{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:19:41Z","timestamp":1790961581826,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["10\/E-389\/SPUB\/SP\/2020"],"award-info":[{"award-number":["10\/E-389\/SPUB\/SP\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gamma delta (\u03b3\u03b4) T cells are a heterogeneous population of cells that play roles in inflammation, host tissue repair, clearance of viral and bacterial pathogens, regulation of immune processes, and tumor surveillance. Recent research suggests that these are the main skin cells that produce interleukin-17 (I-17). Furthermore, \u03b3\u03b4 T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. \u03b3\u03b4 T cells are found in epithelial tissues, where many cancers develop. There, they participate in antitumor immunity as cytotoxic cells or as immune coordinators. \u03b3\u03b4 T cells also participate in host defense, immune surveillance, and immune homeostasis. The aim of this review is to present the importance of \u03b3\u03b4 T cells in physiological and pathological diseases, such as psoriasis, atopic dermatitis, autoimmune diseases, cancer, and lymphoma.<\/jats:p>","DOI":"10.3390\/ijms25147960","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T07:57:23Z","timestamp":1721721443000},"page":"7960","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role of Gamma Delta T Lymphocytes in Physiological and Pathological Condition\u2014Focus on Psoriasis, Atopic Dermatitis, Autoimmune Disorders, Cancer and Lymphomas"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-5701","authenticated-orcid":false,"given":"Joanna","family":"Chojnacka-Purpurowicz","sequence":"first","affiliation":[{"name":"Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-0438","authenticated-orcid":false,"given":"Agnieszka","family":"Owczarczyk-Saczonek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-719 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-0693","authenticated-orcid":false,"given":"Bogus\u0142aw","family":"Nedoszytko","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Diagnostics\u2013Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, 3A M. Sk\u0142odowskiej-Curie Street, 80-210 Gdansk, Poland"},{"name":"Molecular Laboratory, Invicta Fertility and Reproductive Center, 81-740 Sopot, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"O\u2019Neill, K., Pastar, I., Tomic-Canic, M., and Strbo, N. (2020). Perforins Expression by Cutaneous Gamma Delta T Cells. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01839"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Qu, G., Wang, S., Zhou, Z., Jiang, D., Liao, A., and Luo, J. (2022). Comparing Mouse and Human Tissue-Resident \u03b3\u03b4 T Cells. Front. 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