{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T09:20:07Z","timestamp":1772616007868,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Liver ischaemia\u2013reperfusion (IR) during hepatic surgeries can lead to liver cell death via oxidative stress and the activation of immune cells, the release of cytokines, and damage-associated molecular patterns. Ascorbic acid has been shown to confer potential protective effects against IR injury, mainly due to its antioxidant properties. This study evaluated the effect of ascorbic acid infusion at different time points during hepatic IR in rats. Thirty-six male Wistar rats were divided into control and experimental groups that received the same total ascorbic acid dose at three different infusion times: before ischaemia, before reperfusion, or before both ischaemia and reperfusion. All of the animals experienced hepatic IR injury. We measured the hepatic enzymes, cytokines, and portal blood flow. Animals receiving ascorbic acid before both ischaemia and reperfusion had lower liver enzyme levels, reduced inflammation, and better portal venous flow than other animals. Divided doses of ascorbic acid before IR may be beneficial for reducing liver injury associated with IR.<\/jats:p>","DOI":"10.3390\/ijms25168833","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T05:23:27Z","timestamp":1723613007000},"page":"8833","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Ascorbic Acid on Hepatic Ischaemia\u2013Reperfusion Injury in Wistar Rats: An Experimental Study"],"prefix":"10.3390","volume":"25","author":[{"given":"Jorge Luiz Saraiva","family":"Ximenes","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"},{"name":"Disciplina de Anestesiologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-5907","authenticated-orcid":false,"given":"Joel Avancini","family":"Rocha-Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"},{"name":"Disciplina de Anestesiologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio Henrique Ferreira","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"},{"name":"Servi\u00e7o de Transplante de F\u00edgado e \u00d3rg\u00e3os do Aparelho Digestivo, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-1458","authenticated-orcid":false,"given":"Cinthia","family":"Lanchotte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Saldanha","family":"Kubrusly","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Maria Cubero","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-7088","authenticated-orcid":false,"given":"Jose","family":"Jukemura","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"},{"name":"Divis\u00e3o de Cirurgia do Aparelho Digestivo, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-6934","authenticated-orcid":false,"given":"Agustin Vintimilla","family":"Moscoso","sequence":"additional","affiliation":[{"name":"Departamento de Trasplantes do Hospital \u201cJos\u00e9 Carrasco Arteaga\u201d IESS, Cuenca 010109, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio Elias","family":"Abdo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"},{"name":"Divis\u00e3o de Cirurgia do Aparelho Digestivo, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Augusto Carneiro","family":"D\u2019Albuquerque","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"},{"name":"Servi\u00e7o de Transplante de F\u00edgado e \u00d3rg\u00e3os do Aparelho Digestivo, Departamento de Gastroenterologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-220, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-8670","authenticated-orcid":false,"given":"Estela Regina Ramos","family":"Figueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o Medica 37, 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