{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:59:40Z","timestamp":1781665180467,"version":"3.54.5"},"reference-count":106,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["20-15-00262"],"award-info":[{"award-number":["20-15-00262"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["5.F.5.9"],"award-info":[{"award-number":["5.F.5.9"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u201cKurchatov Institute\u201d National Research Center","award":["20-15-00262"],"award-info":[{"award-number":["20-15-00262"]}]},{"name":"\u201cKurchatov Institute\u201d National Research Center","award":["5.F.5.9"],"award-info":[{"award-number":["5.F.5.9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is characterized by a long prodromal period, during which patients often have sleep disturbances. The histaminergic system and circadian rhythms play an important role in the regulation of the sleep\u2013wake cycle. Changes in the functioning of these systems may be involved in the pathogenesis of early stages of PD and may be age-dependent. Here, we have analyzed changes in the expression of genes associated with the regulation of the sleep\u2013wake cycle (Hnmt, Hrh1, Hrh3, Per1, Per2, and Chrm3) in the substantia nigra (SN) and striatum of normal male mice of different ages, as well as in young and adult male mice with an MPTP-induced model of the early symptomatic stage (ESS) of PD. Age-dependent expression analysis in normal mouse brain tissue revealed changes in Hrh3, Per1, Per2, and Chrm3 genes in adult mice relative to young mice. When gene expression was examined in mice with the MPTP-induced model of the ESS of PD, changes in the expression of all studied genes were found only in the SN of adult mice with the ESS model of PD. These data suggest that age is a significant factor influencing changes in the expression of genes associated with sleep\u2013wake cycle regulation in the development of PD.<\/jats:p>","DOI":"10.3390\/ijms25147721","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T18:17:32Z","timestamp":1721067452000},"page":"7721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Age and MPTP-Induced Parkinson\u2019s Disease on the Expression of Genes Associated with the Regulation of the Sleep\u2013Wake Cycle in Mice"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-0476","authenticated-orcid":false,"given":"Ekaterina I.","family":"Semenova","sequence":"first","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita M.","family":"Rudenok","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan N.","family":"Rybolovlev","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-2901","authenticated-orcid":false,"given":"Marina V.","family":"Shulskaya","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Lukashevich","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-7796","authenticated-orcid":false,"given":"Suzanna A.","family":"Partevian","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Budko","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim S.","family":"Nesterov","sequence":"additional","affiliation":[{"name":"Scientific Center for Biomedical Technologies of the Federal Biomedical Agency of Russia, 119435 Krasnogorsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-3223","authenticated-orcid":false,"given":"Denis A.","family":"Abaimov","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, Volokolamskoye Shosse 80, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr A.","family":"Slominsky","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Shadrina","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-4491","authenticated-orcid":false,"given":"Anelya Kh.","family":"Alieva","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.14108","article-title":"Parkinson disease","volume":"27","author":"Balestrino","year":"2020","journal-title":"Eur. 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