{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:06:59Z","timestamp":1774026419092,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T00:00:00Z","timestamp":1722038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Science and Innovation","award":["RED2018-102499-T"],"award-info":[{"award-number":["RED2018-102499-T"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["CT82\/20-CT83\/20"],"award-info":[{"award-number":["CT82\/20-CT83\/20"]}]},{"name":"Spanish Ministry of Science and Innovation","award":["CT58\/21-CT59\/21"],"award-info":[{"award-number":["CT58\/21-CT59\/21"]}]},{"name":"Complutense University of Madrid","award":["RED2018-102499-T"],"award-info":[{"award-number":["RED2018-102499-T"]}]},{"name":"Complutense University of Madrid","award":["CT82\/20-CT83\/20"],"award-info":[{"award-number":["CT82\/20-CT83\/20"]}]},{"name":"Complutense University of Madrid","award":["CT58\/21-CT59\/21"],"award-info":[{"award-number":["CT58\/21-CT59\/21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In Alzheimer\u2019s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F\/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APPNL\/F-NF\/L AD model in comparison to C57BL\/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Both APPNL-F\/NL-F-model and WT animals exhibited thickness changes at the time points studied. While WT showed significant changes in INL, OPL, and ONL, the AD model showed changes in all retinal layers analyzed. The APPNL-F\/NL-F displayed significant thickness variations in the analyzed layers except for the IPL compared to related WT. These thickness changes closely resembled those found in humans during preclinical stages, as well as during mild and moderate AD stages, making this AD model behave more similarly to the disease in humans.<\/jats:p>","DOI":"10.3390\/ijms25158221","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:37:25Z","timestamp":1722332245000},"page":"8221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F\/NL-F Mice: Implications for Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-8782","authenticated-orcid":false,"given":"Lidia","family":"S\u00e1nchez-Puebla","sequence":"first","affiliation":[{"name":"Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-087X","authenticated-orcid":false,"given":"Rosa","family":"de Hoz","sequence":"additional","affiliation":[{"name":"Ramon Castroviejo Institute for Ophthalmic Research, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"},{"name":"Department of Immunology, Ophthalmology and ENT, Faculty of Optics and Optometry, Complutense University of Madrid, 28040 Madrid, 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Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s Disease: The Amyloid Cascade Hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S611","DOI":"10.3233\/JAD-179935","article-title":"Role of Amyloid-\u03b2 and Tau Proteins in Alzheimer\u2019s Disease: Confuting the Amyloid Cascade","volume":"64","author":"Gulisano","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0197-4580(96)00010-3","article-title":"Retinal Pathology in Alzheimer\u2019s Disease. I. Ganglion Cell Loss in Foveal\/Parafoveal Retina","volume":"17","author":"Blanks","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"Leading Edge the Cellular Phase of Alzheimer\u2019s Disease","volume":"164","author":"Karran","year":"2016","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Doustar, J., Torbati, T., Black, K.L., Koronyo, Y., and Koronyo-Hamaoui, M. (2017). Optical Coherence Tomography in Alzheimer\u2019s Disease and Other Neurodegenerative Diseases. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00701"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/wsbm.22","article-title":"Vertebrate Retina and Hypothalamus Development","volume":"1","author":"Byerly","year":"2009","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The Retina as a Window to the Brain\u2014From Eye Research to CNS Disorders","volume":"9","author":"London","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"ref_9","unstructured":"Purves, D., Augustine, G.J., Fitzpatrick, D., Katz, L.C., LaMantia, A.-S., McNamara, J.O., and Williams, S.M. (2001). The Retina. Neuroscience, Sinauer Associates."