{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:40:10Z","timestamp":1790185210739,"version":"4.1.0"},"reference-count":124,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a complex neurodegenerative disorder characterized by numerous motor and non-motor symptoms. Recent data highlight a potential interplay between the gut microbiota and the pathophysiology of PD. The degeneration of dopaminergic neurons in PD leads to motor symptoms (tremor, rigidity, and bradykinesia), with antecedent gastrointestinal manifestations, most notably constipation. Consequently, the gut emerges as a plausible modulator in the neurodegenerative progression of PD. Key molecular changes in PD are discussed in the context of the gut\u2013brain axis. Evidence suggests that the alterations in the gut microbiota composition may contribute to gastroenteric inflammation and influence PD symptoms. Disturbances in the levels of inflammatory markers, including tumor necrosis factor-\u03b1 (TNF \u03b1), interleukin -1\u03b2 (IL-1\u03b2), and interleukin-6 (IL-6), have been observed in PD patients. These implicate the involvement of systemic inflammation in disease pathology. Fecal microbiota transplantation emerges as a potential therapeutic strategy for PD. It may mitigate inflammation by restoring gut homeostasis. Preclinical studies in animal models and initial clinical trials have shown promising results. Overall, understanding the interplay between inflammation, the gut microbiota, and PD pathology provides valuable insights into potential therapeutic interventions. This review presents recent data about the bidirectional communication between the gut microbiome and the brain in PD, specifically focusing on the involvement of inflammatory biomarkers.<\/jats:p>","DOI":"10.3390\/ijms25147741","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T18:17:32Z","timestamp":1721067452000},"page":"7741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Exploring Fecal Microbiota Transplantation for Modulating Inflammation in Parkinson\u2019s Disease: A Review of Inflammatory Markers and Potential Effects"],"prefix":"10.3390","volume":"25","author":[{"given":"Karol","family":"Sadowski","sequence":"first","affiliation":[{"name":"Students Scientific Group NEKON by the Department of Neurology, Faculty of Health Science, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weronika","family":"Zaj\u0105c","sequence":"additional","affiliation":[{"name":"Students Scientific Group NEKON by the Department of Neurology, Faculty of Health Science, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-8518","authenticated-orcid":false,"given":"\u0141ukasz","family":"Milanowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Science, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Koziorowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Science, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-9905","authenticated-orcid":false,"given":"Monika","family":"Figura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Science, Medical University of Warsaw, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"ref_1","first-page":"S3","article-title":"The Emerging Evidence of the Parkinson Pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Park. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s disease: Clinical features and diagnosis","volume":"79","author":"Jankovic","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_5","first-page":"e13275","article-title":"Spectrum of Non-Motor Symptoms in Parkinson\u2019s Disease","volume":"13","author":"Kumaresan","year":"2021","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/mds.26605","article-title":"Neuropathological basis of nonmotor manifestations of Parkinson\u2019s disease","volume":"31","author":"Adler","year":"2016","journal-title":"Mov. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Garretti, F., Agalliu, D., Lindestam Arlehamn, C.S., Sette, A., and Sulzer, D. (2019). Autoimmunity in Parkinson\u2019s Disease: The Role of \u03b1-Synuclein-Specific T Cells. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00303"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Marogianni, C., Sokratous, M., Dardiotis, E., Hadjigeorgiou, G.M., Bogdanos, D., and Xiromerisiou, G. (2020). Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228421"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Multi-organ distribution of phosphorylated \u03b1-synuclein histopathology in subjects with Lewy body disorders","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the development of Parkinson\u2019s disease-related pathology","volume":"318","author":"Braak","year":"2004","journal-title":"Cell Tissue Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2990.2007.00874.x","article-title":"Parkinson\u2019s disease: A dual-hit hypothesis","volume":"33","author":"Hawkes","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4518023","DOI":"10.1155\/2020\/4518023","article-title":"Minireview on the Relations between Gut Microflora and Parkinson\u2019s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities","volume":"2020","author":"Ilie","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1093\/brain\/awab156","article-title":"The role of gut dysbiosis in Parkinson\u2019s disease: Mechanistic insights and therapeutic options","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rutsch, A., Kantsjo, J.B., and Ronchi, F. (2020). The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.604179"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sender, R., Fuchs, S., and Milo, R. (2016). Revised Estimates for the Number of Human and Bacteria Cells in the Body. PLoS Biol., 14.","DOI":"10.1101\/036103"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/acs.chemrev.2c00431","article-title":"Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies","volume":"123","author":"Aggarwal","year":"2023","journal-title":"Chem. