{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:10:36Z","timestamp":1788797436347,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>APC is a tumor suppressor gene that exerts its effect through the regulation of the Wnt signaling pathway. Loss of function mutations of the gene are associated with familial adenomatous polyposis (FAP). Early diagnosis in FAP patients is essential to prevent the development of colorectal cancer. Extraintestinal manifestations often precede the formation of the polyposis; therefore, these manifestations may serve as a clinical indicator for the condition. The aim of this study was to assess genotype\u2013phenotype associations between the location of APC mutations and various extraintestinal features, mainly focusing on osseous and dental anomalies. Analyses of our cases and the mutations available in the literature with these manifestations revealed that mutations in the N-terminal region (amino acids 1\u2013~1000) of the protein are more frequently associated with only osseous anomalies, whereas dental manifestations are more prevalent in mutations in the middle region (amino acids 1000\u2013~2100). In addition, supernumerary teeth were found to be the most common dental feature. Since dental abnormalities often precede intestinal polyposis, dentists have a crucial role in the early identification of patients at risk.<\/jats:p>","DOI":"10.3390\/ijms25158189","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T14:39:08Z","timestamp":1722004748000},"page":"8189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rare Germline Variants in the Adenomatous Polyposis Coli Gene Associated with Dental and Osseous Anomalies"],"prefix":"10.3390","volume":"25","author":[{"given":"Gergely","family":"B\u00fcki","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Clinical Center, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9ta","family":"Antal","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Oral and Maxillofacial Surgery, Clinical Center, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-6244","authenticated-orcid":false,"given":"Judit","family":"Bene","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Clinical Center, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2005.07.024","article-title":"Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein","volume":"361","author":"Hanson","year":"2005","journal-title":"Gene"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1073\/pnas.90.7.2846","article-title":"The APC gene product in normal and tumor cells","volume":"90","author":"Smith","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1242\/jcs.00862","article-title":"Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion","volume":"117","author":"Faux","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1083\/jcb.137.7.1651","article-title":"Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis","volume":"137","author":"Pollack","year":"1997","journal-title":"J. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ncb1160","article-title":"EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration","volume":"6","author":"Wen","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(81)90021-0","article-title":"Identification and characterization of the familial adenomatous polyposis coli gene","volume":"66","author":"Groden","year":"1991","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10555-017-9725-6","article-title":"Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: Implications for therapeutic targeting","volume":"37","author":"Hankey","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"djw332","DOI":"10.1093\/jnci\/djw332","article-title":"Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer","volume":"109","author":"Zhang","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e23443","DOI":"10.1016\/j.heliyon.2023.e23443","article-title":"Molecular and immunohistochemical study of APC exon 16 and its possible role in colorectal carcinoma development","volume":"10","author":"Abid","year":"2024","journal-title":"Heliyon"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/humu.1380030206","article-title":"Familial adenomatous polyposis (FAP): Frequency, penetrance, and mutation rate","volume":"3","author":"Bisgaard","year":"1994","journal-title":"Hum. Mutat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/jmg.2004.022822","article-title":"Large submicroscopic genomic APC deletions are a common cause of typical familial adenomatous polyposis","volume":"42","author":"Aretz","year":"2005","journal-title":"J. Med. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/bmb\/64.1.27","article-title":"Genetics of colorectal cancer: Hereditary aspects and overview of colorectal tumorigenesis","volume":"64","author":"Fearnhead","year":"2002","journal-title":"Br. Med. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/01.MP.0000062992.54036.E4","article-title":"Gastrointestinal inherited polyposis syndromes","volume":"16","author":"Bronner","year":"2003","journal-title":"Mod. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1073\/pnas.040564697","article-title":"APC mutations are sufficient for the growth of early colorectal adenomas","volume":"97","author":"Lamlum","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1053\/gast.1996.v110.pm8612989","article-title":"Colorectal polyp counts and cancer risk in familial adenomatous polyposis","volume":"110","author":"Debinski","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Antohi, C., Haba, D., Caba, L., Ciofu, M.L., Drug, V.L., Barboi, O.B., Dobrovat, B.I., Panzaru, M.C., Gorduza, N.C., and Lupu, V.V. (2021). Novel Mutation in APC Gene Associated with Multiple Osteomas in a Family and Review of Genotype-Phenotype Correlations of Extracolonic Manifestations in Gardner Syndrome. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091560"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/hmg\/10.7.721","article-title":"The ABC of APC","volume":"10","author":"Fearnhead","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1572-0241.2006.00375.x","article-title":"Familial adenomatous polyposis","volume":"101","author":"Galiatsatos","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0092-8674(93)90538-2","article-title":"Alleles of the APC gene: An attenuated form of familial polyposis","volume":"75","author":"Spirio","year":"1993","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10350-004-6127-y","article-title":"Attenuated familial adenomatous polyposis: An evolving and poorly understood entity","volume":"45","author":"Hernegger","year":"2002","journal-title":"Dis. Colon. Rectum"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/mgg3.114","article-title":"Familial adenomatous polyposis in an adolescent with coexisting schizophrenia: Treatment strategies and implications","volume":"3","author":"Gonzalez","year":"2015","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/mp.2014.61","article-title":"Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities","volume":"19","author":"Mohn","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-6606-7-21","article-title":"Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia","volume":"7","author":"Onouchi","year":"2014","journal-title":"Mol. Brain"},{"key":"ref_24","first-page":"167","article-title":"A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum","volume":"3","author":"Gardner","year":"1951","journal-title":"Am. J. Hum. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/01676830.2022.2080231","article-title":"Orbital osteomas associated with Gardner\u2019s syndrome: A case presentation and review of literature","volume":"43","author":"Avila","year":"2024","journal-title":"Orbit"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"148051","DOI":"10.1016\/j.gene.2023.148051","article-title":"A novel APC mutation associated with Gardner syndrome in a Chinese family","volume":"896","author":"Zeng","year":"2024","journal-title":"Gene"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.5144\/0256-4947.1997.542","article-title":"Gardner\u2019s syndrome presenting with a giant osteoma","volume":"17","author":"Dawlatly","year":"1997","journal-title":"Ann. Saudi Med."},{"key":"ref_28","first-page":"535","article-title":"Gardner\u2019s syndrome presenting with dental complaints","volume":"10","author":"Madani","year":"2007","journal-title":"Arch. Iran. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.3748\/wjg.v11.i34.5408","article-title":"Gardner\u2019s syndrome: A case report and review of the literature","volume":"11","author":"Fotiadis","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.5858\/arpa.2018-0570-RA","article-title":"Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations","volume":"143","author":"Dinarvand","year":"2019","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0007-117X(70)80068-3","article-title":"Gardner\u2019s syndrome--a case report","volume":"8","author":"Davies","year":"1970","journal-title":"Br. J. Oral Surg."},{"key":"ref_32","first-page":"139","article-title":"Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis","volume":"5","author":"Gardner","year":"1953","journal-title":"Am. J. Hum. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1051\/medsci\/201834f104","article-title":"Bone and dental abnormalities as first signs of familial Gardner\u2019s syndrome in a Chinese family: A literature review and a case report","volume":"34","author":"Yu","year":"2018","journal-title":"Med. Sci. (Paris)"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e1-6","DOI":"10.1016\/j.oooo.2011.10.020","article-title":"Gardner\u2019s syndrome: A clinical and genetic study of a family","volume":"115","author":"Cristofaro","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0030-4220(81)90164-X","article-title":"Osteomatous changes and tooth abnormalities found in the jaw of patients with adenomatosis coli","volume":"52","author":"Ida","year":"1981","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_36","first-page":"384","article-title":"Familial polyposis coli: Clinical manifestations, evaluation, management and treatment","volume":"71","author":"Nandakumar","year":"2004","journal-title":"Mt. Sinai J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1148\/radiographics.19.2.g99mr21546","article-title":"Gastrointestinal case of the day. Gardner syndrome","volume":"19","author":"Newman","year":"1999","journal-title":"Radiographics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/nar\/24.1.121","article-title":"APC gene: Database of germline and somatic mutations in human tumors and cell lines","volume":"24","author":"Beroud","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/hmg\/1.4.229","article-title":"Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene","volume":"1","author":"Miyoshi","year":"1992","journal-title":"Hum. Mol. Genet."