{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:48:58Z","timestamp":1791978538242,"version":"4.4.0"},"reference-count":110,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONAHCYT","award":["CVU\/Becario: 1032291\/003797"],"award-info":[{"award-number":["CVU\/Becario: 1032291\/003797"]}]},{"name":"CONAHCYT","award":["CD.CBS.081.2023 14409018"],"award-info":[{"award-number":["CD.CBS.081.2023 14409018"]}]},{"name":"DCBS, Universidad Aut\u00f3noma Metropolitana-Iztapalapa","award":["CVU\/Becario: 1032291\/003797"],"award-info":[{"award-number":["CVU\/Becario: 1032291\/003797"]}]},{"name":"DCBS, Universidad Aut\u00f3noma Metropolitana-Iztapalapa","award":["CD.CBS.081.2023 14409018"],"award-info":[{"award-number":["CD.CBS.081.2023 14409018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Zinc (Zn) is an essential trace element; it exhibits a plethora of physiological properties and biochemical functions. It plays a pivotal role in regulating the cell cycle, apoptosis, and DNA organization, as well as in protein, lipid, and carbohydrate metabolism. Among other important processes, Zn plays an essential role in reproductive health. The ZIP and ZnT proteins are responsible for the mobilization of Zn within the cell. Zn is an inert antioxidant through its interaction with a variety of proteins and enzymes to regulate the redox system, including metallothioneins (MTs), metalloenzymes, and gene regulatory proteins. The role of Zn in the reproductive system is of great importance; processes, such as spermatogenesis and sperm maturation that occur in the testicle and epididymis, respectively, depend on this element for their development and function. Zn modulates the synthesis of androgens, such as testosterone, for these reproductive processes, so Zn deficiency is related to alterations in sperm parameters that lead to male infertility.<\/jats:p>","DOI":"10.3390\/ijms25168991","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:11:28Z","timestamp":1724062288000},"page":"8991","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Zinc and Its Impact on the Function of the Testicle and Epididymis"],"prefix":"10.3390","volume":"25","author":[{"given":"Sergio","family":"Mar\u00edn de Jes\u00fas","sequence":"first","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Ciudad de Mexico 09340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-1994","authenticated-orcid":false,"given":"Rosa Mar\u00eda","family":"Vigueras-Villase\u00f1or","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n, Instituto Nacional de Pediatr\u00eda, Coyoac\u00e1n, Ciudad de Mexico 04530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-7338","authenticated-orcid":false,"given":"Edith","family":"Cort\u00e9s-Barberena","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Avenida San Rafael Atlixco 186, Ciudad de Mexico 09340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1194-7633","authenticated-orcid":false,"given":"Joel","family":"Hern\u00e1ndez-Rodriguez","sequence":"additional","affiliation":[{"name":"Cuerpo Acad\u00e9mico de Investigaci\u00f3n en Quiropr\u00e1ctica, Universidad Estatal del Valle de Ecatepec, Av. 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