{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:48:38Z","timestamp":1785473318676,"version":"3.56.0"},"reference-count":73,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic beryllium disease (CBD), or berylliosis, is an interstitial lung disease caused by the chronic inhalation of finely particulate beryllium, frequently mistaken for sarcoidosis. It is rarely associated with skin nodular lesions, asymptomatic granulomatous hepatitis or calcium nephrolithiasis. To date, it has never been reported as a diffused multi-organ granulomatous disease. A 60-year-old Pakistani man, a former excavation worker with ancient history of suspected sarcoidosis, underwent a left nephroureterectomy for suspected papillary kidney carcinoma. The histopathological analysis showed a benign non-necrotic granulomatous infiltration of the renal pelvis and ureter. Six months later, he suffered from two consecutive episodes of acute kidney failure. Bladder biopsies found similar noncaseous granulomatosis and kidney biopsies showed interstitial nephritis. Known for suspected asthma, sleep apnea, and usual interstitial pneumonia, the patient would regularly consult for episodes of pyrexia, chills, nocturnal coughing, and wheezing. As kidney function gradually worsened, he ultimately started hemodialysis and was transferred to our facility. A positive blood beryllium lymphocyte proliferation test confirmed the diagnosis of CBD. This original report is the first description of multi-organ berylliosis with diffused urothelial granulomatosis and pseudo-tumor. The patient\u2019s pulmonary disease is minimal compared with renal and urinary tract involvement, eventually responsible for end-stage kidney disease. Berylliosis usually responds to glucocorticoids. This case report highlights the importance of evoking the diagnosis of CBD in the presence of any granulomatosis, even extra-thoracic, especially if associated with pulmonary symptoms, however atypical.<\/jats:p>","DOI":"10.3390\/ijms25158166","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T14:39:08Z","timestamp":1722004748000},"page":"8166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multisystemic Beryllium Disease: An Exceptional Case Revealed by a Urinary Tract Granulomatosis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-0349","authenticated-orcid":false,"given":"Lucas","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Brugmann University Hospital, Universit\u00e9 libre de Bruxelles, 1020 Bruxelles, Belgium"},{"name":"Department of Nephrology and Dialysis, Brugmann University Hospital, Universit\u00e9 libre de Bruxelles, 1020 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-9716","authenticated-orcid":false,"given":"Maxime","family":"Taghavi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis, Brugmann University Hospital, Universit\u00e9 libre de Bruxelles, 1020 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fallas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institut Jules Bordet, Universit\u00e9 libre de Bruxelles, 1070 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Geers","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brugmann University Hospital, Universit\u00e9 libre de Bruxelles, 1020 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Libertalis","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis, Etterbeek-Ixelles Hospital, 1050 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Smet","sequence":"additional","affiliation":[{"name":"Immunology Department, LHUB-ULB, Universit\u00e9 libre de Bruxelles, 1000 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Nortier","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis, Brugmann University Hospital, Universit\u00e9 libre de Bruxelles, 1020 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Carmo Filomena","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis, Brugmann University Hospital, Universit\u00e9 libre de Bruxelles, 1020 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/pmj.76.898.457","article-title":"A clinicopathological classification of granulomatous disorders","volume":"76","author":"James","year":"2000","journal-title":"Postgrad. 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