{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:18:44Z","timestamp":1776133124194,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Mexicano del Seguro Social","award":["FIS\/IMSS\/PROT\/G15\/1477"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G15\/1477"]}]},{"name":"Instituto Mexicano del Seguro Social","award":["FIS\/IMSS\/PROT\/1548"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/1548"]}]},{"name":"Instituto Mexicano del Seguro Social","award":["CB-2015-1-258042"],"award-info":[{"award-number":["CB-2015-1-258042"]}]},{"name":"Instituto Mexicano del Seguro Social","award":["HIM\/2021\/068"],"award-info":[{"award-number":["HIM\/2021\/068"]}]},{"name":"National Council of Science and Technology","award":["FIS\/IMSS\/PROT\/G15\/1477"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G15\/1477"]}]},{"name":"National Council of Science and Technology","award":["FIS\/IMSS\/PROT\/1548"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/1548"]}]},{"name":"National Council of Science and Technology","award":["CB-2015-1-258042"],"award-info":[{"award-number":["CB-2015-1-258042"]}]},{"name":"National Council of Science and Technology","award":["HIM\/2021\/068"],"award-info":[{"award-number":["HIM\/2021\/068"]}]},{"name":"Direction of Research at the Hospital Infantil de M\u00e9xico Federico G\u00f3mez","award":["FIS\/IMSS\/PROT\/G15\/1477"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/G15\/1477"]}]},{"name":"Direction of Research at the Hospital Infantil de M\u00e9xico Federico G\u00f3mez","award":["FIS\/IMSS\/PROT\/1548"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/1548"]}]},{"name":"Direction of Research at the Hospital Infantil de M\u00e9xico Federico G\u00f3mez","award":["CB-2015-1-258042"],"award-info":[{"award-number":["CB-2015-1-258042"]}]},{"name":"Direction of Research at the Hospital Infantil de M\u00e9xico Federico G\u00f3mez","award":["HIM\/2021\/068"],"award-info":[{"award-number":["HIM\/2021\/068"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Congenital heart disease (CHD) can be complicated by pulmonary arterial hypertension (PAH). Cardiopulmonary bypass (CPB) for corrective surgery may cause endothelial dysfunction, involving endothelin-1 (ET-1), circulating endothelial cells (CECs), and endothelial progenitor cells (EPCs). These markers can gauge disease severity, but their levels in children\u2019s peripheral blood still lack consensus for prognostic value. The aim of our study was to investigate changes in ET-1, cytokines, and the absolute numbers (\u019d) of CECs and EPCs in children 24 h before and 48 h after CPB surgery to identify high-risk patients of complications. A cohort of 56 children was included: 41 cases with CHD-PAH (22 with high pulmonary flow and 19 with low pulmonary flow) and 15 control cases. We observed that \u019d-CECs increased in both CHD groups and that \u019d-EPCs decreased in the immediate post-surgical period, and there was a strong negative correlation between ET-1 and CEC before surgery, along with significant changes in ET-1, IL8, IL6, and CEC levels. Our findings support the understanding of endothelial cell precursors\u2019 role in endogenous repair and contribute to knowledge about endothelial dysfunction in CHD.<\/jats:p>","DOI":"10.3390\/ijms25168895","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T09:29:41Z","timestamp":1723714181000},"page":"8895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Levels of Plasma Endothelin-1, Circulating Endothelial Cells, Endothelial Progenitor Cells, and Cytokines after Cardiopulmonary Bypass in Children with Congenital Heart Disease: Role of Endothelin-1 Regulation"],"prefix":"10.3390","volume":"25","author":[{"given":"Ang\u00e9lica","family":"Rangel-L\u00f3pez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Nefrol\u00f3gicas, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional (CMN) Siglo XXI (SXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City 06720, Mexico"},{"name":"Unidad de Investigaci\u00f3n en Enfermedades Infecciosas, Hospital Infantil de M\u00e9xico Federico G\u00f3mez-Secretar\u00eda de Salud (SS), Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Gonz\u00e1lez-Cabello","sequence":"additional","affiliation":[{"name":"Departamento de Neonatolog\u00eda e Infantes, UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5307-1625","authenticated-orcid":false,"given":"Mar\u00eda Eugenia","family":"Paniagua-Medina","sequence":"additional","affiliation":[{"name":"Departamento de Trasplantes, UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"L\u00f3pez-Romero","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Biomedicina y Oncolog\u00eda Gen\u00f3mica, Hospital de Gineco-Pediatr\u00eda 3A, IMSS, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-2106","authenticated-orcid":false,"given":"Lourdes Andrea","family":"Arriaga-Pizano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Inmunoqu\u00edmica, UMAE Hospital de Especialidades, CMN SXXI IMSS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lozano-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Nefrol\u00f3gicas, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional (CMN) Siglo XXI (SXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"P\u00e9rez-Barrag\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Neonatolog\u00eda e Infantes, UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"},{"name":"Departamento de Trasplantes, UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"M\u00e1rquez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Cardiopat\u00edas Cong\u00e9nitas-UMAE Hospital de Cardiolog\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"},{"name":"Departamento de Investigaci\u00f3n Cl\u00ednica, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, SS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-0618","authenticated-orcid":false,"given":"Dulce Mar\u00eda","family":"L\u00f3pez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica, UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"},{"name":"Centro de Investigaci\u00f3n en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, SS, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minerva","family":"Mata-Rocha","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Gen\u00e9tica Humana-UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-9707","authenticated-orcid":false,"given":"Ramon","family":"Paniagua-Sierra","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Nefrol\u00f3gicas, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional (CMN) Siglo XXI (SXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Majluf-Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Hemostasia, Trombosis y Aterog\u00e9nesis, Hospital General Regional 1, IMSS, Mexico City 03103, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Villanueva-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Neonatolog\u00eda, Hospital Infantil de M\u00e9xico Federico G\u00f3mez, SS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Zavala-Vega","sequence":"additional","affiliation":[{"name":"Laboratorio Cl\u00ednico y Banco de Sangre, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, SS, Mexico City 14269, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-9727","authenticated-orcid":false,"given":"Juan Carlos","family":"N\u00fa\u00f1ez-Enr\u00edquez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda Cl\u00ednica, UMAE Hospital de Pediatr\u00eda, CMN SXXI IMSS, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-6231","authenticated-orcid":false,"given":"Juan Manuel","family":"Mej\u00eda-Arangur\u00e9","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en 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