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/MOG.0000000000000139","article-title":"The gut microbiome in health and in disease","volume":"31","author":"Shreiner","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev-micro-090110-102830","article-title":"The human gut microbiome: Ecology and recent evolutionary changes","volume":"65","author":"Walter","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.chembiol.2015.12.008","article-title":"Exploring and Understanding the Biochemical Diversity of the Human Microbiota","volume":"23","author":"Koppel","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hrncir, T. (2022). Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options. Microorganisms, 10.","DOI":"10.3390\/microorganisms10030578"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Murros, K.E., Huynh, V.A., Takala, T.M., and Saris, P.E.J. (2021). Desulfovibrio Bacteria Are Associated With Parkinson\u2019s Disease. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.652617"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/mds.26942","article-title":"Parkinson\u2019s disease and Parkinson\u2019s disease medications have distinct signatures of the gut microbiome","volume":"32","author":"Debelius","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mann, E.R., Lam, Y.K., and Uhlig, H.H. (2024). Short-chain fatty acids: Linking diet, the microbiome and immunity. Nat. Rev. Immunol., 1\u201319.","DOI":"10.1038\/s41577-024-01014-8"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/mds.26307","article-title":"Colonic bacterial composition in Parkinson\u2019s disease","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2020.1854675","article-title":"The role of short-chain fatty acids in immunity, inflammation and metabolism","volume":"62","author":"Yao","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/mds.29063","article-title":"Parkinson\u2019s Disease Is Associated with Impaired Gut-Blood Barrier for Short-Chain Fatty Acids","volume":"37","author":"Yang","year":"2022","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"eaau6323","DOI":"10.1126\/science.aau6323","article-title":"Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism","volume":"364","author":"Bess","year":"2019","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1523-5378.2010.00768.x","article-title":"Differential effect of Helicobacter pylori eradication on time-trends in brady\/hypokinesia and rigidity in idiopathic parkinsonism","volume":"15","author":"Dobbs","year":"2010","journal-title":"Helicobacter"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s41380-022-01910-2","article-title":"Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson\u2019s disease","volume":"28","author":"Ahn","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e53111","DOI":"10.7554\/eLife.53111","article-title":"A gut bacterial amyloid promotes \u03b1-synuclein aggregation and motor impairment in mice","volume":"9","author":"Sampson","year":"2020","journal-title":"eLife"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/acs.jafc.1c07711","article-title":"Lactobacillus plantarum DP189 Reduces \u03b1-SYN Aggravation in MPTP-Induced Parkinson\u2019s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/cns.13990","article-title":"Gut bacterial profiles in Parkinson\u2019s disease: A systematic review","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"112444","DOI":"10.1016\/j.exger.2024.112444","article-title":"Association between increased and decreased gut microbiota abundance and Parkinson\u2019s disease: A systematic review and subgroup meta-analysis","volume":"191","author":"Bai","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1994834","DOI":"10.1080\/19490976.2021.1994834","article-title":"Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: Experience of a large-volume European FMT center","volume":"13","author":"Ianiro","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gtc.2016.09.012","article-title":"Fecal Microbiota Transplantation","volume":"46","author":"Vindigni","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.3748\/wjg.v23.i19.3565","article-title":"Fecal microbiota transplantation cured epilepsy in a case with Crohn\u2019s disease: The first report","volume":"23","author":"He","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.nbd.2012.09.007","article-title":"Colonic inflammation in Parkinson\u2019s disease","volume":"50","author":"Devos","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40478-015-0196-0","article-title":"Structural alterations of the intestinal epithelial barrier in Parkinson\u2019s disease","volume":"3","author":"Clairembault","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.arr.2014.02.004","article-title":"The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: A systematic review and meta-analysis","volume":"15","author":"Kelly","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/mds.27326","article-title":"Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson\u2019s Disease","volume":"33","author":"Houser","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: Is intestinal inflammation a silent driver of Parkinson\u2019s disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"npj Park. