{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:37:02Z","timestamp":1783525022644,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000938","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RX001818-01"],"award-info":[{"award-number":["RX001818-01"]}],"id":[{"id":"10.13039\/501100000938","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Implant surface nanofiber (NF) coatings represent an alternative way to prevent\/treat periprosthetic joint infection (PJI) via local drug release. We developed and characterized a coaxial erythromycin (EM)-doped PLGA\/PCL-PVA NF coating. The purpose of this study was to determine the efficacy of EM-NF coatings (EM0, no EM, EM100 (100 mg\/mL), and EM1000 (1000 mg\/mL) wt\/wt) in a rat PJI model. A strong bond of the EM-NF coating to the surface of titanium (Ti) pins was confirmed by in vitro mechanical testing. Micro-computed tomography (mCT) analysis showed that both EM100 and EM1000 NF effectively reduced periprosthetic osteolysis compared to EM0 at 8 and 16 weeks after implantation. Histology showed that EM100 and EM1000 coatings effectively controlled infection and enhanced periprosthetic new bone formation. The bone implant contact (BIC) of EM100 (35.08%) was higher than negative controls and EM0 (3.43% and 0%, respectively). The bone area fraction occupancy (BAFO) of EM100 (0.63 mm2) was greater than controls and EM0 (0.390 mm2 and 0.0 mm2, respectively). The BAFO of EM100 was higher than that of EM1000 (0.3 mm2). These findings may provide a basis for a new implant surface fabrication strategy aimed at reducing the risks of defective osseointegration and PJI.<\/jats:p>","DOI":"10.3390\/ijms25147926","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T15:15:19Z","timestamp":1721402119000},"page":"7926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic Efficacy of an Erythromycin-Loaded Coaxial Nanofiber Coating in a Rat Model of S. aureus-Induced Periprosthetic Joint Infection"],"prefix":"10.3390","volume":"25","author":[{"given":"David C.","family":"Markel","sequence":"first","affiliation":[{"name":"The CORE Institute, 26750 Providence Pkwy #200, Novi, MI 48374, USA"},{"name":"Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA"},{"name":"Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1397-5168","authenticated-orcid":false,"given":"Dexter","family":"Powell","sequence":"additional","affiliation":[{"name":"Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0268-9775","authenticated-orcid":false,"given":"Paula","family":"Pawlitz","sequence":"additional","affiliation":[{"name":"Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-906X","authenticated-orcid":false,"given":"Therese","family":"Bou-Akl","sequence":"additional","affiliation":[{"name":"Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Ren","sequence":"additional","affiliation":[{"name":"Section of Orthopaedic Surgery, Ascension Providence Hospital Orthopaedic Research Laboratory, 16001 West Nine Mile Road, Southfield, MI 48075, USA"},{"name":"John D. Dingell VA Medical Center, 4646 John R St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1007\/s11999-008-0209-4","article-title":"Periprosthetic joint infection: The incidence, timing, and predisposing factors","volume":"466","author":"Pulido","year":"2008","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Le Vavasseur, B., and Zeller, V. (2022). Antibiotic Therapy for Prosthetic Joint Infections: An Overview. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040486"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11999-009-0825-7","article-title":"Patients with prosthetic joint infection on IV antibiotics are at high risk for readmission","volume":"467","author":"Duggal","year":"2009","journal-title":"Clin. Orthop. 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