},{"key":"ref_40","first-page":"1151","article-title":"Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene","volume":"57","author":"Davies","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1399-0004.2011.01740.x","article-title":"Genotype-phenotype correlation in colorectal polyposis","volume":"81","author":"Newton","year":"2012","journal-title":"Clin. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10689-017-0035-5","article-title":"Dental anomalies in pediatric patients with familial adenomatous polyposis","volume":"17","author":"Septer","year":"2018","journal-title":"Fam. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1007\/s00784-020-03220-9","article-title":"Dento-osseous anomalies in patients with familial adenomatous polyposis: A follow-up study","volume":"24","author":"Almeida","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1179\/1465313315Y.0000000008","article-title":"Gardner\u2019s Syndrome revisited: A clinical case and overview of the literature","volume":"43","author":"Seehra","year":"2016","journal-title":"J. Orthod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jmoldx.2012.07.005","article-title":"APC germline mutations in individuals being evaluated for familial adenomatous polyposis: A review of the Mayo Clinic experience with 1591 consecutive tests","volume":"15","author":"Kerr","year":"2013","journal-title":"J Mol Diagn"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1651563","article-title":"Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients","volume":"253","author":"Nishisho","year":"1991","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Arruda, K.A.R., Normando, A.G.C., Pacheco-Pereira, C., Amorim Dos Santos, J., Yamaguti, P.M., Mazzeu, J.F., Almeida, F.T., Acevedo, A.C., and Guerra, E.N.S. (2021). Phenotypic dento-osseous characterization of a Brazilian family with Familial Adenomatous Polyposis. Arch. Oral Biol., 129.","DOI":"10.1016\/j.archoralbio.2021.105206"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/adc.77.5.431","article-title":"An unusually severe phenotype for familial adenomatous polyposis","volume":"77","author":"Eccles","year":"1997","journal-title":"Arch. Dis. Child."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0002-9440(10)65259-5","article-title":"Familial adenomatous polyposis-associated thyroid cancer: A clinical, pathological, and molecular genetics study","volume":"154","author":"Soravia","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Panyarat, C., Nakornchai, S., Chintakanon, K., Leelaadisorn, N., Intachai, W., Olsen, B., Tongsima, S., Adisornkanj, P., Ngamphiw, C., and Cox, T.C. (2023). Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054255"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3332\/ecancer.2016.623","article-title":"Oral and maxillofacial considerations in Gardner\u2019s syndrome: A report of two cases","volume":"10","author":"Pereira","year":"2016","journal-title":"Ecancermedicalscience"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jcmm.13303","article-title":"A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth","volume":"22","author":"Yu","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1034\/j.1399-0004.2001.600206.x","article-title":"Phenotype variability of two FAP families with an identical APC germline mutation at codon 1465: A potential modifier effect?","volume":"60","author":"Duthel","year":"2001","journal-title":"Clin. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3892\/etm.2021.9919","article-title":"APC c.4621C>T variant causing Gardner\u2019s syndrome in a Han Chinese family may be inherited through maternal mosaicism","volume":"21","author":"Cai","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1080\/003655200750056691","article-title":"Novel germline APC mutations in Swedish patients with familial adenomatous polyposis and Gardner syndrome","volume":"35","author":"Nilbert","year":"2000","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00042737-200401000-00015","article-title":"A case of Gardner syndrome with a mutation at codon 1556 of APC: A suggested case of genotype-phenotype correlation in dental abnormality","volume":"16","author":"Oku","year":"2004","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1611768","DOI":"10.3389\/pore.2024.1611768","article-title":"Case report: Initial atypical skeletal symptoms and dental anomalies as first signs of Gardner syndrome: The importance of genetic analysis in the early diagnosis","volume":"30","author":"Antal","year":"2024","journal-title":"Pathol. Oncol. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1034\/j.1601-0825.2003.00894.x","article-title":"Dento-osseous changes as diagnostic markers in familial adenomatous polyposis families","volume":"9","author":"Aggarwal","year":"2003","journal-title":"Oral Dis."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"D\u2019Agostino, S., Dell\u2019Olio, F., Tempesta, A., Cervinara, F., D\u2019Amati, A., Dolci, M., Favia, G., Capodiferro, S., and Limongelli, L. (2023). Osteoma of the Jaw as First Clinical Sign of Gardner\u2019s Syndrome: The Experience of Two Italian Centers and Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041496"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/jmg.32.6.458","article-title":"The dental phenotype in familial adenomatous polyposis: Diagnostic application of a weighted scoring system for changes on dental panoramic radiographs","volume":"32","author":"Thakker","year":"1995","journal-title":"J. Med. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jgh.13149","article-title":"Oral manifestations in patients with familial adenomatous polyposis: A systematic review and meta-analysis","volume":"31","author":"Almeida","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02553986","article-title":"Mandibular osteomas in familial polyposis coli","volume":"27","author":"Bulow","year":"1984","journal-title":"Dis. Colon Rectum"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S1010-5182(89)80105-2","article-title":"Mandibular lesions in patients with adenomatosis coli","volume":"17","author":"Katou","year":"1989","journal-title":"J. Cranio-Maxillo-Facial Surg. Off. Publ. Eur. Assoc. Cranio-Maxillo-Facial Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1601-0825.2006.01293.x","article-title":"Oral and maxillofacial manifestations of familial adenomatous polyposis","volume":"13","author":"Wijn","year":"2007","journal-title":"Oral Dis."},{"key":"ref_65","first-page":"106","article-title":"Dentistry anomalies in patients with Lynch syndrome and familial adenomatous polyposis","volume":"54","author":"Budzynska","year":"2008","journal-title":"Ann. Acad. Medicae Stetin."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/1097-0215(20010320)95:2<102::AID-IJC1018>3.0.CO;2-8","article-title":"Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis","volume":"95","author":"Bertario","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1200\/JCO.2003.09.118","article-title":"Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis","volume":"21","author":"Bertario","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ajmg.a.31010","article-title":"Familial adenomatous polyposis (FAP): Genotype correlation to FAP phenotype with osteomas and sebaceous cysts","volume":"140","author":"Bisgaard","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1073\/pnas.89.10.4452","article-title":"Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients","volume":"89","author":"Miyoshi","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Fang, X., and Svitkina, T.M. (2022). Adenomatous Polyposis Coli (APC) in cell migration. Eur. J. Cell Biol., 101.","DOI":"10.1016\/j.ejcb.2022.151228"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1242\/dev.033803","article-title":"Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood","volume":"136","author":"Wang","year":"2009","journal-title":"Development"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Hermans, F., Hemeryck, L., Lambrichts, I., Bronckaers, A., and Vankelecom, H. (2021). Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.758203"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0925-4773(97)00115-9","article-title":"Signalling networks regulating dental development","volume":"67","author":"Thesleff","year":"1997","journal-title":"Mech. Dev."},{"key":"ref_74","first-page":"1689","article-title":"Nuclear translocation of beta-catenin in colorectal cancer","volume":"82","author":"Kobayashi","year":"2000","journal-title":"Br. J. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Barua, D., and Hlavacek, W.S. (2013). Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells. PLoS Comput. Biol., 9.","DOI":"10.1371\/journal.pcbi.1003217"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1038\/sj.onc.1203245","article-title":"Mechanism and function of signal transduction by the Wnt\/beta-catenin and Wnt\/Ca2+ pathways","volume":"18","author":"Miller","year":"1999","journal-title":"Oncogene"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1359-6101(00)00011-3","article-title":"Wnt\/beta-catenin signaling","volume":"11","author":"Akiyama","year":"2000","journal-title":"Cytokine Growth Factor. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/15\/8189\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:24:36Z","timestamp":1760109876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/15\/8189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":77,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["ijms25158189"],"URL":"https:\/\/doi.org\/10.3390\/ijms25158189","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]}}}