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.3748\/wjg.v22.i25.5742","article-title":"Gut dysfunction in Parkinson\u2019s disease","volume":"22","author":"Mukherjee","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Hasegawa, S., Goto, S., Tsuji, H., Okuno, T., Asahara, T., Nomoto, K., Shibata, A., Fujisawa, Y., Minato, T., and Okamoto, A. (2015). Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson\u2019s Disease. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142164"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-5-8","article-title":"Neuroinflammation mediated by IL-1\u03b2 increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson\u2019s disease","volume":"5","author":"Koprich","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.4103\/1673-5374.391191","article-title":"Gut microbiota dysbiosis contributes to \u03b1-synuclein-related pathology associated with C\/EBP\u03b2\/AEP signaling activation in a mouse model of Parkinson\u2019s disease","volume":"19","author":"Fang","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Miranda-Morales, E., Meier, K., Sandoval-Carrillo, A., Salas-Pacheco, J., Vazquez-Cardenas, P., and Arias-Carrion, O. (2017). Implications of DNA Methylation in Parkinson\u2019s Disease. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00225"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cellimm.2018.02.011","article-title":"Interleukin-1\u03b2, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-\u03b1 levels in CSF and serum in relation to the clinical diversity of Parkinson\u2019s disease","volume":"327","author":"Karpenko","year":"2018","journal-title":"Cell. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/mds.28015","article-title":"Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson\u2019s Disease","volume":"35","author":"Wijeyekoon","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jang, D.I., Lee, A.H., Shin, H.Y., Song, H.R., Park, J.H., Kang, T.B., Lee, S.R., and Yang, S.H. (2021). The Role of Tumor Necrosis Factor Alpha (TNF-\u03b1) in Autoimmune Disease and Current TNF-\u03b1 Inhibitors in Therapeutics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052719"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2174\/1381612053381620","article-title":"Inflammatory process in Parkinson\u2019s disease: Role for cytokines","volume":"11","author":"Nagatsu","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.parkreldis.2005.05.006","article-title":"Increased plasma levels of TNF-\u03b1 but not of IL1-\u03b2 in MPTP-treated monkeys one year after the MPTP administration","volume":"11","author":"Barcia","year":"2005","journal-title":"Park. Relat. Disord."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1096\/fj.05-5106com","article-title":"Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: Role of TNF-\u03b1","volume":"20","author":"Sriram","year":"2006","journal-title":"FASEB J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1096\/fj.02-0216fje","article-title":"Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson\u2019s disease","volume":"16","author":"Sriram","year":"2002","journal-title":"FASEB J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0165-3806(01)00315-7","article-title":"Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: Roles of tumor necrosis factor-\u03b1, interleukin-1\u03b2, and nitric oxide","volume":"133","author":"Gayle","year":"2002","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"134576","DOI":"10.1016\/j.neulet.2019.134576","article-title":"Impaired metabolism of kynurenine and its metabolites in CSF of parkinson\u2019s disease","volume":"714","author":"Iwaoka","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/gps.5124","article-title":"Inflammation in mild cognitive impairment due to Parkinson\u2019s disease, Lewy body disease, and Alzheimer\u2019s disease","volume":"34","author":"King","year":"2019","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.cyto.2012.07.030","article-title":"Inflammatory cytokines and NT-proCNP in Parkinson\u2019s disease patients","volume":"60","author":"Koziorowski","year":"2012","journal-title":"Cytokine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-019-1528-y","article-title":"Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson\u2019s disease","volume":"16","author":"Lin","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Liu, T.W., Chen, C.M., and Chang, K.H. (2022). Biomarker of Neuroinflammation in Parkinson\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084148"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jamaneurol.2016.2742","article-title":"Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis","volume":"73","author":"Qin","year":"2016","journal-title":"JAMA Neurol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Schroder, J.B., Pawlowski, M., Meyer Zu Horste, G., Gross, C.C., Wiendl, H., Meuth, S.G., Ruck, T., and Warnecke, T. (2018). Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson\u2019s Disease. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.01081"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Hu, W.T., Howell, J.C., Ozturk, T., Gangishetti, U., Kollhoff, A.L., Hatcher-Martin, J.M., Anderson, A.M., and Tyor, W.R. (2019). CSF Cytokines in Aging, Multiple Sclerosis, and Dementia. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00480"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Alrafiah, A., Al-Ofi, E., Obaid, M.T., and Alsomali, N. (2020). Erratum to \u201cAssessment of the Levels of Level of Biomarkers of Bone Matrix Glycoproteins and Inflammatory Cytokines from Saudi Parkinson Patients\u201d. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/7254325"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jocn.2018.10.079","article-title":"Peripheral blood inflammatory markers in early Parkinson\u2019s disease","volume":"58","author":"Kim","year":"2018","journal-title":"J. Clin. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10517-020-04723-x","article-title":"Plasma Cytokines Profile in Patients with Parkinson\u2019s Disease Associated with Mutations in GBA Gene","volume":"168","author":"Miliukhina","year":"2020","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1007\/s12035-017-0404-y","article-title":"Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson\u2019s Disease","volume":"55","author":"Rocha","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.1460-9568.2005.04281.x","article-title":"6-Hydroxydopamine-induced alterations in blood-brain barrier permeability","volume":"22","author":"Carvey","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.nbd.2009.11.018","article-title":"Chronic expression of low levels of tumor necrosis factor-\u03b1 in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia\/macrophage activation","volume":"37","author":"Chertoff","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"ref_72","first-page":"859","article-title":"Successful therapy of Clostridium difficile infection with fecal microbiota transplantation","volume":"67","author":"Konturek","year":"2016","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12967-022-03569-3","article-title":"Fecal microbiota transplantation versus glucocorticoids for the induction of remission in mild to moderate ulcerative colitis","volume":"20","author":"Huang","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Ning, J., Bao, X.Q., Shang, M., Ma, J., Li, G., and Zhang, D. (2021). Fecal microbiota transplantation protects rotenone-induced Parkinson\u2019s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis. Microbiome, 9.","DOI":"10.1186\/s40168-021-01107-9"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s41232-019-0101-5","article-title":"The role of interleukin-1 in general pathology","volume":"39","author":"Kaneko","year":"2019","journal-title":"Inflamm. Regen."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(00)01275-1","article-title":"Increase in level of tumor necrosis factor-\u03b1 in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506","volume":"289","author":"Mogi","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1523\/JNEUROSCI.20-01-00149.2000","article-title":"Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression","volume":"20","author":"Li","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jneuroim.2005.07.009","article-title":"Differential effects of interleukin-1\u03b2 on neurotoxicity, cytokine induction and glial reaction in specific brain regions","volume":"168","author":"Depino","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0006-8993(02)03473-X","article-title":"Differential induction of interleukin-1\u03b2 and tumour necrosis factor-\u03b1 may account for specific patterns of leukocyte recruitment in the brain","volume":"958","author":"Blond","year":"2002","journal-title":"Brain Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"577089","DOI":"10.1016\/j.jneuroim.2019.577089","article-title":"Inflammasome and \u03b1-synuclein in Parkinson\u2019s disease: A cross-sectional study","volume":"338","author":"Chatterjee","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Lian, T.H., Guo, P., Zuo, L.J., Hu, Y., Yu, S.Y., Yu, Q.J., Jin, Z., Wang, R.D., Li, L.X., and Zhang, W. (2019). Tremor-Dominant in Parkinson Disease: The Relevance to Iron Metabolism and Inflammation. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00255"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Almeida, C., Oliveira, R., Baylina, P., Fernandes, R., Teixeira, F.G., and Barata, P. (2022). Current Trends and Challenges of Fecal Microbiota Transplantation-An Easy Method That Works for All?. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112742"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, W.H., Jin, Z.Y., Yang, Z.H., Zhang, J.Y., Ma, X.H., Guan, J., Sun, B.L., and Chen, X. (2022). Fecal Microbiota Transplantation Ameliorates Active Ulcerative Colitis by Downregulating Pro-inflammatory Cytokines in Mucosa and Serum. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.818111"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Tanaka, T., Narazaki, M., and Kishimoto, T. (2014). IL-6 in inflammation, immunity, and disease. Cold Spring Harb. Perspect. Biol., 6.","DOI":"10.1101\/cshperspect.a016295"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/aje\/kwm260","article-title":"Peripheral inflammatory biomarkers and risk of Parkinson\u2019s disease","volume":"167","author":"Chen","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0753-3322(99)80079-1","article-title":"IL-1 \u03b2, IL-2, IL-6 and TNF-\u03b1 production by peripheral blood mononuclear cells from patients with Parkinson\u2019s disease","volume":"53","author":"Bessler","year":"1999","journal-title":"Biomed. Pharmacother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neulet.2008.06.040","article-title":"Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNF\u03b1, and INF\u03b3 concentrations are elevated in patients with atypical and idiopathic parkinsonism","volume":"441","author":"Brodacki","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.parkreldis.2008.05.014","article-title":"Serum inflammatory biomarkers in Parkinson\u2019s disease","volume":"15","author":"Dufek","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2009.10.062","article-title":"Serum levels of interleukin-6 are elevated in patients with Parkinson\u2019s disease and correlate with physical performance","volume":"468","author":"Scalzo","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1034\/j.1600-0404.2000.101003159.x","article-title":"Impaired cytokine production by peripheral blood mononuclear cells and monocytes\/macrophages in Parkinson\u2019s disease","volume":"101","author":"Hasegawa","year":"2000","journal-title":"Acta Neurol. Scand."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1015120930920","article-title":"Impaired production of plasma interleukin-6 in patients with Parkinson\u2019s disease","volume":"133","author":"Selikhova","year":"2002","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"106661","DOI":"10.1016\/j.intimp.2020.106661","article-title":"Pilot study of cytokine changes evaluation after fecal microbiota transplantation in patients with ulcerative colitis","volume":"85","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1093\/brain\/awac193","article-title":"A Mendelian randomization study investigating the causal role of inflammation on Parkinson\u2019s disease","volume":"145","author":"Bottigliengo","year":"2022","journal-title":"Brain"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1600-0404.2008.01103.x","article-title":"Circulating interleukin-10 and interleukin-12 in Parkinson\u2019s disease","volume":"119","author":"Rentzos","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Rathnayake, D., Chang, T., and Udagama, P. (2019). Selected serum cytokines and nitric oxide as potential multi-marker biosignature panels for Parkinson disease of varying durations: A case-control study. BMC Neurol., 19.","DOI":"10.1186\/s12883-019-1286-6"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12974-016-0588-5","article-title":"Inflammatory profile in LRRK2-associated prodromal and clinical PD","volume":"13","author":"Brockmann","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_98","first-page":"2581","article-title":"Effect of fecal microbiota transplantation on experimental colitis in mice","volume":"17","author":"Zhou","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Wei, Y.L., Chen, Y.Q., Gong, H., Li, N., Wu, K.Q., Hu, W., Wang, B., Liu, K.J., Wen, L.Z., and Xiao, X. (2018). Fecal Microbiota Transplantation Ameliorates Experimentally Induced Colitis in Mice by Upregulating AhR. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01921"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4137\/CGast.S20612","article-title":"Characterization of Serum Cytokine Profile in Predominantly Colonic Inflammatory Bowel Disease to Delineate Ulcerative and Crohn\u2019s Colitides","volume":"8","author":"Korolkova","year":"2015","journal-title":"Clin. Med. Insights Gastroenterol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Sanjabi, S., Oh, S.A., and Li, M.O. (2017). Regulation of the Immune Response by TGF-\u03b2: From Conception to Autoimmunity and Infection. Cold Spring Harb. Perspect. Biol., 9.","DOI":"10.1101\/cshperspect.a022236"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0304-3940(95)11686-Q","article-title":"Transforming growth factor-\u03b2 1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson\u2019s disease","volume":"193","author":"Mogi","year":"1995","journal-title":"Neurosci. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Chen, X., Hu, Y., Cao, Z., Liu, Q., and Cheng, Y. (2018). Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer\u2019s Disease, Parkinson\u2019s Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02122"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Santaella, A., Kuiperij, H.B., van Rumund, A., Esselink, R.A.J., van Gool, A.J., Bloem, B.R., and Verbeek, M.M. (2020). Inflammation biomarker discovery in Parkinson\u2019s disease and atypical parkinsonisms. BMC Neurol., 20.","DOI":"10.1186\/s12883-020-1608-8"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"825","DOI":"10.21037\/atm-22-3227","article-title":"Effect of fecal microbiota transplantation on the TGF-\u03b21\/Smad signaling pathway in rats with TNBS-induced colitis","volume":"10","author":"Qiu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Li, B., Yin, G.F., Wang, Y.L., Tan, Y.M., Huang, C.L., and Fan, X.M. (2020). Impact of fecal microbiota transplantation on TGF-\u03b21\/Smads\/ERK signaling pathway of endotoxic acute lung injury in rats. 3 Biotech, 10.","DOI":"10.1007\/s13205-020-2062-4"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Mussbacher, M., Salzmann, M., Brostjan, C., Hoesel, B., Schoergenhofer, C., Datler, H., Hohensinner, P., Basilio, J., Petzelbauer, P., and Assinger, A. (2019). Cell Type-Specific Roles of NF-\u03baB Linking Inflammation and Thrombosis. