{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:19Z","timestamp":1793272759093,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Intra-articular blood, iron and hemosiderin, hydroxyl radical cytokines, and neo-angiogenesis cause synovial inflammation, which leads to cartilage and joint damage. Platelet-rich plasma (PRP) inhibits most of the mediators that produce and maintain synovitis. We compile here our work showing the clinical effectiveness of intra-articular PRP injections and their potential role in stopping articular cartilage damage due to bleeding and its possible repair. A total of 116 joints, including knees (63%), elbows (19.8%), and ankles (17.2%), were treated with intra-articular injections of PRP. Moreover, we also show here the number of extracellular DNA traps (ETs) and the PRP effect in the synovial fluid of patients at the time of treatment and six months after. Clinically, it is demonstrated that PRP is effective in reducing bleeding episodes (p &lt; 0.001) and pain (p &lt; 0.0001) and improving the hemophilia joint health score (HJHS) (p &lt; 0.001) at one year of follow-up. Furthermore, our results demonstrate that PRP inhibits ET formation in vitro and reconstitutes the immune system\u2019s cellular components in the synovial fluid of patients after treatment. We conclude that PRP can be considered an effective, safe, and easy treatment for hemophilic synovitis.<\/jats:p>","DOI":"10.3390\/ijms25179140","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:16:24Z","timestamp":1724649384000},"page":"9140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies"],"prefix":"10.3390","volume":"25","author":[{"given":"Horacio","family":"Caviglia","sequence":"first","affiliation":[{"name":"Department of Medicine, Argentine Catholic University, Buenos Aires C1032ABS, Argentina"},{"name":"Haemophilia Foundation, Buenos Aires 3485, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-2430","authenticated-orcid":false,"given":"Mar\u00eda Eulalia","family":"Landro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Argentine Catholic University, Buenos Aires C1032ABS, Argentina"},{"name":"Haemophilia Foundation, Buenos Aires 3485, Argentina"},{"name":"Department of Traumatology, Juan A. Fern\u00e0ndez Hospital, Buenos Aires 3356, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-7587","authenticated-orcid":false,"given":"Paula","family":"Oneto","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine, Buenos Aires C1032ABS, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Cambiaggi","sequence":"additional","affiliation":[{"name":"Haemophilia Foundation, Buenos Aires 3485, Argentina"},{"name":"Department of Traumatology, Juan A. Fern\u00e0ndez Hospital, Buenos Aires 3356, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Galatro","sequence":"additional","affiliation":[{"name":"Haemophilia Foundation, Buenos Aires 3485, Argentina"},{"name":"Department of Traumatology, Juan A. Fern\u00e0ndez Hospital, Buenos Aires 3356, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2078-0272","authenticated-orcid":false,"given":"Micaela","family":"Berni","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-7337","authenticated-orcid":false,"given":"Laura","family":"Caliogna","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-8213","authenticated-orcid":false,"given":"Eugenio Antonio","family":"Carrera Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine, Buenos Aires C1032ABS, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Pasta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Argentine Catholic University, Buenos Aires C1032ABS, Argentina"},{"name":"Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/hae.14734","article-title":"Synovitis and joint health in patients with haemophilia: Statements from a European e-Delphi consensus study","volume":"29","author":"Mancuso","year":"2023","journal-title":"Haemophilia"},{"key":"ref_2","first-page":"1350","article-title":"Cartilage damage as a result of hemarthrosis in a human in vitro model","volume":"24","author":"Roosendaal","year":"1997","journal-title":"J. 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