{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:13:07Z","timestamp":1780575187713,"version":"3.54.1"},"reference-count":35,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Croatian Science Foundation Grants \u201cGenetic polymorphisms and their association with temporomandibular disorders\u201d","award":["IP-2019-04-6211"],"award-info":[{"award-number":["IP-2019-04-6211"]}]},{"name":"Croatian Science Foundation Grants \u201cGenetic polymorphisms and their association with temporomandibular disorders\u201d","award":["IP-2024-05-7019"],"award-info":[{"award-number":["IP-2024-05-7019"]}]},{"name":"Functional association of gene activity and sensory perception with painful temporomandibular disorders","award":["IP-2019-04-6211"],"award-info":[{"award-number":["IP-2019-04-6211"]}]},{"name":"Functional association of gene activity and sensory perception with painful temporomandibular disorders","award":["IP-2024-05-7019"],"award-info":[{"award-number":["IP-2024-05-7019"]}]},{"name":"Young Researchers\u2019 Career Development Project\u2014Training of Doctoral Students","award":["IP-2019-04-6211"],"award-info":[{"award-number":["IP-2019-04-6211"]}]},{"name":"Young Researchers\u2019 Career Development Project\u2014Training of Doctoral Students","award":["IP-2024-05-7019"],"award-info":[{"award-number":["IP-2024-05-7019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This case-control study investigated single nucleotide polymorphism (SNP) genotypes (CXC motif chemokine ligand 8 (CXCL8): rs2227306 and rs2227307 and tumor necrosis factor (TNF): rs1800629) in 85 patients with pain-related temporomandibular disorders (TMDp) and 85 controls to explore their associations with TMDp presence, pain intensity (low\/high), and the presence of chronic arthralgia\/myalgia. TMDp was diagnosed using a validated protocol, and polymorphisms were genotyped from buccal mucosa swabs using TaqMan assays. High pain intensity individuals had an increased risk for carrying minor allele \u201cG\u201d (rs2227307) and \u201cT\u201d (rs2227306) compared to controls (76% vs. 55.3%, p = 0.012; 72% vs. 54.1%, p = 0.030, respectively). Carriers of the minor allele \u201cG\u201d (rs2227307) were more prevalent in TMDp patients with arthralgia compared to controls (70.30% vs. 55.30%, p = 0.037). According to logistic regression, the most important predictors for high pain intensity were minor allele \u201cG\u201d of rs2227307 (OR 2.435, 95% CI 1.123\u20135.282), increasing age (OR 1.038, 95% CI 1.002\u20131.075), and female sex (OR 4.592, 95% CI 1.289\u201316.361). The explored gene polymorphisms were not significant risk factors for TMDp presence. These findings highlight the importance of genetic variations, particularly rs2227307, in understanding the diverse clinical manifestations of temporomandibular disorders.<\/jats:p>","DOI":"10.3390\/ijms25168730","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T03:46:36Z","timestamp":1723607196000},"page":"8730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Influences of Proinflammatory Cytokines on Pain Severity in Patients with Temporomandibular Disorders"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-0839","authenticated-orcid":false,"given":"Marko","family":"Zlendi\u0107","sequence":"first","affiliation":[{"name":"Department of Removable Prosthodontics, University of Zagreb School of Dental Medicine, Gunduli\u0107eva 5, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-851X","authenticated-orcid":false,"given":"Ema","family":"Vrbanovi\u0107 \u0110uri\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Removable Prosthodontics, University of Zagreb School of Dental Medicine, Gunduli\u0107eva 5, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7501-7614","authenticated-orcid":false,"given":"Koraljka","family":"Gall Tro\u0161elj","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenomics, Division of Molecular Medicine, Ru\u0111er Bo\u0161kovi\u0107 Institute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Tomljanovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Epigenomics, Division of Molecular Medicine, Ru\u0111er Bo\u0161kovi\u0107 Institute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Vukovi\u0107 \u0110erfi","sequence":"additional","affiliation":[{"name":"Laboratory for Personalized Medicine, Division of Molecular Medicine, Ru\u0111er Bo\u0161kovi\u0107 Institute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva Z.","family":"Alajbeg","sequence":"additional","affiliation":[{"name":"Department of Removable Prosthodontics, University of Zagreb School of Dental Medicine, Gunduli\u0107eva 5, 10000 Zagreb, Croatia"},{"name":"Department of Dentistry, Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41423-023-00974-6","article-title":"The chemokines CXCL8 and CXCL12: Molecular and functional properties, role in disease and efforts towards pharmacological intervention","volume":"20","author":"Cambier","year":"2023","journal-title":"Cell. 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