{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:50:01Z","timestamp":1791409801233,"version":"4.3.3"},"reference-count":44,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technology, and Innovation, the Ministry of Education, the Ministry of In-dustry, Commerce and Tourism, and ICETEX, Programme Ecosistema Cient\u00edfico - Colombia Cient\u00edfica, from the Francisco Jos\u00e9 de Caldas Fund","award":["RC-FP44842-212-2018"],"award-info":[{"award-number":["RC-FP44842-212-2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute myelogenous leukemia (AML) is one of the most lethal cancers, lacking a definitive curative therapy due to essential constraints related to the toxicity and efficacy of conventional treatments. This study explores the co-adjuvant potential of Lippia alba essential oils (EO) for enhancing the effectiveness and selectivity of two chemotherapy agents (cytarabine and clofarabine) against AML cells. EO derived from L. alba citral chemotype were produced using optimized and standardized environmental and extraction protocols. Rational fractionation techniques were employed to yield bioactive terpene-enriched fractions, guided by relative chemical composition and cytotoxic analysis. Pharmacological interactions were established between these fractions and cytarabine and clofarabine. The study comprehensively evaluated the cytotoxic, genotoxic, oxidative stress, and cell death phenotypes induced by therapies across AML (DA-3ER\/GM\/EVI1+) cells. The fraction rich in citral (F2) exhibited synergistic pharmacological interactions with the studied chemotherapies, intensifying their selective cytotoxic, genotoxic, and pro-oxidant effects. This shift favored transitioning from necrosis to a programmed cell death phenotype (apoptotic). The F2-clofarabine combination demonstrated remarkable synergistic anti-leukemic performance while preserving cell integrity in healthy cells. The observed selective antiproliferative effects may be attributed to the potential dual prooxidant\/antioxidant behavior of citral in L. alba EO.<\/jats:p>","DOI":"10.3390\/ijms25168920","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T06:23:20Z","timestamp":1723789400000},"page":"8920","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhancing Selectivity and Inhibitory Effects of Chemotherapy Drugs Against Myelogenous Leukemia Cells with Lippia alba Essential Oil Enriched in Citral"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-697X","authenticated-orcid":false,"given":"Wendy Lorena","family":"Quintero-Garc\u00eda","sequence":"first","affiliation":[{"name":"Corporaci\u00f3n Acad\u00e9mica Ciencias B\u00e1sicas Biom\u00e9dicas, Universidad de Antioquia, Medell\u00edn 050010, Colombia"},{"name":"Facultad de Ciencias M\u00e9dicas y de la Salud, Departamento de Postgrado en Enfermedades Infecciosas, Universidad de Santander, Bucaramanga 680006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denerieth Ximena","family":"Espinel-Mesa","sequence":"additional","affiliation":[{"name":"Corporaci\u00f3n Acad\u00e9mica Ciencias B\u00e1sicas Biom\u00e9dicas, Universidad de Antioquia, Medell\u00edn 050010, Colombia"},{"name":"Facultad de Ciencias M\u00e9dicas y de la Salud, Departamento de Postgrado en Enfermedades Infecciosas, Universidad de Santander, Bucaramanga 680006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-7540","authenticated-orcid":false,"given":"Erika Marcela","family":"Moreno","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas y de la Salud, Departamento de Postgrado en Enfermedades Infecciosas, Universidad de Santander, Bucaramanga 680006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-932X","authenticated-orcid":false,"given":"Elena","family":"Stashenko","sequence":"additional","affiliation":[{"name":"National Research Center for the Agroindustrialization of Aromatic and Medicinal Tropical Species (CENIVAM), Universidad Industrial de Santander, Bucaramanga 680002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cecilia","family":"Mesa-Arango","sequence":"additional","affiliation":[{"name":"Corporaci\u00f3n Acad\u00e9mica Ciencias B\u00e1sicas Biom\u00e9dicas, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-9328","authenticated-orcid":false,"given":"Liliana Torcoroma","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas y de la Salud, Departamento de Postgrado en Enfermedades Infecciosas, Universidad de Santander, Bucaramanga 680006, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer Statistics for the Year 2020: An Overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. 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