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00085"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zhang, S., Paul, S., and Kundu, P. (2022). NF-\u03baB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.874940"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"105803","DOI":"10.1016\/j.micpath.2022.105803","article-title":"Fecal microbiota transplantation improves intestinal inflammation in mice with ulcerative colitis by modulating intestinal flora composition and down-regulating NF-kB signaling pathway","volume":"173","author":"Li","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Jing, Y., Yu, Y., Bai, F., Wang, L., Yang, D., Zhang, C., Qin, C., Yang, M., Zhang, D., and Zhu, Y. (2021). Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: Involvement of brain-gut axis. Microbiome, 9.","DOI":"10.1186\/s40168-021-01007-y"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.immuni.2018.04.010","article-title":"Cell-Specific Imd-NF-\u03baB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection","volume":"48","author":"Zhai","year":"2018","journal-title":"Immunity"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3892\/etm.2021.10974","article-title":"Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson\u2019s disease by protecting the function of dopamine neurons","volume":"23","author":"Zhang","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1053\/j.gastro.2013.02.038","article-title":"Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice","volume":"144","author":"Sun","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"102563","DOI":"10.1016\/j.eclinm.2024.102563","article-title":"Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson\u2019s disease (GUT-PARFECT): A double-blind, placebo-controlled, randomised, phase 2 trial","volume":"71","author":"Bruggeman","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"DuPont, H.L., Suescun, J., Jiang, Z.D., Brown, E.L., Essigmann, H.T., Alexander, A.S., DuPont, A.W., Iqbal, T., Utay, N.S., and Newmark, M. (2023). Fecal microbiota transplantation in Parkinson\u2019s disease-A randomized repeat-dose, placebo-controlled clinical pilot study. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1104759"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12934-021-01589-0","article-title":"Evaluation of fecal microbiota transplantation in Parkinson\u2019s disease patients with constipation","volume":"20","author":"Kuai","year":"2021","journal-title":"Microb. Cell Factories"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"106791","DOI":"10.1016\/j.clineuro.2021.106791","article-title":"Fecal microbiota transplant as a potential treatment for Parkinson\u2019s disease\u2014A case series","volume":"207","author":"Segal","year":"2021","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e16163","DOI":"10.1097\/MD.0000000000016163","article-title":"Fecal microbiota transplantation to treat Parkinson\u2019s disease with constipation: A case report","volume":"98","author":"Huang","year":"2019","journal-title":"Medicine"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e22035","DOI":"10.1097\/MD.0000000000022035","article-title":"Fecal microbiota transplantation therapy for Parkinson\u2019s disease: A preliminary study","volume":"99","author":"Xue","year":"2020","journal-title":"Medicine"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5946\/ce.2019.009","article-title":"Fecal Microbiota Transplantation: An Update on Clinical Practice","volume":"52","author":"Kim","year":"2019","journal-title":"Clin. Endosc."},{"key":"ref_122","first-page":"S281","article-title":"Brain-First versus Gut-First Parkinson\u2019s Disease: A Hypothesis","volume":"9","author":"Borghammer","year":"2019","journal-title":"J. Park. Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/brain\/awaa238","article-title":"Brain-first versus body-first Parkinson\u2019s disease: A multimodal imaging case-control study","volume":"143","author":"Horsager","year":"2020","journal-title":"Brain"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/mds.28052","article-title":"Microbiota Composition and Metabolism Are Associated With Gut Function in Parkinson\u2019s Disease","volume":"35","author":"Cirstea","year":"2020","journal-title":"Mov. Disord."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/14\/7741\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:17:05Z","timestamp":1760109425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/14\/7741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":124,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["ijms25147741"],"URL":"https:\/\/doi.org\/10.3390\/ijms25147741","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]}}}