{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:37:02Z","timestamp":1792291022058,"version":"4.4.0"},"reference-count":70,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IFOM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Angiogenesis, or the development of blood vessels by growing from already-formed vessels, is observed in embryonic development, physiological cyclical processes such as wound healing, the encapsulation of foreign bodies, tumor growth, and some other situations. In this review, we analyze the cellular mechanisms of angiogenesis, namely, angiogenesis by sprouting, ansiform (by loop formation) angiogenesis, coalescent angiogenesis, and angiogenesis by intussusception (splitting the capillary into two channels). The analysis of data revealed a lot of unanswered questions and contradictions. Here, we propose several new models of angiogenesis explaining these contradictions.<\/jats:p>","DOI":"10.3390\/ijms25168575","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T11:54:19Z","timestamp":1722945259000},"page":"8575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New Interpretations for Sprouting, Intussusception, Ansiform, and Coalescent Types of Angiogenesis"],"prefix":"10.3390","volume":"25","author":[{"given":"Alexander V.","family":"Korablev","sequence":"first","affiliation":[{"name":"Department of Pathological Anatomy, Yaroslavl State Medical University, Yaroslavl 150000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina S.","family":"Sesorova","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Topographic Anatomy, Ivanovo State Medical University, Ivanovo 153012, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly V.","family":"Sesorov","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Topographic Anatomy, Ivanovo State Medical University, Ivanovo 153012, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel S.","family":"Vavilov","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Topographic Anatomy, Ivanovo State Medical University, Ivanovo 153012, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mironov","sequence":"additional","affiliation":[{"name":"Sacco Hospital, Universita degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Zaitseva","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Saint Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeny V.","family":"Bedyaev","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Topographic Anatomy, Ivanovo State Medical University, Ivanovo 153012, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-1651","authenticated-orcid":false,"given":"Alexander A.","family":"Mironov","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, IFOM ETS\u2014The AIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10456-018-9613-x","article-title":"Consensus guidelines for the use and interpretation of angiogenesis assays","volume":"21","author":"Alitalo","year":"2018","journal-title":"Angiogenesis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-0916-3_1","article-title":"Historical overview of in vivo and in vitro angiogenesis assays","volume":"2206","author":"Cimpean","year":"2021","journal-title":"Methods Mol. 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