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increasingly understood. Studies have demonstrated that SIRTs can aid in metabolism and affect various physiological processes, such as atherosclerosis, heart failure (HF), hypertension, type 2 diabetes, and other related disorders. Although the pathogenesis of HF with preserved ejection fraction (HFpEF) has not yet been clarified, SIRTs have a role in its development. Therefore, SIRTs may offer a fresh approach to the diagnosis, treatment, and prevention of HFpEF as a novel therapeutic intervention target.<\/jats:p>","DOI":"10.3390\/ijms25147740","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T18:17:32Z","timestamp":1721067452000},"page":"7740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring Sirtuins: New Frontiers in Managing Heart Failure with Preserved Ejection Fraction"],"prefix":"10.3390","volume":"25","author":[{"given":"Ying","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruowen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"ref_1","first-page":"1281","article-title":"Complete interpretation on 2021 ESC guideline for acute and chronic heart failure","volume":"14","author":"Cui","year":"2022","journal-title":"Chin. 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