{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:18:40Z","timestamp":1770009520377,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UCV","award":["VIDI UCV2023_2026"],"award-info":[{"award-number":["VIDI UCV2023_2026"]}]},{"name":"UCV","award":["UCV2020-270-001"],"award-info":[{"award-number":["UCV2020-270-001"]}]},{"name":"UCV","award":["RYC2022-035438-I"],"award-info":[{"award-number":["RYC2022-035438-I"]}]},{"name":"Ministerio de Ciencia e Innovacion","award":["VIDI UCV2023_2026"],"award-info":[{"award-number":["VIDI UCV2023_2026"]}]},{"name":"Ministerio de Ciencia e Innovacion","award":["UCV2020-270-001"],"award-info":[{"award-number":["UCV2020-270-001"]}]},{"name":"Ministerio de Ciencia e Innovacion","award":["RYC2022-035438-I"],"award-info":[{"award-number":["RYC2022-035438-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic fatigue syndrome (CFS) is a heterogeneous disorder with a genetically associated vulnerability of the catecholamine metabolism (e.g., catechol O-methyltransferase polymorphisms), in which environmental factors have an important impact. Alpha-methyl-p-tyrosine (AMPT; also referred to as metyrosine) is an approved medication for the treatment of pheochromocytoma. As a tyrosine hydroxylase inhibitor, AMPT may be a potential candidate for the treatment of diseases involving catecholamine alterations. However, only small-scale clinical trials have tested AMPT repurposing in a few other illnesses. The current case report compiles genetic and longitudinal biochemical data for over a year of follow-up of a male patient sequentially diagnosed with sustained overstress, neurasthenia, CFS (diagnosed in 2012 as per the Center for Disease Control (CDC\/Fukuda)), and postural orthostatic tachycardia syndrome (POTS) over a 10-year period and reports the patient\u2019s symptom improvement in response to low\u2013medium doses of AMPT. This case was recognized as a stress-related CFS case. Data are reported from medical records provided by the patient to allow a detailed response to treatment targeting the hyperadrenergic state presented by the patient. We highlight the lack of a positive response to classical approaches to treating CFS, reflecting the limitations of CFS diagnosis and available treatments to alleviate patients\u2019 symptoms. The current pathomechanism hypothesis emphasizes monoamine alterations (hyperadrenergic state) in the DA\/adrenergic system and a dysfunctional autonomic nervous system resulting from sympathetic overactivity. The response of the patient to AMPT treatment highlights the relevance of pacing with regard to stressful situations and increased activity. Importantly, the results do not indicate causality between AMPT and its action on the monoamine system, and future studies should evaluate the implications of other targets.<\/jats:p>","DOI":"10.3390\/ijms25147778","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T15:05:51Z","timestamp":1721142351000},"page":"7778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stress-Related Chronic Fatigue Syndrome: A Case Report with a Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment"],"prefix":"10.3390","volume":"25","author":[{"given":"Maria","family":"Ljungstr\u00f6m","sequence":"first","affiliation":[{"name":"Escuela de Doctorado, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-2907","authenticated-orcid":false,"given":"Elisa","family":"Oltra","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Health Sciences, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, 46001 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-1303","authenticated-orcid":false,"given":"Marta","family":"Pardo","sequence":"additional","affiliation":[{"name":"Department of Psychobiology, Universidad de Valencia, 46010 Valencia, Spain"},{"name":"Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), 46022 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12911-021-01534-6","article-title":"ICD-11: An international classification of diseases for the twenty-first century","volume":"21","author":"Harrison","year":"2021","journal-title":"BMC Med. 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