},{"key":"ref_10","first-page":"469","article-title":"Beyond Vision: A View from Eye to Alzheimer\u2019s Disease and Dementia","volume":"11","author":"Zheng","year":"2023","journal-title":"J. Prev. Alzheimer\u2019s Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Salobrar-Garc\u00eda, E., De Hoz, R., Ram\u00edrez, A.I., L\u00f3pez-Cuenca, I., Rojas, P., Vazirani, R., Amarante, C., Yubero, R., Gil, P., and Pinazo-Dur\u00e1n, M.D. (2019). Changes in Visual Function and Retinal Structure in the Progression of Alzheimer\u2019s Disease. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220535"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/alz.12006","article-title":"Developing Retinal Biomarkers for the Earliest Stages of Alzheimer\u2019s Disease: What We Know, What We Don\u2019t, and How to Move Forward","volume":"16","author":"Alber","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Salobrar-Garc\u00eda, E., L\u00f3pez-Cuenca, I., S\u00e1nchez-Puebla, L., de Hoz, R., Fern\u00e1ndez-Albarral, J.A., Ram\u00edrez, A.I., Bravo-Ferrer, I., Medina, V., Moro, M.A., and Saido, T.C. (2021). Retinal Thickness Changes Over Time in a Murine AD Model APPNL-F\/NL-F. Front. Aging Neurosci., 12.","DOI":"10.3389\/fnagi.2020.625642"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41419-018-0740-5","article-title":"Inflammation, Neurodegeneration and Protein Aggregation in the Retina as Ocular Biomarkers for Alzheimer\u2019s Disease in the 3xTg-AD Mouse Model","volume":"9","author":"Grimaldi","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1567205018666210414113634","article-title":"Retinal Changes in Transgenic Mouse Models of Alzheimer\u2019s Disease","volume":"18","author":"Guo","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neulet.2016.04.059","article-title":"Amyloid \u03b2 Accumulation and Inner Retinal Degenerative Changes in Alzheimer\u2019s Disease Transgenic Mouse","volume":"623","author":"Gupta","year":"2016","journal-title":"Neurosci. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.exer.2014.08.006","article-title":"Retinal Macroglia Changes in a Triple Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"127","author":"Edwards","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1742-4658.2010.07564.x","article-title":"Animal Models of Amyloid-\u03b2-Related Pathologies in Alzheimer\u2019s Disease","volume":"277","author":"Philipson","year":"2010","journal-title":"FEBS. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12987-022-00386-0","article-title":"Transgenic Animal Models to Explore and Modulate the Blood Brain and Blood Retinal Barriers of the CNS","volume":"19","author":"Goncalves","year":"2022","journal-title":"Fluids. Barriers. CNS"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/cen3.12475","article-title":"Neuroinflammation in Mouse Models of Alzheimer\u2019s Disease","volume":"9","author":"Saito","year":"2018","journal-title":"Clin. Exp. Neuroimmunol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP Mouse Models for Alzheimer\u2019s Disease Preclinical Studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical Coherence Tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1167\/iovs.06-0815","article-title":"In Vivo Three-Dimensional High-Resolution Imaging of Rodent Retina with Spectral-Domain Optical Coherence Tomography","volume":"48","author":"Ruggeri","year":"2007","journal-title":"Investig. Ophthalmol Vis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Alexopoulos, P., Madu, C., Wollstein, G., and Schuman, J.S. (2022). The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques. Front. Med., 9.","DOI":"10.3389\/fmed.2022.891369"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.2144\/000112090","article-title":"Spectral Domain Optical Coherence Tomography: A Better OCT Imaging Strategy","volume":"39","author":"Yaqoob","year":"2005","journal-title":"Biotechniques"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/tvst.4.4.9","article-title":"Quantitative Analysis of Mouse Retinal Layers Using Automated Segmentation of Spectral Domain Optical Coherence Tomography Images","volume":"4","author":"Dysli","year":"2015","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Fischer, M.D., Huber, G., Beck, S.C., Tanimoto, N., Muehlfriedel, R., Fahl, E., Grimm, C., Wenzel, A., Rem\u00e9, C.E., and van de Pavert, S.A. (2009). Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007507"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1017\/cjn.2016.415","article-title":"The Ontario Neurodegenerative Disease Research Initiative (ONDRI)","volume":"44","author":"Farhan","year":"2017","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ophtha.2013.09.035","article-title":"Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography","volume":"121","author":"Polo","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.8.5.6","article-title":"Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease","volume":"8","author":"Wong","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Batista, A., Guimar\u00e3es, P., Serranho, P., Nunes, A., Martins, J., Moreira, P.I., Ambr\u00f3sio, A.F., Morgado, M., Castelo-Branco, M., and Bernardes, R. (2023). Retinal Imaging in Animal Models: Searching for Biomarkers of Neurodegeneration. Front. Ophthalmol., 3.","DOI":"10.3389\/fopht.2023.1156605"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kuo, C.Y., Stachiv, I., and Nikolai, T. (2020). Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer\u2019s Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17207475"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-animal-022114-110829","article-title":"Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases","volume":"3","author":"Mitchell","year":"2015","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yanai, S., and Endo, S. (2021). Functional Aging in Male C57BL\/6J Mice Across the Life-Span: A Systematic Behavioral Analysis of Motor, Emotional, and Memory Function to Define an Aging Phenotype. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.697621"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App Knock-in Mouse Models of Alzheimer\u2019s Disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ma, G., Ding, J., Kim, T.H., and Yao, X. (2022). Quantitative Optical Coherence Tomography for Longitudinal Monitoring of Postnatal Retinal Development in Developing Mouse Eyes. Appl. Sci., 12.","DOI":"10.20944\/preprints202201.0139.v1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16685","DOI":"10.1038\/s41598-019-53082-9","article-title":"Longitudinal OCT and OCTA Monitoring Reveals Accelerated Regression of Hyaloid Vessels in Retinal Degeneration 10 (Rd10) Mice","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ferguson, L.R., Grover, S., Dominguez, J.M., Balaiya, S., and Chalam, K.V. (2014). Retinal Thickness Measurement Obtained with Spectral Domain Optical Coherence Tomography Assisted Optical Biopsy Accurately Correlates with Ex Vivo Histology. PLoS. ONE., 9.","DOI":"10.1371\/journal.pone.0111203"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/iovs.62.7.9","article-title":"Age-Related Retinal Changes in Wild-Type C57BL\/6J Mice Between 2 and 32 Months","volume":"62","author":"Ferdous","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"De Hoz, R., Gallego, B.I., Ram\u00edrez, A.I., Rojas, B., Salazar, J.J., Valiente-Soriano, F.J., Avil\u00e9s-Trigueros, M., Villegas-Perez, M.P., Vidal-Sanz, M., and Trivi\u00f1o, A. (2013). Rod-Like Microglia Are Restricted to Eyes with Laser-Induced Ocular Hypertension but Absent from the Microglial Changes in the Contralateral Untreated Eye. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083733"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuron.2012.12.023","article-title":"Microglia: New Roles for the Synaptic Stripper","volume":"77","author":"Kettenmann","year":"2013","journal-title":"Neuron"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"83038","DOI":"10.18632\/oncotarget.19886","article-title":"The C-Jun N-Terminal Kinase Plays a Key Role in Ocular Degenerative Changes in a Mouse Model of Alzheimer Disease Suggesting a Correlation between Ocular and Brain Pathologies","volume":"8","author":"Buccarello","year":"2017","journal-title":"Oncotarget"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Batista, A., Guimar\u00e3es, P., Martins, J., Moreira, P.I., Ambr\u00f3sio, A.F., Castelo-Branco, M., Serranho, P., and Bernardes, R. (2023). Normative Mice Retinal Thickness: 16-Month Longitudinal Characterization of Wild-Type Mice and Changes in a Model of Alzheimer\u2019s Disease. