNAs differentially expressed between cases and controls. The expression of 28,909 lncRNAs was quantified. Of these, 18 were found to be differentially expressed and harbored in pivotal genes related to AD. Two lncRNAs, ENST00000608936 and ENST00000433747, show promise as diagnostic markers for AD, with ML models achieving &gt; 95% sensitivity, specificity, and accuracy in both the training and testing datasets. These findings suggest that the expression profiles of lncRNAs could significantly contribute to advancing personalized AD diagnosis in this community, offering promising avenues for early detection and follow-up.<\/jats:p>","DOI":"10.3390\/ijms25147641","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T08:47:41Z","timestamp":1720774061000},"page":"7641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long Non-Coding RNAs and Alzheimer\u2019s Disease: Towards Personalized Diagnosis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-2925","authenticated-orcid":false,"given":"Maria I.","family":"Mosquera-Heredia","sequence":"first","affiliation":[{"name":"Department of Medicine, Universidad del Norte, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7807-1242","authenticated-orcid":false,"given":"Oscar M.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universidad del Norte, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universidad del Norte, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Silvera-Redondo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universidad del Norte, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Instituto Colombiano de Neuropedagog\u00eda, Barranquilla 080020, Colombia"},{"name":"Department of Health Sciences, Universidad de La Costa, Barranquilla 080002, Colombia"},{"name":"Grupo Internacional de Investigaci\u00f3n Neuro-Conductual (GIINCO), Universidad de La Costa, Barranquilla 080002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-1234","authenticated-orcid":false,"given":"Ricardo","family":"Allegri","sequence":"additional","affiliation":[{"name":"Institute for Neurological Research FLENI, Monta\u00f1eses 2325, Buenos Aires C1428AQK, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Arcos-Burgos","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Psiquiatr\u00eda (GIPSI), Departamento de Psiquiatr\u00eda, Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina, Universidad de Antioquia, Medellin 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-7899","authenticated-orcid":false,"given":"Jorge I.","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, Universidad del Norte, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Garavito-Galofre","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universidad del Norte, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"ref_1","unstructured":"(2024, February 24). 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