{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:41:04Z","timestamp":1787168464130,"version":"build-2736575974"},"reference-count":180,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atopic dermatitis and psoriasis are prevalent inflammatory skin conditions that significantly impact the quality of life of patients, with diverse treatment options available. Despite advances in understanding their underlying mechanisms, recent research highlights the significance of interleukins IL-18 and IL-37, in Th1, Th2, and Th17 inflammatory responses, closely associated with the pathogenesis of psoriasis and atopic dermatitis. Hence, IL-18 and IL-37 could potentially become therapeutic targets. This narrative review synthesizes knowledge on these interleukins, their roles in atopic dermatitis and psoriasis, and emerging treatment strategies. Findings of a literature search up to 30 May 2024, underscore a research gap in IL-37-targeted therapies. Conversely, IL-18-focused treatments have demonstrated promise in adult-onset Still\u2019s Disease, warranting further exploration for their potential efficacy in psoriasis and atopic dermatitis.<\/jats:p>","DOI":"10.3390\/ijms25158437","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T13:14:42Z","timestamp":1722604482000},"page":"8437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3421-7756","authenticated-orcid":false,"given":"Llu\u00eds","family":"Rusi\u00f1ol","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"},{"name":"Institut de Recerca Sant Pau (IR Sant Pau), Sant Quint\u00ed 77-79, 08041 Barcelona, Spain"},{"name":"Unitat Docent Hospital Universitari Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-0952","authenticated-orcid":false,"given":"Llu\u00eds","family":"Puig","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"},{"name":"Institut de Recerca Sant Pau (IR Sant Pau), Sant Quint\u00ed 77-79, 08041 Barcelona, Spain"},{"name":"Unitat Docent Hospital Universitari Sant Pau, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/imr.12606","article-title":"The Family of the Interleukin-1 Receptors","volume":"281","author":"Boraschi","year":"2018","journal-title":"Immunol. 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