{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:37:59Z","timestamp":1768685879715,"version":"3.49.0"},"reference-count":110,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Caveolin is a structural protein within caveolae that may be involved in transmembrane molecular transport and\/or various intercellular interactions within cells. Specific mutations of caveolin-3 in muscle fibers are well known to cause limb\u2013girdle muscular dystrophy. Altered expression of caveolin-3 has also been detected in Duchenne muscular dystrophy, which may be a part of the pathological process leading to muscle weakness. Interestingly, it has been shown that the renovation of nitric oxide synthase (NOS) in sarcolemma with muscular dystrophy could improve muscle health, suggesting that NOS may be involved in the pathology of muscular dystrophy. Here, we summarize the notable function of caveolin and\/or NOS in skeletal muscle fibers and discuss their involvement in the pathology as well as possible tactics for the innovative treatment of muscular dystrophies.<\/jats:p>","DOI":"10.3390\/ijms25168771","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T05:23:27Z","timestamp":1723613007000},"page":"8771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Caveolin and NOS in the Development of Muscular Dystrophy"],"prefix":"10.3390","volume":"25","author":[{"given":"Moeka","family":"Nakashima","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-5345","authenticated-orcid":false,"given":"Satoru","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Nara Women\u2019s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.molmed.2007.10.003","article-title":"New therapies for Duchenne muscular dystrophy: Challenges, prospects and clinical trials","volume":"13","author":"Cossu","year":"2007","journal-title":"Trends Mol. 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