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1161847"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7912","DOI":"10.1038\/s41598-020-64827-2","article-title":"Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer\u2019s Disease in a Mouse Model","volume":"10","author":"Song","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Puebla, L., L\u00f3pez-Cuenca, I., Salobrar-Garc\u00eda, E., Ram\u00edrez, A.I., Fern\u00e1ndez-Albarral, J.A., Matamoros, J.A., Elvira-Hurtado, L., Salazar, J.J., Ram\u00edrez, J.M., and de Hoz, R. (2024). OCT Imaging in Murine Models of Alzheimer\u2019s Disease in a Systematic Review: Findings, Methodology and Future Perspectives. Biomedicines, 12.","DOI":"10.3390\/biomedicines12030528"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40478-020-01102-5","article-title":"The AppNL-G-F Mouse Retina Is a Site for Preclinical Alzheimer\u2019s Disease Diagnosis and Research","volume":"9","author":"Vandenabeele","year":"2021","journal-title":"Acta. Neuropathol. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/tvst.9.5.18","article-title":"Scattering Angle Resolved Optical Coherence Tomography Detects Early Changes in 3xTg Alzheimer\u2019s Disease Mouse Model","volume":"9","author":"Gardner","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13195-019-0542-8","article-title":"Retinal Thinning of Inner Sub-Layers Is Associated with Cortical Atrophy in a Mouse Model of Alzheimer\u2019s Disease: A Longitudinal Multimodal in Vivo Study","volume":"11","author":"Chiquita","year":"2019","journal-title":"Alzheimers Res. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s10072-023-07256-z","article-title":"Correlation between Serum Biomarkers, Brain Volume, and Retinal Neuronal Loss in Early-Onset Alzheimer\u2019s Disease","volume":"45","author":"Zhang","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ophtha.2018.08.009","article-title":"Spectral-Domain OCT Measurements in Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"126","author":"Chan","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lim, J.K.H., Li, Q.X., He, Z., Vingrys, A.J., Chinnery, H.R., Mullen, J., Bui, B.V., and Nguyen, C.T.O. (2020). Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer\u2019s Disease. Front. Neurosci., 14.","DOI":"10.3389\/fnins.2020.00862"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainresbull.2010.04.001","article-title":"Dysfunction of the Magnocellular Stream in Alzheimer\u2019s Disease Evaluated by Pattern Electroretinograms and Visual Evoked Potentials","volume":"82","author":"Sartucci","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_53","first-page":"575","article-title":"Inflammation as a Central Mechanism in Alzheimer\u2019s Disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13000","DOI":"10.1038\/s41598-019-49353-0","article-title":"Spatial Analysis of Thickness Changes in Ten Retinal Layers of Alzheimer\u2019s Disease Patients Based on Optical Coherence Tomography","volume":"9","author":"Yubero","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Cuenca, I., de Hoz, R., Salobrar-Garc\u00eda, E., Elvira-Hurtado, L., Rojas, P., Fern\u00e1ndez-Albarral, J.A., Barabash, A., Salazar, J.J., Ram\u00edrez, A.I., and Ram\u00edrez, J.M. (2020). Macular Thickness Decrease in Asymptomatic Subjects at High Genetic Risk of Developing Alzheimer\u2019s Disease: An OCT Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061728"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ferguson, L.R., Dominguez, J.M., Balaiya, S., Grover, S., and Chalam, K.V. (2013). Retinal Thickness Normative Data in Wild-Type Mice Using Customized Miniature SD-OCT. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067265"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13195-023-01375-7","article-title":"The Fluorescent Ligand BTVBT2 Reveals Increased P-Tau Uptake by Retinal Microglia in Alzheimer\u2019s Disease Patients and App NL\u2212F\/NL\u2212F Mice","volume":"16","author":"Andersson","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40035-021-00230-9","article-title":"Advances in Retina Imaging as Potential Biomarkers for Early Diagnosis of Alzheimer\u2019s Disease","volume":"10","author":"Zhang","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/EB.S235238","article-title":"Optical Coherence Tomography in Patients with Alzheimer\u2019s Disease: What Can It Tell Us?","volume":"13","author":"Song","year":"2021","journal-title":"Eye Brain"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/15\/8221\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:25:08Z","timestamp":1760109908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/25\/15\/8221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":59,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["ijms25158221"],"URL":"https:\/\/doi.org\/10.3390\/ijms25158221","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,27]]}}}