{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:00:52Z","timestamp":1780452052361,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health\u2019s National Institute of Nursing Research","award":["R01NR013520"],"award-info":[{"award-number":["R01NR013520"]}]},{"name":"National Institutes of Health\u2019s National Institute of Nursing Research","award":["TL1TR001875"],"award-info":[{"award-number":["TL1TR001875"]}]},{"name":"National Institutes of Health\u2019s National Center for Advancing Translational Sciences","award":["R01NR013520"],"award-info":[{"award-number":["R01NR013520"]}]},{"name":"National Institutes of Health\u2019s National Center for Advancing Translational Sciences","award":["TL1TR001875"],"award-info":[{"award-number":["TL1TR001875"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) The prevalence of depression is two times higher in women than men. Black women have an increased risk of depression due to stressors such as low socioeconomic status and perceived discrimination. Depression is likely influenced by both genetic and environmental factors. Psychosocial stressors can influence DNA methylation (DNAm), leading to changes in gene expression and ultimately, depression. The objective of this study was to examine associations between DNAm and depressive symptoms in Black women. (2) This study was a secondary analysis of data from the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study. Perceived discrimination was assessed using Krieger\u2019s Experiences of Discrimination and Waelde\u2019s Race-Related Events Scale, and participants were screened for depressive symptoms with the Beck Depression Inventory. Raw data from saliva samples were analyzed using the Illumina Infinium Epic (850 K) BeadChip and then preprocessed in RStudio. (3) Differential methylation analysis identified DNAm sites and regions associated with depressive symptoms. Six DNAm sites had a q-value less than 0.05. Additionally, of the 25 regions identified, 12 were associated with neurological diseases or disorders. (4) These findings suggest that there is a neurological component to depression, which should be considered during treatment.<\/jats:p>","DOI":"10.3390\/ijms25147681","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T16:23:41Z","timestamp":1720801421000},"page":"7681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epigenome-Wide Association Study of Depressive Symptoms in Black Women in the InterGEN Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-5215","authenticated-orcid":false,"given":"Brittany","family":"Taylor","sequence":"first","affiliation":[{"name":"School of Nursing, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0476","authenticated-orcid":false,"given":"Yihong","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Nursing, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-509X","authenticated-orcid":false,"given":"Nicole B.","family":"Perez","sequence":"additional","affiliation":[{"name":"Rory Meyers College of Nursing, New York University, New York, NY 10010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-0852","authenticated-orcid":false,"given":"Stephanie","family":"Potts-Thompson","sequence":"additional","affiliation":[{"name":"School of Nursing, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Crusto","sequence":"additional","affiliation":[{"name":"School of Medicine, Yale University, New Haven, CT 06510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Masterson","family":"Creber","sequence":"additional","affiliation":[{"name":"School of Nursing, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-7358","authenticated-orcid":false,"given":"Jacquelyn Y.","family":"Taylor","sequence":"additional","affiliation":[{"name":"School of Nursing, Columbia University, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/pcn.12621","article-title":"Epigenetic mechanisms of major depression: Targeting neuronal plasticity","volume":"72","author":"Uchida","year":"2018","journal-title":"Psychiatry Clin. 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