{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:01:41Z","timestamp":1787497301920,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute (KHIDI)","doi-asserted-by":"publisher","award":["HR16C0001"],"award-info":[{"award-number":["HR16C0001"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is a chronic inflammatory disease caused by autoantibodies. Serum samples from patients with SLE (n = 10) were compared with those from normal controls (NCs, n = 5) using 21K protein chip analysis to identify a biomarker for SLE, revealing 63 SLE-specific autoantibodies. The anti-chaperonin-containing t-complex polypeptide-1 (TCP1) antibody exhibited higher expression in patients with SLE than in NCs. To validate the specificity of the anti-TCP1 antibody in SLE, dot blot analysis was conducted using sera from patients with SLE (n = 100), rheumatoid arthritis (RA; n = 25), Beh\u00e7et\u2019s disease (BD; n = 28), and systemic sclerosis (SSc; n = 30) and NCs (n = 50). The results confirmed the detection of anti-TCP1 antibodies in 79 of 100 patients with SLE, with substantially elevated expression compared to both NCs and patients with other autoimmune diseases. We performed an enzyme-linked immunosorbent assay to determine the relative amounts of anti-TCP1 antibodies; markedly elevated anti-TCP1 antibody levels were detected in the sera of patients with SLE (50.1 \u00b1 17.3 arbitrary unit (AU), n = 251) compared to those in NCs (33.9 \u00b1 9.3 AU), RA (35 \u00b1 8.7 AU), BD (37.5 \u00b1 11.6 AU), and SSc (43 \u00b1 11.9 AU). These data suggest that the anti-TCP1 antibody is a potential diagnostic biomarker for SLE.<\/jats:p>","DOI":"10.3390\/ijms25168612","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T11:33:52Z","timestamp":1723030432000},"page":"8612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-TCP1 Antibody Is a Potential Biomarker for Diagnosing Systemic Lupus Erythematosus"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-9629","authenticated-orcid":false,"given":"Sang-Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-4439","authenticated-orcid":false,"given":"Wook-Young","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-0770","authenticated-orcid":false,"given":"Jee-Min","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon 16499, Republic of Korea"},{"name":"Department of Mathematics, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Chul","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Yang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-393X","authenticated-orcid":false,"given":"Chang-Hee","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"},{"name":"Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7403796","DOI":"10.1155\/2019\/7403796","article-title":"Regulation of Inflammation in Autoimmune Disease","volume":"2019","author":"Duan","year":"2019","journal-title":"J. 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