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Inclusion criteria encompassed original English articles focusing on molecular mechanisms of kidney cancer. On the other hand, all non-original articles and articles published in any language other than English were excluded. Hereditary kidney cancer represents 5\u20138% of all kidney cancer cases and is associated with syndromes such as von Hippel\u2013Lindau syndrome, Birt\u2013Hogg\u2013Dub\u00e8 syndrome, succinate dehydrogenase-deficient renal cell cancer syndrome, tuberous sclerosis complex, hereditary papillary renal cell carcinoma, fumarate hydratase deficiency syndrome, BAP1 tumor predisposition syndrome, and other uncommon hereditary cancer syndromes. These conditions are characterized by distinct genetic mutations and related extra-renal symptoms. The majority of renal cell carcinoma predispositions stem from loss-of-function mutations in tumor suppressor genes. These mutations promote malignant advancement through the somatic inactivation of the remaining allele. This review aims to elucidate the main molecular mechanisms underlying the pathophysiology of major syndromes associated with renal cell carcinoma. By providing a comprehensive overview, it aims to facilitate early diagnosis and to highlight the principal therapeutic options available.<\/jats:p>","DOI":"10.3390\/ijms25169060","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:16:24Z","timestamp":1724649384000},"page":"9060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis of Hereditary Cancer Syndrome"],"prefix":"10.3390","volume":"25","author":[{"given":"Rossella","family":"Cicchetti","sequence":"first","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Basconi","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Litterio","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4831-2669","authenticated-orcid":false,"given":"Marco","family":"Mascitti","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Tamborino","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9372-5847","authenticated-orcid":false,"given":"Angelo","family":"Orsini","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Digiacomo","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-7858","authenticated-orcid":false,"given":"Matteo","family":"Ferro","sequence":"additional","affiliation":[{"name":"Division of Urology, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Schips","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-4127","authenticated-orcid":false,"given":"Michele","family":"Marchioni","sequence":"additional","affiliation":[{"name":"Department of Medical Oral and Biotechnological Science, Universit\u00e0 degli Studi \u201cG. d\u2019Annunzio\u201d of Chieti, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal Cell Carcinoma","volume":"3","author":"Hsieh","year":"2017","journal-title":"Nat. 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