{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:21:55Z","timestamp":1791285715219,"version":"4.1.0"},"reference-count":297,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research PRIN 2022","award":["20225AZ22F"],"award-info":[{"award-number":["20225AZ22F"]}]},{"name":"Italian Ministry of University and Research PRIN 2022","award":["2022RK9X2KMB"],"award-info":[{"award-number":["2022RK9X2KMB"]}]},{"name":"Italian Ministry of University and Research PRIN 2022","award":["22818"],"award-info":[{"award-number":["22818"]}]},{"name":"Italian Association for Cancer Research","award":["20225AZ22F"],"award-info":[{"award-number":["20225AZ22F"]}]},{"name":"Italian Association for Cancer Research","award":["2022RK9X2KMB"],"award-info":[{"award-number":["2022RK9X2KMB"]}]},{"name":"Italian Association for Cancer Research","award":["22818"],"award-info":[{"award-number":["22818"]}]},{"name":"Ricerca Corrente IRCCS Multi Medica","award":["20225AZ22F"],"award-info":[{"award-number":["20225AZ22F"]}]},{"name":"Ricerca Corrente IRCCS Multi Medica","award":["2022RK9X2KMB"],"award-info":[{"award-number":["2022RK9X2KMB"]}]},{"name":"Ricerca Corrente IRCCS Multi Medica","award":["22818"],"award-info":[{"award-number":["22818"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>MicroRNAs (miRNAs) are mighty post-transcriptional regulators in cell physiology and pathophysiology. In this review, we focus on the role of miR-223-3p (henceforth miR-223) in various cancer types. MiR-223 has established roles in hematopoiesis, inflammation, and most cancers, where it can act as either an oncogenic or oncosuppressive miRNA, depending on specific molecular landscapes. MiR-223 has also been linked to either the sensitivity or resistance of cancer cells to treatments in a context-dependent way. Through this detailed review, we highlight that for some cancers (i.e., breast, non-small cell lung carcinoma, and glioblastoma), the oncosuppressive role of miR-223 is consistently reported in the literature, while for others (i.e., colorectal, ovarian, and pancreatic cancers, and acute lymphocytic leukemia), an oncogenic role prevails. In prostate cancer and other hematological malignancies, although an oncosuppressive role is frequently described, there is less of a consensus. Intriguingly, NLRP3 and FBXW7 are consistently identified as miR-223 targets when the miRNA acts as an oncosuppressor or an oncogene, respectively, in different cancers. Our review also describes that miR-223 was increased in biological fluids or their extracellular vesicles in most of the cancers analyzed, as compared to healthy or lower-risk conditions, confirming the potential application of this miRNA as a diagnostic and prognostic biomarker in the clinic.<\/jats:p>","DOI":"10.3390\/ijms25158191","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T14:39:08Z","timestamp":1722004748000},"page":"8191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["MiR-223-3p in Cancer Development and Cancer Drug Resistance: Same Coin, Different Faces"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-4554","authenticated-orcid":false,"given":"Davide","family":"Barbagallo","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics \u201cGiovanni Sichel\u201d, University of Catania, Via Santa Sofia 89, 95123 Catania, Italy"},{"name":"Interdisciplinary Research Centre on the Diagnosis and Therapy of Brain Tumors, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Ponti","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Corso della Repubblica 79, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-1607","authenticated-orcid":false,"given":"Barbara","family":"Bassani","sequence":"additional","affiliation":[{"name":"Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Via Fantoli 16\/15, 20138 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4790-0861","authenticated-orcid":false,"given":"Antonino","family":"Bruno","sequence":"additional","affiliation":[{"name":"Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry, and Immunology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica, Via Fantoli 16\/15, 20138 Milano, Italy"},{"name":"Department of Biotechnology and Life Sciences, DBSV, University of Insubria, Via J.H. Dunant 3, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pulze","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, DBSV, University of Insubria, Via J.H. Dunant 3, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya A.","family":"Akkihal","sequence":"additional","affiliation":[{"name":"Independent Researcher, 35004 SE Swenson St, Snoqualmie, WA 98065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-1241","authenticated-orcid":false,"given":"Jonahunnatha N.","family":"George-William","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Fratelli Cervi, 93, 20054 Segrate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-3003","authenticated-orcid":false,"given":"Rohit","family":"Gundamaraju","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA"},{"name":"ER Stress and Mucosal Immunology Team, School of Health Sciences, University of Tasmania, Launceston, TAS 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-1134","authenticated-orcid":false,"given":"Paola","family":"Campomenosi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences, DBSV, University of Insubria, Via J.H. Dunant 3, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1101\/gad.1706508","article-title":"Chromatin Structure Analyses Identify miRNA Promoters","volume":"22","author":"Ozsolak","year":"2008","journal-title":"Genes Dev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2174\/138920210793175895","article-title":"MicroRNA: Biogenesis, Function and Role in Cancer","volume":"11","author":"Macfarlane","year":"2010","journal-title":"Curr. 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