{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:07:12Z","timestamp":1784948832168,"version":"3.55.0"},"reference-count":65,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Saint Petersburg Pasteur Institute","award":["121030200299\u20133"],"award-info":[{"award-number":["121030200299\u20133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cytokine storm is usually described as one of the main reasons behind COVID-associated mortality. Cytokines are essential protein molecules engaged in immune responses; they play a critical role in protection against infections. However, they also contribute to inflammatory reactions and tissue damage, becoming a double-edged sword in the context of COVID-19. Recent studies have suggested various cytokines and chemokines that play a crucial role in the immune response to SARS-CoV-2 infection. One such cytokine is interleukin 27 (IL-27), which has been found to be elevated in the blood plasma of patients with COVID-19. Within this study, we will explore the role of IL-27 in immune responses and analyze both the existing literature and our own prior research findings on this cytokine in the context of COVID-19. It affects a wide variety of immune cells. Regardless of the pathological process it is involved in, IL-27 is critical for upholding the necessary balance between tissue damage and cytotoxicity against infectious agents and\/or tumors. In COVID-19, it is involved in multiple processes, including antiviral cytotoxicity via CD8+ cells, IgG subclass switching, and even the activation of Tregs.<\/jats:p>","DOI":"10.3390\/ijms25147953","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T07:57:23Z","timestamp":1721721443000},"page":"7953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-5014","authenticated-orcid":false,"given":"Zoia R.","family":"Korobova","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, Saint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia"},{"name":"Department of Immunology, Pavlov First State Medical University of Saint Petersburg, 197022 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Arsentieva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Saint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Santoni","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Pasteur Institute\u2013Cenci Bolognetti Foundation, Sapienza University of Rome, 00162 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-8799","authenticated-orcid":false,"given":"Areg A.","family":"Totolian","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Saint Petersburg Pasteur Institute, 197101 Saint Petersburg, Russia"},{"name":"Department of Immunology, Pavlov First State Medical University of Saint Petersburg, 197022 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Filip, R., Gheorghita Puscaselu, R., Anchidin-Norocel, L., Dimian, M., and Savage, W.K. 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