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(UFPA)","award":["#302935\/2021-5"],"award-info":[{"award-number":["#302935\/2021-5"]}]},{"name":"Federal University of Par\u00e1 (UFPA)","award":["#303837\/2023-3"],"award-info":[{"award-number":["#303837\/2023-3"]}]},{"name":"Federal University of Par\u00e1 (UFPA)","award":["INCT-VER#406360\/2022-7"],"award-info":[{"award-number":["INCT-VER#406360\/2022-7"]}]},{"name":"Federal University of Par\u00e1 (UFPA)","award":["#09\/2021"],"award-info":[{"award-number":["#09\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The IgG response against SARS-CoV-2 infection can persist for over six months (long response; LR). However, among 30% of those infected, the duration can be as short as three months or less (short response; SR). The present study assembled serological data on the anti-SARS-CoV-2 IgG response duration of two previous studies and integrated these results with the plasmatic cytokine levels and genetic profile of 10 immune-relevant SNPs that were also previously published, along with the plasmatic total IgG, IgA, and IgM levels, allowing for the genetic, clinical, immunological, and epidemiological aspects of the post-COVID-19 IgG response duration to be understood. The SR was associated with previous mild acute COVID-19 and with an SNP (rs2228145) in IL6R related to low gene expression. Additionally, among the SR subgroup, no statistically significant Spearman correlations were observed between the plasma levels of IL-17A and the Th17 regulatory cytokines IFN-\u03b3 (rs = 0.2399; p = 0.1043), IL-4 (rs = 0.0273; p = 0.8554), and IL-2 (rs = 0.2204; p = 0.1365), while among the LR subgroup, weaker but statistically significant Spearman correlations were observed between the plasma levels of IL-17A and IFN-\u03b3 (rs = 0.3873; p = 0.0016), IL-4 (rs = 0.2671; p = 0.0328), and IL-2 (rs = 0.3959; p = 0.0012). These results suggest that the Th17 response mediated by the IL-6 pathway has a role in the prolonged IgG response to SARS-CoV-2 infection.<\/jats:p>","DOI":"10.3390\/ijms25168740","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T03:46:36Z","timestamp":1723607196000},"page":"8740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic, Clinical, Epidemiological, and Immunological Profiling of IgG Response Duration after SARS-CoV-2 Infection"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5667-0754","authenticated-orcid":false,"given":"Fl\u00e1via","family":"P\u00f3voa da Costa","sequence":"first","affiliation":[{"name":"Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Par\u00e1, Brazil"},{"name":"Graduate Program in Biology of Infectious and Parasitic 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