{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:23:02Z","timestamp":1782213782857,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel (CAPES)","doi-asserted-by":"publisher","award":["0001"],"award-info":[{"award-number":["0001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bisphosphonates are widely used for the treatment of postmenopausal osteoporosis; however, they cause several long-term side effects, necessitating the investigation of local ways to improve osseointegration in compromised bone tissue. The purpose of this study was to evaluate peri-implant bone repair using implants functionalized with zoledronic acid alone (OVX ZOL group, n = 11), zoledronic acid + teriparatide (OVX ZOL + TERI group, n = 11), and zoledronic acid + ruterpy (OVX ZOL + TERPY group, n = 11) compared to the control group (OVX CONV, n = 11). Analyses included computer-assisted microtomography, qualitative histologic analysis, and real-time PCR analysis. Histologically, all functionalized surfaces improved peri-implant repair, with the OVX ZOL + TERI group standing out. Similar results were found in computerized microtomography analysis. In real-time PCR analysis, however, the OVX ZOL and OVX ZOL + TERPY groups showed better results for bone formation, with the OVX ZOL + TERPY group standing out, while there were no statistical differences between the OVX CONV and OVX ZOL + TERI groups for the genes studied at 28 postoperative days. Nevertheless, all functionalized groups showed a reduced rate of bone resorption. In short, all surface functionalization groups outperformed the control group, with overall better results for the OVX ZOL + TERI group.<\/jats:p>","DOI":"10.3390\/ijms25168963","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T07:37:21Z","timestamp":1724053041000},"page":"8963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Smart Delivery of Biomolecules Interfering with Peri-Implant Repair in Osteoporotic Rats"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-8604","authenticated-orcid":false,"given":"Laura Vidoto","family":"Paludetto","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-9195","authenticated-orcid":false,"given":"Naara Gabriela","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora","family":"Breseghello","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Roberto","family":"de Souza Batista","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-6161","authenticated-orcid":false,"given":"Cristina","family":"Antoniali","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-4069","authenticated-orcid":false,"given":"Paulo Noronha","family":"Lisboa-Filho","sequence":"additional","affiliation":[{"name":"Department of Physics and Meteorology, Bauru Sciences School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Bauru 17033-360, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0140-6736(16)32381-9","article-title":"Future life expectancy in 35 industrialised countries: Projections with a Bayesian model ensemble","volume":"389","author":"Kontis","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.mcna.2021.05.016","article-title":"Update on Osteoporosis Screening and Management","volume":"105","author":"Anam","year":"2021","journal-title":"Med. 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